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Intrathecal Drug Delivery: Pharmacokinetics and Dynamics

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Advanced Procedures for Pain Management

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Abstract

Implantation of an intrathecal drug delivery system (IDDS) requires a comprehensive knowledge of the process, including selection of appropriate patients and indications for implantation, the method of performing a trial, the surgical procedure of implantation, and the choice of pharmacologic agents. Additionally, knowledge of cerebrospinal fluid (CSF) dynamics plays an important role in determining IDDS success. This chapter addresses the pharmacologic fundamentals of the intrathecal agents that are typically used in an IDDS.

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Author information

Authors and Affiliations

  1. Olympus Pain and Orthopedics, Dallas, TX, USA

    Kenneth Sunghoon Choi

  2. Department of Anesthesiology and Pain Management, University Hospitals Cleveland Medical Center, Cleveland, OH, USA

    Salim M. Hayek

Authors
  1. Kenneth Sunghoon Choi
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  2. Salim M. Hayek
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Corresponding author

Correspondence to Kenneth Sunghoon Choi .

Editor information

Editors and Affiliations

  1. Lenox Hill Hospital, New York, New York, USA

    Sudhir Diwan

  2. The Center for Pain Relief, Charleston, West Virginia, USA

    Timothy R Deer

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Choi, K.S., Hayek, S.M. (2018). Intrathecal Drug Delivery: Pharmacokinetics and Dynamics. In: Diwan, S., Deer, T. (eds) Advanced Procedures for Pain Management. Springer, Cham. https://doi.org/10.1007/978-3-319-68841-1_29

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  • DOI: https://doi.org/10.1007/978-3-319-68841-1_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-68839-8

  • Online ISBN: 978-3-319-68841-1

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