Notch and Stem Cells

Bigas, Anna; Porcheri, Cristina

doi:10.1007/978-3-319-89512-3_12

Anna Bigas^8,9 &
Cristina Porcheri⁸

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1066))

3768 Accesses
27 Citations

Abstract

The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated signalling controls several aspects of tissue homeostasis in both embryonic and adult tissues, balancing stem cells maintenance and differentiation. Although the major elements of the pathway are well conserved throughout evolution, its fine regulation varies among different systems. In this review, we are focusing at the differences and analogies of Notch activity in different animal models, comparing stem cells of various tissues in both adulthood and development. We summarize the major mode of action of the Notch-pathway in dependency to the type of ligand, cross-talk control and transcriptional regulation adopted by stem cells to preserve their undifferentiation status or complete their maturation.

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Abbreviations

Dll:: Delta-like
Jag:: Jagged
RBPJ:: Recombination signal binding protein for immunoglobulin kappa J region
Ngn2:: Neurogenin2
ES:: Embryonic stem cells
LIF:: Leukemia inhibitory factor
BMP:: Bone morphogenetic protein
NSCs:: Neural stem cells
SOP:: Sensory organ precursor
GFAP:: Glial fibrillary acidic protein
EGF:: Epidermal growth factor
HSCs:: Hematopoietic stem cells
EMPs:: Erythroid-myeloid progenitors
Hes1:: Hairy and enhancer of split 1
Hey2:: Hairy/enhancer-of-split related with YRPW motif 2
TAD:: Transactivation domain
AGM:: Aorta-gonad-mesonephros
BM:: Bone marrow
DN1/DN3:: Double negative (thymocytes)
TCR:: T-cell receptor
Th1:: Lymphocyte T-helper1
Th2:: Lymphocyte T-helper2
T-ALL:: T-cell acute lymphoblastic leukemia
B-CLL:: Chronic lymphocytic leukemia of the B-cell lineage
LGR5:: Leucine rich repeat containing G protein-coupled receptor 5
IFE:: Interfollicular epidermis
HF:: Hair follicles
SG:: Sebaceous glands
ROCK2:: Rho-associated protein kinase 2
RECK:: Reversion-inducing Cysteine-rich Protein with Kazal Motifs
ADAM:: A disintegrin and metalloproteinase
NRARP:: NOTCH-regulated ankyrin repeat-containing protein
MyoD:: Myogenic differentiation antigen
TRAF6:: TNF-receptor-associated factor 6
POGLUT1:: Protein O-glucosyltransferase 1
PTEN:: Phosphatase and tensin homologue
PAX3/7:: Paired homeobox transcription factors
BRG1 :: Brahma-related gene-1
APC:: Adenomatous polyposis coli
NLK:: Nemo-like kinase
GDE2:: Glycerophosphodiester phosphodiesterase 2

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Acknowledgements

We would like to thank L. Espinosa for comments and discussion on the manuscript and H.B.F. Pohl for the help with the graphics. This work was supported by Spanish Ministry of Economy and Innovation (MINECO) (SAF2013-40922-R and SAF2016 -75613-R). CP is a recipient of Juan de la Cierva fellowship (FJCI2014-19870).

The authors declare no competing financial interests.

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Program in Cancer Research, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
Anna Bigas & Cristina Porcheri
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain
Anna Bigas

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Correspondence to Anna Bigas .

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Institute of Biochemistry, University of Giessen, Giessen, Germany
Tilman Borggrefe
Institute of Biochemistry, University of Giessen, Giessen, Germany
Benedetto Daniele Giaimo

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Bigas, A., Porcheri, C. (2018). Notch and Stem Cells. In: Borggrefe, T., Giaimo, B. (eds) Molecular Mechanisms of Notch Signaling. Advances in Experimental Medicine and Biology, vol 1066. Springer, Cham. https://doi.org/10.1007/978-3-319-89512-3_12

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DOI: https://doi.org/10.1007/978-3-319-89512-3_12
Published: 19 July 2018
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