Skip to main content
SpringerLink
Log in

Sweet’s Syndrome

  • Chapter
  • First Online:
Neutrophilic Dermatoses

Abstract

Sweet’s syndrome is the prototypic neutrophilic dermatosis first reported in 1964 by Robert Douglas Sweet who describes a new dermatosis entitled an ‘acute febrile neutrophilic dermatosis”. Although the pathogenesis of Sweet’s syndrome still remains to be determined, this condition is now classified as an autoinflammatory disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349–56.

    Article  CAS  PubMed  Google Scholar 

  2. Marzano AV, Fanoni D, Antiga E, Quaglino P, Caproni M, Crosti C, Meroni PL, Cugno M. Expression of cytokines, chemokines and other effector molecules in two prototypic autoinflammatory skin diseases, pyoderma gangrenosum and Sweet’s syndrome. Clin Exp Immunol. 2014;178:48–56.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Sujobert P, Cuccuini W, Vignon-Pennamen D, Martin-Garcia N, Albertini AF, Uzunov M, Redjoul R, Dombret H, Raffoux E. Evidence of differenciation in myeloid malignancies associated neutrophilic dermatosis: a fluorescent in situ hybridization study of 14 patients. J Invest Dermatol. 2013;133:1111–4.

    Article  CAS  PubMed  Google Scholar 

  4. Chavan RN, Cappel MA, Ketterling RP, Wada DA, Rochet NM, Knudson R, Gibson LE. Histiocytoid Sweet syndrome may indicate leukemia cutis: a novel application of fluorescent in situ hybridization. J Am Acad Dermatol. 2014;70:1021–7.

    Article  PubMed  Google Scholar 

  5. Cohen PR, Talpaz M, Kurzrock R. Malignancy-associated Sweet’s syndrome: review of the world literature. J Clin Oncol. 1988;6:1887–97.

    Article  CAS  PubMed  Google Scholar 

  6. Cohen PR, Kurzrock R. Sweet’s syndrome and cancer. Clin Dermatol. 1993;11:149–57.

    Article  CAS  PubMed  Google Scholar 

  7. von den Driesch P. Sweet’s syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol. 1994;31:535–56.

    Article  PubMed  Google Scholar 

  8. Cohen PR, Kurzrock R. Sweet’s syndrome: a neutrophilic dermatosis classically associated with acute onset and fever. Clin Dermatol. 2000;18:265–82.

    Article  CAS  PubMed  Google Scholar 

  9. Cohen PR, Kurzrock R. Sweet’s syndrome revisited: a review of disease concepts. Int J Dermatol. 2003;42:761–78.

    Article  PubMed  Google Scholar 

  10. Wallach D, Vignon-Pennamen MD. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses. Br J Dermatol. 2015. https://doi.org/10.1111/bjd.13955.

  11. Costello MJ, Canizares O, Montague M, Buncke CM. Cutaneous manifestations of myelogenous leukemia. Arch Dermatol. 1955;71:605–14.

    Article  CAS  Google Scholar 

  12. Matta M, Malak J, Tabet E, Kurban AK. Sweet’s syndrome: systemic associations. Cutis. 1973;12:561–5.

    Google Scholar 

  13. Kemmett D, Hunter JA. Sweet’s syndrome: a clinicopathologic review of twenty-nine cases. J Am Acad Dermatol. 1990;23:503–7.

    Article  CAS  PubMed  Google Scholar 

  14. Hommel L, Harms M, Saurat JH. The incidence of Sweet’s syndrome in Geneva. Dermatology. 1993;187:303–5.

    Article  CAS  PubMed  Google Scholar 

  15. Sitjas D, Puig L, Cuatrecasas M, De Moragas JM. Acute febrile neutrophilic dermatosis (Sweet’s syndrome). Int J Dermatol. 1993;32:261–8.

    Article  CAS  PubMed  Google Scholar 

  16. Chan HL, Lee YS, Kuo TT. Sweet’s syndrome: clinicopathologic study of eleven cases. Int J Dermatol. 1994;33:425–32.

    Article  CAS  PubMed  Google Scholar 

  17. Fett DL, Gibson LE, Su WPD. Sweet’s syndrome: systemic signs and symptoms and associated disorders. Mayo Clin Proc. 1995;70:234–40.

