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Dementia and the Health of the Nation

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Cognitive Changes after Surgery in Clinical Practice

Part of the book series: In Clinical Practice ((ICP))

Abstract

This chapter gives a brief overview of dementia demographics with a particular emphasis on predicting future risks, from the perspective of both individuals and populations. The focus is on Alzheimer’s disease since this is the most common form of dementia, but much that is said in terms of risk prediction and population screening may be applicable, mutatis mutandis, to other common forms of dementia (vascular, Parkinson’s disease, frontotemporal). These novel approaches will in all likelihood be required if current practice is to be reconciled with future trends of dementia prevalence and incidence.

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References

  1. Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift fur Psychiatrie und Psychisch-Gerichtlich Medizine. 1907;64:146–8.

    Google Scholar 

  2. Fuller SC. Alzheimer’s disease (senium praecox): the report of a case and review of published cases. J Nerv Ment Dis. 1912;39:440–455 and 536–557.

    Article  Google Scholar 

  3. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968;114:797–811.

    Article  CAS  Google Scholar 

  4. Katzman R. Editorial: the prevalence and malignancy of Alzheimer disease. A major killer. Arch Neurol. 1976;33:217–8.

    Article  CAS  Google Scholar 

  5. World Health Organization. Dementia: a public health priority. Geneva: World Health Organization; 2012.

    Google Scholar 

  6. Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366:2112–7.

    Article  Google Scholar 

  7. Alzheimer’s Society, Dementia UK. A report into the prevalence and cost of dementia prepared by the Personal Social Services Research Unit (PSSRU) at the London School of Economics and the Institute of Psychiatry at King’s College London, for the Alzheimer’s Society. London: Alzheimer’s Society; 2007.

    Google Scholar 

  8. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9:63–75.e2.

    Article  Google Scholar 

  9. Prince M, Wimo A, Guerchet M, et al. World Alzheimer report 2015. The global impact of dementia. An analysis of prevalence, incidence, cost and trends. London: Alzheimer’s Disease International; 2015.

    Google Scholar 

  10. Lang L, Clifford A, Wei L, et al. Prevalence and determinants of undetected dementia in the community: a systematic literature review and a meta-analysis. BMJ Open. 2017;7(2):e011146.

    Article  Google Scholar 

  11. Prince M, Albanese E, Guerchet M, Prina M. World Alzheimer report 2014. Dementia and risk reduction. An analysis of protective and modifiable factors. London: Alzheimer’s Disease International; 2014.

    Google Scholar 

  12. Kostoff RN, Zhang Y, Ma J, Porter AL, Buchtel HA. Prevention and reversal of Alzheimer’s Disease: Georgia Institute of Technology; 2017. PDF. https://smartech.gatech.edu/handle/1853/56646.

  13. Amieva H, Jacqmin-Gadda H, Orgogozo JM, et al. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain. 2005;128:1093–101.

    Article  Google Scholar 

  14. Jack CR Jr, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013;12:207–16.

    Article  CAS  Google Scholar 

  15. Dubois B, Feldman HH, Jacova C, et al. Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol. 2010;9:1118–27.

    Article  Google Scholar 

  16. Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. 2014;13:614–29 [Erratum Lancet Neurol 2014;13:757].

    Google Scholar 

  17. Litvan I, Goldman JG, Troster AI, et al. Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society task force guidelines. Mov Disord. 2012;27:349–56.

    Article  Google Scholar 

  18. Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:2672–713.

    Article  Google Scholar 

  19. de Mendonça A, Ribeiro F, Guerreiro M, Garcia C. Frontotemporal mild cognitive impairment. J Alzheimers Dis. 2004;6:1–9.

    Article  Google Scholar 

  20. Bertram L, Tanzi RE. Genome-wide association studies in Alzheimer’s disease. Hum Mol Genet. 2009;18:R137–45.

    Article  CAS  Google Scholar 

  21. Cuyvers E, Sleegers K. Genetic variations underlying Alzheimer’s disease: evidence from genome-wide association studies and beyond. Lancet Neurol. 2016;15:857–68.

    Article  CAS  Google Scholar 

  22. Desikan RS, Fan CC, Wang Y, et al. Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score. PLoS Med. 2017;14(3):e1002258. https://doi.org/10.1371/journal.pmed.1002258.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Larner AJ, Bracewell RM. Predicting Alzheimer’s disease: a polygenic hazard score. J R Coll Physicians Edinb. 2017;47:151–2.

    Article  CAS  Google Scholar 

  24. Baum ML. The neuroethics of biomarkers. What the development of bioprediction means for moral responsibility, justice, and the nature of mental disorder. Oxford: Oxford University Press; 2016.

    Google Scholar 

  25. Wilson JMG, Jungner G. Principles and practice of screening for disease. Public health paper no. 34. Geneva: World Health Organisation; 1968.

    Google Scholar 

  26. Larner AJ. Introduction to cognitive screening instruments: rationale and desiderata. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 3–13.

    Chapter  Google Scholar 

  27. Brunet MD, McCartney H, Heath I, et al. There is no evidence base for proposed dementia screening. BMJ. 2012;345:e8588.

    Article  Google Scholar 

  28. Philips E, Walters A, Biju M, Kuruvilla T. Population-based screening for dementia: controversy and current status. Prog Neurol Psychiatry. 2016;20(1):6–9.

    Article  Google Scholar 

  29. Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017.

    Google Scholar 

  30. Alzheimer’s Society. Mapping the Dementia Gap. Progress on improving diagnosis of dementia 2011–2012. London: Alzheimer’s Society; 2012. p. 2013.

    Google Scholar 

  31. Cagliarini AM, Price HL, Livemore ST, Larner AJ. Will use of the Six-Item Cognitive Impairment Test help to close the dementia diagnosis gap? Aging Health. 2013;9:563–6.

    Article  CAS  Google Scholar 

  32. Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18:691–701.

    Article  Google Scholar 

  33. Gottesman RF, Schneider AL, Zhou Y, et al. Association between midlife vascular risk factors and estimated brain amyloid deposition. JAMA. 2017;317:1443–50.

    Article  CAS  Google Scholar 

  34. Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006;5:735–41.

    Article  Google Scholar 

  35. Vasunilashorn SM, Fong TG, Albuquerque A, et al. Delirium severity post-surgery and its relationship with long-term cognitive decline in a cohort of patients without dementia. J Alzheimers Dis. 2017;61:347–58.

    Article  Google Scholar 

  36. Larner AJ. “Dementia unmasked”: atypical, acute aphasic, presentations of neurodegenerative dementing disease. Clin Neurol Neurosurg. 2005;108:8–10.

    Article  CAS  Google Scholar 

  37. National Institute for Health and Care Excellence. Dementia, disability and frailty in later life – mid-life approaches to delay or prevent onset. London: NICE; 2015. NICE guidelines [NG16]. https://www.nice.org.uk/guidance/ng16

    Google Scholar 

  38. Matthews FE, Stephan BC, Robinson L, et al. A two decade dementia incidence comparison from the cognitive function and ageing studies I and II. Nat Commun. 2016;7:11398.

    Article  CAS  Google Scholar 

  39. Wu YT, Fratiglioni L, Matthews FE, et al. Dementia in western Europe: epidemiological evidence and implications for policy making. Lancet Neurol. 2016;15:116–24.

    Article  Google Scholar 

  40. Bennett DA. Banking against Alzheimer’s. Sci Am Mind. 2016;27(4):28–37.

    Article  Google Scholar 

  41. Northey JM, Cherbuin N, Pumpa KL, Smee DJ, Rattray B. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med. 2018;52:154–60.

    Article  Google Scholar 

  42. Department of Health. Living well with dementia: a National Dementia Strategy. London: Department of Health; 2009.

    Google Scholar 

  43. Department of Health. Prime Minister’s Challenge on Dementia. Delivering major improvements in dementia care and research by 2015. London: Department of Health; 2012.

    Google Scholar 

  44. Department of Health. Prime Minister’s Challenge on Dementia 2020. London: Department of Health; 2015.

    Google Scholar 

  45. Department of Health. G8 dementia summit declaration. London: Department of Health; 2013. https://www.gov.uk/government/publications/g8-dementia-summit-agreements/g8-dementia-summit-declaration

    Google Scholar 

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Acknowledgement

Thanks to Dr. Lauren Fratalia for critical comments on this manuscript.

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Authors and Affiliations

  1. Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK

    Andrew Larner

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  1. Andrew Larner
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Correspondence to Andrew Larner .

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Editors and Affiliations

  1. Department of Anaesthesia, Royal Lancaster Infirmary, Lancaster, Lancashire, UK

    Andrew Severn

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Larner, A. (2018). Dementia and the Health of the Nation. In: Severn, A. (eds) Cognitive Changes after Surgery in Clinical Practice. In Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-75723-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-75723-0_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75722-3

  • Online ISBN: 978-3-319-75723-0

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