Abstract
The incidence of renal cell carcinoma (RCC) at all stages is rising, with clear cell histologic type being the commonest [1]. However, it has been reported that 15% of small renal masses are benign [2]. Partial or total nephrectomy is the current treatment for RCC. Contrast-enhanced computed tomography (CECT)-renal protocol [3] is the imaging modality of choice in detection and differentiation of solid renal masses versus cystic ones, even small ones of size <2 cm; however, it faces certain limitations consisting of its lower ability to differentiate between benign and malignant lesions, as well as indolent from aggressive phenotype [2, 3]. The role of magnetic resonance imaging (MRI) is currently mostly restricted to characterization of equivocal computed tomography (CT) findings, evaluation of perirenal fat, and venous cava thrombosis. The urge of functional characterization of renal masses has brought the utilization of PET/CT at the foreground [2, 3].
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References
Cairns P (2011) Renal cell carcinoma. Cancer Biomark 9(1–6):461–473
Smaldone MC, Chen DY, Yu JQ, Plimack ER (2012) Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics 6:395–407
Khandani AH, Rathmell WK (2012) Positron emission tomography in renal cell carcinoma: an imaging biomarker in development. Semin Nucl Med 42(4):221–230
Lawrentschuk N, Davis ID, Bolton DM, Scott AM (2010) Functional imaging of renal cell carcinoma. Nat Rev Urol 7(5):258–266
Takahashi M, Kume H, Koyama K et al (2015) Preoperative evaluation of renal cell carcinoma by using 18F-FDG PET/CT. Clin Nucl Med 40(12):936–940
Ramdave S, Thomas GW, Berlangieri SU et al (2001) Clinical role of F-18 fluorodeoxyglucose positron emission tomography for detection and management of renal cell carcinoma. J Urol 166(3):825–830
Aide N, Cappele O, Bottet P et al (2003) Efficiency of [(18)F]FDG PET in characterising renal cancer and detecting distant metastases: a comparison with CT. Eur J Nucl Med Mol Imaging 30(9):1236–1245
Ozülker T, Ozülker F, Ozbek E, Ozpaçaci T (2011) A prospective diagnostic accuracy study of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography in the evaluation of indeterminate renal masses. Nucl Med Commun 32(4):265–272
Kang DE, White RL Jr, Zuger JH et al (2004) Emission tomography for detection of renal cell carcinoma. J Urol 171(5):1806–1809
Wu HC, Yen RF, Shen YY et al (2002) Comparing whole body 18F–2-deoxyglucose positron emission tomography and technetium-99 m methylene diphosphate bone scan to detect bone metastases in patients with renal cell carcinomas: a preliminary report. J Cancer Res Clin Oncol 128(9):503–506
Kayani I, Avril N, Bomanji J et al (2011) Sequential FDG-PET/CT as a biomarker of response to Sunitinib in metastatic clear cell renal cancer. Clin Cancer Res 17(18):6021–6028
Namura K, Minamimoto R, Yao M et al (2010) Impact of maximum standardized uptake value (SUVmax) evaluated by 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) on survival for patients with advanced renal cell carcinoma: a preliminary report. BMC Cancer 10:667
Misch D, Steffen IG, Schönberger S et al (2008) Use of positron emission tomography for staging, preoperative response assessment and posttherapeutic evaluation in children with Wilms tumour. Eur J Nucl Med Mol Imaging 35(9):1642–1650
Nakatani K, Nakamoto Y, Saga T et al (2011) The potential clinical value of FDG-PET for recurrent renal cell carcinoma. Eur J Radiol 79(1):29–35
Park JW, Jo MK, Lee HM (2009) Significance of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography for the postoperative surveillance of advanced renal cell carcinoma. BJU Int 103(5):615–619
Safaei A, Figlin R, Hoh CK et al (2002) The usefulness of F-18 deoxyglucose whole-body positron emission tomography (PET) for re-staging of renal cell cancer. Clin Nephrol 57(1):56–62
Kumar R, Shandal V, Shamim SA et al (2010) Role of FDG PET-CT in recurrent renal cell carcinoma. Nucl Med Commun 31(10):844–850
Alongi P, Picchio M, Zattoni F et al (2016) Recurrent renal cell carcinoma: clinical and prognostic value of FDG PET/CT. Eur J Nucl Med Mol Imaging 43(3):464–473
Nakaigawa N, Kondo K, Tateishi U et al (2016) FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma. BMC Cancer 16:67
Ueno D, Yao M, Tateishi U et al (2012) Early assessment by FDG-PET/CT of patients with advanced renal cell carcinoma treated with tyrosine kinase inhibitors is predictive of disease course. BMC Cancer 12:162
Divgi CR, Pandit-Taskar N, Jungbluth AA et al (2007) Preoperative characterisation of clear- cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial. Lancet Oncol 8(4):304–310
Divgi CR, Uzzo RG, Gatsonis C et al (2013) Positron emission tomography/computed tomography identification of clear cell renal cell carcinoma: results from the REDECT trial. J Clin Oncol 31(2):187–194
Gerety EL, Lawrence EM, Wason J et al (2015) Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design. Ann Oncol 26(10):2113–2118
Hugonnet F, Fournier L, Medioni J et al (2011) Metastatic renal cell carcinoma: relationship between initial metastasis hypoxia, change after 1 month’s sunitinib, and therapeutic response: an 18F- Fluoromisonidazole PET/CT study. J Nucl Med 52:1048–1055
Liu G, Jeraj R, Vanderhoek M et al (2011) Pharmacodynamic study using FLT PET/CT in patients with renal cell cancer and other solid malignancies treated with sunitinib malate. Clin Cancer Res 17(24):7634–7644
Middendorp M, Maute L, Sauter B et al (2010) Initial experience with 18F-fluoroethylcholine PET/ CT in staging and monitoring therapy response of advanced renal cell carcinoma. Ann Nucl Med 24(6):441–446
Horn KP, Yap JT, Agarwal N et al (2015) FDG and FLT-PET for early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma. Cancer Imaging 15:15
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Nikaki, A.V. (2018). PET/CT Findings in Renal Cancer. In: Gouliamos, A., Andreou, J., Kosmidis, P. (eds) Imaging in Clinical Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-68873-2_76
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DOI: https://doi.org/10.1007/978-3-319-68873-2_76
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