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Drugs and Supplements

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Sport and Physical Activity in the Heat

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Abstract

The use of performance enhancing drugs and supplements in sport and physical activity has been around for decades; however, the impact of these drugs and supplements on performance in the heat has been garnering new attention. Although there are some drugs and supplements that can enhance performance in the heat, there are also many that may hinder performance, even potentially increasing the risk of serious illness or death in select circumstances. This chapter will describe and discuss specific drugs and supplements and their effects on performance and safety in the heat.

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References

  1. Calfee R, Fadale P. Popular ergogenic drugs and supplements in young athletes. Pediatrics. 2006;117(3):e577–89.

    Article  PubMed  Google Scholar 

  2. Sawka MN, Burke LM, Eichner ER, Maughan RJ, Montain SJ, Stachenfeld NS. American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc. 2007;39(2):377–90.

    Article  PubMed  Google Scholar 

  3. Burke LM. Nutritional needs for exercise in the heat. Comp Biochem Physiol. 2001;128(4):735–48.

    Article  CAS  Google Scholar 

  4. Goulet ED, Aubertin-Leheudre M, Plante GE, Dionne IJ. A meta-analysis of the effects of glycerol-induced hyperhydration on fluid retention and endurance performance. Int J Sport Nutr Exerc Metab. 2007;17(4):391–410.

    Article  CAS  PubMed  Google Scholar 

  5. Thomas DT, Erdman KA, Burke LM. Nutrition and athletic performance: joint position statement of American College of Sports Medicine, Academy of Nutrition and Dietetics, and Dietitians of Canada. Med Sci Sports Exerc. 2016;48(3):543–68.

    Google Scholar 

  6. Adams WM, Hosokawa Y, Casa DJ. Body-cooling paradigm in sport: maximizing safety and performance during competition. J Sport Rehabil. 2016;25(4):382–94.

    Google Scholar 

  7. Jager R, Purpura M, Shao A, et al. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids. 2011;40(5):1369–83.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Aedma M, Timpmann S, Latt E, et al. Short-term creatine supplementation has no impact on upper-body anaerobic power in trained wrestlers. J Int Soc Sports Nutr. 2015;12:45.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lopez RM, Casa DJ, McDermott BP, et al. Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analysis. J Athl Train. 2009;44(2):215–23.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Cooper R, Naclerio F, Allgrove J, et al. Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sports Nutr. 2012;9:33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Coutts A, Reaburn P, Mummery K. The effect of glycerol hyperhydration on olympic distance triathlon performance in high ambient temperatures. Int J Sport Nutr Exerc Metab. 2002;12(1):105–19.

    Article  CAS  PubMed  Google Scholar 

  12. Kavouras SA, Armstrong LE. Rehydration with glycerol: endocrine, cardiovascular, and thermoregulatory responses during exercise in the heat. J Appl Physiol. 2006;100(2):442.

    Article  CAS  PubMed  Google Scholar 

  13. Wingo JE, Casa DJ, Berger EM. Influence of a pre-exercise glycerol hydration beverage on performance and physiologic function during mountain-bike races in the heat. J Athl Train. 2004;39(2):169–75.

    PubMed  PubMed Central  Google Scholar 

  14. Goulet EDB, Rousseau SF, Lamboley CRH. Pre-exercise hyperhydration delays dehydration and improves endurance capacity during 2 h of cycling in a temperate climate. J Physiol Anthropol. 2008;27(5):263–71.

    Article  PubMed  Google Scholar 

  15. Beis LY, Polyviou T, Malkova D. The effects of creatine and glycerol hyperhydration on running economy in well trained endurance runners. J Int Soc Sports Nutr. 2011;8(1):1–9.

    Article  Google Scholar 

  16. Rosendal SP, Strobel NA, Osborne MA. Hydration and endocrine responses to intravenous fluid and oral glycerol. Scand J Med Sci Sports. 2015;25(1):112–25.

    Article  PubMed  Google Scholar 

  17. Leiper JB. Fate of ingested fluids: factory affecting gastric emptying and intestinal absorption of beverages in humans. Nutr Rev. 2015;73(2):57–72.

