Abstract
Patients with chronic liver diseases experience common psychiatric disorders and specific symptoms that have psychiatric and psychological implications. Thus, mental health-care professionals must understand both the inherent liver disease process and the mental health disorders that commonly co-occur with liver diseases. For some types of liver diseases (e.g., Wilson’s disease, hepatic porphyrias), the presenting features may be neuropsychiatric in nature, and clinicians should be aware of the common characteristics of these diseases. Additionally, certain psychiatric disorders are relatively common in patients with liver disease, such as addiction disorders and depression. Specific consideration of the severity of liver disease for pharmacotherapeutic management is required. Patients with liver disease face specific challenges in their daily functioning and with psychological stressors. Interventions tailored to these issues may be most effective. Patients’ complex health-care needs may be best provided through collaborative care models capitalizing on the expertise of multiple disciplines.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bell BP, Manos MM, Zaman A, Terrault N, Thomas A, Navarro VJ, et al. The epidemiology of newly diagnosed chronic liver disease in gastroenterology practices in the United States: results from population-based surveillance. Am J Gastroenterol. 2008;103(11):2727–36.
Davis GL, Albright JE, Cook SF, Rosenberg DM. Projecting future complications of chronic hepatitis C in the United States. Liver Transpl. 2003;9(4):331–8.
Goldberg D, Ditah IC, Saeian K, Lalehzari M, Aronsohn A, Gorospe EC, et al. Changes in the prevalence of hepatitis C virus infection, nonalcoholic steatohepatitis, and alcoholic liver disease among patients with cirrhosis or liver failure on the waitlist for liver transplantation. Gastroenterology. 2017;152(5):1090–9.
Younossi ZM, Otgonsuren M, Henry L, Venkatesan C, Mishra A, Erario M, et al. Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology. 2015;62(6):1723–30. https://doi.org/10.1002/hep.28123.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Monograph on cirrhosis. 2014. https://www.niddk.nih.gov/health-information/liver-disease/cirrhosis.
Organ Procurement and Transplantation Network. Data tables. Updated December 15, 2017. https://optn.transplant.hrsa.gov/data/.
Jinjuvadia R, Jinjuvadia C, Puangsricharoen P, Chalasani N, Crabb DW, Liangpunsakul S, et al. Concomitant psychiatric and nonalcohol-related substance use disorders among hospitalized patients with alcoholic liver disease in the United States. Alcohol Clin Exp Res. 2018;42(2):397–402.
Diehl AM. Alcoholic liver disease: natural history. Liver Transpl Surg. 1997;3(3):206–11.
Nielsen JK, Olafsson S, Bergmann OM, Runarsdottir V, Hansdottir I, Sigurdardottir R, et al. Lifetime drinking history in patients with alcoholic liver disease and patients with alcohol use disorder without liver disease. Scand J Gastroenterol. 2017;52(6–7):762–7.
DiMartini AF, Beresford TP. Alcoholism and liver transplantation. Curr Opin Organ Transplant. 1999;4(2):177–81.
DiMartini AF, Crone C, Dew MA. Alcohol and substance use in liver transplant patients. Clin Liver Dis. 2011;15(4):727–51.
Addolorato G, Mirijello A, Leggio L, Ferrulli A, Landolfi R. Management of alcohol dependence in patients with liver disease. CNS Drugs. 2013;27(4):287–99.
Beresford TP. Predictive factors for alcoholic relapse in the selection of alcohol-dependent persons for hepatic transplant. Liver Transpl Surg. 1997;3(3):280–91.
DiMartini AF, Dew MA, Javed L, Fitzgerald MG, Jain A, Day N. Pretransplant psychiatric and medical comorbidity of alcoholic liver disease patients who received liver transplant. Psychosomatics. 2004;45(6):517–23.
DiMartini A, Dew MA, Fitzgerald MG, Fontes P. Clusters of alcohol use disorders diagnostic criteria and predictors of alcohol use after liver transplantation for alcoholic liver disease. Psychosomatics. 2008;49(4):332–40.
Beresford TP, Wongngamnit N, Temple BA. Alcoholism: diagnosis and natural history in the context of medical disease. In: Neuberger J, DiMartini A, editors. Alcohol abuse and liver disease. Oxford: Wiley; 2015. p. 22–34.
Centers for Disease Control and Prevention. Hepatitis C FAQs for health professionals. 2018. https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm#section1.
