Abstract
Human factors play an important role in health-care outcomes of heart failure patients. A systematic review and meta-analysis of clinical trial studies on heart failure hospitalization may yield positive proofs of the beneficial effect of specific care management strategies.
We investigate how the eight guiding principles of choice, rest, environment, activity, trust, interpersonal relationships, outlook, and nutrition may reduce heart failure (HF) readmissions.
Appropriate keywords were identified related to the (1) independent variable of hospitalization and treatment, (2) moderating variable of care management principles, (3) dependent variable of readmission, and (4) disease of HF to conduct searches in nine databases on clinical trial studies. In the meta-analysis, data were collected from studies that measured HF readmission for individual patients. The results indicate that an intervention involving any human factor principles may nearly double an individual’s probability of not being readmitted. Interventions with human factor principles reduce readmissions among HF patients. Overall, this review may help reconfigure the design, implementation, and evaluation of clinical practice for reducing HF readmissions in the future.
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Appendix 1: Characteristics of Included Studies
Appendix 1: Characteristics of Included Studies
Authors | Year | Country | Sample (intervention) | Sample (control) | Setting | Timinga |
|---|---|---|---|---|---|---|
Aguado et al. | Spain | 42 | 64 | After discharge | 24 months | |
Albert et al. | US | 20 | 26 | After discharge | 60 days | |
Aldamiz-Echevarria Iraúrgui et al. | 2007 | Spain | 137 | 142 | After discharge | 12 months |
Anderson et al. | US | 44 | 77 | During hospitalizationDuring dischargeAfter discharge | 6 months | |
Andryukhin et al. | Russia | 44 | 41 | After discharge | 6, 18 months | |
Atienza et al. | Spain | 164 | 174 | During hospitalization | 12 months | |
Belardinelli et al. | US | 50 | 49 | After discharge | 14 months | |
Benatar et al. | US | 108 | 108 | After discharge | 3 months | |
Brandon et al. | US | 10 | 10 | After discharge | 12 weeks | |
Brotons et al. | Spain | 144 | 139 | After discharge | 12 months | |
Bull et al. | US | 40 | 71 | During hospitalizationAfter discharge | 2 weeks, 2 months | |
Byszewski et al. | Canada | 45 | 46 | After discharge | 6 weeks | |
Chen et al. | Taiwan | 275 | 275 | After discharge | 6 months | |
Cline et al. | Sweden | 80 | 110 | During hospitalizationAfter discharge | 12 months | |
Cordisco et al. | US | 30 | 51 | After discharge | 1 year | |
Dahl and Penque | US | 381 | 203 | During hospitalizationAfter discharge | 90 days | |
Davidson et al. | Australia | 52 | 53 | After discharge | 12 months | |
Davis et al. | US | 63 | 62 | During hospitalizationAfter discharge | 30 days | |
Dekker et al. | US | 21 | 20 | During hospitalizationAfter discharge | 3 months | |
Delaney and Apostolidis | US | 12 | 12 | After discharge | 90 days | |
DeWalt et al. | US | 59 | 64 | After discharge | 12 months | |
Domingo et al. | Spain | A = 48B = 44 | N/A | After discharge | 12 months | |
Domingues et al. | Brazil | 48 | 63 | During hospitalizationAfter discharge | 3 months | |
Doughty et al. | New Zealand | 100 | 97 | After discharge | 12 months | |
Dracup et al. | US | 86 | 87 | After discharge | 3, 6, 12 months | |
Dracup et al. | US | A = 200B = 193 | 209 | After discharge | 2 years | |