    Article  PubMed  Google Scholar 

  18. Polyviou TP, Pitsiladis YP, Lee WC, et al. Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists. J Int Soc Sports Nutr. 2012;9:29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Casa DJ, DeMartini JK, Bergeron MF, et al. National Athletic Trainers’ Association position statement: exertional heat illnesses. J Athl Train. 2015;50(9):986–1000.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Cadwallader AB, Torre X, Tieri A, et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis. Br J Pharmacol. 2010;161:1–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Yusko DA, Buckman JF, White HR, et al. Alcohol, tobacco, illicit drugs, and performance enhancers: a comparison of use by college student athletes and nonathletes. J Am Coll Heal. 2008;57(3):281–90.

    Article  Google Scholar 

  22. Vella LD, Cameron-Smith D. Alcohol, athletic performance and recovery. Forum Nutr. 2010;2(8):781–9.

    CAS  Google Scholar 

  23. Fonseca SF, Mendonca VA, Teles MC, et al. Inflammatory cytokines and plasma redox status responses in hypertensive subjects after heat exposure. Braz J Med Biol Res. 2016;49(3):e5026.

    Article  PubMed Central  Google Scholar 

  24. Claremont AD, Costill DL, Fink W, et al. Heat tolerance following diuretic induced dehydration. Med Sci Sports. 1976;8(4):239–43.

    CAS  PubMed  Google Scholar 

  25. Kalant H, Le AD. Effects of ethanol on thermoregulation. Pharmacol Ther. 1983;23(3):313–64.

    Article  CAS  PubMed  Google Scholar 

  26. Naughton J. NCAA and federal agencies investigate the death of 3 college wrestlers. Chron Higher Educ. Published January 9th, 1998.

    Google Scholar 

  27. Brown. Williams III v. Board of Supervisors of University of Louisiana system. 2014.

    Google Scholar 

  28. Salinero JJ, Lara B, Abian-Vicen J, et al. The use of energy drinks in sport: perceived ergogenicity and side effects in male and female athletes. Br J Nutr. 2014;112:1494–502.

    Article  CAS  PubMed  Google Scholar 

  29. Sokmen B, Armstrong LE, Kraemer WJ, et al. Caffeine use in sports: considerations for the athlete. J Strength Cond Res. 2008;22:978–86.

    Article  PubMed  Google Scholar 

  30. Cappelletti S, Daria P, Sani G, et al. Caffeine: cognitive and physical performance enhancer or psychoactive drug? Curr Neuropharmacol. 2015;13:71–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Mora-Rodriguez R, Pallares JG. Performance outcomes and unwanted side effects associated with energy drinks. Nutr Rev. 2014;72(S1):108–20.

    Article  PubMed  Google Scholar 

  32. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014;44(Suppl 2):175–84.

    Article  PubMed Central  Google Scholar 

  33. Mueller PD, Korey WS. Death by “ecstasy”: the serotonin syndrome? Ann Emerg Med. 1998;32(3 Pt 1):377–80.

    Article  CAS  PubMed  Google Scholar 

  34. Mills EM, Weaver KL, Abramson E, et al. Influence of dietary fats on ecstasy-induced hyperthermia. Br J Pharmacol. 2007;151(7):1103–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Lakhan SE, Kirchgessner A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain Behav. 2012;2(5):661–7.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Keisler BD, Hosey RG. Ergogenic aids: an update on ephedra. Curr Sports Med Rep. 2005;4:231–5.

    Article  PubMed  Google Scholar 

  37. Stohs SJ, Badmaev V. A review of natural stimulant and non-stimulant thermogenic agents. Phytother Res. 2016;30:732–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Epstein Y, Albukrek D, Kalmovitc B, et al. Heat intolerance induced by antidepressants. Ann N Y Acad Sci. 1997;813:553–8.

    Article  CAS  PubMed  Google Scholar 

  39. Stollberger C, Lutz W, Finsterer J. Heat-related side effects of neurological and non-neurological medication may increase heatwave fatalities. Eur J Neurol. 2009;16(7):879–82.

    Article  CAS  PubMed  Google Scholar 

  40. Qiuping G, Paulose-Ram R, Burt VL, et al. Prescription cholesterol-lowering medication use in adults aged 40 and over: united states, 2003–2012. NCHS Data Brief. 2014;177:1–8.