    Article  CAS  PubMed  Google Scholar 

  18. Bourke JF, Keohane S, Long CC, Kemmett D, Davies M, Zaki I, Graham-Brown RA. Sweet’s syndrome and malignancy in the U.K. Br J Dermatol. 1997;137:609–13.

    Article  CAS  PubMed  Google Scholar 

  19. Cho KH, Han KH, Kim SW, Youn SW, Youn JI, Kim BK. Neutrophilic dermatoses associated with myeloid malignancy. Clin Exp Dermatol. 1997;22:269–73.

    Article  CAS  PubMed  Google Scholar 

  20. Neoh CY, Tan AW, Ng SK. Sweet’s syndrome: a spectrum of unusual clinical presentations and associations. Br J Dermatol. 2007;156:480–5.

    Article  CAS  PubMed  Google Scholar 

  21. Borges da Costa J, Silva R, Soares de Almeda L, Filipe P, Marques Gomes M. Sweet’s syndrome: a retrospective study of 42 admitted patients in a Portuguese hospital. Int J Dermatol. 2009;48:953–5.

    Article  PubMed  Google Scholar 

  22. Abbas O, Kibbi AG, Rubeiz N. Sweet’s syndrome: retrospective study of clinical and histologic features of 44 cases from a tertiary care center. Int J Dermatol. 2010;49:1244–9.

    Article  PubMed  Google Scholar 

  23. Wojcik AS, Nishimori FS, Santamaria JR. Sweet’s syndrome: a study of 23 cases. An Bras Dermatol. 2011;86:265–71.

    Article  PubMed  Google Scholar 

  24. Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations and response to treatment in 77 patients. J Am Acad Dermatol. 2013;69:557–64.

    Article  CAS  PubMed  Google Scholar 

  25. Uilhein LC, Brandling-Bennett HA, Lio PA, Liang MG. Sweet syndrome in children. Pediatr Dermatol. 2012;29:38–44.

    Article  Google Scholar 

  26. Demitsu T, Tadaki T. Atypical neutrophilic dermatosis on the upper extremitiy affected by postmastectomy lymphedema: report of 2 cases. Dermatologica. 1991;183:230–3.

    Article  CAS  PubMed  Google Scholar 

  27. Minocha R, Sebaratnam DF, Choi JY. Sweet’s syndrome following surgery: cutaneous trauma as a possible aetiological co-factor in neutrophilic dermatoses. Australas J Dermatol. 2015;56:e74–6.

    Article  PubMed  Google Scholar 

  28. Caughman W, Stern R, Haynes H. Neutrophilic dermatosis of myeloproliferative disorders. Atypical forms of pyoderma gangrenosum and Sweet’s syndrome associated with myeloproloferative disorders. J Am Acad Dermatol. 1983;9:751–8.

    Article  CAS  PubMed  Google Scholar 

  29. Cooper PH, Innes DJ, Greer KE. Acute febrile neutrophilic dermatosis (Sweet’s syndrome) and myeloproliferative disorders. Cancer. 1983;51:1518–26.

    Article  CAS  PubMed  Google Scholar 

  30. Strutton G, Weedon D, Robertson I. Pustular vasculitis of the hands. J Am Acad Dermatol. 1995;32:192–8.

    Article  CAS  PubMed  Google Scholar 

  31. Galaria NA, Junkins-Hopkins JM, Kligman D, James WD. Neutrophilic dermatosis of the dorsal hands: pustular vasculitis revisited. J Am Acad Dermatol. 2000;43:870–4.

    Article  CAS  PubMed  Google Scholar 

  32. DiCaudo DJ, Connolly SM. Neutrophilic dermatosis (pustular vasculitis) of the dorsal hands. A report of 7 cases and review of the literature. Arch Dermatol. 2002;138:361–5.

    Article  PubMed  Google Scholar 

  33. Cohen PR. Skin lesions of Sweet syndrome and its dorsal hand variant contain vasculitis. An oxymoron or an epiphenomenon? Arch Dermatol. 2002;138:400–3.

