Abstract
Biomaterials are made from different classes of known materials including metals and alloys, ceramics, glasses, as well as natural and synthetic polymers. This great variety of materials is a result of the different application profiles, biomaterials normally have to fulfil in the body. The basis for the specific properties of a distinct biomaterial is its composition and structure at an atomic and molecular level determining the chemical nature and finally the behaviour of these materials in a living organism. In this chapter it is aimed to introduce the fundamental concepts describing the atomic bondings and the corresponding molecular structures of the main classes of material. Main correlations between these molecular structures of materials and their resulting chemical behaviour will be discussed to better understand and predict the properties of those materials with regard to their use in contact with the living matter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walters P (2002) Molecular biology of the cell. Garland Science, New York
Angelini E, Caputo A, Zucchi F (2002) Degradation processes on metallic surfaces. In: Barbucci R (ed) Integrated biomaterials science. Kluwer Academic/Plenum Press, New York, pp 297–324
FW Billmeyer Jr (1984) Textbook of polymer science. Wiley, New York
Brauer DS (2015) Bioactive glasses—structure and properties. Angew Chem Int Ed 54:4160–4181
Brunski JB (2004) Metals. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 137–153
Carrodeguas RG, De Aza S (2011) α-Tricalcium phosphate: synthesis, properties and biomedical applications. Acta Biomaterialia 3536–3546
Cigada, A Chiesa R, Pinasco MR, Hisatsune K (2002) Metallic materials. In: Barbucci R (ed) Integrated biomaterials science, Kluwer Academic/Plenum Press, New York, pp 257–296
Chen Y, Xu Z, Smith C, Sankar J (2014) Recent advances on the development of magnesium alloys for biodegradable implants. Acta biomaterialia 10(11):4561–4573
Chevalier J (2006) What future for zirconia as a biomaterial? Biomaterials 27:535–543
Cooke FW (2004) Bulk properties of materials. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 23–32
Cooper SL, Visser SA, Hergenrother RW, Lamba NMK (2004) Polymers. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 67–79
De Aza AH, Chevalier J, Fantozzi G, Schehl M, Torrecillas R (2002) Crack growth resistance of alumina, zirconia and zirconia toughened alumina ceramics for joint prostheses. Biomaterials 23:937–945
Dee KC, Puleo DA, Bizios R (2002) An introduction to biomaterial interactions. Wiley-Lyss, Hoboken
Dorozhkin SV (2011) Biocomposites and hybrid biomaterials based on calcium orthophosphates. Biomatter 2011, 1, 1–53
Gerhardt L-C, Boccaccini AR (2010) Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 3:3867–3910
Doppalapudi S, Katiyar S, Domb AJ, Khan W (2015) Biodegradable natural polymers. In: Puoci F (ed) Advanced polymers in medicine. Springer, Cham, pp 32–66
Dorozhkin SV (2012) Biphasic, triphasic and multiphasic calcium orthophosphates. Acta Biomater 8:963–977
Dräger G, Krause A, Möller L, Dumitriu S (2011) Carbohydrates. In: Lendlein A, Sisson A (eds) Handbook of biodegradable polymers. Wiley-VCH, Weinheim, pp 155–193
Gadow R, Kern F (2010) Novel zirconia–alumina nanocomposites combining high strength and toughness. Adv Eng Mater 12:1220–1223
Gagner JE, Kim W, Chaikof EL (2014) Designing protein-based biomaterials for medical applications. Acta Biomater 10:1542–1557
Godbey WT, Wu KK, Mikos AG (1999) Poly(ethylenimine) and its role in gene delivery. J Controlled Release 60:149–160
Göpferich A (1997) Mechanisms of polymer degradation and elimination. In: Domb AJ, Kost J, Wiseman DM (eds) Handbook of biodegradable polymers. OPA, Amsterdam, pp 451–471
Gray E, Hogwood J, Mulloy B (2012) The anticoagulant and antuthrombotic mechanisms of heparin. In: Lever R, Mulloy B, Page CP (eds) Heparin-a century of progress. Handbook of experimental pharmacology, vol 207. Springer, Berlin, pp 43–61
Hench LL (1988) Bioactive ceramics. Ann N Y Acad Sci 523:54–71
Hench LL (1991) Bioceramics: from concept to clinic. J Am Ceram Soc 74:1487–1510
Hench LL (1999) Bioactive glasses and glass-ceramics. Mat Sci Forum 293:27–64
Hench LL, Best S (2004) Ceramics, glasses, and glass-ceramics. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 153–170
Hornberger H, Virtanen S, Boccaccini AR (2012) Biomedical coatings on magnesium alloys—a review. Acta Biomater 8:2442–2455
Jones JR (2013) Review of bioactive glass: from Hench to hybrids. Acta Biomaterials 9:4457–4486
Kaplan DL (1989) Introduction to biopolymers from renewable resources. In: Kaplan DL (ed) biopolymers from renewable resources. Springer, Berlin, pp 1–29
Keenan TR (1997) Gelatin. In: Domb AJ, Kost J, Wiseman DM (eds) Handbook of biodegradable polymers. OPA, Amsterdam, pp 307–317
Kelly JR, Denry I (2008) Stabilized zirconia as a structural ceramic: an overview. Dent Mater 24:289–298
Kenawy E-R, Worley SD, Broughton R (2007) The chemistry and applications of antimicrobial polymers: a state-of-the-art review. Biomacromol 8:1359–1384
Khan W, Yadav D, Domb AJ, Kumar N (2011) Collagen. In: Domb AJ, Kumar N, Ezra A (eds) Biodegradable polymers in clinical use and clinical development. Wiley, Hoboken, pp 61–89
Krajewski A, Ravaglioli A (2002) Bioceramics and biological glasses. In: Barbucci R (ed) Integrated biomaterials science. Kluwer Academic/Plenum Press, New York, pp 189–254
Krueger O (2004) Kunststoffe. In: Bargel H-J, Schulze G (eds) Werkstoffkunde. Springer, Berlin, pp 304–335
Lee HB, Khang G, Lee JH (2003) Polymeric biomaterials. In: Park JB, Bronzino JD (eds) Biomaterials: principles and applications. CRS Press, Boca Raton, pp 55–77
Liu B, Lun DX (2012) Current application of β-tricalcium phosphate composites in orthopaedics. Orthopaedic Surg 4:139–144
Marek M (2009) Metal corrosion. In: Narayan R (ed) Biomedical materials. Springer, New York, pp 155–181
Niinomi M, Nakai M, Hieda J (2012) Development of new metallic alloys for biomedical applications. Acta Biomater 8:3888–3903
Omidian H, Park K (2010) Introduction to hydrogels. In: Ottenbrite RM (ed) Biomedical applications of hydrogels handbook. Springer, New York, pp 1–16
Parisi OI, Curcio M, Puoci F (2015) Polymer chemistry and synthetic polymers. In: Puoci F (ed) Advanced polymers in medicine. Springer, Cham, pp 1–31
Park J (2008) Bioceramics: Properties, characterizations, and applications. Springer, New York
Park JB, Kim YK (2003) Metallic biomaterials. In: Park JB, Bronzino JD (eds) Biomaterials: principles and applications. CRC Press, Boca Raton, pp 1–20
Piconi C, Maccauro G, Muratori F, Brach Del Prever E (2003) Alumina and zirconia ceramics in joint replacements. J Appl Biomat Biomech 1:19–32
Pilliar RM (2009) Metallic biomaterials. In: Narayan R (ed) Biomedical materials. Springer, New York, pp 41–81
Pourbaix M (1984) Electrochemical corrosion of metallic biomaterials. Biomaterials 5:122–134
Reifenrath J, Bormann D, Meyer-Lindenberg A (2011) Magnesium alloys as promising degradable implant materials in orthopaedic research. In: Czerwinski F (ed) Magnesium alloys—corrosion and surface treatments. InTech, Rijeka, pp 93–108
Ren F, Leng Y, Xin R, Ge X (2010) Synthesis, characterization and ab initio simulation of magnesium-substituted hydroxyapatite. Acta Biomater 6:2787–2796
Sadat-Shojai M, Khorasani M-T, Dinpanah-Khoshdargi E, Jamshidi A (2013) Synthesis methods for nanosized hydroxyapatite with diverse structures. Acta Biomater 9:7591–7621
Schnabelrauch M, Scharnweber D, Schiller J (2013) Sulfated glycosaminoglycans as promising artificial extracellular matrix components to improve the regeneration of tissues. Curr Med Chem 20:2501–2523
Sewald N, Jakubke H-D (2002) Peptides: Chemistry and biology. Wiley-VCH, Weinheim
Silver FH, Garg AT (1997) Collagen: characterization, processing and medical applications. In: Domb AJ, Kost J, Wiseman DM (eds) Handbook of biodegradable polymers. OPA, Amsterdam, pp 319–346
Srichana T, Domb AJ (2009) Polymeric biomaterials. In: Narayan R (ed) Biomedical materials. Springer, New York, pp 83–119
Tsuji H (2010) Hydrolytic degradation. In: Auras R, Lim L-T, Tsuji H (eds) Poly(lactic acid): synthesis, structures, properties, processing, and applications. Wiley, Hoboken, pp 345–381
Turner IG (2009) Ceramics and glasses. In: Narayan R (ed) Biomedical materials. Springer, New York, pp 3–39
Van Vlierberghe S, Dubruel P, Schacht E (2011) Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromol 12:1387–1408
Virtanen S (2008) Corrosion of biomedical implant materials. Corrosion of biomedical implant materials 26:147–171
Vogel W, Höland W (1987) The development of bioglass ceramics for medical applications. Angew Chem Int Ed 26:527–544
Vogler EA (2004) Role of water in biomaterials. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 59–65
Volpi N (2006) Therapeutic applications of glycosaminoglycans. Curr Med Chem 13:1799–1810
Weisel JW, Cederholm-Williams SA (1997) Fibrinogen and fibrin: characterization, processing and medical applications. In: Domb AJ, Kost J, Wiseman DM (eds) Handbook of biodegradable polymers. OPA, Amsterdam, pp 347–365
Williams DF, Williams RL (2004) Degradative effects of the biological environment on metals and ceramics. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 430–439
Wilson J, Pigott GH, Schoen FJ, Hench LL (1981) Toxicology and biocompatibility of bioglasses. J Biomed Mater Res 15:805–817
Witte F, Hort N, Vogt C, Cohen S, Kainer KU, Willumeit R, Feyerabend F (2008) Degradable biomaterials based on magnesium corrosion. Curr Opin Solid State Mater Sci 12:63–72
Yannas IV (2004) Natural materials. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) An introduction to materials in medicine. Elsevier, San Diego, pp 127–137
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Schnabelrauch, M. (2018). Chemical Bulk Properties of Biomaterials. In: Zivic, F., Affatato, S., Trajanovic, M., Schnabelrauch, M., Grujovic, N., Choy, K. (eds) Biomaterials in Clinical Practice . Springer, Cham. https://doi.org/10.1007/978-3-319-68025-5_15
Download citation
DOI: https://doi.org/10.1007/978-3-319-68025-5_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-68024-8
Online ISBN: 978-3-319-68025-5
eBook Packages: EngineeringEngineering (R0)