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Collagen-Based Hydrogels and Their Applications for Tissue Engineering and Regenerative Medicine

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Cellulose-Based Superabsorbent Hydrogels

Part of the book series: Polymers and Polymeric Composites: A Reference Series ((POPOC))

Abstract

A promising solution for soft tissue regeneration is tissue engineering, a multidisciplinary field of research which involves the use of biomaterials, growth factors, and stem cells in order to repair, replace, or regenerate tissues and organs damaged by injury or disease. The success of tissue engineering (TE) depends on the composition and microstructure of the used scaffolds. Ideally, scaffolds have to be similar to natural tissues. Collagen is the major component of the extracellular matrix of most soft tissues. The interactions between collagen and cells are vital in the wound healing process and in adult tissue remodeling, collagen being able to support differentiation and maintenance of cellular phenotype. As a natural molecule, collagen possesses the major advantage of being biodegradable, biocompatible, easily available, and highly versatile and presents low antigenicity. This chapter aims to present an overview on the structure, properties, and biomedical applications of collagen hydrogels. Moreover, it introduces the reader to the latest research in the field of tissue engineering related to collagen. It also displays the results we obtained as a joint bioengineering group on collagen hydrogels designed for soft (ATE) or cartilage tissue engineering (CTE) applications: type I collagen hydrogels improved with either silk sericin (CollSS) or with pro-chondrogenic factors – hyaluronic acid and chondroitin sulfate (CollSSHACS). Results indicated in both cases the positive influence of sericin on the interaction between cells and the surface of the hydrogels. In the absence of HA and CS, specific chondrogenic inducers, CollSS hydrogel is adapted for soft tissue reconstruction, whether the addition of HA and CS transforms CollSSHACS into a suitable hydrogel formula for semihard tissue repair via modern strategies in tissue engineering and regenerative medicine.

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Acknowledgments

The authors would like to acknowledge the funding sources that supported this work: grant 65PCCDI/2018 (REGMED), Project 3- dedicated to regeneration of soft tissues and to national project Bridge Grant PNIII-P2-2.1-BG-2016660 0458 (123BG/2016), as well as the National Executive Agency for Research Funding.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania

    Sorina Dinescu, Leona Chitoiu, Simona Ignat & Marieta Costache

  2. Collagen Department, INCDTP – Leather and Footwear Research Institute, Bucharest, Romania

    Madalina Albu Kaya

  3. Department of Medicinal and Aromatic Plants, Mustafa-Kemal University, Hatay, Turkey

    Durmus Alpaslan Kaya

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  1. Sorina Dinescu
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  2. Madalina Albu Kaya
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  4. Simona Ignat
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  6. Marieta Costache
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Correspondence to Marieta Costache .

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  1. Department of Applied Chemistry & Chemical Engineering, University of Rajshahi, Rajshahi, Bangladesh

    Md. Ibrahim H. Mondal

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Dinescu, S., Albu Kaya, M., Chitoiu, L., Ignat, S., Kaya, D.A., Costache, M. (2018). Collagen-Based Hydrogels and Their Applications for Tissue Engineering and Regenerative Medicine. In: Mondal, M. (eds) Cellulose-Based Superabsorbent Hydrogels. Polymers and Polymeric Composites: A Reference Series. Springer, Cham. https://doi.org/10.1007/978-3-319-76573-0_54-1

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  • DOI: https://doi.org/10.1007/978-3-319-76573-0_54-1

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