Centers for Disease Control and Prevention. Hepatitis B FAQs for health professionals. 2018. https://www.cdc.gov/hepatitis/hbv/hbvfaq.htm#overview.
Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2007;45(2):507–39.
Fontana RJ, Hussain KB, Schwartz SM, Moyer CA, Su GL, Lok AS. Emotional distress in chronic hepatitis C patients not receiving antiviral therapy. J Hepatol. 2002;36(3):401–7.
Karaivazoglou K, Iconomou G, Triantos C, Hyphantis T, Thomopoulos K, Lagadinou M, et al. Fatigue and depressive symptoms associated with chronic viral hepatitis patients. Health-related quality of life (HRQOL). Ann Hepatol. 2010;9(4):419–27.
Modabbernia A, Poustchi H, Malekzadeh R. Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review. Hepat Mon. 2013;13(1):e8340.
Rifai MA, Gleason OC, Sabouni D. Psychiatric care of the patient with hepatitis C: a review of the literature. Prim Care Companion J Clin Psychiatry. 2010;12(6):PCC.09r00877. https://doi.org/10.4088/PCC.09r00877whi.
el-Serag HB, Kunik M, Richardson P, Rabeneck L. Psychiatric disorders among veterans with hepatitis C infection. Gastroenterology. 2002;123(2):476–82.
Golden J, O’Dwyer AM, Conroy RM. Depression and anxiety in patients with hepatitis C: prevalence, detection rates and risk factors. Gen Hosp Psychiatry. 2005;27(6):431–8.
Ozkan M, Corapcioglu A, Balcioglu I, Ertekin E, Khan S, Ozdemir S, et al. Psychiatric morbidity and its effect on the quality of life of patients with chronic hepatitis B and hepatitis C. Int J Psychiatry Med. 2006;36(3):283–97.
Quelhas R, Lopes A. Psychiatric problems in patients infected with hepatitis C before and during antiviral treatment with interferon-alpha: a review. J Psychiatr Pract. 2009;15(4):262–81.
Weinstein AA, Kallman Price J, Stepanova M, Poms LW, Fang Y, Moon J, et al. Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C. Psychosomatics. 2011;52(2):127–32.
Navines R, Castellvi P, Moreno-Espana J, Gimenez D, Udina M, Canizares S, et al. Depressive and anxiety disorders in chronic hepatitis C patients: reliability and validity of the Patient Health Questionnaire. J Affect Disord. 2012;138(3):343–51.
Altindag A, Cadirci D, Sirmatel F. Depression and health related quality of life in non-cirrhotic chronic hepatitis B patients and hepatitis B carriers. Neurosciences (Riyadh). 2009;14(1):56–9.
Modabbernia A, Ashrafi M, Malekzadeh R, Poustchi H. A review of psychosocial issues in patients with chronic hepatitis B. Arch Iran Med. 2013;16(2):114–22.
Ashrafi M, Modabbernia A, Dalir M, Taslimi S, Karami M, Ostovaneh MR, et al. Predictors of mental and physical health in non-cirrhotic patients with viral hepatitis: a case control study. J Psychosom Res. 2012;73(3):218–24.
Grant BF, Saha TD, Ruan WJ, Goldstein RB, Chou SP, Jung J, et al. Epidemiology of DSM-5 drug use disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. JAMA Psychiat. 2016;73(1):39–47.
Yovtcheva SP, Rifai MA, Moles JK, Van der Linden BJ. Psychiatric comorbidity among hepatitis C-positive patients. Psychosomatics. 2001;42(5):411–5.
Cheung RC. Epidemiology of hepatitis C virus infection in American veterans. Am J Gastroenterol. 2000;95(3):740–7.
Lansky A, Finlayson T, Johnson C, Holtzman D, Wejnert C, Mitsch A, et al. Estimating the number of persons who inject drugs in the United States by meta-analysis to calculate national rates of HIV and hepatitis C virus infections. PLoS One. 2014;9(5):e97596.
Banini BA, Sanyal AJ. Nonalcoholic fatty liver disease: epidemiology, pathogenesis, natural history, diagnosis, and current treatment options. Clin Med Insights Ther. 2016;8:75–84.
Demir M, Lang S, Steffen HM. Nonalcoholic fatty liver disease—current status and future directions. J Dig Dis. 2015;16(10):541–57.
