Abstract
The prevalence of GERD is estimated to be between 10% and 20% in the Western world, with a higher predilection in developed countries. Obesity itself has been shown to be an independent risk factor for GERD, with an observed dose-response relationship between frequency of heartburn or regurgitation and higher BMI. A report of the US National Health and Education Survey (NHANES) found that approximately 66% of the US adult population is either overweight or obese, with this number on the rise annually. Roughly 5% of the total global health-care cost is allocated toward treating obese patients, as there is clearly a rising economic burden associated with obesity. The direct health-care costs associated with GERD in all patient populations are estimated to be around $9–$10 billion annually. Indirect costs such as decrease in work productivity, disability, and absent workdays should also be considered. Given the limited effectiveness of lifestyle modifications and medications, bariatric surgery has been shown to be the only modality with long-term sustained weight loss, reduction in morbidity, and improvement in all-cause mortality.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.
El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol. 2005;100(6):1243–50.
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–55.
Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.
Sandler RS, Everhart JE, Donowitz M, Adama E, Cronin K, Goodman C, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122(5):1500–11.
Shaheen NJ, Hansen RA, Morgan DR, Gangarosa LM, Ringel Y, Thiny MT, et al. The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol. 2006;101(9):2128–38.
Swedish Obese Subjects Study Scientific Group, Sjöström L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Varlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.
Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.
Puzziferri N, Roshek TB III, Mayo HG, Gallagher R, Belle SH, Livingston EH. Long-term follow-up after bariatric surgery: a systematic review. JAMA. 2014;312(9):934–42.
Vaezi MF, Brill JV, Mills MR, Bernstein BB, Ness RM, Richards WO, et al. An episode payment framework for gastroesophageal reflux disease. Gastroenterology. 2016;150(4):1019–25.
Poelmans J, Tack J. Extraoesophageal manifestations of gastro-oesophageal reflux. Gut. 2005;54(10):1492–9.
Trus TL, Hunter JG. Minimally invasive surgery of the esophagus and stomach. Am J Surg. 1997;173(3):242–55.
Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143(3):199–211.
Wilson LJ, Ma W, Hirschowitz BI. Association of obesity with hiatal hernia and esophagitis. Am J Gastroenterol. 1999;94(10):2840–4.
Jung HS, Choi MG, Baeg MK, Lim CH, Kim JS, Cho YK, et al. Obesity is associated with increasing esophageal acid exposure in korean patients withgastroesophageal reflux disease symptoms. J Neurogastroenterol Motil. 2013;19(3):338–43.
Fass R. The pathophysiological mechanism of GERD in the obese patient. Dig Dis Sci. 2008;53:2300–6.
Fornari F, Madalosso CA, Farré R, Gurski RR, Thiesen V, Callegari-Jacques SM. The role of gastro-oesophageal pressure gradient and sliding hiatal hernia on pathological gastro-oesophageal reflux in severely obese patients. Eur J Gastroenterol Hepatol. 2010;22:404–11.
De Vries DR, Van Herwaarden MA, Smout AJ, Samsom M. Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with hiatal hernia, body mass index, and esophageal acid exposure. Am J Gastroenterol. 2008;103:1349–54.
Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006;130:639–49.
Roman S, Pandolfino JE. Environmental – lifestyle related factors. Best Pract Res Clin Gastroenterol. 2010;24:847–59.
Tosato F, Marano S, Mattachione S, Luongo B, Paltrinieri G, Mingarelli V, et al. Surgical treatment of gastroesophageal reflux disease. In: Advances in endoscopic surgery: InTech; 2011;1:259–90.
Pandolfino JE, Shi G, Trueworthy B, Kahrilas PJ. Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects. Gastroenterology. 2003;125:1018–24.
Devendran N, Chauhan N, Armstrong D, Upton AR, Kamath MV. GERD and obesity: is the autonomic nervous system the missing link? Crit Rev Biomed Eng. 2014;42(1):17–24. Review.
Dobrek L, Nowakowski M, Sygula A, Lipczynski A, Barylak H, Herman RM, et al. 24-hour heart rate variability in patients with gastroesophageal reflux disease. Folia Med Cracov. 2005;46(1–2):53–64.
Blevins CH, Shama AN, Johnson ML, Geno D, Gupta M, Bharucha AE, et al. Influence of reflux and central obesity on intercellular space diameter of esophageal squamous epithelium. United European Gastroenterol J. 2016;4(2):177–83.
He F, Peng J, Deng XL, et al. Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier. Cytokine. 2012;59:264–72.
Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011;73:283–309.
Close H, Mason JM, Wilson D, Hungin AP. Hormone replacement therapy is associated with gastro-oesophageal reflux disease: a retrospective cohort study. BMC Gastroenterol. 2012;12:56.
Khan A, Kim A, Sanossian C, Francois F. Impact of obesity treatment on gastroesophageal reflux disease. World J Gastroenterol. 2016;22(4):1627–38.
Nahata M, Saegusa Y, Harada Y, Tsuchiya N, Hattori T, Takeda H. Changes in ghrelin-related factors in gastroesophageal reflux disease in rats. Gastroenterol Res Pract. 2013;2013:504816.
Rubenstein JH, Morgenstern H, McConell D, Scheiman JM, Schoenfeld P, Appelman H, et al. Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett’s esophagus. Gastroenterology. 2013;145:1237–44. e1–5.
Abdelkader NA, Montasser IF, Bioumy EE, Saad WE. Impact of anthropometric measures and serum leptin on severity of gastroesophageal reflux disease. Dis Esophagus. 2015;28:691–8.
Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, et al. Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups. J Gastroenterol. 2011;46:1361–7.
American Gastroenterological Association. GERD care pathway. Gastroenterology. 2016;150(4):1026–30.
ASGE Standards of Practice Committee, Muthusamy VR, Lightdale JR, Acosta RD, Chandrasekhara V, Chathadi KV, et al. The role of endoscopy in the management of GERD. Gastrointest Endosc. 2015;81(6):1305–10.
Moayyedi P, Talley FMB, Vakil N. Can the clinical history distinguish between organic and functional dyspepsia? JAMA. 2006;295:1566–76.
Numans ME, Lau J, de Wit NJ, Bonis PA. Short-term treatment with proton pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med. 2004;140:518–27.
Kahrilas PJ, Shaheen NJ, Vaezi MF, Hiltz SW, Black E, Modlin IM, et al. American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease. Gastroenterology. 2008;35:1383–91; 1391.e1–5.
Sonnenberg A, Delcò F, El-Serag HB. Empirical therapy versus diagnostic tests in gastroesophageal reflux disease: a medical decision analysis. Dig Dis Sci. 1998;43(5):1001–8.
Ates F, Vaezi MF. New approaches to management of PPI-refractory gastroesophageal reflux disease. Curr Treat Options Gastroenterol. 2014;12(1):18–33.
Johnsson F, Joelsson B, Gudmundsson K, Greiff L. Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease. Scand J Gastroenterol. 1987;22(6):714–8.
Patti MG, Diener U, Tamburini A, Molena D, Way LW. Role of esophageal function tests in diagnosis of gastroesophageal reflux disease. Dig Dis Sci. 2001;46(3):597–602.
Ravi K, Katzka DA. Esophageal impedance monitoring: clinical pearls and pitfalls. Am J Gastroenterol. 2016;111:1245–56.
Vaezi MF. Diagnosing gastroesophageal reflux disease with endoscopic-guided mucosal impedance. Gastroenterol Hepatol (N Y). 2016;12(4):266–8.
Saritas Yuksel E, Higginbotham T, Slaughter JC, Mabary J, Kavitt RT, Garrett CG, et al. Use of direct, endoscopicguided measurements of mucosal impedance in diagnosis of gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012;10(10):1110–6.
Ates F, Yuksel ES, Higginbotham T, Slaughter JC, Mabary J, Kavitt RT, et al. Mucosal impedance discriminates GERD from non-GERD conditions. Gastroenterology. 2015;148(2):334–43.
Stefanidis D, Hope WW, Kohn GP, Reardon PR, Richardson WS, Fanelli RD. Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc. 2010;24:2647–69.
Moore M, Afaneh C, Benhuri D, Antonacci C, Abelson J, Zarnegar R. Gastroesophageal reflux disease: a review of surgical decision making. World J Gastrointest Surg. 2016;8(1):77–83.
Brethauer S. ASMBS position statement on preoperative supervised weight loss requirements. Surg Obes Relat Dis. 2011;7(3):257–60.
Kim JJ, Rogers AM, Ballem N, Schirmer B. American Society for Metabolic and Bariatric Surgery Clinical Issues Committee SMBS updated position statement on insurance mandated preoperative weight loss requirements. Surg Obes Relat Dis. 2016;12(5):955–9.
Sauerland S, Angrisani L, Belachew M, Chevallier JM, Favretti F, Finer N, et al. Obesity surgery: evidence-based guidelines of the European Association for Endoscopic Surgery (EAES). Surg Endosc. 2005;19:200–21.
Anderson MA, Gan SI, Fanelli RD, Baron TH, Banerjee S, Cash BD, et al. Role of endoscopy in the bariatric surgery patient. Gastrointest Endosc. 2008;68:1–10.
De Palma GD, Forestieri P. Role of endoscopy in the bariatric surgery of patients. World J Gastroenterol. 2014;20(24):7777–84.
Sharaf RN, Weinshel EH, Bini EJ, Rosenberg J, Sherman A, Ren CJ. Endoscopy plays an important preoperative role in bariatric surgery. Obes Surg. 2004;14:1367–72.
Kuper MA, Kratt T, Kramer KM, Zdichavsky M, Schneider JH, Glatzle J, et al. Effort, safety, and findings of routine preoperative endoscopic evaluation of morbidly obese patients undergoing bariatric surgery. Surg Endosc. 2010;24(8):1996–2001.
Azagury D, Dumonceau JM, Morel P, Chassot G, Huber O. Preoperative work-up in asymptomatic patients undergoing rouxen-Y gastric bypass: is endoscopymandatory? Obes Surg. 2006;16:1304–11.
Mong C, Van Dam J, Morton J, Gerson L, Curet M, Banerjee S. Preoperative endoscopic screening for laparoscopic roux-en-Y gastric bypass has a low yield for anatomic findings. Obes Surg. 2008;18:1067–73.
Zanotti D, Elkalaawy M, Hashemi M, Jenkinson A, Adamo M. Current status of preoperative oesophago-gastro-duodenoscopy (OGD) in bariatric NHS units – a BOMSS survey. Obes Surg. 2016;26:2257–62.
Bennett S, Gostimir M, Shorr R, Mallick R, Mamazza J, Neville A. The role of routine preoperative upper endoscopy in bariatric surgery: a systematic review and meta-analysis. Surg Obes Relat Dis. 2016;12(5):1116–25.
DuPree CE, Blair K, Steele SR, Martin MJ. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surg. 2014;149:328–34.
Chiu S, Birch DW, Shi X, et al. Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review. Surg Obes Relat Dis. 2011;7:510–5.
Padwal R, Klarenbach S, Wiebe N, Birch D, Karmali S, Manns B, et al. Bariatric surgery: a systemic review and network meta-analysis of randomized trials. Obes Rev. 2011;12:602–21.
Hutter MM, Schirmer BD, Jones DB, Ko CY, Cohen ME, Merkow RP, et al. First report from the American College of Surgeons bariatric center network: laparoscopic sleeve gastrectomy has morbidity and effectiveness positioned between the band and bypass. Ann Surg. 2011;254:410–20.
Zhang N, Maffei A, Cerabona T, Pahuja A, Omena J, Kaul A. Reduction in obesity-related comorbidities: is gastric bypass better than sleeve gastrectomy? SurgEndosc. 2013;27:1273–80.
Vakil N, Talley N, van Zanten SV, Flook N, Persson T, Bjorck E, et al. Cost of detecting malignant lesions by endoscopy in 2741 primary care dyspeptic patients without alarm symptoms. Clin Gastroenterol Hepatol. 2009;7(7):756–61.
Madhok BM, Carr WR, McCormack C, Boyle M, Jennings N, Schroeder N, et al. Preoperative endoscopy may reduce the need for revisional surgery for gastro-oesophageal reflux disease following laparoscopic sleeve gastrectomy. Clin Obes. 2016;6(4):268–72.
Gómez V, Bhalla R, Heckman MG, Florit PT, Diehl NN, Rawal B, et al. Routine screening endoscopy before bariatric surgery: is it necessary? Bariatric Surg Pract Patient Care. 2014;9(4):143–9.
Che F, Nguyen B, Cohen A, Nguyen NT. Prevalence of hiatal hernia in the morbidly obese. Surg Obes Relat Dis. 2013;9(6):920–4.
Sharaf RN, Weinshel EH, Bini EJ, Rosenberg J, Ren CJ. Radiologic assessment of the upper gastrointestinal tract: does it play an important preoperative role in bariatric surgery? Obes Surg. 2004;14:313–7.
Rosenthal RJ, Diaz AA, Arvidsson D, et al. International sleeve gastrectomy expert panel consensus statement: best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis. 2012;8:8–19.
Boeckxstaens GE. Review article: the pathophysiology of gastroesophageal reflux disease. Aliment Pharmacol Ther. 2007;15(26):149–60.
Nelson LG, Gonzalez R, Haines K, Gallagher SF, Murr MM. Amelioration of gastroesophageal reflux symptoms following Roux – en –Y gastric bypass for clinically significant obesity. Am Surg. 2005;71:950–3.
Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25:1822–32.
Santonicola A, Angrisani L, et al. The effect of laparoscopic sleeve gastrectomy with or without hiatal hernia repair on gastroesophageal reflux disease in obese patients. Surg Obes Relat Dis. 2014;10:250–6.
Iannelli A, Sans A, Martini F. Hiatal hernia, GERD and Sleeve gastrectomy: a complex interplay. Obes Surg. 2016;26(10):2485–7.
Lyon A, et al. Gastroesophageal reflux in laparoscopic sleeve gastrectomy: hiatal findings and their management influence outcomes. Surg Obes Releat Dis. 2015;11:530–7.