    Google Scholar 

  41. Shack S, Gorospe M, Fawcett TW, et al. Activation of the cholesterol pathway and RAS maturation in response to stress. Oncogene. 1999;18(44):6021–8.

    Article  CAS  PubMed  Google Scholar 

  42. Morozova E, Yoo Y, Behrouzvaziri A, et al. Amphetamine enhances endurance by increasing heat dissipation. Physiol Rep. 2016;4(17):e12955.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Watson P, Hasegawa H, Roelands B, et al. Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions. J Physiol. 2005;565:873–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Roelands B, Hasegawa H, Watson P, et al. The effects of acute dopamine reuptake inhibition on performance. Med Sci Sports Exerc. 2008;40(5):879–85.

    Article  CAS  PubMed  Google Scholar 

  45. Calfee R, Fadale P. Popular ergogenic drugs and supplements in young athletes. Pediatrics. 2006;117:e577–89.

    Article  PubMed  Google Scholar 

  46. Page LA, Hajat S, Kovats RS, et al. Temperature-related deaths in people with psychosis, dementia and substance misuse. Br J Psychiatry. 2012;200(6):485–90.

    Article  PubMed  Google Scholar 

  47. Kudoh A, Takase H, Takazawa T. Chronic treatment with antidepressants decreases intraoperative core hypothermia. Anesth Analg. 2003;97(1):275–9.

    Article  CAS  PubMed  Google Scholar 

  48. Adesman AR. The diagnosis and management of attention-deficit/hyperactivity disorder in pediatric patients. Prim Care Companion J Clin Psychiatry. 2001;3(2):66–77.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Mendes P, Robles PG, Mathur S. Statin-induced rhabdomyolysis: a comprehensive review of case reports. Physiother Can. 2014 Spring;66(2):124–32.

    Article  PubMed  PubMed Central  Google Scholar 

  50. CBS News. Coach to site ADD drug in student death. CBS. 2009. http://www.cbsnews.com/news/coach-to-cite-add-drug-in-student-death/.

  51. World Anti-Doping Agency. Major changes—2018 WADA prohibited list. U.S. Anti-Doping Agency. 2018. https://www.usada.org/substances/prohibited-list/major-changes-2018-wadaprohibited-list/.

  52. National Collegiate Athletic Association. 2016–2017 NCAA banned drugs. NCAA. 2016;1–2. http://www.ncaa.org/sites/default/files/2016_17_%20Banned_%20Drugs_%20Educational_%20Document_20160531.pdf.

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Authors and Affiliations

  1. Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, CT, USA

    Rachel K. Katch MS, ATC, Luke N. Belval MS, ATC, CSCS & Yuri Hosokawa PhD, MAT, ATC

  2. Department of Orthopedics and Rehabilitation, Shands Hospital at University of Florida, Gainesville, FL, USA

    Michael S. Smith MD, CAQ-SM, PharmD

  3. Department of Sports Medicine, InterMed P.A., South Portland, ME, USA

    Michele LaBotz MD, CAQ-SM

Authors
  1. Rachel K. Katch MS, ATC
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  2. Michael S. Smith MD, CAQ-SM, PharmD
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  3. Michele LaBotz MD, CAQ-SM
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  4. Luke N. Belval MS, ATC, CSCS
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  5. Yuri Hosokawa PhD, MAT, ATC
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Corresponding author

Correspondence to Rachel K. Katch MS, ATC .

Editor information

Editors and Affiliations

  1. Department of Kinesiology Director, Athletic Training Education Research Associate, Human Performance Laboratory College of Agriculture, Health, and Natural Resources, University of Connecticut, Storrs, Connecticut, USA

    Douglas J. Casa

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Katch, R.K., Smith, M.S., LaBotz, M., Belval, L.N., Hosokawa, Y. (2018). Drugs and Supplements. In: Casa, D. (eds) Sport and Physical Activity in the Heat. Springer, Cham. https://doi.org/10.1007/978-3-319-70217-9_19

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  • DOI: https://doi.org/10.1007/978-3-319-70217-9_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-70216-2

  • Online ISBN: 978-3-319-70217-9

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