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Atopic Dermatitis

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Gender and Dermatology
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Abstract

Atopic Dermatitis (AD) is a chronic pruritic inflammatory skin disease.

The etiology is unknown. It usually starts in early infancy, but also affects adults.

It is often associated with elevated serum level of immunoglobulin E and personal or family history of eczema, asthma and allergic rhinitis.

Female to male ratio 1.14:1.

Treatment goals are to reduce symptoms (pruritus and dermatitis), prevent exacerbations and minimize therapeutic risks.

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References

  1. Sprengel JM. From atopic dermatitis to asthma: the atopic march. Am Allergy Asthma Immunol. 2010;105:99.

    Article  Google Scholar 

  2. Schlapbach C, Simon D. Update on skin allergy. Allergy. 2014;69:1571–81.

    Article  CAS  PubMed  Google Scholar 

  3. Brown MM, Chamlin SL. Quality of life in pediatric dermatology. Dermatol Clin. 2013;31:211–21.

    Article  CAS  PubMed  Google Scholar 

  4. Carroll CL, Balkrishnan R, Feldman SR, et al. The burden of atopic dermatitis: impact on the patent, family and society. Pediatr Dermatol. 2005;22:192–9.

    Article  PubMed  Google Scholar 

  5. Asher MI, Montfort S, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis and eczema in childhood. Lancet. 2006;368(9537):733–43.

    Article  PubMed  Google Scholar 

  6. William HC. Atopic dermatitis. N Engl J Med. 2005;352(22):2314–66.

    Article  Google Scholar 

  7. Pesce G, Harcon A, Carosso A, et al. Adult eczema in Italy: prevalence and associations with environmental factors. J Eur Acad Dermatol Venerol. 2015;29(6):1180–7.

    Article  CAS  Google Scholar 

  8. Wohly Y, Wainstein J, Bar-Dayan Y. Atopic dermatitis in Israeli adolescents—a large retrospective cohort study. Acta Derm Venereol. 2014;94(6):695–8.

    Article  Google Scholar 

  9. Ziyab HA, Raza A, Karmaus W, et al. Trends in eczema in the first 18 years of life. Results from the isle of Wight birth cohort study. Clin Exp Allerg. 2010;40(12):1776–84.

    Article  CAS  Google Scholar 

  10. Simonsen AB, Deleuran M, et al. Allergic contact dermatitis in Danish children referred from patch testing—a nationwide multicenter study. Contact Dermatitis. 2014;70(2):104–11.

    Article  PubMed  Google Scholar 

  11. Hwang CY, Chen YJ, Lin MW, et al. Prevalence of atopic dermatitis, allergic rhinitis and asthma in Taiwan. A national study 2000–2007. Acta Derm Venereol. 2010;96(6):589–94.

    Google Scholar 

  12. Tay YK, Khool L, Cl G, Giam YC. The prevalence and descriptive epidemiology of atopic dermatitis in Singapore school children. Br J Dermatol. 2002;146(1):101–6.

    Article  PubMed  Google Scholar 

  13. Shamssain MH, Shamsian N. Prevalence and severity of asthma, rhinitis and atopic eczema in 13–14 years old school children from northeast of England. Ann Allergy Asthma Immunol. 2001;86(4):428–32.

    Article  CAS  PubMed  Google Scholar 

  14. Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis. Section 1: diagnosis and assessment of atopic dermtitis. J Am Acad Dermatol. 2014;70:338.

    Article  PubMed  Google Scholar 

  15. Schultz LF. Atopic dermatitis: a genetic epidemiologic study in a population based twin sample. J Am Acad Dermatol. 1993;28:719.

    Article  Google Scholar 

  16. Palmer CNA, Irvine AD, et al. Common loss of function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–6.

    Article  CAS  PubMed  Google Scholar 

  17. Strachan DP. Hay fever, hygiene and household size. Br Med J. 1989;299(6710):1259–60.

    Article  CAS  Google Scholar 

  18. Von Mutius E. Maternal farm exposure ingestion of unpasteurized cow milk and allergic disease. Curr Opin Gastroenterol. 2012;28:570–6.

    Article  Google Scholar 

  19. De Bendetto A, Kubo A, Beck LA. Skin barrier disruption: a requirement for allergen sensitization. J Invest Dermatol. 2012;132(3):949–63.

    Article  Google Scholar 

  20. Thomsen SF. Atopic dermatitis: natural history diagnosis and treatment. ISRN Allergy. 2014;2014:354250.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Eyerich K, Novak N. Immunology of atopic eczema overcoming the Th1/Th2 paradigm. Allergy. 2013;68:974–82.

    Article  CAS  PubMed  Google Scholar 

  22. Leung DYM, Guttmn-Yassky E. Diciphering the complexties of atopic dermatitis shifting paradigms in treatment approaches. J Allergy Clin Immunol. 2014;134:769.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Radikoff D, Lebwohl M. Atopic dermatitis. Lancet. 1998;351:1715.

    Article  Google Scholar 

  24. William L Weston, William Howe. Atopic dermatitis (eczema), pathogenesis, clinical manifestation and diagnosis. Uptodate 10/2017.

    Google Scholar 

  25. Williams HC. Clinical practice. Atopic dermatitis. N Engl J Med. 2005;352:2314.

    Article  CAS  PubMed  Google Scholar 

  26. Williams HC, et al. The UK working party‘s diagnostic criteria for atopic dermatitis. BR J Dermat. 1994;131:406.

    Article  CAS  Google Scholar 

  27. Ring J, Alomar A, Bieber T, et al. Guidelines for treatment of atopic eczema. J Eur Acad Dermatol Venereol. 2012;26:1045–60.

    Article  CAS  PubMed  Google Scholar 

  28. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis section 2: management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Sibbury R, Davis DM, Cogen DE, et al. Guidelines of care for the management of atopic dermatitis section 3: management and treatment with phototherpy and systemic agents. J Am Acad Dermatol. 2014;71:327.

    Article  Google Scholar 

  30. Simpson EL. Atopic dermatitis: a review of topical treatment options. Curr Med Res Opin. 2010;26(3):633–40.

    Article  CAS  PubMed  Google Scholar 

  31. Ricci G, Dondi A, Patrizi A. Useful tools for the management of atopic dermatitis. Am J Clin Dermatol. 2009;10(5):287–300.

    Article  PubMed  Google Scholar 

  32. Hoare C, Li Wan Po A, Williams H. Systematic review of treatments for atopic eczema. Health Technol Assess. 2000;4:1.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Green C, Colquitt JL, Kirby J, et al. Clinical and cost effectiveness of once daily versus more frequent use of same potency topical corticosteroids for atopic eczema. A systematic review and economic evaluation. Health Technol Assess. 2004;8(47):1–120.

    Article  Google Scholar 

  34. El-Batawy MMY, Bassrila MA, Mashaly HM. Topical calcineurin inhibitors in atopic dermatitis: a systemic review and meta-analysis. J Dermatol Sci. 2009;54(2):76–87.

    Article  CAS  PubMed  Google Scholar 

  35. Ascroft DM, Dimmock P, Garside R, et al. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis; meta-analysis of randomized controlled trials. Br Med J. 2005;330:516.

    Article  Google Scholar 

  36. Garristen FM, Brouner MW. Photo (chemo) therpy in the management of atopic dermatitis: and updated systematic review with implications for practice and research. Br J Dermatol. 2014;170:501.

    Article  Google Scholar 

  37. Stern RS, Nicholsky KT. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet radiation (PUVA) the PUVA follow up study. N Engl J Med. 1997;336:1041.

    Article  CAS  PubMed  Google Scholar 

  38. Ring J, Alomar A, Bieber T, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part II. J Eur Acad Dermatol Venereol. 2012;26:1176.

    Article  CAS  PubMed  Google Scholar 

  39. Beck LA, Thaci D, Hamilton JD, et al. Dupilumab treatment in adults with moderate to severe atopic dermatitis inadequately controlled by topical treatment: a randomized, placebo controlled dose ranging phase IIB trial. Lancet. 2016;387:40.

    Article  PubMed  Google Scholar 

  40. Pajno GB, Caminitil L, Vita D, et al. Sublingual immunotherapy in mite sensitized children with atopic dermatitis; a randomized, double blind, placebo controlled study. J Allergy Clin Immunol. 2007;120:164.

    Article  CAS  PubMed  Google Scholar 

  41. Bissonnette R, Papp KA, Poulin Y, et al. Topical tofacitinib for atopic dermatitis a phase IIa randomized trial. Br J Dermatol. 2016;175:902.

    Article  CAS  PubMed  Google Scholar 

  42. Ruzicka T, Hanifin JM, Furue M, et al. Anti interleukin-31 receptor A antibody for atopic dermatitis. N Engl J Med. 2017;376:826.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Vered Atar-Snir .

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Atar-Snir, V. (2018). Atopic Dermatitis. In: Tur, E., Maibach, H. (eds) Gender and Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-72156-9_19

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  • DOI: https://doi.org/10.1007/978-3-319-72156-9_19

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  • Publisher Name: Springer, Cham

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