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The Evidence for and Against Parathyroid Cryopreservation: Should We Continue to Promote Parathyroid Cryopreservation?

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Difficult Decisions in Endocrine Surgery

Abstract

Permanent hypoparathyroidism is a rare, yet life-altering complication of thyroid and parathyroid surgery. However, the advent of parathyroid cryopreservation, and subsequent autotransplantation of parathyroid tissue, revolutionized the management of this devastating complication. However, cryopreservation of parathyroid tissue is not widely performed due to the rarity of utilization, the potential high costs, and need for specialized expertise. Furthermore, studies have shown that the viability of the parathyroid tissue is diminished after 2 years, raising more debate about need for cryopreservation. In this chapter, we evaluate data justifying and contradicting the practice of parathyroid cryopreservation.

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References

  1. Flechner SM, Berber E, Askar M, Stephany B, Agarwal A, Milas M. Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient. Am J Transplant. 2010;10:2061–5.

    Article  CAS  PubMed  Google Scholar 

  2. Larrad Jiménez A, Hernández Hernández JR. Parathyroid transplantation. Endocrinología y Nutrición (English Edition). 2013;60(4):161–3.

    Article  Google Scholar 

  3. Caccitolo JA, Farley DR, van Heerden JA, Grant CS, Thompson GB, Sterioff S. The current role of parathyroid cryopreservation and autotransplantation in parathyroid surgery: an institutional experience. Surgery. 1997;122:1062–7.

    Article  CAS  PubMed  Google Scholar 

  4. Cohen MS, Dilley WG, Wells SA Jr, et al. Long-term functionality of cryopreserved parathyroid autografts: a 13-year prospective analysis. Surgery. 2005;138:1033–40.

    Article  PubMed  Google Scholar 

  5. Guerrero MA. Cryopreservation of parathyroid glands. Int J Endocrinol. 2010.

    Google Scholar 

  6. Wells SA Jr, Ellis GJ, Gunnells JC, et al. Parathyroid autotransplantation in primary parathyroid hyperplasia. N Engl J Med. 1976;295:57–62.

    Article  PubMed  Google Scholar 

  7. Wells SA Jr, Farndon JR, Dale JK, Leight GS, Dilley WG. Long-term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation. Ann Surg. 1980;192:451–8.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Agarwal A, Waghray A, Gupta S, Sharma R, Milas M. Cryopreservation of parathyroid tissue: an illustrated technique using the Cleveland Clinic protocol. J Am Coll Surg. 2013;216(1):e1–9.

    Article  PubMed  Google Scholar 

  9. Schneider R, Ramaswamy A, Slater EP, Bartsch DK, Schlosser K. Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense? World J Surg. 2012;36(11):2598–604.

    Article  PubMed  Google Scholar 

  10. Herrera M, Grant C, van Heerden JA, Fitzpatrick LA. Parathyroid autotransplantation. Arch Surg. 1992;127:825–9.

    Article  CAS  PubMed  Google Scholar 

  11. Saxe AW, Spiegel AM, Marx SJ, Brenman MF. Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery. Arch Surg. 1982;117(5):538–43.

    Article  CAS  PubMed  Google Scholar 

  12. Brennan MF, Brown EM, Sears HF, Aurbach GD. Human parathyroid cryopreservation: in vitro testing of function by parathyroid hormone release. Ann Surg. 1978;187(1):87–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Guerrero MA, Evans DB, Lee JE, et al. Viability of cryopreserved parathyroid tissue: when is continued storage versus disposal indicated? World J Surg. 2008;32:836–9.

    Article  PubMed  Google Scholar 

  14. Wagner PK, Seesko HG, Rothmund M. Replantation of cryopreserved human parathyroid tissue. World J Surg. 1991;15(6):751–5.

    Article  CAS  PubMed  Google Scholar 

  15. Feldman AL, Sharaf RN, Skarulis MC, et al. Results of heterotopic parathyroid autotransplantation: a 13-year experience. Surgery. 1999;126:1042–8.

    Article  CAS  PubMed  Google Scholar 

  16. Saxe A. Parathyroid transplantation: a review. Surgery. 1984;95:507–26.

    PubMed  CAS  Google Scholar 

  17. Wagner PK, Rumpelt HJ, Krause U, Rothmund M. The effect of cryopreservation on hormone secretion in vitro and morphology of human parathyroid tissue. Surgery. 1986;99:257–64.

    PubMed  CAS  Google Scholar 

  18. Wells SA Jr, Gunnells JC, Shelburne JD. Transplantation of the parathyroid glands in man: clinical indications and results. Surgery. 1975;78:34–44.

    PubMed  Google Scholar 

  19. Borot S, Lapierre V, Carnaille B, Goudet P, Penfornis A. Results of cryopreserved parathyroid autografts: a retrospective multicenter study. Surgery. 2010;147(4):529–35.

    Article  PubMed  Google Scholar 

  20. Herrera MF, Grant CS, Van Heerden JA, Jacobsen D, Weaver A, Fitzpatrick LA. The effect of cryopreservation on cell viability and hormone secretion in human parathyroid tissue. Surgery. 1992;112:1096–102.

    PubMed  CAS  Google Scholar 

  21. Shepet K, Alhefdhi A, Usedom R, Sippel R, Chen H. Parathyroid cryopreservation after parathyroidectomy: a worthwhile practice? Ann Surg Oncol. 2013;20(7):2256–60.

    Article  PubMed  PubMed Central  Google Scholar 

  22. U.S. Preventive Services Task Force Ratings. Strength of recommendations and quality of evidence. Guide to clinical preventive services, third edition: periodic updates. Rockville: Agency for Healthcare Research and Quality; 2000–2003.

    Google Scholar 

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Correspondence to Marlon A. Guerrero .

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Samuel, S., Guerrero, M.A. (2018). The Evidence for and Against Parathyroid Cryopreservation: Should We Continue to Promote Parathyroid Cryopreservation?. In: Angelos, P., Grogan, R. (eds) Difficult Decisions in Endocrine Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-92860-9_22

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  • DOI: https://doi.org/10.1007/978-3-319-92860-9_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92858-6

  • Online ISBN: 978-3-319-92860-9

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