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Principles of Care in the Diabetic Surgical Patient

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The Diabetic Foot

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Currently, around 29 million or 11% of US adults have diabetes and 86 million are thought to have prediabetes. The healthcare spending on diabetes is soaring with an estimate of $250 billion, of which 43% are spent in hospital care to treat diabetes and its complications. Patients with diabetes are frequently admitted to the hospital for surgical interventions. Common surgical reasons in relation to diabetes include diabetic foot problems, vascular surgeries, coronary artery bypass, kidney transplant, and eye surgeries. Meanwhile, patients with diabetes are frequently admitted for any other surgical interventions unrelated to diabetes. During admission, diabetes management may vary based on the location of patient whether in surgical intensive care units or in regular wards. It also varies based on nutrition whether it is regular oral feeding, enteral tube feeding, parental feeding, or just clear intravenous fluids. Good diabetes control shortens length of hospital stay, reduces complications, and reduces hospital mortality and hospital 30- and 90-day readmission rate. While oral medications and/or insulin are commonly used to treat diabetes in outpatient setting, only insulin is recommended for treating diabetes during surgical admission. Insulin method of administration, insulin type, and dose vary significantly between patients. Use of steroids may complicate insulin regimen. Patients on insulin infusion pump also require specific consideration. The major risk of insulin use is hypoglycemia, which is infrequently severe. This chapter comprehensively covers the principals of diabetes management during hospital admission.

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References

  1. Pomposelli JJ, Baxter JK 3rd, Babineau TJ, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients. JPEN J Parenter Enteral Nutr. 1998;22(2):77–81.

    Article  CAS  PubMed  Google Scholar 

  2. Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax. 2006;61(4):284–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. McAlister FA, Majumdar SR, Blitz S, Rowe BH, Romney J, Marrie TJ. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care. 2005;28(4):810–5.

    Article  PubMed  Google Scholar 

  4. McAlister FA, Man J, Bistritz L, Amad H, Tandon P. Diabetes and coronary artery bypass surgery: an examination of perioperative glycemic control and outcomes. Diabetes Care. 2003;26(5):1518–24.

    Article  PubMed  Google Scholar 

  5. Umpierrez GE, Hellman R, Korytkowski MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38.

    Article  CAS  PubMed  Google Scholar 

  6. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978–82.

    Article  CAS  PubMed  Google Scholar 

  7. Ainla T, Baburin A, Teesalu R, Rahu M. The association between hyperglycaemia on admission and 180-day mortality in acute myocardial infarction patients with and without diabetes. Diabet Med. 2005;22(10):1321–5.

    Article  CAS  PubMed  Google Scholar 

  8. Clement S, Braithwaite SS, Magee MF, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004;27(2):553–91.

    Article  PubMed  Google Scholar 

  9. Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32(6):1119–31.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Seaquist ER, Anderson J, Childs B, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013;36(5):1384–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. American Diabetes A. Standards of medical care in diabetes-2016 abridged for primary care providers. Clin Diabetes. 2016;34(1):3–21.

    Article  Google Scholar 

  12. Draznin B, Gilden J, Golden SH, et al. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care. 2013;36(7):1807–14.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Healy SJ, Black D, Harris C, Lorenz A, Dungan KM. Inpatient diabetes education is associated with less frequent hospital readmission among patients with poor glycemic control. Diabetes Care. 2013;36(10):2960–7.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Curll M, Dinardo M, Noschese M, Korytkowski MT. Menu selection, glycaemic control and satisfaction with standard and patient-controlled consistent carbohydrate meal plans in hospitalised patients with diabetes. Qual Saf Health Care. 2010;19(4):355–9.

    Article  PubMed  Google Scholar 

  15. Umpierrez GE, Gianchandani R, Smiley D, et al. Safety and efficacy of sitagliptin therapy for the inpatient management of general medicine and surgery patients with type 2 diabetes: a pilot, randomized, controlled study. Diabetes Care. 2013;36(11):3430–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Umpierrez GE, Korytkowski M. Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: Insulin therapy has proven itself and is considered the mainstay of treatment. Diabetes Care. 2013;36(7):2112–7.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Thomsen HS. European Society of Urogenital R. European Society of Urogenital Radiology guidelines on contrast media application. Curr Opin Urol. 2007;17(1):70–6.

    Article  PubMed  Google Scholar 

  18. McDonnell ME, Umpierrez GE. Insulin therapy for the management of hyperglycemia in hospitalized patients. Endocrinol Metab Clin N Am. 2012;41(1):175–201.

    Article  CAS  Google Scholar 

  19. Grommesh B, Lausch MJ, Vannelli AJ, et al. Hospital Insulin Protocol Aims for Glucose Control in Glucocorticoid-Induced Hyperglycemia. Endocr Pract. 2016;22(2):180–9.

    Article  PubMed  Google Scholar 

  20. Joslin Diabetes Center Inpatient Hyperglycemia Protocol. 2016.

    Google Scholar 

  21. Baldwin D, Zander J, Munoz C, et al. A randomized trial of two weight-based doses of insulin glargine and glulisine in hospitalized subjects with type 2 diabetes and renal insufficiency. Diabetes Care. 2012;35(10):1970–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Gillaizeau F, Chan E, Trinquart L, et al. Computerized advice on drug dosage to improve prescribing practice. Cochrane Database Syst Rev. 2013;11:CD002894.

    Google Scholar 

  23. Kennihan M, Zohra T, Devi R, et al. Individualization through standardization: electronic orders for subcutaneous insulin in the hospital. Endocr Pract. 2012;18(6):976–87.

    Article  PubMed  Google Scholar 

  24. Liu XX, Zhu XM, Miao Q, Ye HY, Zhang ZY, Li YM. Hyperglycemia induced by glucocorticoids in nondiabetic patients: a meta-analysis. Ann Nutr Metab. 2014;65(4):324–32.

    Article  CAS  PubMed  Google Scholar 

  25. Donihi AC, Raval D, Saul M, Korytkowski MT, DeVita MA. Prevalence and predictors of corticosteroid-related hyperglycemia in hospitalized patients. Endocr Pract. 2006;12(4):358–62.

    Article  PubMed  Google Scholar 

  26. Ali NA, O’Brien JM Jr, Blum W, et al. Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality. Cancer. 2007;110(1):96–102.

    Article  PubMed  Google Scholar 

  27. Derr RL, Hsiao VC, Saudek CD. Antecedent hyperglycemia is associated with an increased risk of neutropenic infections during bone marrow transplantation. Diabetes Care. 2008;31(10):1972–7.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Garg R, Bhutani H, Alyea E, Pendergrass M. Hyperglycemia and length of stay in patients hospitalized for bone marrow transplantation. Diabetes Care. 2007;30(4):993–4.

    Article  PubMed  Google Scholar 

  29. Burt MG, Drake SM, Aguilar-Loza NR, Esterman A, Stranks SN, Roberts GW. Efficacy of a basal bolus insulin protocol to treat prednisolone-induced hyperglycaemia in hospitalised patients. Intern Med J. 2015;45(3):261–6.

    Article  CAS  PubMed  Google Scholar 

  30. Low Wang CC, Draznin B. Use of Nph Insulin for Glucocorticoid-Induced Hyperglycemia. Endocr Pract. 2016;22(2):271–3.

    Article  PubMed  Google Scholar 

  31. Dhital SM, Shenker Y, Meredith M, Davis DB. A retrospective study comparing neutral protamine hagedorn insulin with glargine as basal therapy in prednisone-associated diabetes mellitus in hospitalized patients. Endocr Pract. 2012;18(5):712–9.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Gosmanov AR, Goorha S, Stelts S, Peng L, Umpierrez GE. Management of hyperglycemia in diabetic patients with hematologic malignancies during dexamethasone therapy. Endocr Pract. 2013;19(2):231–5.

    Article  PubMed  Google Scholar 

  33. Dhaliwal R, Cahill N, Lemieux M, Heyland DK. The Canadian critical care nutrition guidelines in 2013: an update on current recommendations and implementation strategies. Nutr Clin Pract. 2014;29(1):29–43.

    Article  PubMed  Google Scholar 

  34. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137(3):544–51.

    Article  CAS  PubMed  Google Scholar 

  35. Leon-Sanz M, Garcia-Luna PP, Sanz-Paris A, et al. Glycemic and lipid control in hospitalized type 2 diabetic patients: evaluation of 2 enteral nutrition formulas (low carbohydrate-high monounsaturated fat vs high carbohydrate). JPEN J Parenter Enteral Nutr. 2005;29(1):21–9.

