Skip to main content
SpringerLink
Log in

Principles of Soft Tissue Engineering for Craniomaxillofacial Reconstruction

  • Chapter
  • First Online:
Regenerative Strategies for Maxillary and Mandibular Reconstruction

  • 970 Accesses

Abstract

Craniomaxillofacial soft tissue reconstruction is necessary to restore tissue defects caused by trauma, diseases, tumor removal, or congenital abnormality. The use of autologous native tissue will cause a second morbidity to the patient, especially when a large native tissue is required to repair the defect. The application of autologous tissue-engineered devices becomes a logical therapeutic consideration. The recent successful identification of oral and skin stem/progenitor cells and the improvement of scaffolds make it possible to manufacture various types of soft tissue-engineered devices and provide surgeons the materials to restore different areas of soft tissue defects. For craniomaxillofacial soft tissue reconstruction, we should consider esthetics and function in addition to merely anatomical tissue restoration. The ex vivo manufacture and post-manufacture manipulation of the tissue-engineered devices to create a custom-designed product before implantation into a recipient are important to achieve these goals. In this chapter, we report and discuss the concepts and protocols for craniomaxillofacial soft tissue reconstruction with special emphasis on tissue engineering functional human lips.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ơbrien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today. 2011;14:88–95.

    Article  Google Scholar 

  2. Steel MP, Roessler BJ. Compliance with good manufacturing practices for facilities engaged in vector production, cell isolation, and genetic manipulations. Curr Opin Biotechnol. 1999;10:295–7.

    Article  CAS  Google Scholar 

  3. Izumi K, Song J, Feinberg SE. Development of a tissue-engineered human oral mucosa: from the bench to the bed side. Cells Tissues Organs. 2004;176:134–52.

    Article  Google Scholar 

  4. Izumi K, Takacs G, Terashi H, Feinberg SE. Ex vivo development of a composite human oral mucosal equivalent. J Oral Maxillofac Surg. 1999;57:571–7.

    Article  CAS  Google Scholar 

  5. Kuo S, Zhou Y, Kim HM, Kato H, Kim RY, Bayar GR, Marcelo CL, Kennedy RT, Feinberg SE. Biochemical indicators of implantation success of tissue-engineered oral mucosa. J Dent Res. 2015;94:78–84.

    Article  CAS  Google Scholar 

  6. Kuo S, Kim HM, Wang Z, Bingham EL, Miyazawa A, Marcelo CL, Feinberg SE. Comparison of two decellularized dermal equivalents. J Tissue Eng Regen Med. 2017;12:983. https://doi.org/10.1002/term.2530.

    Article  CAS  PubMed  Google Scholar 

  7. Izumi K, Neiva RF, Feinberg SE. Intraoral grafting of tissue-engineered human oral mucosa. Int J Oral Maxillofac Implants. 2013;28:e295–303.

    Article  Google Scholar 

  8. Squier CA, Kremer MJ. Biology of oral mucosa and esophagus. J Natl Cancer Inst Monogr. 2001;2001(29):7–15.

    Article  Google Scholar 

  9. Calenic B, Ishkitiev N, Yaegaki K, Imai T, Kumazawa Y, Nasu M, Hirata T. Magnetic separation and characterization of keratinocyte stem cells from human gingiva. J Periodontal Res. 2010;45:703–8.

    Article  CAS  Google Scholar 

  10. Calenic B, Greabu M, Caruntu C, Tanase C, Battino M. Oral keratinocyte stem/progenitor cells: specific markers, molecular signaling pathways and potential uses. Periodontol. 2015;69:68–82.

    Article  Google Scholar 

  11. Izumi K, Tobita T, Feinberg SE. Isolation of human oral keratinocyte progenitor/stem cells. J Dent Res. 2007;86:341–6.

    Article  CAS  Google Scholar 

  12. Trempus CS, Morris RJ, Bortner CJ, Cotsarelis G, Faircloth RS, Reece JM, Tennant RW. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol. 2003;120:501–11.

    CAS  PubMed  Google Scholar 

  13. Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008;40:1291–9.

    Article  CAS  Google Scholar 

  14. Webb A, Li A, Kaur P. Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation. 2004;72:387–95.

    Article  Google Scholar 

  15. Metral E, Bechetoille N, Demarne F, Rachidi W, Damour O. α6 Integrin (α6 high)/transferrin receptor (CD71) low keratinocyte stem cells are more potent for generating reconstructed skin epidermis than rapid adherent cells. Int J Mol Sci. 2017;18:282. https://doi.org/10.3390/ijms18020282.

    Article  CAS  PubMed Central  Google Scholar 

  16. Peramo A, Marcelo CL, Feinberg SE. Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction. Tissue Eng Part C Methods. 2012;18:273–82.

    Article  CAS  Google Scholar 

  17. Bayar GR, Kuo S, Marcelo CL, Feinberg SE. In vitro development of a mucocutaneous junction for lip reconstruction. J Oral Maxillofac Surg. 2016;74:2317–26.

    Article  Google Scholar 

  18. Kim RY, Bae SS, Feinberg SE. Soft tissue engineering. Oral Maxillofac Surg Clin North Am. 2017;29:89–104.

    Article  Google Scholar 

  19. Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. PNAS. 2011;108:7950–5.

