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Sinus Node Disease and Cardiac Conduction Disease

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Channelopathies in Heart Disease

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 6))

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Abstract

Primary sinus node disease (SND) and cardiac conduction defect (CCD) are frequent clinical entities with significant morbidity and mortality, which are major indications for the implantation of electronic pacemakers. Throughout the previous two decades, pathogenetic mechanisms underlying both disorders have been investigated in detail, and it has been demonstrated that distinct genetic defects and/or predisposing genetic constellations play important roles in a considerable number of cases. Furthermore it has been shown that both entities often are related to a broader clinical spectrum including overlapping arrhythmia syndromes and structural cardiac abnormalities, indicating that specified genetic defects are key to distinct clinical phenotypes. This book chapter summarizes the work, which most profoundly influences the current understanding of primary excitation and conduction disorders of the heart. The novel mechanistic insight into important pathogenetic aspects of these disorders may lay the groundwork for more mechanism-based, individually tailored clinical management of patients with primary SND and CCD in the future.

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Acknowledgments

This work was supported in parts by grants from the Molecular Medicine Partnership Unit, Heidelberg (Senior Career Fellowship to P.A.S.).

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Authors and Affiliations

  1. Department of Cardiology, Heidelberg Center for Rhythm Disorders (HCR), Medical University Hospital Heidelberg, Heidelberg, Germany

    Patrick A. Schweizer

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  1. Patrick A. Schweizer
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Correspondence to Patrick A. Schweizer .

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Editors and Affiliations

  1. Department of Cardiology and HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Heidelberg, Germany

    Dierk Thomas

  2. Dept. of Clinical & Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Carol Ann Remme

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Dr. Schweizer indicates no potential conflicts of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Schweizer, P.A. (2018). Sinus Node Disease and Cardiac Conduction Disease. In: Thomas, D., Remme, C. (eds) Channelopathies in Heart Disease . Cardiac and Vascular Biology, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-77812-9_9

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