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Polymeric Micelles

  • Living reference work entry
  • First Online:
Functional Biopolymers

Part of the book series: Polymers and Polymeric Composites: A Reference Series ((POPOC))

Abstract

Polymeric micelles (PM) are means of novel drug carriers for poorly soluble hydrophobic drugs. Outer shell of polymeric micelles is hydrophilic in nature which further led these carriers to stay longer in blood and can accumulate in tumor-specific region due to their smaller size through enhanced permeation and retention (EPR) effect. The polymeric micelles can also be modified through different ligand to achieve active targeting of drugs. Polymeric micelles can be synthesized and prepared through different self-assembly methods. These can be used to improve solubility, residence time of drug in blood, and inhibition of efflux pump, to enhance pharmacokinetic parameters, and to achieve sustained release of drugs at target site without any side effects in an efficient manner. These types of novel drug delivery systems are aimed to enhance the efficacy and reduce the side effects of anticancer drugs in an efficient way. The present chapter highlights the structure, methods of preparation, the micellar architecture, and the role of these carriers in the anticancer drugs.

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Abbreviations

(mPEG-b-p(HPMAm-lactate):

(Poly(ethyleneglycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]

(PEG-b-PPhe):

poly(ethylene glycol)-block-poly(phenylalanine)

(Vitamin E TPGS2k):

D-α-Tocopheryl polyethylene glycol succinate 2000

ABC:

Accelerated blood clearance

ATP:

Adenosine triphosphate

BCS:

Biopharmaceutics classification system

CMC:

Critical micelle concentration

DMF:

Dimethylformamide

DOX:

Doxorubicin

DSC:

Differential scanning calorimetric

EPR:

Enhanced permeability and retention

GIT:

Gastro-intestinal tract

mPEG-PDLLA:

monomethoxy poly(ethylene glycol)-block-poly (D,L-lactide)

MPS:

Mononuclear phagocyte system

MRI:

Magnetic resonance imaging

NMR:

Nuclear magnetic resonance

PCL:

Poly ϵ-caprolactone

PEO:

poly(ethylene oxide)

pHPMAmDL-b-PEG:

poly(N-(2-hydroxypropyl) methacrylamide lactate) poly(ethylene glycol)

PLA:

Polylactic acid

PLL-PEG:

Poly-l-lysine-poly(ethylene glycol)

PM:

Polymeric micelles

ppm:

Parts per million

SEM:

Scanning electron microscopy

TEM:

Transmission electron microscopy

THF:

Tetrahydrofuran

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Acknowledgment

The authors are grateful and would like to acknowledge the University Grants Commission (UGC) New Delhi, India, and Science and Engineering Research Board (SERB), Department of Science and Technology (DST), New Delhi, India, for providing research funding to the corresponding author.

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Authors and Affiliations

  1. Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, India

    Iliyas Khan, Avinash Gothwal, Gaurav Mishra & Umesh Gupta

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  1. Iliyas Khan
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  2. Avinash Gothwal
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  3. Gaurav Mishra
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  4. Umesh Gupta
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Correspondence to Umesh Gupta .

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  1. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Mohammad Abu Jafar Mazumder

  2. McMaster University, Hamilton, ON, Canada

    Heather Sheardown

  3. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Amir Al-Ahmed

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Khan, I., Gothwal, A., Mishra, G., Gupta, U. (2018). Polymeric Micelles. In: Jafar Mazumder, M., Sheardown, H., Al-Ahmed, A. (eds) Functional Biopolymers. Polymers and Polymeric Composites: A Reference Series. Springer, Cham. https://doi.org/10.1007/978-3-319-92066-5_11-1

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  • DOI: https://doi.org/10.1007/978-3-319-92066-5_11-1

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