Dunagan et al. | US | 76 | 75 | After discharge | 6, 12 months | |
Ekman et al. | Sweden | 125 | 123 | During hospitalization | 6 months | |
Evangelista et al. | US | 48 | 51 | After discharge | 6 months | |
Falces et al. | Spain | 53 | 50 | During discharge | 6, 12 months | |
Ferrante et al. | Argentina | 760 | 758 | After discharge | 1, 3 years | |
Fonarow et al. | US | 214 | N/A | During hospitalizationAfter discharge | 6 months | |
Gambetta et al. | US | 158 | 124 | After discharge | 7 months | |
Gámez-López et al. | Spain | A = 25B = 28C = 28 | 35 | After discharge | 10.8 ± 3.2 months | |
Gattis et al. | US | 90 | 91 | After discharge | 2, 12, 24 weeks | |
Gau et al. | Taiwan, China | 30 | 30 | During hospitalizationAfter discharge | 1 month | |
Giordano et al. | Italy | 230 | 230 | During hospitalizationAfter discharge | 12 months | |
Goldberg et al. | US | 138 | 142 | During dischargeAfter discharge | 6 months | |
Grundtvig et al. | Norway | 1169 | N/A | After discharge | 12 months | |
Hägglund et al. | Sweden | 32 | 40 | After discharge | 3 months | |
Harrison et al. | Canada | 92 | 100 | After discharge | 12 weeks | |
Heisler et al. | US | 135 | 131 | During hospitalizationAfter discharge | 12 months | |
Hershberger et al. | US | 108 | N/A | After discharge | 6 months | |
Ho et al. | Taiwan | 247 | N/A | After discharge | 139 ± 96 days | |
Holst et al. | Australia | 42 | N/A | During hospitalizationAfter discharge | 6 months | |
Houchen et al. | UK | 17 | N/A | After discharge | 12 months | |
Howlett et al. | Canada | 990 | 7741 | After discharge | 12 months | |
Hudson et al. | US | 91 | N/A | After discharge | 6 months | |
Jaarsma et al. | Netherlands | 84 | 95 | During hospitalizationAfter discharge | 9 months | |
Jaarsma et al. | Netherlands | A = 340B = 344 | 339 | After discharge | 18 months | |
Jayadevappa et al. | US | 13 | 10 | After discharge | 6 months | |
Jerant et al. | US | A = 12B = 13 | 12 | After discharge | 6 months | |
Jiang | China | 101 | 89 | During hospitalizationAfter discharge | 6 months | |
Jurgens et al. | US | 48 | 51 | During dischargeAfter discharge | 90 days | |
Kanoksilp et al. | Thailand | 50 | 50 | After discharge | 12 months | |
Kashem et al. | US | 24 | 24 | After discharge | 12 months | |
Koelling et al. | US | 107 | 116 | During discharge | 180 days | |
Korajkic et al. | Australia | 35 | 35 | After discharge | 3 months | |
Lee et al. | US | 23 | 21 | After discharge | 3 months | |
Lee et al. | US | 473 | 475 | During hospitalization | 30 days | |
Li et al. | US | 202 | 205 | During hospitalization | 60 days | |
Linden and Butterworth | 2014 | US | 128 | 129 | During hospitalizationAfter discharge | 30, 90 days |
Liou et al. | Taiwan | 56 | 75 | During hospitalizationAfter discharge | 30, 90 days | |
Löfvenmark et al. | Sweden | 65 | 63 | After discharge | 18 months | |
López-Cabezas et al. | Spain | 70 | 64 | During dischargeAfter discharge | 12 months | |
Mao et al. | Taiwan | 174 | 175 | After discharge | Median 2 years | |
McDonald et al. | Ireland | 51 | 47 | During hospitalizationAfter discharge | 3 months | |
Mejhert et al. | Sweden | 103 | 105 | After discharge | 18 months | |
Méndez Bailón et al. | Spain | 51 | 131 | During discharge | 90 days | |
Miller and Cox | US | 68 | N/A | After discharge | 90 days, 1 year | |
Morcillo et al. | Spain | 34 | 36 | After discharge | 6 months | |
Naylor et al. | US | 118 | 121 | During hospitalizationAfter discharge | 52 weeks | |
Ojeda et al. | Spain | 76 | 77 | After discharge | 16 ± 8 months | |
Otsu and Moriyama | Japan | 47 | 47 | After discharge | 7–12, 24 months | |
Parrinello et al. | Italy | A = 87B = 86 | N/A | After discharge | 12 months | |
Paterna et al. | Italy | A = 52, B = 51, C = 51, D = 51, E = 52, F = 50, G = 52, H = 51 | N/A | After discharge | 6 months | |
Piamjariyakul et al. | US | 20 | N/A | After discharge | 6 months | |
Piepoli et al. | Italy | 509 | N/A | After discharge | 12 months | |
Pugh et al. | US | 27 | 31 | During hospitalizationAfter discharge | 12 months | |
Rich et al. | US | 63 | 35 | During hospitalizationDuring dischargeAfter discharge | 90 days | |
Rich et al. | US | 142 | 140 | During hospitalizationDuring dischargeAfter discharge | 90 days | |
Riegel et al. | US | 126 | 226 | After discharge | 3, 6 months | |
Riegel and Carlson | US | 45 | 43 | After discharge | 30 days, 3 months | |
Roig et al. | Spain | 61 | N/A | After discharge | 11 ± 10 months | |
Roth et al. | Israel | 118 | N/A | After discharge | 12 months | |
Saleh et al. | US | 173 | 160 | During dischargeAfter discharge | 12 months | |
Sales et al. | US | 70 | 67 | During hospitalizationAfter discharge | 30 days | |
Sethares and Elliott | US | 33 | 37 | During hospitalizationAfter discharge | 3 months | |
Shao and Yeh | Taiwan, China | 93 | N/A | After discharge | 1 month | |
Shao et al. | Taiwan | 47 | 46 | After discharge | 12 weeks | |
Sisk et al. | US | 203 | 203 | After discharge | 12 months | |
Slater et al. | US | 612 | N/A | During hospitalizationAfter discharge | 6 months | |
Smith et al. | US | 92 | 106 | After discharge | 12 months | |
Stewart et al. | Australia | 100 | 100 | After discharge | 6 months | |
Stewart et al. | Australia | 49 | 48 | After discharge | 6 months | |
Stewart et al. | Australia | 143 | 137 | After discharge | 18 months | |
Stewart et al. | Australia | 137 | 143 | After discharge | 12–18 months | |
Sullivan et al. | US | 108 | 100 | After discharge | 12 months | |
Sun et al. | China | 433 | 288 | After discharge | 4 years | |
Szkiladz et al. | US | 86 | 94 | During dischargeAfter discharge | 30 days | |
Tsuyuki et al. | Canada | 140 | 136 | During hospitalizationAfter discharge | 6 months | |
Tully et al. | Australia | A = 15B = 14 | N/A | After discharge | 6 months | |
Varma et al. | UK | 42 | 41 | After discharge | 12 months | |
Vavouranakis et al. | Greece | 28 | N/A | After discharge | 12 months | |
Wang et al. | Taiwan, China | 14 | 13 | During hospitalizationAfter discharge | 3 months | |
Wang et al. | China | 32 | 34 | During hospitalizationAfter discharge | 6 months | |
West et al. | US | 51 | N/A | After discharge | 94–182 days | |
Wheeler and Waterhouse | US | 20 | 20 | After discharge | 14 weeks | |
White and Hill | US | 59 | N/A | During hospitalizationAfter discharge | 2 months | |
Witham et al. | UK | 41 | 41 | After discharge | 6 months | |
Wright et al. | New Zealand | 100 | 97 | After discharge | 12 months | |
Wu et al. | US | A = 27B = 27 | 28 | After discharge | 9 months | |
Zeitler et al. | US | 1159 | 1172 | After discharge | Every 3 months for 2 years |
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Wan, T.T.H. (2018). Strategies to Modify the Risk for Heart Failure Readmission: A Systematic Review and Meta-analysis. In: Population Health Management for Poly Chronic Conditions. Springer, Cham. https://doi.org/10.1007/978-3-319-68056-9_6
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