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Cerebral Vascular Injury in Diabetic Ischemia and Reperfusion

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Cerebral Ischemic Reperfusion Injuries (CIRI)

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

About 30% of stroke patients are diabetic and more than 90% of them comprise type 2 diabetes (T2D). Diabetic stroke patients have higher mortality and worse neurological outcomes. Emerging clinical and experimental data suggest that blood-brain barrier (BBB) disruption, neuroinflammation, and stroke recovery impairment are exacerbated in diabetic patients. Hence, finding therapeutic approaches that can target these specific diabetic mechanisms in stroke is the thrust of the present translational study. Here, we summarize the ischemia-reperfusion injury in stroke, presenting the clinical evidence for involvement of hyperglycemia in severe damage of cerebral ischemia-reperfusion. We go on to consider the mechanisms that underlie such pathology, and highlight areas for future basic research and clinical studies into diabetic ischemia and reperfusion.

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Author information

Authors and Affiliations

  1. Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Wenlu Li & Haibin Dai

Authors
  1. Wenlu Li
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  2. Haibin Dai
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Correspondence to Haibin Dai .

Editor information

Editors and Affiliations

  1. Department of Vascular Neurosurgery, PLA Rocket Force General Hospital, Beijing, China

    Weijian Jiang

  2. Department of Neurology, University of California Irvine, Irvine, California, USA

    Wengui Yu

  3. Department of Neurosurgery, Tangdu Hospital of Air Force Medical University, Xi’an, China

    Yan Qu

  4. Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Zhongsong Shi

  5. Department of Neurology, The First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Benyan Luo

  6. Department of Anesthesiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Li, W., Dai, H. (2018). Cerebral Vascular Injury in Diabetic Ischemia and Reperfusion. In: Jiang, W., Yu, W., Qu, Y., Shi, Z., Luo, B., Zhang, J. (eds) Cerebral Ischemic Reperfusion Injuries (CIRI). Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90194-7_10

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  • DOI: https://doi.org/10.1007/978-3-319-90194-7_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90193-0

  • Online ISBN: 978-3-319-90194-7

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