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Click Chemistry for Radionanomedicine Platform

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

The emerging radionanomedicine has multifunctional and theranostic purposes. To fulfill these purposes, the radionanomedicine should achieve efficient and specific delivery of therapeutic agents by their multifunctionality with very low amount of nanomaterials used in vivo. Recent researches on radiolabeled micelle-encapsulated nanomaterials are promising for their efficacy and safety as one-step surface modification method. This one-step multifunctional approach to the nanoparticles is important to meet the challenges of manufacturing and is the basis for making the effective nano-platforms for disease-targeted imaging and therapy. Based on ‘click chemistry’ concept, great progress have been achieved in the field of radiochemistry and nanomedicine. Click chemistry can be used for the surface modification of nanomedicines, such as hydrophilization, target molecule ligation, therapeutic drug conjugation, and labeling sensor molecules including fluorescence dyes or radioisotopes. By the conventional step-by-step chemical modification method of nanomaterials, two or more combination of those modifications can hardly achieve practicability, because of the low yield of each step of the purification and modification. Another beauty of click chemistry for nanomedicine is the avoidance of harsh reaction condition, such as high/low pH, temperature, or reducing/oxidizing conditions, which result in the aggregation of nanomaterials or degradation of biomolecules. Numerous nanomedicine platforms have been proposed and used in in vitro assay, in vivo imaging, drug delivery, or theranostics. However, in considering manufacturing or commercialization of radionanomedicine platform , still there are much rooms to be improved. In this chapter, we focus on the current status for the ