Abstract
Tracking of tissue oxygenation around chronic foot wounds may help direct therapy decisions in patients with peripheral artery disease (PAD). Novel sensing technology to enable such monitoring was tested over 9 months in a Sinclair mini-pig model. No adverse events were observed over the entire study period. Systemic and acute hypoxia challenges were detected during each measurement period by the microsensors. The median time to locate the sensor signal was 13 s. Lumee Oxygen microsensors appear safe for long-term repeated oxygen measurements over 9 months.
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Acknowledgments
This work was funded in part by R01EB016414, R42HL127933, R44HL134532, and R44HL131366 from the National Institutes of Health, W911NF-16-1-0341, W911NF-11-1-0119 and W31P4Q-12-C-0205 from the Defense Advanced Research Projects Agency and the U.S. Army Research Office. The authors would like to thank Lauren A. Russell and Sierra J. Guidry for pre-clinical support.
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Nichols, S.P., Balaconis, M.K., Gant, R.M., Au-Yeung, K.Y., Wisniewski, N.A. (2018). Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring. In: Thews, O., LaManna, J., Harrison, D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, vol 1072. Springer, Cham. https://doi.org/10.1007/978-3-319-91287-5_56
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