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Inflammation-Induced Photoreceptor Cell Death

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1074))

Abstract

Neuroinflammation is an important aspect of many diseases of the eye, and experimental animal models have been widely used to determine its impact on retinal homeostasis and neuron survival. Physical separation of the neurosensory retina from the underlying retinal pigment epithelium (RPE) results in activation and infiltration of macrophages. Numerous studies have shown the critical role of macrophages in retinal disease processes. In retinal detachment, accumulation of macrophages in the subretinal space is associated with changes in cytokine and chemokine profile which lead to photoreceptor cell death. Targeted disruption of macrophage chemotaxis significantly reduces retinal detachment-induced photoreceptor degeneration. Apoptosis is the predominant mechanism of cell death; however regulated necrosis is also a contributor of photoreceptor loss. Therefore, effective neuroprotective approaches could integrate combined inhibition of both apoptotic and regulated necrosis pathways.

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Acknowledgements

This work was supported by the Foundation Fighting Blindness Travel Fellowship, The Starr Foundation, The Jeffrey Fort Innovation Fund, a Research to Prevent Blindness Physician Scientist Award (RSA) and a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa. The Department of Ophthalmology, Washington University School of Medicine, is supported by an unrestricted grant from the Research to Prevent Blindness, New York City, NY.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA

    Abdoulaye Sene & Rajendra S. Apte

  2. Department of Developmental Biology and Medicine, Washington University School of Medicine, St. Louis, MO, USA

    Rajendra S. Apte

  3. Department of Biology, Allergan, Inc., Irvine, CA, USA

    Rajendra S. Apte

Authors
  1. Abdoulaye Sene
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  2. Rajendra S. Apte
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Corresponding author

Correspondence to Abdoulaye Sene .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. Ophthalmology and Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  3. School of Medicine Beckman Vision Center, University of California San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  4. Departments of Ophthalmology and Cell Biology, Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  5. Division of Ophthalmology, Case Western Reserve University, Cleveland, Ohio, USA

    Joe G. Hollyfield

  6. Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

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Sene, A., Apte, R.S. (2018). Inflammation-Induced Photoreceptor Cell Death. In: Ash, J., Anderson, R., LaVail, M., Bowes Rickman, C., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1074. Springer, Cham. https://doi.org/10.1007/978-3-319-75402-4_25

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