    Article  CAS  Google Scholar 

  20. Marcelo CL, Peramo A, Ambati A, Feinberg SE. Characterization of a unique technique for culturing primary adult human epithelial progenitor/“stem cells”. BMC Dermatol. 2012;12:8. https://doi.org/10.1186/1471-5945-12-8.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Peramo A, Feinberg SF, Marcelo CL. Characterization of cultured epithelial cells using a novel technique not requiring enzymatic digestion for subculturing. Cell Tissue Bank. 2013;14:423–35.

    Article  CAS  Google Scholar 

  22. Spector M. Tissue engineering. In: Basic principles of tissue engineering, chap. 1. Chicago: Quintessence; 1999.

    Google Scholar 

  23. Evans DM. Facial reconstruction after a burn injury using two circumferential radial forearm flaps, and a dorsalis pedis flap for the nose. Br J Plast Surg. 1995;48:471–6.

    Article  CAS  Google Scholar 

  24. Pribaz JJ, Fine N, Orgill DP. Flap prefabrication in the head and neck: a 10-year experience. Plast Reconstr Surg. 1999;103:808–20.

    Article  CAS  Google Scholar 

  25. Pribaz JJ, Weiss DD, Mulliken JB, Eriksson E. Prelaminated free flap reconstruction of complex central facial defects. Plast Reconstr Surg. 1999;104:357–365; discussion 366-367.

    Article  CAS  Google Scholar 

  26. Teot L, Cherenfant E, Otman S, Giovannini UM. Prefabricated vascularized supraclavicular flaps for face resurfacing after postburns scarring. Lancet. 2000;355:1695–6.

    Article  CAS  Google Scholar 

  27. Guo L, Pribaz JJ. Clinical flap prefabrication. Plast Reconstr Surg. 2009;124:e340.

    Article  CAS  Google Scholar 

  28. Vranckx JJ, Delaere P, Vanderpoorten V. Prefabrication and prelamination procedures for larynx and tracheal reconstruction. Paper presented at Fourth Congress of the World Society for Reconstructive Microsurgery, Buenos Aires, Argentina, 23–25 October 2005. 2005.

    Google Scholar 

  29. Vranckx JJ, Delaere P, Vanderpoorten V. Prefabrication and prelamination procedures for larynx and tracheal reconstruction. Paper presented at 17th Congress of the European Association of Plastic Surgeons, Istanbul, Turkey, 25–28 May 2006. 2006.

    Google Scholar 

  30. Faria JC, Scopel GP, Alonso N, Ferreira MC. Muscle transplants for facial reanimation: rationale and results of insertion technique using the palmaris longus tendon. Ann Plast Surg. 2009;63:148–52.

    Google Scholar 

  31. Lew TA, Walker JA, Wenke JC, Blackbourne LH, Hale RG. Characterization of craniomaxillofacial battle injuries sustained by United States service members in the current conflicts of Iraq and Afghanistan. J Oral Maxillofac Surg. 2010;68:3–7.

    Google Scholar 

  32. Izumi K, Feinberg SE, Terashi H, Marcelo CL. Evaluation of transplanted tissue-engineered oral mucosa equivalents in severe combined immunodeficient mice. Tissue Eng. 2003;9:163–74.

    Article  Google Scholar 

  33. Huang H-L, Hsing H-W, Lai T-C, Chen Y-W, Lee T-R, Chan H-T, Lyu P-C, Wu C-L, Lu Y-C, Lin S-T, Lin C-W, Lai C-H, Chang H-T, Chou H-C, Chan H-L. Trypsin-induced proteome alteration during cell subculture in mammalian cells. J Biomed Sci. 2010;17:36. https://doi.org/10.1186/1423-0127-17-36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgment

We would like to thank our colleagues, Dr. Cynthia Marcelo, Dr. Hiroko Kato, Eve Bingham, and James Washington, for their contributions to our projects presented in this manuscript. Dr. Feinberg’s laboratory was supported by NIH grants R01 DE 019431 and R01 DE 013417 and the Department of Defense grants W81XWH-08-2-0034, W81XWH-12-2-0057, and W81XWH-13-2-0052.

Author information

Author notes

  1. Author contributed equally with all other contributors.Shiuhyang Kuo and Atsuko Miyazawa

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University of Michigan Health System, Ann Arbor, MI, USA

    Shiuhyang Kuo, Atsuko Miyazawa & Stephen E. Feinberg

Authors
  1. Shiuhyang Kuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsuko Miyazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen E. Feinberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen E. Feinberg .

Editor information

Editors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center Department of Oral and Maxillofacial Surgery, Oral, Head & Neck Oncology and Micro-vascular Reconstructive Surgery, Houston, TX, USA

    James C. Melville

  2. Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center Department of Oral and Maxillofacial Surgery, Oral, Head & Neck Oncology and Micro-vascular Reconstructive Surgery, Houston, TX, USA

    Jonathan W. Shum

  3. Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center Department of Oral and Maxillofacial Surgery, Houston, TX, USA

    Simon Young

  4. Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center Department of Oral and Maxillofacial Surgery, Houston, TX, USA

    Mark E. Wong

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kuo, S., Miyazawa, A., Feinberg, S.E. (2019). Principles of Soft Tissue Engineering for Craniomaxillofacial Reconstruction. In: Melville, J., Shum, J., Young, S., Wong, M. (eds) Regenerative Strategies for Maxillary and Mandibular Reconstruction. Springer, Cham. https://doi.org/10.1007/978-3-319-93668-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-93668-0_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93667-3

  • Online ISBN: 978-3-319-93668-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation