Skip to main content
SpringerLink
Log in

Cardiac Scintigraphy in RBD

  • Chapter
  • First Online:
Rapid-Eye-Movement Sleep Behavior Disorder

  • 1273 Accesses

Abstract

Rapid eye movement sleep behavior disorder (RBD) is a heterogeneous disease entity consisting of a variety of manifestations. Patients with RBD demonstrate clinical and subclinical phenomena suggestive of impending α-synucleinopathy; when fully developed, these disorders manifest as either Parkinson’s disease (PD), multiple system atrophy (MSA), or dementia with Lewy bodies (DLB). In RBD, autonomic dysfunction is consistent with an evolving neurodegenerative disorder. Cardiovascular autonomic dysfunction is particularly common in idiopathic RBD, and cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy enables the quantification of postganglionic cardiac sympathetic innervation. A marked reduction in cardiac 123I-MIBG uptake has been found in most patients with idiopathic RBD compared to control subjects and patients with clinically diagnosed MSA, progressive supranuclear palsy, corticobasal degeneration, and Alzheimer’s disease but is similar to those with clinically diagnosed PD and DLB. Therefore, cardiac 123I-MIBG scintigraphy may be a very useful marker of idiopathic RBD (iRBD) with Lewy body-related syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014. p. 246–53.

    Google Scholar 

  2. Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, Ito Y, Yoshimura M, Okawa M. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology. 1995;45(4):709–12. PubMedPMID: 7723959.

    Article  CAS  PubMed  Google Scholar 

  3. Boeve BF, Silber MH, Ferman TJ, Lin SC, Benarroch EE, Schmeichel AM, Ahlskog JE, Caselli RJ, Jacobson S, Sabbagh M, Adler C, Woodruff B, Beach TG, Iranzo A, Gelpi E, Santamaria J, Tolosa E, Singer C, Mash DC, Luca C, Arnulf I, Duyckaerts C, Schenck CH, Mahowald MW, Dauvilliers Y, Graff-Radford NR, Wszolek ZK, Parisi JE, Dugger B, Murray ME, Dickson DW. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med. 2013;14(8):754–62. https://doi.org/10.1016/j.sleep.2012.10.015. Epub 2013 Mar 7. PubMed PMID: 23474058; PubMed Central PMCID: PMC3745815.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a Parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744–8. https://doi.org/10.1016/j.sleep.2012.10.009. Epub 2013 Jan 22. PubMedPMID: 23347909.

    Article  PubMed  Google Scholar 

  5. Iranzo A, Tolosa E, Gelpi E, Molinuevo JL, Valldeoriola F, Serradell M, Sanchez-Valle R, Vilaseca I, Lomeña F, Vilas D, Lladó A, Gaig C, Santamaria J. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12(5):443–53. https://doi.org/10.1016/S1474-4422(13)70056-5. Epub 2013 Apr 3. PubMed PMID: 23562390.

    Article  PubMed  Google Scholar 

  6. Gagnon JF, Postuma RB, Mazza S, Doyon J, Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol. 2006;5(5):424–32. Review. PubMed PMID: 16632313.

    Article  PubMed  Google Scholar 

  7. Postuma RB, Aarsland D, Barone P, Burn DJ, Hawkes CH, Oertel W, Ziemssen T. Identifying prodromal Parkinson’s disease: pre-motor disorders in Parkinson’s disease. Mov Disord. 2012;27(5):617–26. https://doi.org/10.1002/mds.24996. Review. PubMed PMID: 22508280.

    Article  PubMed  Google Scholar 

  8. Travin MI. Cardiac autonomic imaging with SPECT tracers. J Nucl Cardiol. 2013;20(1):128–43. https://doi.org/10.1007/s12350-012-9655-1; quiz 146. Review. PubMedPMID: 23188628.

    Article  PubMed  Google Scholar 

  9. Wieland DM, Wu J, Brown LE, Mangner TJ, Swanson DP, Beierwaltes WH. Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [131I] iodobenzylguanidine. J Nucl Med. 1980;21(4):349–53. PubMedPMID: 7381563.

    PubMed  CAS  Google Scholar 

  10. Kline RC, Swanson DP, Wieland DM, Thrall JH, Gross MD, Pitt B, Beierwaltes WH. Myocardial imaging in man with I-123 meta-iodobenzylguanidine. J Nucl Med. 1981;22(2):129–32. PubMed PMID: 7463156.

    PubMed  CAS  Google Scholar 

  11. Wieland DM, Brown LE, Rogers WL, Worthington KC, Wu JL, Clinthorne NH, Otto CA, Swanson DP, Beierwaltes WH. Myocardial imaging with a radioiodinated norepinephrine storage analog. J Nucl Med. 1981;22(1):22–31. PubMed PMID: 7452352.

    PubMed  CAS  Google Scholar 

  12. Wieland DM, Brown LE, Tobes MC, Rogers WL, Marsh DD, Mangner TJ, Swanson DP, Beierwaltes WH. Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzylguanidine: concise communication. J Nucl Med. 1981;22(4):358–64. PubMed PMID: 7205383.

    PubMed  CAS  Google Scholar 

  13. Solanki KK, Bomanji J, Moyes J, Mather SJ, Trainer PJ, Britton KE. A pharmacological guide to medicines which interfere with the biodistribution of radiolabelled meta-iodobenzylguanidine (MIBG). Nucl Med Commun. 1992;13(7):513–21. Review. PubMed PMID: 23188628.

    Article  CAS  PubMed  Google Scholar 

  14. Teresińska A. Metaiodobenzylguanidine scintigraphy of cardiac sympathetic innervation. Nucl Med Rev Cent East Eur. 2012;15(1):61–70. https://doi.org/10.5603/nmr-18732. Review. PubMed PMID: 23047575.

    Article  PubMed  Google Scholar 

  15. Flotats A, Carrió I, Agostini D, Le Guludec D, Marcassa C, Schäfers M, Somsen GA, Unlu M, Verberne HJ, EANM Cardiovascular Committee, European Council of Nuclear Cardiology. Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology. Eur J Nucl Med Mol Imaging. 2010;37(9):1802–12. https://doi.org/10.1007/s00259-010-1491-4. Erratum in: Eur J Nucl Med Mol Imaging. 2011 Jan;38(1):190. Schaffers, Michael [corrected to Schäfers, Michael]. PubMed PMID: 20577740.

    Article  PubMed  Google Scholar 

  16. Okuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S. Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging. J Nucl Cardiol. 2011;18(1):82–9. https://doi.org/10.1007/s12350-010-9313-4. Epub 2010 Nov 23. PubMed PMID: 21104360.

    Article  PubMed  Google Scholar 

  17. Nakajima K, Nakata T. Cardiac 123I-MIBG imaging for clinical decision making: 22-year experience in Japan. J Nucl Med. 2015;56(Suppl 4):11S–9S. https://doi.org/10.2967/jnumed.114.142794. Review. PubMed PMID: 26033897.

    Article  PubMed  CAS  Google Scholar 

  18. Wakabayashi K, Takahashi H, Ohama E, Takeda S, Ikuta F. Lewy bodies in the visceral autonomic nervous system in Parkinson’s disease. Adv Neurol. 1993;60:609–12. PubMed PMID: 8420198.

    PubMed  CAS  Google Scholar 

  19. Orimo S, Amino T, Itoh Y, Takahashi A, Kojo T, Uchihara T, Tsuchiya K, Mori F, Wakabayashi K, Takahashi H. Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol. 2005;109(6):583–8. Epub 2005 Jun 3. PubMed PMID: 15933869.

    Article  PubMed  Google Scholar 

  20. Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson’s disease. Brain. 2008;131(Pt 3):642–50. Epub 2007 Dec 13. PubMed PMID: 18079166.

    Article  PubMed  Google Scholar 

  21. Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24(2):197–211. PubMed PMID: 12498954.

    Article  PubMed  Google Scholar 

  22. Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson’s disease. Brain Pathol. 2007;17(1):24–30. PubMed PMID: 17493034.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Hakusui S, Yasuda T, Yanagi T, Takahashi A, Hasegawa Y, Inoue M. [123I-MIBG myocardial scintigraphical analysis in patients with and without autonomic disorder]. Rinsho Shinkeigaku. 1994;34(4):402–4. Japanese. PubMed PMID: 8026141.

    Google Scholar 

  24. Orimo S, Ozawa E, Nakade S, Sugimoto T, Mizusawa H. (123) I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;67(2):189–94. PubMed PMID: 10406987; PubMed Central PMCID: PMC1736461.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Oka H, Toyoda C, Yogo M, Mochio S. Reduced cardiac 123I-MIBG uptake reflects cardiac sympathetic dysfunction in de novo Parkinson’s disease. J Neural Transm (Vienna). 2011;118(9):1323–7. https://doi.org/10.1007/s00702-011-0598-5. Epub 2011 Feb 18. PubMed PMID: 21331459.

    Article  Google Scholar 

  26. Kim JS, Park HE, Oh YS, Lee SH, Park JW, Son BC, Lee KS. Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder. J Neurol Sci. 2016;362:59–63. https://doi.org/10.1016/j.jns.2016.01.020. Epub 2016 Jan 15. PubMed PMID: 26944118.

    Article  PubMed  Google Scholar 

  27. Braune S, Reinhardt M, Schnitzer R, Riedel A, Lücking CH. Cardiac uptake of [123I] MIBG separates Parkinson’s disease from multiple system atrophy. Neurology. 1999;53(5):1020–5. PubMed PMID: 10496261.

    Article  CAS  PubMed  Google Scholar 

  28. Yoshita M, Hayashi M, Hirai S. [Iodine 123-labeled meta-iodobenzylguanidine myocardial scintigraphy in the cases of idiopathic Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy]. Rinsho Shinkeigaku. 1997;37(6):476–82. Japanese. PubMed PMID: 9366173.

    Google Scholar 

  29. Orimo S, Suzuki M, Inaba A, Mizusawa H. 123I-MIBG myocardial scintigraphy for differentiating Parkinson’s disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2012;18(5):494–500. https://doi.org/10.1016/j.parkreldis.2012.01.009. Epub 2012 Feb 8. Review. PubMed PMID: 22321865.

    Article  PubMed  Google Scholar 

  30. Yoshita M, Taki J, Yokoyama K, Noguchi-Shinohara M, Matsumoto Y, Nakajima K, Yamada M. Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology. 2006;66(12):1850–4. PubMed PMID: 16801649.

    Article  CAS  PubMed  Google Scholar 

  31. Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, Orimo S, Samuraki M, Takahashi A, Taki J, Tokuda T, Urakami K, Utsumi K, Wada K, Washimi Y, Yamasaki J, Yamashina S, Yamada M. Diagnostic accuracy of 123I-meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: a multicenter study. PLoS One. 2015;10(3):e0120540. https://doi.org/10.1371/journal.pone.0120540. eCollection 2015 Mar 20. PubMed PMID: 25793585; PubMed Central PMCID: PMC4368705.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Hanyu H, Shimizu S, Hirao K, Kanetaka H, Iwamoto T, Chikamori T, Usui Y, Yamashina A, Koizumi K, Abe K. Comparative value of brain perfusion SPECT and [(123) I] MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2006;33(3):248–53. Epub 2005 Nov 22. PubMed PMID: 16328506.

    Article  PubMed  Google Scholar 

  33. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology. 2006;67(12):2236–8. PubMed PMID: 17190953.

    Article  CAS  PubMed  Google Scholar 

  34. Miyamoto T, Miyamoto M, Suzuki K, Nishibayashi M, Iwanami M, Hirata K. 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. Sleep. 2008;31(5):717–23. PubMed PMID: 18517041; PubMed Central PMCID: PMC2398741.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Kashihara K, Imamura T. Reduced myocardial 123I-MIBG uptake in a patient with idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 2007;22(1):150–1. PubMed PMID: 17080465.

    Article  PubMed  Google Scholar 

  36. Kashihara K, Imamura T, Shinya T. Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson’s disease. Parkinsonism Relat Disord. 2010;16(4):252–5. https://doi.org/10.1016/j.parkreldis.2009.12.010. Epub 2010 Jan 25. PubMed PMID: 20097595.

    Article  PubMed  Google Scholar 

  37. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Cardiac 123I-MIBG accumulation in Parkinson’s disease differs in association with REM sleep behavior disorder. Parkinsonism Relat Disord. 2011;17(3):219–20. https://doi.org/10.1016/j.parkreldis.2010.11.020. Epub 2010 Dec 18. PubMed PMID: 21169047.

    Article  PubMed  Google Scholar 

  38. Koyama S, Tachibana N, Masaoka Y, Homma I, Kawamura M. Decreased myocardial (123) I-MIBG uptake and impaired facial expression recognition in a patient with REM sleep behavior disorder. Mov Disord. 2007;22(5):746–7. PubMed PMID: 17357134.

    Article  PubMed  Google Scholar 

  39. Oguri T, Tachibana N, Mitake S, Kawanishi T, Fukuyama H. Decrease in myocardial 123I-MIBG radioactivity in REM sleep behavior disorder: two patients with different clinical progression. Sleep Med. 2008;9(5):583–5. Epub 2007 Oct 24. PubMed PMID: 17921052.

    Article  PubMed  Google Scholar 

  40. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Three-year follow-up on the accumulation of cardiac (123)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Sleep Med. 2009;10(9):1066–7. https://doi.org/10.1016/j.sleep.2009.02.003. Epub 2009 Mar 23. PubMed PMID: 19307152.

    Article  PubMed  Google Scholar 

  41. Paglionico S, Labate A, Salsone M, Morelli M, Novellino F, Cascini G, Quattrone A. Involvement of cardiac sympathetic nerve endings in a patient with idiopathic RBD and intact nigrostriatal pathway. Parkinsonism Relat Disord. 2009;15(10):789–91. https://doi.org/10.1016/j.parkreldis.2009.03.008. Epub 2009 Apr 29. PubMed PMID: 19406681.

    Article  PubMed  CAS  Google Scholar 

  42. Salsone M, Labate A, Quattrone A. Cardiac denervation precedes nigrostriatal damage in idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 2012;27(8):1068–9. https://doi.org/10.1002/mds.25002. Epub 2012 May 17. PubMed PMID: 22605537.

    Article  PubMed  Google Scholar 

  43. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Follow-up study of cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Eur J Neurol. 2011;18(10):1275–8. https://doi.org/10.1111/j.1468-1331.2011.03392.x. Epub 2011 Mar 28. PubMed PMID: 21914050.

    Article  PubMed  CAS  Google Scholar 

  44. Iranzo A, Santamaría J. Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder. Sleep. 2005;28(2):203–6. PubMed PMID: 16171244.

    Article  PubMed  Google Scholar 

  45. Miyamoto T, Miyamoto M, Suzuki K, Ikematsu A, Usui Y, Inoue Y, Hirata K. Comparison of severity of obstructive sleep apnea and degree of accumulation of cardiac 123I-MIBG radioactivity as a diagnostic marker for idiopathic REM sleep behavior disorder. Sleep Med. 2009;10(5):577–80. https://doi.org/10.1016/j.sleep.2008.04.013. Epub 2008 Aug 26. PubMed PMID: 18752998.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Medicine for Nursing, Dokkyo Medical University, School of Nursing, Mibu, Tochigi, Japan

    Masayuki Miyamoto

  2. Center of Sleep Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, Japan

    Masayuki Miyamoto

  3. Department of Neurology, Dokkyo Medical University, Saitama Medical Center, Koshigaya, Saitama, Japan

    Tomoyuki Miyamoto

  4. Department of Neurology, Dokkyo Medical University, Mibu, Tochigi, Japan

    Koichi Hirata

Authors
  1. Masayuki Miyamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomoyuki Miyamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koichi Hirata
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Masayuki Miyamoto or Tomoyuki Miyamoto .

Editor information

Editors and Affiliations

  1. Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN, USA

    Carlos H. Schenck

  2. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

    Birgit Högl

  3. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Aleksandar Videnovic

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Miyamoto, M., Miyamoto, T., Hirata, K. (2019). Cardiac Scintigraphy in RBD. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-90152-7_33

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90151-0

  • Online ISBN: 978-3-319-90152-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation