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Endophytes of Nothapodytes nimmoniana (J. Graham) Mabb.

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Endophytes and Secondary Metabolites

Part of the book series: Reference Series in Phytochemistry ((RSP))

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Abstract

Endophytes are excellent source of bioactive natural products. Fungal and bacterial endophytes have been isolated from medicinal plant Nothapodytes nimmoniana, and majority of them have the capability of accumulating camptothecin (CPT) similar to host plant. Entrophospora infrequens, Neurospora crassa, Fusarium oxysporum, Colletotrichum fructicola, and Corynespora cassiicola are some of the fungal isolates which have been cultured by following submerged fermentation and solid-state fermentation methods for the production of CPT. Here we presented the detailed account of various endophytes isolated from Nothapodytes nimmoniana and recent research developments made in this area.

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Abbreviations

9-MCPT:

9-methoxycamptothecin

A-549:

Adenocarcinomic human alveolar basal epithelial cells (lung cancer cell line)

BEB:

Beef extract broth

BOD:

Biological oxygen demand

CCD:

Central composite design

CDB:

Czapek dox broth

COD:

Chemical oxygen demand

CPT:

Camptothecin

FDA:

US Food and Drug Administration

HEP-2:

Human epithelial type 2 (liver cancer cell line)

HPLC:

High performance liquid chromatography

LC/MS:

Liquid chromatography/mass spectroscopy

MEB:

Malt extract broth

MS/MS:

Mass spectroscopy/mass spectroscopy

OVCAR-2:

Human epithelial carcinoma cell line of the ovary (ovarian cancer cell line)

PDB:

Potato dextrose broth

RSM:

Response surface methodology

SB:

Sabouraud broth

SSF:

Solid-state fermentation

TDS:

Total dissolved solids

TSS:

Total soluble solids

YEB:

Yeast extract broth

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Acknowledgments

This study was supported by DST-PURSE Phase II program and UGC-BSR Mid-Career Award grant [No. F.19-223/2018(BSR)].

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Authors and Affiliations

  1. Department of Botany, Karnatak University, Dharwad, India

    Hosakatte Niranjana Murthy & Dayanand Dalawai

  2. Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, Republic of Korea

    Hosakatte Niranjana Murthy, So-Young Park & Kee-Yoeup Paek

Authors
  1. Hosakatte Niranjana Murthy
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  2. Dayanand Dalawai
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  3. So-Young Park
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  4. Kee-Yoeup Paek
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Corresponding author

Correspondence to Hosakatte Niranjana Murthy .

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Editors and Affiliations

  1. Department of Botany, University of Calcutta, Kolkata, West Bengal, India

    Sumita Jha

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Murthy, H.N., Dalawai, D., Park, SY., Paek, KY. (2018). Endophytes of Nothapodytes nimmoniana (J. Graham) Mabb.. In: Jha, S. (eds) Endophytes and Secondary Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-76900-4_3-1

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  • DOI: https://doi.org/10.1007/978-3-319-76900-4_3-1

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  • Print ISBN: 978-3-319-76900-4

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