    Article  PubMed  Google Scholar 

  34. Sarkany RP, Burrows NP, Grant JW, Pye RJ, Norris PG. The pustular eruption of ulcerative colitis: a variant of Sweet’s syndrome? Br J Dermatol. 1998;138:365–6.

    Article  CAS  PubMed  Google Scholar 

  35. Yoon TY, Ahn GB, Yang TH, Shin HS. Sweet’s syndrome with abscess-like lesions in a patient with acute myelogenous leukemia. J Dermatol. 2000;27:794–7.

    Article  CAS  PubMed  Google Scholar 

  36. Horiguchi Y, Lee SG, Matsumoto I, Arima N, Fugiino H, Ohnuma Y, Imamura S. Abscess-forming neutrophilic dermatosis: report of three cases associated with hemopathies. Dermatology. 1998;197:174–7.

    Article  CAS  PubMed  Google Scholar 

  37. Cohen PR. Subcutaneous Sweet’s syndrome: a variant of acute febrile neutrophilic dermatosis that is included in the histopathologic differential diagnosis of neutrophilic panniculitis. J Am Acad Dermatol. 2005;52:927–8.

    Article  PubMed  Google Scholar 

  38. Sutra-Loubet C, Carlotti A, Guillemette J, Wallach D. Neutrophilic panniculitis. J Am Acad Dermatol. 2004;50:280–5.

    Article  PubMed  Google Scholar 

  39. Chan MP, Duncan LM, Nazarian RM. Subcutaneous Sweet syndrome in the setting of myeloid disorders: a case series and review of the literature. J Am Acad Dermatol. 2013;68:1006–15.

    Article  PubMed  Google Scholar 

  40. Chen HC, Kao WY, Chang DM, Gao HW, Lai WY, Lai JH. Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: case report and review of the literature. Am J Hematol. 2004;76:61–5.

    Article  PubMed  Google Scholar 

  41. Dompmartin A, Troussard X, Lorier E, Jacobs F, Reman O, Leroy D, Leporrier M. Sweet syndrome associated with acute myelogenous leukemia. Atypical form simulating facial erysipelas. Int J Dermatol. 1991;30:644–7.

    Article  CAS  PubMed  Google Scholar 

  42. Khatri ML, Taha M. Sweet’s syndrome associated with myelodysplastic syndrome presenting as periorbital cellulitis. Int J Dermatol. 2007;46:496–9.

    Article  PubMed  Google Scholar 

  43. Kroshinsky D, Alloo A, Rothschild B, Cummins J, Tan J, Montecino R, Hoang MP, Duncan L, Minh M, Sepehr A. Necrotizing Sweet syndrome: a new variant of neutrophilic dermatosis mimicking necrotizing fasciitis. J Am Acad Dermatol. 2012;67:945–54.

    Article  PubMed  Google Scholar 

  44. Surovy AM, Pelivani N, Hegyi I, Buettiker U, Beltraminelli H, Borradori L. Giant cellulitis-like Sweet syndrome, a new variant of neutrophilic dermatosis. JAMA Dermatol. 2013;149:79–83.

    Article  PubMed  Google Scholar 

  45. Vignon-Pennamen MD, Wallach D. Cutaneous manifestations of neutrophilic disease. Dermatologica. 1991;183:255–64.

    Article  CAS  PubMed  Google Scholar 

  46. Vignon-Pennamen MD. The extracutaneous involvement in the neutrophilic dermatoses. Clin Dermatol. 2000;18:339–47.

    Article  CAS  PubMed  Google Scholar 

  47. Ferguson PJ, Chen S, Tayeh MK, Ochoa L, Leal SM, Pelet A, Munnich A, Lyonnet S, Majeed HA, El-Shanti H. Homozygous mutations in LIPN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome). J Med Genet. 2005;42:551–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  48. Marie I, Boyer A, Heron F, Joly P, Levesque H, Thomine E, Courtois H. Focal aseptic osteitis underlying neutrophilic dermatosis. Br J Dermatol. 1998;139:744–5.

    Article  CAS  PubMed  Google Scholar 

  49. Gottlieb CC, Mishra A, Belliveau D, Green P, Heathcote JG. Ocular involvement in acute febrile neutrophilic dermatosis (Sweet syndrome): new cases and review of the literature. Surv Ophthalmol. 2008;53:219–26.

