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Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona

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Cellular and Molecular Toxicology of Nanoparticles

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1048))

Abstract

The physico-chemical properties of nanoparticles, as characterized under idealized laboratory conditions, have been suggested to differ significantly when studied under complex physiological environments. A major reason for this variation has been the adsorption of biomolecules (mainly proteins) on the nanoparticle surface, constituting the so-called “biomolecular corona”. The formation of biomolecular corona on the nanoparticle surface has been reported to influence various nanoparticle properties viz. cellular targeting, cellular interaction, in vivo clearance, toxicity, etc. Understanding the interaction of nanoparticles with proteins upon administration in vivo thus becomes important for the development of effective nanotechnology-based platforms for biomedical applications. In this chapter, we describe the formation of protein corona on nanoparticles and the differences arising in its composition due to variations in nanoparticle properties. Also discussed is the influence of protein corona on various nanoparticle activities.

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Acknowledgements

SMA acknowledges Council for Scientific and Industrial Research (CSIR) for the research associate fellowship. CMR acknowledges the Department of Science and Technology, India for Sir J.C. Bose Fellowship. MFA acknowledges Dr. Chris Dealwis and NIH for supporting Postdoctoral/Senior Research associate fellowship. Also, we would like to thank Uzma Nisar for proofreading.

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Authors and Affiliations

  1. Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, Telangana State, India

    Saad Mohammad Ahsan & Chintalagiri Mohan Rao

  2. Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Md. Faiz Ahmad

Authors
  1. Saad Mohammad Ahsan
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  2. Chintalagiri Mohan Rao
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  3. Md. Faiz Ahmad
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Correspondence to Saad Mohammad Ahsan or Md. Faiz Ahmad .

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Editors and Affiliations

  1. Zoology Department, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Quaiser Saquib

  2. Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Mohammad Faisal

  3. Zoology Department, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Abdulaziz A. Al-Khedhairy

  4. Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Abdulrahman A. Alatar

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Ahsan, S.M., Rao, C.M., Ahmad, M.F. (2018). Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona. In: Saquib, Q., Faisal, M., Al-Khedhairy, A., Alatar, A. (eds) Cellular and Molecular Toxicology of Nanoparticles. Advances in Experimental Medicine and Biology, vol 1048. Springer, Cham. https://doi.org/10.1007/978-3-319-72041-8_11

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