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Neuroophthalmologic Disease of the Retina

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Albert and Jakobiec's Principles and Practice of Ophthalmology

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Abstract

The retina is a unique part of the brain because it can be directly visualized in a clinical examination and imaged by a variety of methods. These attributes enable observation of diagnostic signs and anatomical consequences of blinding disease that affect the retina. Ischemia is the most common mechanism of acute visual dysfunction, and this chapter primarily addresses this entity. The reader is advised to refer to relevant chapters in this publication to obtain a more complete perspective on neuroophthalmic disease that affects the retina, including inflammatory retinopathies and degenerative retinopathies that are only sparingly covered or not discussed at all in this chapter.

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References

  1. Gowers W. Subjective visual sensations. Trans Ophthalmol Soc UK. 1895;15:1.

    Google Scholar 

  2. Spector R. Migraine. Surv Ophthalmol. 1984;29:193.

    Article  CAS  PubMed  Google Scholar 

  3. Hupp S, Kline L, Corbett J. Visual disturbances of migraine. Surv Ophthalmol. 1989;33:221.

    Article  CAS  PubMed  Google Scholar 

  4. O’Connor P, Tredici T. Acephalgic migraine: fifteen years experience. Ophthalmology. 1981;88:999.

    Article  PubMed  Google Scholar 

  5. Queiroz L, Rapoport A, Weeks R, et al. Characteristics of migraine visual aura. Headache. 1997;37:137–41.

    Article  CAS  PubMed  Google Scholar 

  6. Vincent M, Hadjikhani N. Migraine aura and related phenomena: beyond scotomata and scintillations. Cephalgia. 2007;27:1368–77.

    Article  CAS  Google Scholar 

  7. Olesen J, Edvinsson L. Migraine: a research field matured for the basic neurosciences. Trends Neurosci. 1991;14:3.

    Article  CAS  PubMed  Google Scholar 

  8. Leao A. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol. 1947;10:409–14.

    Article  CAS  PubMed  Google Scholar 

  9. Fisher C. Late-life migraine accompaniments as a cause of unexplained transient ischemic attacks. J Can Sci Neurol. 1980;7:9.

    CAS  Google Scholar 

  10. Wijeratne T, Tang HM, Crewther D, et al. Prevalence of migraine in the elderly: a narrated review. Neuroepidemiology. 2019;52:104.

    Article  PubMed  Google Scholar 

  11. Troost B, Mark L, Maroon J. Resolution of classic migraine after removal of an occipital lobe AVM. Ann Neurol. 1979;5:199.

    Article  CAS  PubMed  Google Scholar 

  12. Troost B, Newton T. Occipital lobe arteriovenous malformations: clinical and radiologic features in 26 cases with comments on the differentiation from migraine. Arch Ophthalmol. 1975;93:250.

    Article  CAS  PubMed  Google Scholar 

  13. Waltimo O, Hokkanen E, Pirskanen R. Intracranial arteriovenous malformations and headache. Headache. 1975;15:133.

    Article  CAS  PubMed  Google Scholar 

  14. Donders R. Clinical features of transient monocular blindness and the likelihood of artherosclerotic lesions of the internal carotid artery. J Neurol Neurosurg Psychiatry. 2001;71:247–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nakajima M, Kimura K, Minematsu K, et al. A case of frequently recurring amaurosis fugax with atherothrombotic ophthalmic artery occlusion. Neurology. 2004;62:117–8.

    Article  CAS  PubMed  Google Scholar 

  16. Pessin M, Duncan G, Mohr J, et al. Clinical and angiographic features of carotid transient ischemic attacks. N Engl J Med. 1977;296:358.

    Article  CAS  PubMed  Google Scholar 

  17. Volkers EJ, Donders R, Koudstaal P, et al. Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study. J Neurol. 2016;263:1771–7.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Fisher C. “Transient monocular blindness” versus “amaurosis fugax”. Neurology. 1989;39:1622.

    Article  CAS  PubMed  Google Scholar 

  19. Goodwin J, Gorelick P, Helgason C. Symptoms of amaurosis fugax in artherosclerotic carotid artery disease. Neurology. 1987;37:829.

    Article  CAS  PubMed  Google Scholar 

  20. Knox D. Ischemic ocular inflammation. Am J Ophthalmol. 1965;60:995.

    Article  CAS  PubMed  Google Scholar 

  21. Ross-Russell R, Ikeda H. Clinical and electrophysiological observations in patients with low pressure retinopathy. Br J Ophthalmol. 1986;70:651.

    Article  Google Scholar 

  22. Jacobs N, Ridgway A. Syndrome of ischaemic ocular inflammation: six cases and a review. Br J Ophthalmol. 1985;69:681.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Ros M, Magargal L, Hedges T, et al. Ocular ischemic syndrome: long-term ocular complications. Ann Ophthalmol. 1987;19:270.

    CAS  PubMed  Google Scholar 

  24. Michelson P, Knox D, Green W. Ischemic ocular inflammation: a clinicopathologic case report. Arch Ophthalmol. 1971;86:274.

    Article  CAS  PubMed  Google Scholar 

  25. Young L, Appen R. Ischemic oculopathy: a manifestation of carotid artery disease. Arch Neurol. 1981;38:358.

    Article  CAS  PubMed  Google Scholar 

  26. Carter J. Chronic ocular ischemia and carotid vascular disease. Stroke. 1985;16:721.

    Article  CAS  PubMed  Google Scholar 

  27. Duker J, Belmont J. Ocular ischemic syndrome secondary to carotid artery dissection. Am J Ophthalmol. 1988;106:750.

    Article  CAS  PubMed  Google Scholar 

  28. Cogan D. Blackouts not obviously due to carotid occlusion. Arch Ophthalmol. 1961;66:56.

    Article  Google Scholar 

  29. Hayreh S. Anterior ischaemic optic neuropathy: differentiation of arteritic from non-arteritic type and its management. Eye. 1990;4:25.

    Article  PubMed  Google Scholar 

  30. Plant G, Landau K. Thrombolysis for central retinal artery occlusion. J Neurol Neurosurg Psychiatry. 2005;76:159–60.

    Article  Google Scholar 

  31. Andreoli C, Leff G, Rizzo JI. Sneeze-induced visual and ocular motor dysfunction. Am J Ophthalmol. 2002;133:725–7.

    Article  PubMed  Google Scholar 

  32. Heckmann J, Harazny J. Vasospastic amaurosis fugax. J Neurol Neurosurg Psychiatry. 2003;74:149.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Fisher C. Observations of the fundus oculi in transient monocular blindness. Neurology. 1959;9:333.

    Article  CAS  PubMed  Google Scholar 

  34. Rizzo JI. The retina. In: Lesell S, van Dalen J, editors. Current neuro-ophthalmology. 2nd ed. St. Louis: Mosby-Year Book; 1990. p. 223.

    Google Scholar 

  35. Eddie M, Sutherland J, Tyrer J. Recurrent monocular blindness of uncertain cause. Lancet. 1968;1:319.

    Article  Google Scholar 

  36. Fisher C. Cerebral ischemia – less familiar types. Clin Neurosurg. 1970;18:267.

    Article  Google Scholar 

  37. Wray S. Visual aspects of extracranial internal carotid artery disease. In: Bernstein E, editor. Amaurosis fugax. New York: Springer; 1988. p. 81.

    Chapter  Google Scholar 

  38. Poole C, Ross Russell R, Harrison P, et al. Amaurosis fugax under the age of 40 years. J Neurol Neurosurg Psychiatry. 1987;50:81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Tippin J, Corbett J, Kerber R, et al. Amaurosis fugax and ocular infarction in adolescents and young adults. Ann Neurol. 1989;26:69.

    Article  CAS  PubMed  Google Scholar 

  40. Appleton R, Farrell K, Buncic J, et al. Amaurosis fugax in teenagers: a migraine variant. Am J Dis Child. 1988;142:2331.

    Article  Google Scholar 

  41. Fisher C. Migraine accompaniments versus arteriosclerotic ischemia. Trans Am Neurol Assoc. 1968;93:211.

    CAS  PubMed  Google Scholar 

  42. Lewis R, Vijayan N, Watson C, et al. Visual field loss in migraine. Ophthalmology. 1989;96:321.

    Article  CAS  PubMed  Google Scholar 

  43. Coppeto J, Lessell S, Sciarra R, et al. Vascular retinopathy in migraine. Neurology. 1986;36:267.

    Article  CAS  PubMed  Google Scholar 

  44. Raymond L, Kranias G, Glueck H, et al. Significance of scintillating scotoma of late onset. Surv Ophthalmol. 1980;25:107.

    Article  CAS  PubMed  Google Scholar 

  45. Rothrock J, Walicke P, Swenson M, et al. Migrainous stroke. Arch Neurol. 1988;45:63.

    Article  CAS  PubMed  Google Scholar 

  46. Dorfman L, Marshall W, Enzmann D. Cerebral infarction and migraine: clinical and radiologic correlations. Neurology. 1979;29:317.

    Article  CAS  PubMed  Google Scholar 

  47. Caplan L. Migraine and vertebrobasilar ischemia. Neurology. 1991;41:55.

    Article  CAS  PubMed  Google Scholar 

  48. Williams J, Baumbach G, Armstrong M, Heistad D. Hypothesis: vasoconstriction contributes to amaurosis fugax. J Cereb Blood Flow Metab. 1989;9:111.

    Article  CAS  PubMed  Google Scholar 

  49. Burger S, Saul R, Selhorst J, Thurston S. Transient monocular blindness caused by vasospasm. N Engl J Med. 1991;325:870.

    Article  CAS  PubMed  Google Scholar 

  50. Gorelick P. Stroke prevention. Arch Neurol. 1995;52:347.

    Article  CAS  PubMed  Google Scholar 

  51. Rothrock J, North J, Madden K, et al. Migraine and migrainous stroke: risk factors and prognosis. Neurology. 1993;43:2473.

    Article  CAS  PubMed  Google Scholar 

  52. Petitti D, Sidney S, Bernstein A, et al. Stroke in users of low-dose oral contraceptives. N Engl J Med. 1996;335:8.

    Article  CAS  PubMed  Google Scholar 

  53. Frishberg B. The utility of neuroimaging in the evaluation of headache in patients with normal neurologic examinations. Neurology. 1994;44:1191.

    Article  CAS  PubMed  Google Scholar 

  54. Walsh F, Hoyt W. Clinical neuro-ophthalmology. 3rd ed. Baltimore: Williams & Wilkins; 1969. p. 1670.

    Google Scholar 

  55. Lees F. The migrainous symptoms of cerebral angiomata. J Neurol Neurosurg Psychiatry. 1962;25:45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Pearee J, Foster J. An investigation of complicated migraine. Neurology. 1965;15:333.

    Article  Google Scholar 

  57. Featherstone H. Clinical features of stroke in migraine: a review. Headache. 1986;26:128.

    Article  CAS  PubMed  Google Scholar 

  58. Selby G, Lance J. Observations on 500 cases of migraine and allied vascular headache. J Neurol Neurosurg Psychiatry. 1960;23:23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Rizzo JI. Occult retinal and choroidal vascular disease. The value of timed and directed fluorescein angiography. Ophthalmology. 1993;100:1407.

    Article  PubMed  Google Scholar 

  60. Winterkorn J, Teman A. Recurrent attacks of amaurosis fugax treated with calcium channel blocker. Ann Neurol. 1991;30:423.

    Article  CAS  PubMed  Google Scholar 

  61. Winterkorn J, Kupersmith M, Wirtschafter J, Forman S. Brief report. Treatment of vasospastic amaurosis fugax with calcium-channel blockers. N Engl J Med. 1993;329:396.

    Article  CAS  PubMed  Google Scholar 

  62. Glaser JS. Neuro-ophthalmology. 2nd ed. Philadelphia: JB Lippincott; 1990.

    Google Scholar 

  63. Ellenberger C, Epstein A. Ocular complications of atherosclerosis: what do they mean? Semin Neurol. 1986;6:185.

    Article  PubMed  Google Scholar 

  64. Hurwitz B, Heyman A, Wilkinson W, et al. Comparison of amaurosis fugax and transient cerebral ischemia: a prospective clinical and arteriographic study. Ann Neurol. 1985;18:698.

    Article  CAS  PubMed  Google Scholar 

  65. Marshall J, Meadows S. The natural history of amaurosis fugax. Brain. 1968;91:419.

    Article  CAS  PubMed  Google Scholar 

  66. Parkin P, Kendall B, Marshall J, et al. Amaurosis fugax: some aspects of management. J Neurol Neurosurg Psychiatry. 1982;45:1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Poole C, Ross Russell R. Mortality and stroke after amaurosis fugax. J Neurol Neurosurg Psychiatry. 1985;48:902.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Harrison M, Marshall J. Prognostic significance of severity of carotid atheroma in early manifestations of cerebrovascular disease. Stroke. 1982;13:567.

    Article  CAS  PubMed  Google Scholar 

  69. Ross Russell R. Natural history of amaurosis fugax. In: Bernstein E, editor. Amaurosis fugax. New York: Springer; 1988. p. 174.

    Chapter  Google Scholar 

  70. Adams H, Putman S, Corbett J, et al. Amaurosis fugax: the results of arteriography in 59 patients. Stroke. 1983;14:742.

    Article  PubMed  Google Scholar 

  71. Bernstein E, Dilley R. Late results after carotid endarterectomy for amaurosis fugax. J Vasc Surg. 1987;6:333.

    Article  CAS  PubMed  Google Scholar 

  72. Harrison M. Angiography in amaurosis fugax. In: Bernstein E, editor. Amaurosis fugax. New York: Springer; 1988. p. 277.

    Google Scholar 

  73. Kvickstrom P, Lindblom B, Bergstrom G, et al. Amaurosis fugax – delay between symptoms and surgery by specialty. Clin Ophthalmol. 2016;10:2291–6.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Benavente O, Eliasziw M, Streifler J, et al. Prognosis after transient monocular blindness associated with carotid-artery stenosis. N Engl J Med. 2001;345:1084–90.

    Article  CAS  PubMed  Google Scholar 

  75. Hankey G, Slattery J, Warlow C. The prognosis of hospital-referred transient ischemic attacks. J Neurol Neurosurg Psychiatry. 1991;54:793–802.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Johansson E, Cuadrado-Godia E, Hayden D, et al. Recurrent stroke in symptomatic carotid stenosis awaiting revascularization. Neurology. 2016;86:498–504.

    Article  CAS  PubMed  Google Scholar 

  77. Lavallee P, Cabrejo L, Labreuche J, et al. Spectrum of transient visual symptoms in a transient ischemic attack cohort. Stroke. 2013;44:3312–7.

    Article  PubMed  Google Scholar 

  78. Biousse V, Nahab F, Newman NJ. Management of acute retinal ischemia. Ophthalmology. 2018;125:1597–607.

    Article  PubMed  Google Scholar 

  79. Easton J, Hart R, Sherman D, et al. Diagnosis and management of ischemic stroke. I: threatened stroke and its management. Curr Probl Cardiol. 1983;8:1.

    Article  CAS  PubMed  Google Scholar 

  80. Whisnant J, Wiebers D. Clinical epidemiology of transient cerebral ischemic attacks (TIA) in the anterior and posterior cerebral circulation. In: Sundt T, editor. Occlusive cerebrovascular disease: diagnosis and surgical management. Philadelphia: WB Saunders; 1987. p. 60.

    Google Scholar 

  81. Rokey R, Rolak L, Harati Y, et al. Coronary artery disease in patients with cerebrovascular disease: a prospective study. Ann Neurol. 1984;16:50.

    Article  CAS  PubMed  Google Scholar 

  82. Savino P, Glaser J, Cassady J. Retinal stroke: is the patient at risk? Arch Ophthalmol. 1977;95:1185.

    Article  CAS  PubMed  Google Scholar 

  83. Howard R, Ross Russell R. Prognosis of patients with retinal embolism. J Neurol Neurosurg Psychiatry. 1987;50:1142.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Pfaffenbach D, Hollenhorst R. Morbidity and survivorship of patients with embolic cholesterol crystallization in the ocular fundus. Am J Ophthalmol. 1973;75:66.

    Article  CAS  PubMed  Google Scholar 

  85. Singh N, Moody AR, Roifman I, et al. Advanced MRI for carotid plaque imaging. Int J Cardiovasc Imaging. 2016;32:83–9.

    Article  PubMed  Google Scholar 

  86. Motoyama R, Saito K, Tonomura S, et al. Utility of complementary magnetic resonance plaque imaging and contrast-enhanced ultrasound to detect carotid vulnerable plaques. J Am Heart Assoc. 2019;8:e011302. https://doi.org/10.1161/JAHA.118.011302.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Brinjikji W, Huston J III, Rabinstein A, et al. Contemporary carotid imaging: from degree of stenosis to plaque vulnerability. J Neurosurg. 2016;124:27–42.

    Article  CAS  PubMed  Google Scholar 

  88. Saba L, Anzidei M, Sanfilipo R, et al. Imaging of the carotid artery. Atherosclerosis. 2012;220:294–309.

    Article  CAS  PubMed  Google Scholar 

  89. Manninen AL, Isokangas JM, Karttunen A, et al. A comparison of radiation exposure between diagnostic CTA and DSA examinations of cerebral and cervicocerebral vessels. Am J Neuroradiol. 2012;33:2038–42.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Mouradian M, Wijmann C, Tomasian D, et al. Echocardiographic findings of patients with retinal ischemia or embolism. J Neuroimaging. 2002;12:219–23.

    Article  PubMed  Google Scholar 

  91. Di Tullio M, Sacco R, Gersony D, et al. Aortic atheromas and acute ischemic stroke: a transesophageal echocardiographic study in an ethnically mixed population. Neurology. 1996;46:1560.

    Article  PubMed  Google Scholar 

  92. Romano J, Babikian V, Wijman C, Hedges T. Retinal ischemia in aortic arch atheromatous disease. J Neuroophthalmol. 1998;18:237–41.

    Article  CAS  PubMed  Google Scholar 

  93. Sposato LA, Cipriano LE, Saposnik G, et al. Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol. 2015;14:377–87.

    Article  PubMed  Google Scholar 

  94. Babikian V, Wijman C, Koleini B, et al. Retinal ischemia and embolism. Etiologies and outcomes based on a prospective study. Cerebrovasc Dis. 2001;12:108–13.

    Article  CAS  PubMed  Google Scholar 

  95. Helenius J, Arsava E, Goldstein G, et al. Concurrent acute brain infarcts in patients with monocular visual loss. Ann Neurol. 2012;72(2):286–93.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Lee J, Kim SW, Lee SC, et al. Co-occurrence of acute retinal artery occlusion and acute ischemic stroke: diffusion-weighted magnetic resonance imaging study. Am J Ophthalmol. 2014;157:1231–8.

    Article  PubMed  Google Scholar 

  97. Lauda F, Neugebauer H, Reiber L, et al. Acute silent brain infarction in monocular visual loss of ischemic origin. Cerebrovasc Dis. 2015;40:151–6.

    Article  CAS  PubMed  Google Scholar 

  98. Rizzo JI. The retina. In: Lesell S, van Dalen J, editors. Current neuro-ophthalmology. 3rd ed. St. Louis: Mosby-Year Book; 1991. p. 237.

    Google Scholar 

  99. Petersen P, Boysen G, Godtfredsen J, et al. Placebo controlled, randomized trial of warfarin and aspirin for prevention of thromboembolic complications in chronic and atrial fibrillation: the Copenhagen AFASAK study. Lancet. 1989;1:175.

    Article  CAS  PubMed  Google Scholar 

  100. Petersen P, Boysen G. Prevention of stroke in atrial fibrillation. N Engl J Med. 1990;323:482.

    Google Scholar 

  101. Stroke Prevention in Atrial Fibrillation Study Group Investigators. Preliminary report of the stroke prevention in atrial fibrillation study. N Engl J Med. 1990;322:863.

    Article  Google Scholar 

  102. Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with non-rheumatic atrial fibrillation. N Engl J Med. 1990;323:1505.

    Article  Google Scholar 

  103. Chesbro J, Fuster V, Halperin J. Atrial fibrillation – risk marker for stroke. N Engl J Med. 1990;323:1556.

    Article  Google Scholar 

  104. Hobsob R, Weiss D, Fields W, et al. Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. N Engl J Med. 1993;328:221.

    Article  Google Scholar 

  105. Barnett HJM, Taylor DW, Eliasziw M, et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. N Engl J Med. 1999;339(20):1415–25.

    Article  Google Scholar 

  106. Boiten J, Rothwell PM, Slattery J, et al. Randomized trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ESCT). Lancet. 1998;351:1379–87.

    Article  Google Scholar 

  107. Orrapin S, Rerkasem L. Carotid endarterectomy for symptomatic carotid stenosis. Cochrane Database Syst Rev. 2017;6:CD001081. https://doi.org/10.1002/14651858.

    Article  CAS  PubMed  Google Scholar 

  108. Brott TG, Hobson RW II, Howard G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med. 2010;363:11–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Brott TG, Hobson RW II, Howard G, et al. Long-term results of stenting versus endarterectomy for carotid-artery stenosis. N Engl J Med. 2016;374:1021–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Kernan WN, Wilson JA, Ovbiagele B, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke. 2014;45:2160–236.

    Article  PubMed  Google Scholar 

  111. Geraghty P, Goodney PP, Brothers TE, et al. Preoperative symptom type influences the 30-day perioperative outcomes of carotid endarterectomy and carotid stenting in the Society for Vascular Surgery Vascular Registry. J Vasc Surg. 2014;60:639–44.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Antiplatelet Trialists’ Collaboration. Secondary prevention of vascular disease by prolonged anti-platelet treatment. Br Med J. 1988;296:320.

    Article  Google Scholar 

  113. Trobe J. Carotid endarterectomy: who needs it? Ophthalmology. 1987;94:725.

    Article  CAS  PubMed  Google Scholar 

  114. Jones S. Can carotid endarterectomy be justified? No. Arch Neurol. 1987;44:652.

    Article  Google Scholar 

  115. Committee on Health Care Issues, American Neurological Association. Does carotid endarterectomy decrease stroke and death in patients with transient ischemic attacks? Ann Neurol. 1987;22:72.

    Article  Google Scholar 

  116. Winslow C, Solomon D, Chassin M, et al. The appropriateness of carotid endarterectomy. N Engl J Med. 1988;318:721.

    Article  CAS  PubMed  Google Scholar 

  117. Patterson R. Can carotid endarterectomy be justified? Yes. Arch Neurol. 1987;44:651.

    Article  PubMed  Google Scholar 

  118. Hachinski V. Carotid endarterectomy. Arch Neurol. 1987;44:654.

    Article  CAS  PubMed  Google Scholar 

  119. Report of the American Academy of Neurology, Therapeutics and Technology Assessment Subcommittee. Interim assessment: carotid endarterectomy. Neurology. 1990;40:682.

    Article  Google Scholar 

  120. Rossouw J, Lewis B, Rifkind B, et al. The value of lowering cholesterol after myocardial infarction. N Engl J Med. 1990;323:1112.

    Article  CAS  PubMed  Google Scholar 

  121. Hypertension Detection and Follow-up Program Cooperative Group. Five year findings of the hypertensive detection and follow-up program. III: reduction in stroke incidence among persons with high blood pressure. JAMA. 1982;247:663.

    Google Scholar 

  122. Whelton P. Declining mortality from hypertension and stroke. South Med J. 1982;75:33.

    Article  CAS  PubMed  Google Scholar 

  123. Yatsu F, Fisher C. Atherosclerosis: current concepts on pathogenesis and interventional therapies. Ann Neurol. 1989;26:3.

    Article  CAS  PubMed  Google Scholar 

  124. Rothwell PM, Mehta Z, Giles MF, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischemic attack. Lancet. 2005;366:29–36.

    Article  CAS  PubMed  Google Scholar 

  125. Johnston SC, Sidney S, Rothwell PM, et al. Validation and refinement of scores to predict very early stroke risk after transient ischemic attack. Lancet. 2007;369:283–92.

    Article  PubMed  Google Scholar 

  126. Giles MF, Albers GW, Amarenco P, et al. Early stroke risk and ABCD2 score performance in tissue-vs time-defined TIA. Neurology. 2011;77:1222–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. Merwick A, Albers GW, Amarenco P, et al. Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after a transient ischemic attack: a multicenter observational study. Lancet Neurol. 2010;9:1060–9.

    Article  PubMed  Google Scholar 

  128. Kiyohara T, Kamouchi M, Kumai Y, et al. ABCD3 and ABCD3I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke. 2014;45:418–25.

    Article  PubMed  Google Scholar 

  129. Johnston CS, Gress DR, Browner WS, et al. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284:2901–6.

    Article  CAS  PubMed  Google Scholar 

  130. Reiffel J, Verma A, Kowey P, et al. Incidence of previously undiagnosed atrial fibrillation using insertable cardiac monitors in a high-risk population. JAMA Cardiol. 2017;2(10):1120–7.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Tsivgoulis G, Katsanos A, Mac Grory B, et al. Prolonged cardiac rhythm monitoring and secondary stroke prevention in patients with cryptogenic cerebral ischemia. Stroke. 2019;50:2175–80.

    Article  PubMed  Google Scholar 

  132. Scheinberg P. Controversies in the management of cerebral vascular disease. Neurology. 1988;38:1609.

    Article  CAS  PubMed  Google Scholar 

  133. Andaluz N, Zuccarello M. Place of drug therapy in the treatment of carotid stenosis. CNS Drugs. 2005;19:597–622.

    Article  CAS  PubMed  Google Scholar 

  134. Goldstein L, Bonito A, Matchar D, et al. US national survey of physician practices for the secondary and tertiary prevention of ischemic stroke. Design, service availability and common practice. Stroke. 1995;26:1607–15.

    Article  CAS  PubMed  Google Scholar 

  135. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet. 2001;9287:1033–41.

    Google Scholar 

  136. Skalen K, Gustafsson M, Rydberg E, et al. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature. 2002;417:750–4.

    Article  CAS  PubMed  Google Scholar 

  137. Tzourio C, Anderson C, Chapman N, et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med. 2003;163:1069–75.

    Article  CAS  PubMed  Google Scholar 

  138. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837–53. https://pubmed.ncbi.nlm.nih.gov/9742976/

  139. von Graefe A. Ueber Embolie der arteria centralis retinae als Ursache plotzlicher Erblindung. Arch Ophthalmol. 1859;5:136.

    Google Scholar 

  140. Hayreh S, Kolder H, Weingeist T. Central retinal artery occlusion and retinal tolerance time. Ophthalmology. 1980;87:75.

    Article  CAS  PubMed  Google Scholar 

  141. Hayreh S, Weingeist T. Experimental occlusion of the central artery of the retina. IV: retinal tolerance time to acute ischaemia. Br J Ophthalmol. 1980;64:818.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Lessell S, Miller J. Optic nerve and retina after experimental circulatory arrest. Investig Ophthalmol. 1975;14:146.

    Google Scholar 

  143. Hayreh S, Zimmerman M, Kimura A, Sanon A. Central retinal artery occlusion. Retinal survival time. Exp Eye Res. 2004;78:723–36.

    Article  CAS  PubMed  Google Scholar 

  144. Leavitt J, Larson T, Hodge D, et al. The incidence of central retinal artery occlusion in Olmsted County, Minnesota. Am J Ophthalmol. 2011;152(5):820–3.

    Article  PubMed  PubMed Central  Google Scholar 

  145. Locastro A, Novak K, Biglan A. Central retinal artery occlusion in a child after general anesthesia. Am J Ophthalmol. 1991;112:91.

    Article  CAS  PubMed  Google Scholar 

  146. Evans L, Van de Graaff W, Baker W, Trimble S. Central retinal artery occlusion after neck irradiation. Am J Ophthalmol. 1992;114:224.

    Article  CAS  PubMed  Google Scholar 

  147. Jumper J, Horton J. Central retinal artery occlusion after manipulation of the neck by a chiropractor. Am J Ophthalmol. 1996;121:321.

    Article  CAS  PubMed  Google Scholar 

  148. Brown G, Magargal L, Shields J, et al. Retinal arterial obstruction in children and young adults. Ophthalmology. 1981;88:18.

    Article  CAS  PubMed  Google Scholar 

  149. Greven C, Slusher M, Weaver R. Retinal arterial occlusions in young adults. Am J Ophthalmol. 1995;120:776.

    Article  CAS  PubMed  Google Scholar 

  150. Glacet-Bernard A, Bayani N, Chretein P, et al. Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. Arch Ophthalmol. 1994;112:790.

    Article  CAS  PubMed  Google Scholar 

  151. Coppeto J, Lessell S. Retinopathy in systemic lupus erythematosus. Arch Ophthalmol. 1977;95:794.

    Article  CAS  PubMed  Google Scholar 

  152. Wilson R, Ruiz R. Bilateral central retinal artery occlusion in homocystinuria: a case report. Arch Ophthalmol. 1969;82:267.

    Article  CAS  PubMed  Google Scholar 

  153. Sher N, Reiff W, Letson R, et al. Central retinal artery occlusion complicating Fabry’s disease. Arch Ophthalmol. 1978;96:815.

    Article  CAS  PubMed  Google Scholar 

  154. Jampol L, Wong A, Albert D. Atrial myxoma and central retinal artery occlusion. Am J Ophthalmol. 1973;75:242.

    Article  CAS  PubMed  Google Scholar 

  155. Silverman J, Olwin J, Graettinger J. Cardiac myxomas with systemic embolization. Circulation. 1962;26:99.

    Article  CAS  PubMed  Google Scholar 

  156. Sybers H, Boake W. Coronary and retinal embolism from left atrial myxoma. Arch Pathol. 1971;91:178.

    Google Scholar 

  157. Manschot W. Embolism of the central retinal artery originating from an endocardial myxoma. Am J Ophthalmol. 1959;48:381.

    Article  CAS  PubMed  Google Scholar 

  158. Cho N, Han H. Central retinal artery occlusion after varicella. Am J Ophthalmol. 1992;114:235.

    Article  CAS  PubMed  Google Scholar 

  159. Cohen R, Hedges T, Duker J. Central retinal artery occlusion in a child with T-cell lymphoma. Am J Ophthalmol. 1995;120:118.

    Article  CAS  PubMed  Google Scholar 

  160. Werner M, Latchaw R, Baker L, Wirtschafter J. Relapsing and remitting central retinal artery occlusion. Am J Ophthalmol. 1994;118:393.

    Article  CAS  PubMed  Google Scholar 

  161. Hayreh S, Zimmerman M. Central retinal artery occlusion: visual outcome. Am J Ophthalmol. 2005;140:376–91.

    Article  PubMed  Google Scholar 

  162. Perkins S, Magargal L, Augsburger J, et al. The idling retina: reversible visual loss in central retinal artery obstruction. Ann Ophthalmol. 1987;19:3.

    CAS  PubMed  Google Scholar 

  163. Duker J, Brown G. Recovery following acute obstruction of the retinal and choroidal circulations. Retina. 1988;8:257.

    Article  CAS  PubMed  Google Scholar 

  164. Brown G, Magargal L, Sergott R. Acute obstruction of the retinal and choroidal circulations. Ophthalmology. 1986;93:1373.

    Article  CAS  PubMed  Google Scholar 

  165. Brown G, Magargal L. Central retinal artery obstruction and visual acuity. Ophthalmology. 1982;89:14.

    Article  CAS  PubMed  Google Scholar 

  166. Appen R, Wray S, Cogan D. Central retinal artery occlusion. Am J Ophthalmol. 1975;79:374.

    Article  CAS  PubMed  Google Scholar 

  167. Karjalainen K. Occlusion of the central retinal artery and retinal branch arterioles: a clinical, tonographic and fluorescein angiographic study of 175 patients. Acta Ophthalmol. 1971;109:12.

    Google Scholar 

  168. Gold D. Retinal artery occlusions. Symposium: retinal vascular disease. Trans Am Acad Ophthalmol Otolaryngol. 1977;83:392.

    Google Scholar 

  169. McLeod D. Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts. Br J Ophthalmol. 2005;89:229–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  170. Velusami P, Doherty M, Gnanaraj L. A case of occult giant cell arteritis presenting with bilateral cotton wool spots. Eye. 2005;20:863–4.

    Article  PubMed  Google Scholar 

  171. Wilentz J, Chati Z, Krafft V, Amor M. Retinal embolization during carotid angioplasty and stenting: mechanisms and role of cerebral protection systems. Catheter Cardiovasc Interv. 2002;56:320–7.

    Article  PubMed  Google Scholar 

  172. Richards R. Simultaneous occlusion of the central retinal artery and vein. Trans Am Ophthalmol Soc. 1979;77:191.

    CAS  PubMed  PubMed Central  Google Scholar 

  173. Schaible E, Golnik K. Combined obstruction of the central retinal artery and vein associated with meningeal carcinomatosis. Arch Ophthalmol. 1993;111:1467.

    Article  CAS  PubMed  Google Scholar 

  174. Liversedge L, Smith V. Neuromedical and ophthalmic aspects of central retinal artery occlusion. Trans Ophthalmol Soc UK. 1962;82:571.

    CAS  PubMed  Google Scholar 

  175. Wisotsky B, Engel H. Transesophageal echocardiography in the diagnosis of branch retinal artery obstruction. Am J Ophthalmol. 1993;115:653.

    Article  CAS  PubMed  Google Scholar 

  176. Callizo J, Feltgen N, Pantenburg S, et al. Cardiovascular risk factors in central retinal artery occlusion. Ophthalmology. 2015;122:1881–8.

    Article  PubMed  Google Scholar 

  177. Augsburger J, Magargal L. Visual prognosis following treatment of acute central retinal obstruction. Br J Ophthalmol. 1980;64:913.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Ffytche T. A rationalization of treatment of central retinal artery occlusion. Trans Ophthalmol Soc UK. 1974;94:468.

    CAS  PubMed  Google Scholar 

  179. Atebara N, Brown G, Cater J. Efficacy of anterior chamber paracentesis and carbogen in treating acute nonarteritic central retinal artery occlusion. Ophthalmology. 1995;102:2029.

    Article  CAS  PubMed  Google Scholar 

  180. Arnold M, Koerner U, Remonda L, et al. Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. J Neurol Neurosurg Psychiatry. 2005;76:196–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  181. Feltgen N, Neubauer S, Jurklies B, et al. Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1. Graefes Arch Clin Exp Ophthalmol. 2005;22:1–7.

    Google Scholar 

  182. Pettersen J, Hill M, Demchuk A, et al. Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience. Can J Neurol Sci. 2005;32:507–11.

    Article  CAS  PubMed  Google Scholar 

  183. Chen C, Lee A, Campbell B, et al. Efficacy of intravenous tissue-type plasminogen activator in central retinal artery occlusion. Stroke. 2011;42:2229–34.

    Article  CAS  PubMed  Google Scholar 

  184. Schumacher M, Schmidt D, Jurklies B, et al. Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial. Ophthalmology. 2010;117:1367–75.

    Article  PubMed  Google Scholar 

  185. Taarnhoj N, Munch I, Kyvik K, et al. Heritability of cilioretinal arteries: a twin study. Invest Ophthalmol Vis Sci. 2005;46:3850–4.

    Article  PubMed  Google Scholar 

  186. Hayreh S. The cilioretinal arteries. Br J Ophthalmol. 1963;47:71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  187. Justice J, Lehmann R. Cilioretinal arteries. Arch Ophthalmol. 1976;94:1355.

    Article  PubMed  Google Scholar 

  188. Brown G, Shields J. Cilioretinal arteries and retinal arterial occlusion. Arch Ophthalmol. 1979;97:84.

    Article  CAS  PubMed  Google Scholar 

  189. Levy A. Obstruction of cilio-retinal artery. Trans Ophthalmol Soc UK. 1909;29:130.

    Google Scholar 

  190. Brown G, Moffatt K, Cruess A, et al. Cilioretinal artery obstruction. Retina. 1983;3:182.

    Article  CAS  PubMed  Google Scholar 

  191. Zentmayer W. Embolism of a cilioretinal artery. Ophthalmol Rec. 1906;15:613.

    Google Scholar 

  192. Krauss F. Embolism of the cilioretinal artery. Ophthalmol Rec. 1907;16:196.

    Google Scholar 

  193. Levitt J. Occlusion of the cilioretinal artery. Arch Ophthalmol. 1948;40:152.

    Article  CAS  Google Scholar 

  194. Brosnan D. Occlusion of a cilioretinal artery. Am J Ophthalmol. 1962;53:687.

    Article  CAS  PubMed  Google Scholar 

  195. Friedman M. Occlusion of the cilioretinal artery. Am J Ophthalmol. 1959;49:684.

    Article  Google Scholar 

  196. Perry H, Mallen F. Cilioretinal artery occlusion associated with oral contraceptives. Am J Ophthalmol. 1997;84:56.

    Article  Google Scholar 

  197. McLoed D. Central retinal vein occlusion with cilioretinal infarction from branch flow exclusion and arterial steal. Retina. 2009;29:1381–95.

    Article  Google Scholar 

  198. Bolling J, Buettner H. Acquired retinal arteriovenous communications in occlusive disease of the carotid artery. Ophthalmology. 1990;97:1148.

    Article  CAS  PubMed  Google Scholar 

  199. Kaiboriboon K, Piriyawat P, Selhorst J. Light-induced amaurosis fugax. Am J Ophthalmol. 2001;131:674–6.

    Article  CAS  PubMed  Google Scholar 

  200. Casson R, Fleming F, Shaikh A, James B. Bilateral ocular ischemic syndrome secondary to giant cell arteritis. Arch Ophthalmol. 2001;119:306–7.

    CAS  PubMed  Google Scholar 

  201. Worrall M, Atebara N, Meredith T, Mann E. Bilateral ocular ischemic syndrome in Takayasu disease. Retina. 2001;21:75–6.

    Article  CAS  PubMed  Google Scholar 

  202. Barletta J, Fanous M, Hamed L. Temporary blindness in the TUR syndrome. J Neuroophthalmol. 1994;14:6.

    Article  CAS  PubMed  Google Scholar 

  203. Manor R, Yassur Y, Hoyt W. Reading-evoked visual dimming. Am J Ophthalmol. 1996;121:212.

    Article  CAS  PubMed  Google Scholar 

  204. Silverman S, Bergman P, Bender M. The dynamics of transient cerebral blindness: report of nine episodes following vertebral angiography. Arch Neurol. 1961;4:333.

    Article  Google Scholar 

  205. Snebold N, Rizzo JI, Lessell S, et al. Transient visual loss in ornithine transcarbamoylase deficiency. Am J Ophthalmol. 1987;104:407.

    Article  CAS  PubMed  Google Scholar 

  206. Kosmorsky G, Rosenfeld S, Burde R. Transient monocular obscuration? Amaurosis fugax: a case report. Br J Ophthalmol. 1985;69:688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  207. Gilliam F, Wyllie E. Ictal amaurosis: MRI, EEG, and clinical features. Neurology. 1995;45:1619.

    Article  CAS  PubMed  Google Scholar 

  208. Teman A, Winterkorn J, Weiner D. Transient monocular blindness associated with sexual intercourse. N Engl J Med. 1995;333:393–4.

    Article  CAS  PubMed  Google Scholar 

  209. Creel D, Wang J, Wong K. Transient blindness associated with transurethral resection of the prostate. Arch Ophthalmol. 1987;105:1537.

    Article  CAS  PubMed  Google Scholar 

  210. Ross Russell R, Page N. Critical perfusion of brain and retina. Brain. 1983;106:419.

    Article  Google Scholar 

  211. Coppeto J, Wand M, Bear L, et al. Neovascular glaucoma and carotid artery obstructive disease. Am J Ophthalmol. 1985;99:567.

    Article  CAS  PubMed  Google Scholar 

  212. Sturrock G, Mueller H. Chronic ocular ishaemia. Br J Ophthalmol. 1984;68:716.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  213. Ruben J, Morris R, Judisch G. Chorioretinal degeneration in infantile malignant osteopetrosis. Am J Ophthalmol. 1990;110:1.

    Article  CAS  PubMed  Google Scholar 

  214. Van Damme H, Sakalihasan N, Limet R. Fibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review. Acta Chir Belg. 1999;99:163–8.

    Article  PubMed  Google Scholar 

  215. Gass J, Tiedeman J, Thomas M. Idiopathic recurrent branch retinal arterial occlusion. Ophthalmology. 1986;93:1148.

    Article  CAS  PubMed  Google Scholar 

  216. Johnson M, Thomley M, Huang S, Gass J. Idiopathic recurrent branch retinal arterial occlusion. Natural history and laboratory evaluation. Ophthalmology. 1994;101:480.

    Article  CAS  PubMed  Google Scholar 

  217. Delaney W, Torrisi P. Occlusive retinal vascular disease and deafness. Am J Ophthalmol. 1976;82:232.

    Article  PubMed  Google Scholar 

  218. Monteiro M, Swanson R, Coppeto J, et al. A microangiopathic syndrome of encephalopathy, hearing loss, and retinal arteriolar occlusions. Neurology. 1985;35:1113.

    Article  CAS  PubMed  Google Scholar 

  219. von Sallman L, Myers R, Lerner EI, et al. Vasculo-occlusive retinopathy in experimental allergic encephalomyelitis. Arch Ophthalmol. 1967;78:112.

    Article  Google Scholar 

  220. Coppeto J, Currie J, Monteiro M, et al. A syndrome of arterial-occlusive retinopathy and encephalopathy. Am J Ophthalmol. 1984;98:189.

    Article  CAS  PubMed  Google Scholar 

  221. Susac J. Susac’s syndrome: the triad of microangiopathy of the brain and retina with hearing loss in young women. Neurology. 1994;44:591.

    Article  CAS  PubMed  Google Scholar 

  222. Egan R, Ha Nguyen T, Gass J, et al. Retinal arterial wall plaques in Susac syndrome. Am J Ophthalmol. 2003;135:483–6.

    Article  PubMed  Google Scholar 

  223. Egan R. Diagnostic criteria and treatment algorithm for Susac syndrome. J Neuroophthalmol. 2019;39:60–7.

    Article  PubMed  Google Scholar 

  224. Susac J, Murtagh F, Egan R, et al. MRI findings in Susac’s syndrome. Neurology. 2003;61:1783–7.

    Article  CAS  PubMed  Google Scholar 

  225. White M, Zhang Y, Smoker W. Evolution of lesions in Susac syndrome at serial MR imaging with diffusion-weighted imaging and apparent diffusion coefficient values. AJNR Am J Neuroradiol. 2004;25:706–13.

    PubMed  PubMed Central  Google Scholar 

  226. Xu M, Tan C, Umapathi T, Lim C. Susac syndrome: serial diffusion-weighted MR imaging. Magn Reson Imaging. 2004;22:1295–8.

    Article  PubMed  Google Scholar 

  227. Li H, Dejean B, Tang R. Reversal of visual loss with hyperbaric oxygen treatment in a patient with Susac syndrome. Ophthalmology. 1996;103:2091.

    Article  CAS  PubMed  Google Scholar 

  228. Grand M, Kaine J, Fulling K, et al. Cerebroretinal vasculopathy: a new hereditary syndrome. Ophthalmology. 1988;95:649.

    Article  CAS  PubMed  Google Scholar 

  229. Sawyer R, Selhorst J, Zimmerman L, et al. Blindness caused by photoreceptor degeneration as a remote effect of cancer. Am J Ophthalmol. 1976;81:606.

    Article  CAS  PubMed  Google Scholar 

  230. Rizzo JI, Volpe N. Cancer-associated retinopathy. In: Pepose J, Holland G, Wilhelmus K, editors. Ocular infection and immunity. St. Louis: CV Mosby; 1996.

    Google Scholar 

  231. Rizzo JI, Gittinger J. Selective immunohistochemical staining in the paraneoplastic retinopathy syndrome. Ophthalmology. 1992;99:1286.

    Article  PubMed  Google Scholar 

  232. Aranow M, Adamus G, Abu-Asab M, et al. Paraneoplastic vitelliform retinopathy: clinicopathologic correlation and review of the literature. Surv Ophthalmol. 2012;57(6):558–64.

    Article  Google Scholar 

  233. Gordon L. Paraneoplastic syndromes in neuro-ophthalmology. J Neuroophthalmol. 2015;35:305–14.

    Article  Google Scholar 

  234. Kornguth S, Klein R, Appen R, et al. Occurrence of anti-retinal ganglion cell antibodies in patients with small cell carcinoma of the lung. Cancer. 1982;50:1289.

    Article  CAS  PubMed  Google Scholar 

  235. Kornguth S, Kalinke T, Grunwald G, et al. Anti-neurofilament antibodies in the sera of patients with small cell carcinoma of the lung and with visual paraneoplastic syndrome. Cancer Res. 1986;46:2588.

    CAS  PubMed  Google Scholar 

  236. Keltner J, Roth A, Chang R. Photoreceptor degeneration: possible autoimmune disorder. Arch Ophthalmol. 1983;101:564.

    Article  CAS  PubMed  Google Scholar 

  237. Buchanan T, Gardiner T, Archer D. An ultrastructural study of retinal photoreceptor degeneration associated with bronchial carcinoma. Am J Ophthalmol. 1984;97:277.

    Article  CAS  PubMed  Google Scholar 

  238. Klingele T, Burde R, Rappazzo J, et al. Paraneoplastic retinopathy. J Clin Neuroophthalmol. 1984;4:239.

    CAS  PubMed  Google Scholar 

  239. Grunwald G, Klein R, Simmonds M, et al. Autoimmune basis for visual paraneoplastic syndrome in patients with small cell lung carcinoma. Lancet. 1985;1:658.

    Article  CAS  PubMed  Google Scholar 

  240. Grunwald G, Kornguth S, Towfighi J, et al. Autoimmune basis for visual paraneoplastic syndrome in patients with small cell lung carcinoma. Cancer. 1987;60:780.

    Article  CAS  PubMed  Google Scholar 

  241. Thirkill C, Roth A, Keltner J. Cancer-associated retinopathy. Arch Ophthalmol. 1987;105:372.

    Article  CAS  PubMed  Google Scholar 

  242. Van Der Pol B, Planten J. A non-metastatic remote effect of lung carcinoma. Doc Ophthalmol. 1987;67:89.

    Article  PubMed  Google Scholar 

  243. Berson E, Lessell S. Paraneoplastic night blindness with malignant melanoma. Am J Ophthalmol. 1988;106:307.

    Article  CAS  PubMed  Google Scholar 

  244. Thirkill C, Fitzgerald P, Sergott R, et al. Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med. 1989;321:1589.

    Article  CAS  PubMed  Google Scholar 

  245. Jacobson D, Thirkill C, Tipping S. A clinical triad to diagnose paraneoplastic retinopathy. Ann Neurol. 1990;8:162.

    Article  Google Scholar 

  246. Nunez J, Velasco F, Fernandez-Tejerina J, et al. Degeneracion retiniana paraneoplasica. Med Clin. 1987;88:431.

    Google Scholar 

  247. Crofts J, Bachynski B, Odel J. Visual paraneoplastic syndrome associated with undifferentiated endometrial carcinoma. Can J Ophthalmol. 1988;23:128.

    CAS  PubMed  Google Scholar 

  248. Yamada G, Ohguro H, Aketa K, et al. Invasive thymoma with paraneoplastic retinopathy. Hum Pathol. 2003;34:717–9.

    Article  PubMed  Google Scholar 

  249. Suhler E, Chan C, Caruso R, et al. Presumed teratoma-associated paraneoplastic retinopathy. Arch Ophthalmol. 2003;121:133–7.

    Article  PubMed  Google Scholar 

  250. Dot C, Guigay J, Adamus G. Anti-á-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung. Am J Ophthalmol. 2005;139:746–7.

    Article  CAS  PubMed  Google Scholar 

  251. Jacobson D, Thirkill C. Paraneoplastic cone dysfunction: an unusual visual remote effect of cancer. Arch Ophthalmol. 1995;113:1580.

    Article  CAS  PubMed  Google Scholar 

  252. Dilraj S, Fishman G, Jampol L. Autoimmune retinopathy and antiretinal antibodies: a review. Retina. 2014;34:827–45.

    Article  CAS  Google Scholar 

  253. Remulla J, Rineda R, Gaudio A, Milam A. Cutaneous melanoma-associated retinopathy with retinal periphlebitis. Arch Ophthalmol. 1995;113:854.

    Article  CAS  PubMed  Google Scholar 

  254. Singh A, Milam A, Shields C, et al. Melanoma-associated retinopathy. Am J Ophthalmol. 1995;119:369.

    Article  CAS  PubMed  Google Scholar 

  255. Thirkill C, Tait R, Tyler N, et al. Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. Arch Ophthalmol. 1993;111:974.

    Article  CAS  PubMed  Google Scholar 

  256. Keltner J, Thirkill CE, Yip PT. Clinical and immunologic characteristics of melanoma associated retinopathy syndrome: eleven new cases and a review of 51 previously published cases. J Neuroophthalmol. 2001;21(3):173–87.

    Article  CAS  PubMed  Google Scholar 

  257. Adamus G, Guy J, Schmied J, et al. Role of anti-recoverin autoantibodies in cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993;34:2626.

    CAS  PubMed  Google Scholar 

  258. Guy J, Adamus G, Aptsiauri N, et al. Cancer associated retinopathy: a new antibody. Suppl Ophthalmol. 1993;100:116.

    Google Scholar 

  259. Lennon V. Paraneoplastic autoantibodies: the case for a descriptive generic nomenclature. Neurology. 1994;44:2236.

    Article  CAS  PubMed  Google Scholar 

  260. Dalmau J, Posner J. Neurologic paraneoplastic autoantibodies (anti-Yo; anti-Hu; anti-Ri): the case for a nomenclature based on antibody and antigen specificity. Neurology. 1994;44:2241.

    Article  CAS  PubMed  Google Scholar 

  261. Ohguro H, Maruyama I, Nakazawa M, Oohira A. Antirecoverin antibody in the aqueous humor of a patient with cancer-associated retinopathy. Am J Ophthalmol. 2002;134:605–7.

    Article  PubMed  Google Scholar 

  262. Maeda A, Maeda T, Ohguro H, et al. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002;32:2300–7.

    Article  CAS  PubMed  Google Scholar 

  263. Adamus G, Machnicki M, Elderding H, et al. Antibodies to recoverin induce apoptosis of photoreceptor and bipolar cells in vivo. J Autoimmun. 1998;11:523–33.

    Article  CAS  PubMed  Google Scholar 

  264. Adamus G, Machnicki M, Seigel G. Apoptotic retinal cell death induced by antirecoverin autoantibodies of cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1997;38:283–91.

    CAS  PubMed  Google Scholar 

  265. Adamus G, Ren G, Weleber R. Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy. BMC Ophthalmol. 2004;4:5–13.

    Article  PubMed  PubMed Central  Google Scholar 

  266. Maeda T, Maeda A, Maruyama I, et al. Mechanisms of photoreceptor cell death in cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 2001;42:705–12.

    CAS  PubMed  Google Scholar 

  267. Maeda A, Ohguro H, Maeda T, et al. Aberrant expression of photoreceptor-specific calcium-binding protein (recoverin) in cancer cell lines. Cancer Res. 2000;60:1914–20.

    CAS  PubMed  Google Scholar 

  268. Miyagawa Y, Ohguro H, Odagiri H, et al. Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. Biochem Biophys Res Commun. 2003;300:669–73.

    Article  CAS  PubMed  Google Scholar 

  269. Keltner J, Thirkill C. Cancer-associated retinopathy vs recoverin-associated retinopathy. Am J Ophthalmol. 1998;126:296–302.

    CAS  PubMed  Google Scholar 

  270. Boghen D, Sebag M, Michaud J. Paraneoplastic optic neuritis and encephalomyelitis: report of a case. Arch Neurol. 1988;45:353.

    Article  CAS  PubMed  Google Scholar 

  271. Malik S, Furlan A, Sweeney P, et al. Optic neuropathy: a rare paraneoplastic syndrome. J Clin Neuroophthalmol. 1992;12:137.

    CAS  PubMed  Google Scholar 

  272. Milam A, Saari J, Jacobson S, et al. Autoantibodies against retinal bipolar cells in cutaneous melanoma-associated retinopathy. Invest Ophthalmol Vis Sci. 1993;34:91.

    CAS  PubMed  Google Scholar 

  273. Weinstein J, Kelman S, Bresnick G, Kornguth S. Paraneoplastic retinopathy associated with antiretinal bipolar cell antibodies in cutaneous malignant melanoma. Ophthalmology. 1994;101:1236.

    Article  CAS  PubMed  Google Scholar 

  274. Gittinger J, Smith T. Cutaneous melanoma-associated paraneoplastic retinopathy: histopathologic observations. Am J Ophthalmol. 1999;127:612–4.

    Article  PubMed  Google Scholar 

  275. Damek D. Paraneoplastic retinopathy/optic neuropathy. Curr Treat Options Neurol. 2005;7:57–67.

    Article  PubMed  Google Scholar 

  276. Ferreyra H, Jayasundera T, Khan NW, et al. Management of autoimmune retinopathies with immunosuppression. Arch Ophthalmol. 2009;127:390–7.

    Article  CAS  PubMed  Google Scholar 

  277. Barr C, Zimmerman L, Curtin V, Font R. Bilateral diffuse uveal tumors associated with systemic malignant neoplasms: a recently recognized syndrome. Arch Ophthalmol. 1982;100:249.

    Article  CAS  PubMed  Google Scholar 

  278. Borruat F, Othenin-Girard P, Uffer S, et al. Natural history of diffuse uveal melanocytic proliferation. Ophthalmology. 1992;99:1698.

    Article  CAS  PubMed  Google Scholar 

  279. Gass J, Gieser R, Wilkinson C, et al. Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma. Arch Ophthalmol. 1990;108:527.

    Article  CAS  PubMed  Google Scholar 

  280. Jaben E, Pulido J, Pittock S, et al. The potential role of plasma exchange as a treatment for bilateral diffuse melanocytic proliferation: a report of two cases. J Clin Apher. 2011;26:356–61.

    Article  PubMed  Google Scholar 

  281. Fletcher W, Imes R, Goodman D, et al. Acute idiopathic blind spot enlargement: a big blind spot syndrome without optic disc edema. Arch Ophthalmol. 1988;106:44.

    Article  CAS  PubMed  Google Scholar 

  282. Hamed L, Glaser J, Gass J, et al. Protracted enlargement of the blind spot in multiple evanescent white dot syndrome. Arch Ophthalmol. 1989;107:194.

    Article  CAS  PubMed  Google Scholar 

  283. Ie D, Glaser B, Murphy R, et al. Indocyanine green angiography in multiple evanescent white-dot syndrome. Am J Ophthalmol. 1994;117:7.

    Article  CAS  PubMed  Google Scholar 

  284. Ray S, Loewenstein J. Atypical manifestation of multiple evanescent white dot syndrome with large peripapillary lesion. Arch Ophthalmol. 2003;121:1794–6.

    Article  PubMed  Google Scholar 

  285. Volpe N, Rizzo J, Lessell S. Acute idiopathic blind spot enlargement syndrome. Arch Ophthalmol. 2001;119:59–63.

    CAS  PubMed  Google Scholar 

  286. Khorram K, Jampol L, Rosenberg M. Blind spot enlargement as a manifestation of multifocal choroiditis. Arch Ophthalmol. 1991;109:1403.

    Article  CAS  PubMed  Google Scholar 

  287. Reddy C, Brown J, Folk J, et al. Enlarged blind spots in chorioretinal inflammatory disorders. Ophthalmology. 1996;103:606.

    Article  CAS  PubMed  Google Scholar 

  288. Dodwell D, Jampol L, Rosenberg M, et al. Optic nerve involvement associated with the multiple evanescent white-dot syndrome. Ophthalmology. 1990;97:862.

    Article  CAS  PubMed  Google Scholar 

  289. Gass J, Hameed L. Acute macular neuroretinopathy and multiple evanescent white dot syndrome occurring in the same patients. Arch Ophthalmol. 1989;107:189.

    Article  CAS  PubMed  Google Scholar 

  290. Miller M, Spalton D, Fitzke F, et al. Acute macular neuroretinopathy. Ophthalmology. 1989;96:265.

    Article  CAS  PubMed  Google Scholar 

  291. Levine S, Welch K. Antiphospholipid antibodies. Ann Neurol. 1989;26:386.

    Article  CAS  PubMed  Google Scholar 

  292. Briley D, Coull B, Goodnight S. Neurological disease associated with antiphospholipid antibodies. Ann Neurol. 1989;25:221.

    Article  CAS  PubMed  Google Scholar 

  293. Michiels J, Koudstaal P, Mulder AH, van Vliet HH. Transient neurologic and ocular manifestations in primary thrombocythemia. Neurology. 1993;43:1107.

    Article  CAS  PubMed  Google Scholar 

  294. Golub B, Sibony P, Coller B. Protein S deficiency associated with central retinal artery occlusion. Arch Ophthalmol. 1990;108:918.

    Article  CAS  PubMed  Google Scholar 

  295. Coller B, Owen J, Jesty J, et al. Deficiency of plasma protein S, protein C, or antithrombin III and arterial thrombosis. Arteriosclerosis. 1987;7:456.

    Article  CAS  PubMed  Google Scholar 

  296. Sadun A, Currie J, Lessell S. Transient visual obscurations with elevated optic discs. Ann Neurol. 1984;16:489.

    Article  CAS  PubMed  Google Scholar 

  297. Wright J. Primary optic nerve meningiomas: clinical presentation and management. Trans Am Acad Ophthalmol Otolaryngol. 1977;83:617.

    CAS  Google Scholar 

  298. Unsold R, Hoyt W. Blickinduzierte monokulare Obskurationen bei orbitalem Haemangiom. Klin Monatsbl Augenheilkd. 1979;174:715.

    CAS  PubMed  Google Scholar 

  299. Orcutt J, Tucker W, Mills R, et al. Gaze-evokes amaurosis. Ophthalmology. 1987;94:213.

    Article  CAS  PubMed  Google Scholar 

  300. Bradbury P, Levy I, McDonald W. Transient uniocular visual loss on deviation of the eye in association with intraorbital tumours. J Neurol Neurosurg Psychiatry. 1987;50:615.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Boston, MA, USA

    Elizabeth Fortin & Joseph F. Rizzo III

  2. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Elizabeth Fortin & Joseph F. Rizzo III

Authors
  1. Elizabeth Fortin
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  2. Joseph F. Rizzo III
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Corresponding author

Correspondence to Elizabeth Fortin .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Oregon Health & Science University Department of Ophthalmology, Portland, OR, USA

    Daniel Albert

  2. Massachusetts Eye and Ear, Boston, MA, USA

    Joan Miller

  3. Department of Ophthalmology, University of Illinois at Chicago Department of Ophthalmology, Chicago, IL, USA

    Dimitri Azar

  4. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Lucy H. Young

Section Editor information

  1. McGill University, Montreal, Canada

    Leonard Levin

  2. Massachusetts Eye and Ear, Boston, USA

    Dean Cestari

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Fortin, E., Rizzo, J.F. (2021). Neuroophthalmologic Disease of the Retina. In: Albert, D., Miller, J., Azar, D., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-90495-5_40-1

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  • DOI: https://doi.org/10.1007/978-3-319-90495-5_40-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90495-5

  • Online ISBN: 978-3-319-90495-5

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