Mahawar, et al. Simultaneous sleeve gastrectomy and hiatus hernia repair: a systematic review. Obes Surg. 2015;25:159–66.
Gibson SC, et al. Laparoscopic sleeve gastrectomy: review of 500 cases in single surgeon Australian. ANZ J Surg. 2013;85:673–7.
Chaudhry UI, Marr BM, Osayi SN, Mikami DJ, Needleman BJ, Melvin WS, Perry KA. Laparoscopic Roux-en-Y gastric bypass for treatment of symptomatic paraesophageal hernia in the morbidly obese: medium-term results. Surg Obes Relat Dis. 2014;10(6):1063–7. https://doi.org/10.1016/j.soard.2014.02.004. Epub 2014 Feb 10
Pham DV, Protyniak B, Binenbaum SJ, Squillaro A, Borao FJ. Simultaneous laparoscopic paraesophageal hernia repair and sleeve gastrectomy in the morbidly obese. Surg Obes Relat Dis. 2014;10(2):257–61. https://doi.org/10.1016/j.soard.2013.08.003. Epub 2013 Aug 23.
Pescarus R, Reavis KM, Swanstorm LL. Gastroesophageal reflux disease in the bariatric population: when is a laparoscoic sleeve gastrectomy the right choice? Surg Obes Relat Dis: Off J Am Soc Bariatric Surg. 2014;10(5):1012.
Rebecchi F, Allaix ME, Giaccone C, Ugliono E, Scozzari G, Morino M. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiophathologic evaluation. Ann Surg. 2014;260(5):909–14; discussion 914 – 905.
Bonavina L, De Meester T, Fockens P, et al. Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one – and 2 year results of a feasibility trial. Ann Surg. 2010;252(5):857–62.
Asti E, Bonitta G, Lovece A, Lazzari V, Bonavina L. Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation: Observational cohort study with propensity score analysis. Medicine (Baltimore). 2016;95(30):e4366.
Desart K, Rossidis G, Michel M, Lux T, Ben-David K. Gastroesophageal reflux management with the LINX® system for gastroesophageal reflux disease following laparoscopic sleeve gastrectomy. J Gastrointest Surg. 2015;19(10):1782–6. https://doi.org/10.1007/s11605-015-2887-z. Epub 2015 Jul 11.
Hawasli A. Laparoscpic management of reflux after roux en Y gastric bypass using the Linx system and repair of hiatal hernia: a case report. Surg Obes Relat Dis. 2016;12:e51–4.
Juan A, Largacha M. Lower esophageal magnetic sphincter augmentation for persistent reflux after roux en y gastric bypass. Obes Surg. 2016;26:464–6.
Csendes A, Burdiles P, Rojas J, et al. Pathological gastroesophageal reflux in patients with severe , morbid and hyper obesity. Rev Med Chil. 2001;129:1038–43.
Varela JE, Hinojosa MW, Nguyen NT. Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disese. Surg Obes Relat Dis. 2009;5:139–43.
Kemdrich ML, Houghton SG. Gastreesophageal reflux disease in obese patients: the role of obesity in management. Dis Esophagus. 2006;19:57–63.
Gomez Escudero O, Herrera Hernandez MF, Valdovinos Diaz MA. Obesity and gastreesophageal reflux disease. Rev Invest Clin. 2002;54:320–7.
Friedenberg FK, Xanthopolous M, Foster GD, et al. The associatioin between gastroesophageal reflux disese and obesity. AM J Gaasstroenterol. 2008;103:2111–22.
Csendes A, Burgos AM, Smok G, Henriquez A, et al. Effect of gastric bypass on Barrett’s esophagus and intestinal metaplasia of cardia in patietns with morbid obesity. J Gastrointest Surg. 2006;10:259.
Pereira N, Csendes A, Smok G, et al. Effect of gastric bypass on Barrett’s esophagus in patients with morbid obesity. Rev Chil Cir. 2012;64:155–60.
Gagner M. Is sleeve gastrectomy always an absolute contraindication in patients with Barrett’s? Obes Surg. 2016;26:715–7.
Rebecchi F, Allaix ME, Giaccone C, Uglino E, Scozzari G, Morino M. Gastreesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiolophathologic evaluation. Ann Surg. 2014;260:909–14.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Payne, I.C., Berry, A.C., Richards, W.O. (2018). Gastroesophageal Reflux Disease. In: Lutfi, R., Palermo, M., Cadière, GB. (eds) Global Bariatric Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-93545-4_39
Download citation
DOI: https://doi.org/10.1007/978-3-319-93545-4_39
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-93544-7
Online ISBN: 978-3-319-93545-4
eBook Packages: MedicineMedicine (R0)