Noureddin M, Zhang A, Loomba R. Promising therapies for treatment of nonalcoholic steatohepatitis. Expert Opin Emerg Drugs. 2016;21(3):343–57.
Elwing JE, Lustman PJ, Wang HL, Clouse RE. Depression, anxiety, and nonalcoholic steatohepatitis. Psychosom Med. 2006;68(4):563–9.
Stewart KE, Levenson JL. Psychological and psychiatric aspects of treatment of obesity and nonalcoholic fatty liver disease. Clin Liver Dis. 2012;16(3):615–29.
Marchesini G, Suppini A, Forlani G. NAFLD treatment: cognitive-behavioral therapy has entered the arena. J Hepatol. 2005;43(6):926–8.
Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology. 2014;60(2):715–35.
Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002;35(3):716–21.
Bajaj JS, Saeian K, Schubert CM, Hafeezullah M, Franco J, Varma RR, et al. Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test. Hepatology. 2009;50(4):1175–83.
Bajaj JS, Heuman DM, Sterling RK, Sanyal AJ, Siddiqui M, Matherly S, et al. Validation of EncephalApp, smartphone-based Stroop test, for the diagnosis of covert hepatic encephalopathy. Clin Gastroenterol Hepatol. 2015;13(10):1828–35.
Bémeur C, Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications. J Clin Exp Hepatol. 2014;4(2):141–50.
Ridley NJ, Draper B, Withall A. Alcohol-related dementia: an update of the evidence. Alzheimers Res Ther. 2013;5(1):3.
Thomson AD, Guerrini I, Marshall EJ. The evolution and treatment of Korsakoff’s syndrome: out of sight, out of mind? Neuropsychol Rev. 2012;22(2):81–92.
Galvin R, Bråthen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010;17(12):1408–18. https://doi.org/10.1111/j.1468-1331.2010.03153.x.
Dening TR, Berrios GE. Wilson’s disease. Psychiatric symptoms in 195 cases. Arch Gen Psychiatry. 1989;46(12):1126–34.
Levenson JL, editor The American Psychiatric Publishing textbook of psychosomatic medicine: psychiatric care of the medically ill. 2nd ed. Washington, DC: American Psychiatric Publishing; 2011.
Srinivas K, Sinha S, Taly AB, Prashanth LK, Arunodaya GR, Janardhana Reddy YC, et al. Dominant psychiatric manifestations in Wilson’s disease: a diagnostic and therapeutic challenge! J Neurol Sci. 2008;266(1–2):104–8. https://doi.org/10.1016/j.jns.2007.09.009.
Carta M, Mura G, Sorbello O, Farina G, Demelia L. Quality of life and psychiatric symptoms in Wilson’s Disease: the relevance of bipolar disorders. Clin Pract Epidemiol Ment Health. 2012a;8:102–9.
Carta MG, Sorbello O, Moro MF, Bhat KM, Demelia E, Serra A, et al. Bipolar disorders and Wilson’s disease. BMC Psychiatry. 2012b;12:52.
Bandmann O, Weiss KH, Kaler SG. Wilson’s disease and other neurological copper disorders. Lancet Neurol. 2015;14(1):103–13.
Crimlisk HL. The little imitator—porphyria: a neuropsychiatric disorder. J Neurol Neurosurg Psychiatry. 1997;62(4):319–28.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Porphyria. 2014. https://www.niddk.nih.gov/health-information/liver-disease/porphyria.
Tracy JA, Dyck PJ. Porphyria and its neurologic manifestations. Handb Clin Neurol. 2014;120:839–49.
Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu Rev Public Health. 2013;34:119–38.
Ewusi-Mensah I, Saunders JB, Williams R. The clinical nature and detection of psychiatric disorders in patients with alcoholic liver disease. Alcohol Alcohol. 1984;19(4):297–302.
Le Strat Y, Le Foll B, Dubertret C. Major depression and suicide attempts in patients with liver disease in the United States. Liver Int. 2015;35(7):1910–6.
Mullish BH, Kabir MS, Thursz MR, Dhar A. Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation. Aliment Pharmacol Ther. 2014;40(8):880–92.
Blaxter M, Cyster R. Compliance and risk-taking: the case of alcoholic liver disease. Sociol Health Illn. 1984;6(3):290–310.
Jonas DE, Garbutt JC, Amick HR, Brown JM, Brownley KA, Council CL, et al. Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2012;157(9):645–54.
Weinrieb RM, Van Horn DH, McLellan AT, Volpicelli JR, Calarco JS, Lucey MR. Drinking behavior and motivation for treatment among alcohol-dependent liver transplant candidates. J Addict Dis. 2001;20(2):105–19.
Weinrieb RM, Lucey MR. Treatment of addictive behaviors in liver transplant patients. Liver Transpl. 2007;13(11 Suppl 2):S79–82.
Bjornsson E, Olsson J, Rydell A, Fredriksson K, Eriksson C, Sjoberg C, et al. Long-term follow-up of patients with alcoholic liver disease after liver transplantation in Sweden: impact of structured management on recidivism. Scand J Gastroenterol. 2005;40(2):206–16.
Burra P, Lucey MR. Liver transplantation in alcoholic patients. Transpl Int. 2005;18(5):491–8.
Gedaly R, McHugh PP, Johnston TD, Jeon H, Koch A, Clifford TM, et al. Predictors of relapse to alcohol and illicit drugs after liver transplantation for alcoholic liver disease. Transplantation. 2008;86(8):1090–5.
Kodali S, Kaif M, Tariq R, Singal A. Alcohol relapse after liver transplantation for alcoholic cirrhosis—impact on liver graft and patient survival: a meta-analysis. Alcohol Alcohol. 2018;53(2):166-72. https://doi.org/10.1093/alcalc/agx098.
Pessione F, Ramond MJ, Peters L, Pham BN, Batel P, Rueff B, et al. Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis, smoking and abstinence. Liver Int. 2003;23(1):45–53.
Yates WR, LaBrecque DR, Pfab D. Personality disorder as a contraindication for liver transplantation in alcoholic cirrhosis. Psychosomatics. 1998;39(6):501–11.
Khan A, Tansel A, White DL, Kayani WT, Bano S, Lindsay J, et al. Efficacy of psychosocial interventions in inducing and maintaining alcohol abstinence in patients with chronic liver disease: a systematic review. Clin Gastroenterol Hepatol. 2016;14(2):191–202.e1–4.
Weinrieb RM, Van Horn DH, Lynch KG, Lucey MR. A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation. Liver Transpl. 2011;17(5):539–47.
Moriarty KJ, Platt H, Crompton S, Darling W, Blakemore M, Hutchinson S, et al. Collaborative care for alcohol-related liver disease. Clin Med (Lond). 2007;7(2):125–8.
DiMartini AF, Dew MA. Monitoring alcohol use on the liver transplant wait list: therapeutic and practical issues. Liver Transpl. 2012;18(11):1267–9.
Crowley P. Long-term drug treatment of patients with alcohol dependence. Aust Prescr. 2015;38(2):41–3.
Falk DE, Yi HY, Hiller-Sturmhofel S. An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Res Health. 2006;29(3):162–71.
Bataller R. Time to ban smoking in patients with chronic liver diseases. Hepatology. 2006;44(6):1394–6.
Kolly P, Knopfli M, Dufour JF. Effect of smoking on survival of patients with hepatocellular carcinoma. Liver Int. 2017;37(11):1682–7.
Bentzley BS, Barth KS, Back SE, Book SW. Discontinuation of buprenorphine maintenance therapy: perspectives and outcomes. J Subst Abus Treat. 2015;52:48–57.
Koch M, Banys P. Liver transplantation and opioid dependence. JAMA. 2001;285(8):1056–8.
Parfieniuk A, Flisiak R. Role of cannabinoids in chronic liver diseases. World J Gastroenterol. 2008;14(40):6109–14.
Patsenker E, Stickel F. Cannabinoids in liver diseases. Clin Liver Dis. 2016;7(2):21–5.
Hézode C, Zafrani ES, Roudot-Thoraval F, Costentin C, Hessami A, Bouvier-Alias M, et al. Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C. Gastroenterology. 2008;134(2):432–9.
Ishida JH, Peters MG, Jin C, Louie K, Tan V, Bacchetti P, et al. Influence of cannabis use on severity of hepatitis C disease. Clin Gastroenterol Hepatol. 2008;6(1):69–75.
Tam J, Liu J, Mukhopadhyay B, Cinar R, Godlewski G, Kunos G. Endocannabinoids in liver disease. Hepatology. 2011;53(1):346–55.
Adejumo AC, Alliu S, Ajayi TO, Adejumo KL, Adegbala OM, Onyeakusi NE, et al. Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: a cross-sectional study. PLoS One. 2017;12(4):e0176416.
Brunet L, Moodie EE, Rollet K, Cooper C, Walmsley S, Potter M, et al. Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis. Clin Infect Dis. 2013;57(5):663–70.
Magen I, Avraham Y, Berry E, Mechoulam R. Endocannabinoids in liver disease and hepatic encephalopathy. Curr Pharm Des. 2008;14(23):2362–9.
Schrot RJ, Hubbard JR. Cannabinoids: Medical implications. Ann Med. 2016;48(3):128–41.
Wilkinson ST, D’Souza DC. Problems with the medicalization of marijuana. JAMA. 2014;311(23):2377–8.
Rogal SS, Bielefeldt K, Wasan AD, Lotrich FE, Zickmund S, Szigethy E, et al. Inflammation, psychiatric symptoms, and opioid use are associated with pain and disability in patients with cirrhosis. Clin Gastroenterol Hepatol. 2015;13(5):1009–16.
Silberbogen AK, Janke EA, Hebenstreit C. A closer look at pain and hepatitis C: preliminary data from a veteran population. J Rehabil Res Dev. 2007;44(2):231–44.
Whitehead AJ, Dobscha SK, Morasco BJ, Ruimy S, Bussell C, Hauser P. Pain, substance use disorders and opioid analgesic prescription patterns in veterans with hepatitis C. J Pain Symptom Manag. 2008;36(1):39–45.
Imani F, Motavaf M, Safari S, Alavian SM. The therapeutic use of analgesics in patients with liver cirrhosis: a literature review and evidence-based recommendations. Hepat Mon. 2014;14(10):e23539.
Rogal SS, Bielefeldt K, Wasan AD, Szigethy E, Lotrich F, DiMartini AF. Fibromyalgia symptoms and cirrhosis. Dig Dis Sci. 2015b;60(5):1482–9.
Riley TR 3rd, Koch K. Characteristics of upper abdominal pain in those with chronic liver disease. Dig Dis Sci. 2003;48(10):1914–8.
Rogal SS, Winger D, Bielefeldt K, Szigethy E. Pain and opioid use in chronic liver disease. Dig Dis Sci. 2013;58(10):2976–85.
Fouad YM, Makhlouf MM, Khalaf H, Mostafa Z, Abdel Raheem E, Meneasi W. Is irritable bowel syndrome associated with chronic hepatitis C? J Gastroenterol Hepatol. 2010;25(7):1285–8.
Dirchwolf M, Ruf AE. Role of systemic inflammation in cirrhosis: from pathogenesis to prognosis. World J Hepatol. 2015;7(16):1974–81.
Acharya C, Betrapally NS, Gillevet PM, Sterling RK, Akbarali H, White MB, et al. Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis. Aliment Pharmacol Ther. 2017;45(2):319–31.
Randall HB, Alhamad T, Schnitzler MA, Zhang Z, Ford-Glanton S, Axelrod DA, et al. Survival implications of opioid use before and after liver transplantation. Liver Transpl. 2017;23(3):305–14.
Adedoyin A, Branch RA. Pharmacokinetics. In: Zakim D, Boyer TD, editors. Hepatology: a textbook of liver disease. 3rd ed. Philadelphia: WB Saunders; 1996. p. 307–22.
Blaschke TF. Protein binding and kinetics of drugs in liver diseases. Clin Pharmacokinet. 1977;2(1):32–44.
DeSanty KP, Amabile CM. Antidepressant-induced liver injury. Ann Pharmacother. 2007;41(7):1201–11.
Russo MW, Watkins PB. Are patients with elevated liver tests at increased risk of drug-induced liver injury? Gastroenterology. 2004;126(5):1477–80.
Bailey DE Jr, Hendrix CC, Steinhauser KE, Stechuchak KM, Porter LS, Hudson J, et al. Randomized trial of an uncertainty self-management telephone intervention for patients awaiting liver transplant. Patient Educ Couns. 2017;100(3):509–17.
Singh N, Gayowski T, Wagener MM, Marino IR. Depression in patients with cirrhosis. Impact on outcome. Dig Dis Sci. 1997;42(7):1421–7.
Engle D. Psychosocial aspects of the organ transplant experience: what has been established and what we need for the future. J Clin Psychol. 2001;57(4):521–49.
Olbrisch ME, Benedict SM, Ashe K, Levenson JL. Psychological assessment and care of organ transplant patients. J Consult Clin Psychol. 2002;70(3):771–83.
Corbett C, Armstrong MJ, Parker R, Webb K, Neuberger JM. Mental health disorders and solid-organ transplant recipients. Transplantation. 2013;96(7):593–600.
Rogal SS, Dew MA, Fontes P, DiMartini AF. Early treatment of depressive symptoms and long-term survival after liver transplantation. Am J Transplant. 2013;13(4):928–35.
Stewart BJ, Turnbull D, Mikocka-Walus AA, Harley HA, Andrews JM. Acceptability of psychotherapy, pharmacotherapy, and self-directed therapies in Australians living with chronic hepatitis C. J Clin Psychol Med Settings. 2013;20(4):427–39.
Bajaj JS, Ellwood M, Ainger T, Burroughs T, Fagan A, Gavis EA, et al. Mindfulness-based stress reduction therapy improves patient and caregiver-reported outcomes in cirrhosis. Clin Transl Gastroenterol. 2017;8(7):e108.
Evon DM, Simpson K, Kixmiller S, Galanko J, Dougherty K, Golin C, et al. A randomized controlled trial of an integrated care intervention to increase eligibility for chronic hepatitis C treatment. Am J Gastroenterol. 2011;106(10):1777–86. https://doi.org/10.1038/ajg.2011.219.
Morana JG. Psychological evaluation and follow-up in liver transplantation. World J Gastroenterol. 2009;15(6):694–6.
Neri S, Bertino G, Petralia A, Giancarlo C, Rizzotto A, Calvagno GS, et al. A multidisciplinary therapeutic approach for reducing the risk of psychiatric side effects in patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin. J Clin Gastroenterol. 2010;44(9):e210–7. https://doi.org/10.1097/MCG.0b013e3181d88af5.
Sharif F, Mohebbi S, Tabatabaee HR, Saberi-Firoozi M, Gholamzadeh S. Effects of psycho-educational intervention on health-related quality of life (QOL) of patients with chronic liver disease referring to Shiraz University of Medical Sciences. Health Qual Life Outcomes. 2005;3:81.
Rizzo M, Creed F, Goldberg D, Meader N, Pilling S. A systematic review of non-pharmacological treatments for depression in people with chronic physical health problems. J Psychosom Res. 2011;71(1):18–27.
Grover S, Sarkar S. Liver transplant-psychiatric and psychosocial aspects. J Clin Exp Hepatol. 2012;2(4):382–92.
Gross CR, Kreitzer MJ, Thomas W, Reilly-Spong M, Cramer-Bornemann M, Nyman JA, et al. Mindfulness-based stress reduction for solid organ transplant recipients: a randomized controlled trial. Altern Ther Health Med. 2010;16(5):30–8.
Larson AM, Curtis JR. Integrating palliative care for liver transplant candidates: “too well for transplant, too sick for life”. JAMA. 2006;295(18):2168–76.
Wright L, Pape D, Ross K, Campbell M, Bowman K. Approaching end-of-life care in organ transplantation: the impact of transplant patients’ death and dying. Prog Transplant. 2007;17(1):57–61.
Baumann AJ, Wheeler DS, James M, Turner R, Siegel A, Navarro VJ. Benefit of early palliative care intervention in end-stage liver disease patients awaiting liver transplantation. J Pain Symptom Manag. 2015;50(6):882–6.
Lamba S, Murphy P, McVicker S, Harris Smith J, Mosenthal AC. Changing end-of-life care practice for liver transplant service patients: structured palliative care intervention in the surgical intensive care unit. J Pain Symptom Manag. 2012;44(4):508–19.
Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, et al. Collaborative care for patients with depression and chronic illnesses. N Engl J Med. 2010;363(27):2611–20.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Nash, R., Golden, E., Dew, M.A., DiMartini, A.F. (2019). Mental Health in Chronic and End-Stage Liver Disease. In: Sher, Y., Maldonado, J. (eds) Psychosocial Care of End-Stage Organ Disease and Transplant Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-94914-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-94914-7_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-94913-0
Online ISBN: 978-3-319-94914-7
eBook Packages: MedicineMedicine (R0)