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The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma

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Molecular Determinants of Head and Neck Cancer

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Recent advances in sequencing technology have enabled unprecedented genome-wide characterization of head and neck squamous cell carcinoma (HNSCC). Integrated analyses of publicly available multiplatform high-throughput data have uncovered the vast genomic, epigenetic, and transcriptional diversity of HNSCC. Recognition of human papillomavirus (HPV) involvement in HNSCC carcinogenesis has resulted in the categorization of two HNSCC subtypes (HPV-driven and HPV-negative) with distinct etiologies, molecular properties, clinical features, and prognostic outcomes. Differences in the molecular landscapes of HPV-driven and HPV-negative HNSCC occur genome-wide and encompass changes in genomic, epigenetic, and transcriptional landscapes. Even within each subtype, HNSCC tumors have substantial inter-tumor and intra-tumor molecular heterogeneity. Improving the understanding of the underlying biological function of these complex molecular landscapes through emerging cross-platform genomic analyses is essential to developing more effective diagnostic and therapeutic strategies for HNSCC.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Farhoud Faraji, Adrian D. Schubert, Marietta Tan, Munfarid Zaidi, Carole Fakhry, Evgeny Izumchenko & Daria A. Gaykalova

  2. Department of Oncology and Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Luciane T. Kagohara & Elana J. Fertig

  3. Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA

    Yanxun Xu

  4. Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Jean-Philippe Fortin

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    Barbara Burtness

  2. Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Erica A. Golemis

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Faraji, F. et al. (2018). The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma. In: Burtness, B., Golemis, E. (eds) Molecular Determinants of Head and Neck Cancer. Current Cancer Research. Humana Press, Cham. https://doi.org/10.1007/978-3-319-78762-6_11

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  • DOI: https://doi.org/10.1007/978-3-319-78762-6_11

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