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Do Vaccines Cause Narcolepsy?

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The Clinician’s Vaccine Safety Resource Guide

Abstract

The AS03-adjuvanted 2009 pandemic H1N1 influenza vaccine (trade name: PandemrixTM) was associated with an increased risk of narcolepsy in several northern European countries. In other countries where there is a lower prevalence of genetic factors associated with narcolepsy, studies did not find an increase in risk with this vaccine or other influenza vaccines. The vaccine in question (PandemrixTM) was not licensed in the United States, and vaccines in routine use in the United States32F have not been shown to cause narcolepsy.

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Notes

  1. 1.

    These conclusions do not consider vaccines recommended only for special populations in the United States such as Yellow Fever vaccine (international travelers) or Smallpox vaccine (military personnel).

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Authors and Affiliations

  1. Epidemiologist, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Matthew Z. Dudley PhD, MSPH

  2. Professor, Departments of International Health and Health, Behavior and Society, Director, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Daniel A. Salmon PhD, MPH

  3. Professor Emeritus, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Professor Emeritus, Department of Pediatrics, Johns Hopkins School of Medicine, Director Emeritus, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Neal A. Halsey MD

  4. Professor of Medicine, Pediatrics, Global Health, and Epidemiology, Emory University, Associate Director, Emory Vaccine Center, Director, Center of Excellence for Influenza Research and Surveillance (Emory-UGA CEIRS), Former President, National Foundation for Infectious Diseases (NFID), Atlanta, GA, USA

    Walter A. Orenstein MD, DSc (Hon)

  5. Associate Director for Behavioral Research, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Rupali J. Limaye PhD, MPH, MA

  6. Associate Professor, Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Denver, CO, USA

    Sean T. O’Leary MD, MPH

  7. William H. Foege Professor of Global Health, Professor of Epidemiology and Pediatrics, Emory University, Atlanta, GA, USA

    Saad B. Omer MBBS, PhD, MPH

Authors
  1. Matthew Z. Dudley PhD, MSPH
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  2. Daniel A. Salmon PhD, MPH
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  3. Neal A. Halsey MD
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  4. Walter A. Orenstein MD, DSc (Hon)
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  5. Rupali J. Limaye PhD, MPH, MA
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  6. Sean T. O’Leary MD, MPH
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  7. Saad B. Omer MBBS, PhD, MPH
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Dudley, M.Z. et al. (2018). Do Vaccines Cause Narcolepsy?. In: The Clinician’s Vaccine Safety Resource Guide. Springer, Cham. https://doi.org/10.1007/978-3-319-94694-8_46

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  • DOI: https://doi.org/10.1007/978-3-319-94694-8_46

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94693-1

  • Online ISBN: 978-3-319-94694-8

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