    Article  PubMed  Google Scholar 

  36. Elia M, Ceriello A, Laube H, Sinclair AJ, Engfer M, Stratton RJ. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysis. Diabetes Care. 2005;28(9):2267–79.

    Article  PubMed  Google Scholar 

  37. Alish CJ, Garvey WT, Maki KC, et al. A diabetes-specific enteral formula improves glycemic variability in patients with type 2 diabetes. Diabetes Technol Ther. 2010;12(6):419–25.

    Article  CAS  PubMed  Google Scholar 

  38. Vaisman N, Lansink M, Rouws CH, et al. Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients. Clin Nutr. 2009;28(5):549–55.

    Article  PubMed  Google Scholar 

  39. Pohl M, Mayr P, Mertl-Roetzer M, et al. Glycemic control in patients with type 2 diabetes mellitus with a disease-specific enteral formula: stage II of a randomized, controlled multicenter trial. JPEN J Parenter Enteral Nutr. 2009;33(1):37–49.

    Article  CAS  PubMed  Google Scholar 

  40. Gosmanov AR, Umpierrez GE. Management of hyperglycemia during enteral and parenteral nutrition therapy. Curr Diab Rep. 2013;13(1):155–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Malone A. Enteral formula selection: a review of selected product categories. Pract Gastroenterol. 2005;28:44–74.

    Google Scholar 

  42. Hsia E, Seggelke SA, Gibbs J, Rasouli N, Draznin B. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy. Nutr Clin Pract. 2011;26(6):714–7.

    Article  PubMed  Google Scholar 

  43. Dickerson RN, Wilson VC, Maish GO 3rd, Croce MA, Minard G, Brown RO. Transitional NPH insulin therapy for critically ill patients receiving continuous enteral nutrition and intravenous regular human insulin. JPEN J Parenter Enteral Nutr. 2013;37(4):506–16.

    Article  CAS  PubMed  Google Scholar 

  44. Korytkowski MT, Salata RJ, Koerbel GL, et al. Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial. Diabetes Care. 2009;32(4):594–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Joslin Diabetes Center Enteral and Parenteral Nutrition Protocol. 2015.

    Google Scholar 

  46. Hongsermeier T, Bistrian BR. Evaluation of a practical technique for determining insulin requirements in diabetic patients receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr. 1993;17(1):16–9.

    Article  CAS  PubMed  Google Scholar 

  47. Jakoby MG, Nannapaneni N. An insulin protocol for management of hyperglycemia in patients receiving parenteral nutrition is superior to ad hoc management. JPEN J Parenter Enteral Nutr. 2012;36(2):183–8.

    Article  CAS  PubMed  Google Scholar 

  48. Grunberger G, Abelseth JM, Bailey TS, et al. Consensus statement by the american association of clinical endocrinologists/american college of endocrinology insulin pump management task force. Endocr Pract. 2014;20(5):463–89.

    Article  PubMed  Google Scholar 

  49. Houlden RL, Moore S. In-hospital management of adults using insulin pump therapy. Can J Diabetes. 2014;38(2):126–33.

    Article  PubMed  Google Scholar 

  50. Bhatt D, Reynolds LR. Keep your hands off my insulin pump! The dilemma of the hospitalized insulin pump patient. Am J Med. 2015;128(9):936–7.

    Article  PubMed  Google Scholar 

  51. Buchleitner AM, Martinez-Alonso M, Hernandez M, Sola I, Mauricio D. Perioperative glycaemic control for diabetic patients undergoing surgery. Cochrane Database Syst Rev. 2012;9:CD007315.

    Google Scholar 

  52. Umpierrez GE, Smiley D, Jacobs S, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34(2):256–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Umpierrez GE, Smiley D, Hermayer K, et al. Randomized study comparing a Basal-bolus with a basal plus correction insulin regimen for the hospital management of medical and surgical patients with type 2 diabetes: basal plus trial. Diabetes Care. 2013;36(8):2169–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Guerra SM, Kitabchi AE. Comparison of the effectiveness of various routes of insulin injection: insulin levels and glucose response in normal subjects. J Clin Endocrinol Metab. 1976;42(5):869–74.

    Article  CAS  PubMed  Google Scholar 

  55. Shahshahani MN, Kitabchi. Glucose-lowering effect of insulin by different routes in obese and lean nonketotic diabetic patients. J Clin Endocrinol Metab. 1978;47(1):34–40.

    Article  CAS  PubMed  Google Scholar 

  56. Skjaervold NK, Lyng O, Spigset O, Aadahl P. Pharmacology of intravenous insulin administration: implications for future closed-loop glycemic control by the intravenous/intravenous route. Diabetes Technol Ther. 2012;14(1):23–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Jacobi J, Bircher N, Krinsley J, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40(12):3251–76.

    Article  PubMed  Google Scholar 

  58. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359–67.

    Article  PubMed  Google Scholar 

  59. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449–61.

    Article  PubMed  Google Scholar 

  60. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125–39.

    Article  CAS  PubMed  Google Scholar 

  61. Investigators N-SS, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97.

    Article  Google Scholar 

  62. Investigators N-SS, Finfer S, Liu B, et al. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367(12):1108–18.

    Article  CAS  Google Scholar 

  63. Vellanki P, Bean R, Oyedokun FA, et al. Randomized controlled trial of insulin supplementation for correction of bedtime hyperglycemia in hospitalized patients with type 2 diabetes. Diabetes Care. 2015;38(4):568–74.

    CAS  PubMed  PubMed Central  Google Scholar 

  64. Umpierrez G, Cardona S, Pasquel F, et al. Randomized controlled trial of intensive versus conservative glucose control in patients undergoing coronary artery bypass graft surgery: GLUCO-CABG trial. Diabetes Care. 2015;38(9):1665–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Task Force on the management of STseamiotESoC, Steg PG, James SK, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33(20):2569–619.

    Article  CAS  Google Scholar 

  66. Krikorian A, Ismail-Beigi F, Moghissi ES. Comparisons of different insulin infusion protocols: a review of recent literature. Curr Opin Clin Nutr Metab Care. 2010;13(2):198–204.

    Article  CAS  PubMed  Google Scholar 

  67. Steil GM, Deiss D, Shih J, Buckingham B, Weinzimer S, Agus MS. Intensive care unit insulin delivery algorithms: why so many? How to choose? J Diabetes Sci Technol. 2009;3(1):125–40.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Boutin JM, Gauthier L. Insulin infusion therapy in critically ill patients. Can J Diabetes. 2014;38(2):144–50.

    Article  PubMed  Google Scholar 

  69. Joslin Diabetes Center Medical Intensive Care Unit Protocol. 2015.

    Google Scholar 

  70. Joslin Diabetes Center Surgical Intensive Care Unit Protocol. 2015.

    Google Scholar 

  71. Schmeltz LR, DeSantis AJ, Thiyagarajan V, et al. Reduction of surgical mortality and morbidity in diabetic patients undergoing cardiac surgery with a combined intravenous and subcutaneous insulin glucose management strategy. Diabetes Care. 2007;30(4):823–8.

    Article  CAS  PubMed  Google Scholar 

  72. Shomali ME, Herr DL, Hill PC, Pehlivanova M, Sharretts JM, Magee MF. Conversion from intravenous insulin to subcutaneous insulin after cardiovascular surgery: transition to target study. Diabetes Technol Ther. 2011;13(2):121–6.

    Article  PubMed  Google Scholar 

  73. DiNardo M, Noschese M, Korytkowski M, Freeman S. The medical emergency team and rapid response system: finding, treating, and preventing hypoglycemia. Jt Comm J Qual Patient Saf. 2006;32(10):591–5.

    Article  PubMed  Google Scholar 

  74. Siminerio LM, Piatt G, Zgibor JC. Implementing the chronic care model for improvements in diabetes care and education in a rural primary care practice. Diabetes Educ. 2005;31(2):225–34.

    Article  PubMed  Google Scholar 

  75. Joslin Diabetes Center Hypoglycemia Protocol. 2015.

    Google Scholar 

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Correspondence to Osama Hamdy MD, PhD .

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Khazai, N., Hamdy, O. (2018). Principles of Care in the Diabetic Surgical Patient. In: Veves, A., Giurini, J., Guzman, R. (eds) The Diabetic Foot. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-319-89869-8_6

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