    Article  PubMed  Google Scholar 

  50. Wilson DM, John GR, Callen JP. Peripheral ulcerative keratitis-an extracutaneous neutrophilic disorder: report of a patient with rheumatoid arthritis, pustular vasculitis, pyoderma gangrenosum, and Sweet’s syndrome with an excellent response to cyclosporine therapy. J Am Acad Dermatol. 1999;40:331–4.

    Article  CAS  PubMed  Google Scholar 

  51. Bilgin AB, Tavas P, Turkoglu EB, Ilhan HD, Toru S, Apaydin KC. An uncommon ocular manifestation of Sweet syndrome: peripheral ulcerative keratitis and nodular scleritis. Arq Bras Oftalmol. 2015;78:53–5.

    Article  PubMed  Google Scholar 

  52. Marie I, Levesque H, Joly P, Reumont G, Courville P, Baudrimont M, Baudion D, Cailleux N, Courtois H. Neutrophilic myositis as an extracutaneous manifestation of neutrophilic dermatosis. J Am Acad Dermatol. 2001;44:137–9.

    Article  CAS  PubMed  Google Scholar 

  53. Mosnier E, Rousset P, Hugol D, Bouscary D, Aslangul E. Neutrophilic myositis sine dermatitis in a neutropenic patient with myelodysplastic syndrome. Ann Hematol. 2013;92:551–2.

    Article  CAS  PubMed  Google Scholar 

  54. Astudillo L, Sailler L, Launay F, Josse AG, Lamant L, Couret B, Arlet-Suau E. Pulmonary involvement in Sweet’s syndrome: a case report and review of the literature. Int J Dermatol. 2006;45:677–80.

    Article  PubMed  Google Scholar 

  55. Lawrence K, Hachem R, Wildes TM, Canizares M. A 54-year old man with a rash and pulmonary infiltrates. Chest. 2008;134:1340–3.

    Article  PubMed  Google Scholar 

  56. Shugarman IL, Schmit JM, Sbicca JA, Wirk B. Easily missed extracutaneous manifestation of malignancy-associated Sweet’s syndrome: systemic inflammatory response syndrome. J Clin Oncol. 2011;29:e702–5.

    Article  PubMed  Google Scholar 

  57. Hisanaga K, Iwasaki Y, Ytoyama Y. Neuro-Sweet disease: clinical manifestations and criteria for diagnosis. Neurology. 2005;64:1756–61.

    Article  PubMed  Google Scholar 

  58. Fain O, Mathieu E, Feton N, Sibony M, Sitbon M, Lejeune F, Thomas M. Intestinal involvement in Sweet’s syndrome. J Am Acad Dermatol. 1996;35:989–90.

    Article  CAS  PubMed  Google Scholar 

  59. Li B, Ma Z, Xu X, Yin J, Wang X, Ren J, Wang S, Yang J, Ma T, Zhang Q, Yu J, Yan B. Multi-organ involvement of Sweet’s syndrome; a case report and literature review. Intern Med. 2015;54:339–43.

    Article  PubMed  Google Scholar 

  60. Aractingi S, Mallet V, Pinquier L, Chosidow O, Vignon-Pennamen MD, Degos L, Dubertret L, Dombret H. Neutrophilic dermatoses during granulocytopenia. Arch Dermatol. 1995;131:1141–5.

    Article  CAS  PubMed  Google Scholar 

  61. von den Driesch P, Weber MF. Are antibodies to neutrophilic cytoplasmic antigens (ANCA) a serologic marker for Sweet’s syndrome. J Am Acad Dermatol. 1993;29:666.

    Article  PubMed  Google Scholar 

  62. Malone JC, Slone SP, Wills-Frank LA, Fearneyhough PK, Lear SC, Goldsmith LJ, Hood AF, Callen JP. Vascular inflammation (vasculitis) in Sweet syndrome: a clinicopathologic study of 28 biopsy specimens from 21 patients. Arch Dermatol. 2002;138:345–9.

    Article  PubMed  Google Scholar 

  63. Rochael MC, Pantaleao L, Vilar EA, Zacaron LH, Spada EQ, Xavier MH, Rodrigues KS. Sweet’s syndrome: study of 73 cases, emphasizing histopathological findings. An Bras Dermatol. 2011;86:702–7.

    Article  PubMed  Google Scholar 

  64. Requena L, Kutzner H, Palmedo G, Pascual M, Fernandez-Herrera J, Fraga J, Garcia-Diez A, Yus ES. Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol. 2005;141:834–42.

    Article  PubMed  Google Scholar 

  65. Ghoufi L, Ortonne N, Ingen-Housz-Oro S, Barhoumi W, Begon E, Haioun C, Pautas C, Beckerich F, Robin C, Wolkenstein P, Cordonnier C, Chosidow O, Toma A. Histiocytoid Sweet syndrome is more frequently associated with myelodysplastic syndromes than the classical neutrophilic variant: a comparative series of 62 patients. Medicine. 2016;95:e3033.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  66. Osio A, Battistella M, Feugeas JP, Cuccuini W, Noguera ME, Petrella T, Raffoux E, Janin A, Vignon Pennamen MD. Myelodysplasia cutis versus leukemia cutis. J Invest Dermatol. 2015;135:2321–4.

    Article  CAS  PubMed  Google Scholar 

  67. Thompson DF, Montarella KE. Drug-induced Sweet’s syndrome. Ann Pharmacother. 2007;41:802–11.

    Article  CAS  PubMed  Google Scholar 

  68. Su WP, Liu HN. Diagnostic criteria for Sweet’s syndrome. Cutis. 1986;37:167–74.

    CAS  PubMed  Google Scholar 

  69. Kieffer C, Cribier B, Lipsker D. Neutrophilic urticarial dermatosis: a variant of neutrophilic urticaria strongly associated with systemic disease. Report of 9 new cases and review of the literature. Medicine. 2009;88:23–31.

    Article  PubMed  Google Scholar 

  70. Hau E, Vignon Pennamen MD, Battistella M, Saussine A, Bergis M, Cavelier-Balloy B, Janier M, Cordoliani F, Bagot M, Rybojad M, Bouaziz JD. Neutrophilic skin lesions in autoimmune connective tissue diseases: nine cases and a literature review. Medicine. 2014;93:e346.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  71. Karadogan SK, Baskan EB, Alkan G, Saricaoglu H, Tunali S. Generalized Sweet syndrome lesions associated with Behçet disease: a true association or simply co-morbidity? Am J Clin Dermatol. 2009;10:331–5.

    Article  PubMed  Google Scholar 

  72. Kawakami T, Ohashi S, Kawa Y, Takahama H, Ito M, Soma Y, Mizoguchi M. Elevated serum granulocyte colony-stimulating factor levels in patients with active phase of Sweet syndrome and patients with active Behçet disease: implication in neutrophil apoptosis dysfunction. Arch Dermatol. 2004;140:570–4.

    Article  CAS  PubMed  Google Scholar 

  73. Waltz KM, Long D, Marks JG, Billingsley EM. Sweet’s syndrome and erythema nodosum. The simultaneous occurrence of 2 reactive dermatoses. Arch Dermatol. 1999;135:62–6.

    Article  CAS  PubMed  Google Scholar 

  74. Burton JL. Sweet’s syndrome, pyoderma gangrenosum and acute leukemia. Br J Dermatol. 1980;102:239.

    Article  CAS  PubMed  Google Scholar 

  75. Salmon P, Rademaker M, Edwards L. A continuum of neutrophilic disease occurring in a patient with ulcerative colitis. Australas J Dermatol. 1998;39:116–8.

    Article  CAS  PubMed  Google Scholar 

  76. Castro-Fernandez M, Sanchez-Munoz D, Ruiz-Granados E, Merchante N, Corzo J. Coexistence of pyoderma gangrenosum and Sweet’s syndrome in a patient with ulcerative colitis. Am J Gastroenterol. 2007;102:2865–6.

    Article  PubMed  Google Scholar 

  77. Wallach D. Les dermatoses neutrophiliques. Presse Med. 1991;20:105–7.

    CAS  PubMed  Google Scholar 

  78. Wallach D, Vignon Pennamen MD. From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of clinical research. J Am Acad Dermatol. 2006;55:1066–71.

    Article  PubMed  Google Scholar 

  79. Scerri L, Zaki I, Allen BR. Pyoderma gangrenosum and subcorneal pustular dermatosis without monoclonal gammopathy. Br J Dermatol. 1994;130:398–9.

    Article  CAS  PubMed  Google Scholar 

  80. Caucanas M, Heylen A, Rolland F, Müller G, Olemans C, Sass U, Vanhooteghem O. Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet’s syndrome: the concept of neutrophilic disease. Int J Dermatol. 2013;52:1185–8.

    Article  PubMed  Google Scholar 

  81. Wang T, Liu H, Wang L, Guo Z, Li L. An unusual case of Sweet syndrome in a child: overlapping presentation with erythema elevatum diutinum. Am J Dermatopathol. 2014;36:e114–6.

    Article  PubMed  Google Scholar 

  82. Cohen PR. Neutrophilic dermatoses occurring in oncology patients. Int J Dermatol. 2007;46:106–11.

    Article  PubMed  Google Scholar 

  83. Buck T, Gonzalez LM, Lambert WC, Schwartz RA. Sweet’s syndrome with hematologic disorders: a review and reappraisal. Int J Dermatol. 2008;47:775–82.

    Article  PubMed  Google Scholar 

  84. Kulasekararaj AG, Kordasti S, Basu T, Salisbury JR, Mufti GJ, du Vivier AW. Chronic relapsing remitting Sweet syndrome—a harbinger of myelodysplastic syndrome. Br J Haematol. 2015;170:649–56.

    Article  CAS  PubMed  Google Scholar 

  85. Kazmi SM, Pemmaraju N, Patel KP, Cohen PR, Daver N, Tran KM, Ravandi F, Duvic M, Garcia-Manero G, Pierce S, Nazha A, Borthakur G, Kantarjian H, Cortes J. Characteristics of Sweet syndrome in patients with acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015;15:358–63.

    Article  PubMed  Google Scholar 

  86. Vignon Pennamen MD, Juillard C, Rybojad M, Wallach D, Daniel MT, Morel P, Verola O, Janin A. Chronic recurrent lymphocytic Sweet syndrome as a predictive marker of myelodysplasia. Arch Dermatol. 2006;142:1170–6.

    Article  PubMed  Google Scholar 

  87. Vignon Pennamen MD, Aractingi S. Sweet’s syndrome and leukemia cutis: a common skin homing mechanism? Dermatology. 2003;206:81–4.

    Article  PubMed  Google Scholar 

  88. Lee SJ, Park JK, Lee EY, Joo SH, Jung KC, Lee EB, Song YW, Yoon SS. Certain autoimmune manifestations are associated with distinctive karyotypes and outcomes in patients with myelodysplastic syndrome. A retrospective cohort study. Medicine. 2016;95:e3091.

    Article  PubMed Central  PubMed  Google Scholar 

  89. Walker DC, Cohen PR. Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet’s syndrome. J Am Acad Dermatol. 1996;34:918–23.

    Article  CAS  PubMed  Google Scholar 

  90. Arbetter KR, Hubbard KW, Markovic SN, Gibson LE, Phyliky RL. Case of granulocyte colony-stimulating factor-induced Sweet’s syndrome. Am J Hematol. 1999;61:126–9.

    Article  CAS  PubMed  Google Scholar 

  91. Draper BK, Robbins JB, Stricklin GP. Bullous Sweet’s syndrome in congenital neutropenia: association with pegfilgrastim. J Am Acad Dermatol. 2005;52:901–5.

    Article  PubMed  Google Scholar 

  92. Al-Saad K, Khanani MF, Naqvi A, Krafchik B, Grant R, Pappo A. Sweet syndrome developing during treatment with all-trans retinoic acid in a child with acute myelogenous leukemia. J Pediatr Hematol Oncol. 2004;26:197–9.

    Article  PubMed  Google Scholar 

  93. Varadarajan N, Boni A, Elder DE, Bagg A, Micheletti R, Perl AE, Rosenbach M. FLT3 inhibitor-associated neutrophilic dermatoses. JAMA Dermatol. 2016;152:480–2.

    Article  PubMed  Google Scholar 

  94. Jovanovic M, Poljacki M, Vujanovic L, Duran V. Acute febrile neutrophilic dermatosis (Sweet’s syndrome) after influenza vaccination. J Am Acad Dermatol. 2005;52:367–8.

    Article  PubMed  Google Scholar 

  95. Gunawardena DA, Gunawardena KA, Ratnayaka RM, Vasanthanathan NS. The clinical spectrum of Sweet’s syndrome (acute febrile neutrophilic dermatosis). A report of eighteen cases. Br J Dermatol. 1975;92:363–73.

    Article  CAS  PubMed  Google Scholar 

  96. Kalai C, Brand R, Yu L. Minocycline-induced Sweet’s syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol. 2012;67:e289–91.

    Article  PubMed  Google Scholar 

  97. Tintle S, Patel V, Ruskin A, Halasz C. Azacitidine: a new medication associated with Sweet syndrome. J Am Acad Dermatol. 2011;64:e77–9.

    Article  PubMed  Google Scholar 

  98. Murase JE, Wu JJ, Theate I, Cole GW, Barr RJ, Dyson SW. Bortezomid-induced histiocytoid Sweet syndrome. J Am Acad Dermatol. 2009;60:496–7.

    Article  PubMed  Google Scholar 

  99. Ayirookuzhi SJ, Ma L, Ramshesh P, Mills G. Imatinib-induced Sweet syndrome in a patient with chronic myeloid leukemia. Arch Dermatol. 2005;141:368–70.

    Article  PubMed  Google Scholar 

  100. Gormley R, Wanat K, Elenitsas R, Giles J, McGettigan S, Schuchter L, Takeshita J. Ipilimumab-associated Sweet syndrome in a melanoma patient. J Am Acad Dermatol. 2014;71:e211–3.

    Article  PubMed  Google Scholar 

  101. Azfar RS, Cohn J, Schaffer A, Kim EJ. Trimethoprim-sulfamethoxazole-induced Sweet syndrome. Arch Dermatol. 2009;145:215–6.

    PubMed  Google Scholar 

  102. Banse C, Sobocinski V, Savoye G, Avenel G, Vittecoq O. Occurrence of Sweet syndrome under anti TNF. Clin Rheumatol. 2015;34:1993–4.

    Article  PubMed  Google Scholar 

  103. Thieu KP, Rosenbach M, Xu X, Kist JM. Neutrophilic dermatosis complicating lenalidomide therapy. J Am Acad Dermatol. 2009;61:709–10.

    Article  PubMed  Google Scholar 

  104. Bidinger JJ, Sky K, Battafarano DF, Henning JS. The cutaneous and systemic manifestations of azathioprine hypersensibility syndrome. J Am Acad Dermatol. 2011;65:184–91.

    Article  CAS  PubMed  Google Scholar 

  105. Cyrus N, Stavert R, Mason AR, Ko CJ, Choi JN. Neutrophilic dermatosis after azathioprine exposure. JAMA Dermatol. 2013;149:592–7.

    Article  PubMed  Google Scholar 

  106. Marzano AV, Ishak RS, Saibeni S, Crosti C, Meroni PL, Cugno M. Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet’s syndrome: a comprehensive review and disease classification criteria. Clin Rev Allergy Immunol. 2013;45:202–10.

    Article  CAS  PubMed  Google Scholar 

  107. Anzalone CL, Cohen PR. Acute febrile neutrophilic dermatosis (Sweet’s syndrome). Curr Opin Hematol. 2013;20:26–35.

    Article  CAS  PubMed  Google Scholar 

  108. Braun-Falco M, Ruzicka T. Skin manifestations in autoinflammatory syndromes. J Dtsch Dermatol Ges. 2011;9:232–46.

    PubMed  Google Scholar 

  109. Oskay T, Anadolu R. Sweet’s syndrome in familial mediterranean fever: possible continuum of the neutrophilic reaction as a new cutaneous feature of FMF. J Cutan Pathol. 2009;36:901–5.

    Article  PubMed  Google Scholar 

  110. Van Loon K, Gill RM, McMahon P, Chigurupati R, Siddiqi I, Fox L, Damon L, McCalmont TH, Jordan R, Wolf J. 20q-clonality in a case of oral Sweet syndrome and myelodysplasia. Am J Clin Pathol. 2012;137:310–5.

    Article  PubMed  Google Scholar 

  111. Schadt CR, Callen JP. Management of neutrophilic dermatoses. Dermatol Ther. 2012;25:158–72.

    Article  PubMed  Google Scholar 

  112. Case JD, Smith SZ, Callen JP. The use of pulse methylprednisolone and chlorambucil in the treatment of Sweet’s syndrome. Cutis. 1989;44:125–9.

    CAS  PubMed  Google Scholar 

  113. Inamadar AC, Anitha B. HIV-seropositive patient with Sweet’s syndrome and nodular scleritis, showing dramatic response after adding dapsone to systemic corticosteroid therapy. Int J Dermatol. 2008;47:836–8.

    Article  PubMed  Google Scholar 

  114. Maillard H, Leclech C, Peria P, Avenel-Audran M, Verret JL. Colchicine for Sweet’s syndrome. A study of 20 cases. Br J Dermatol. 1999;140:565–6.

    Article  CAS  PubMed  Google Scholar 

  115. Horio T, Inamura S, Danno K, Furukawa F, Ofuji S. Treatment of acute febrile neutrophilic dermatosis (Sweet’s syndrome) with potassium iodide. Dermatologica. 1980;160:341–7.

    Article  CAS  PubMed  Google Scholar 

  116. Jeanfils S, Joly P, Young P, Le Corvaisier-Pieto C, Thomine E, Lauret P. Indomethacin treatment of eighteen patients with Sweet’s syndrome. J Am Acad Dermatol. 1997;36:436–9.

    Article  CAS  PubMed  Google Scholar 

  117. Yamauchi PS, Turner L, Lowe NJ, Gindi V, Jackson JM. Treatment of recurrent Sweet’s syndrome with coexisting rheumatoid arthritis with the tumor necrosis factor antagonist etanercept. J Am Acad Dermatol. 2006;54:S121–2.

    Article  PubMed  Google Scholar 

  118. von den Driesch P, Steffan C, Zobe A, Hornstein OP. Sweet’s syndrome—therapy with cyclosporin. Clin Exp Dermatol. 1994;19:274–7.

    Article  PubMed  Google Scholar 

  119. Gill HH, Leung AY, Trendell-Smith NJ, Yeung CK, Liang R. Sweet syndrome due to myelodysplastic syndrome: possible therapeutic role of intravenous immunoglobulin in addition to standard treatment. Adv Hematol. 2010;2010:328316.

    PubMed Central  PubMed  Google Scholar 

  120. Kluger N, Gil-Bistes D, Guillot B, Bessis D. Efficacy of antiinterleukin-1 receptor antagonist anakinra (Kineret) in a case of refractory Sweet’s syndrome. Dermatology. 2011;222:123–7.

    Article  PubMed  Google Scholar 

  121. Browning CE, Dixon JE, Malone JC, Callen JP. Thalidomide in the treatment of recalcitrant Sweet’s syndrome associated with myelodysplasia. J Am Acad Dermatol. 2005;53:S135–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathology Department, APHP Hôpital Saint Louis, Paris, France

    Marie-Dominique Vignon-Pennamen M.D.

Authors
  1. Marie-Dominique Vignon-Pennamen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marie-Dominique Vignon-Pennamen M.D. .

Editor information

Editors and Affiliations

  1. Physician (Hon.) of Paris Hospitals, Paris, France

    Daniel Wallach

  2. Pathology Department, APHP Hôpital Saint Louis, Paris, France

    Marie-Dominique Vignon-Pennamen

  3. Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Universita’ degli Studi di Milano, Unita’ Operativa di Dermatologia, IRCCS Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy

    Angelo Valerio Marzano

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vignon-Pennamen, MD. (2018). Sweet’s Syndrome. In: Wallach, D., Vignon-Pennamen, MD., Valerio Marzano, A. (eds) Neutrophilic Dermatoses. Springer, Cham. https://doi.org/10.1007/978-3-319-72649-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-72649-6_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-72648-9

  • Online ISBN: 978-3-319-72649-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation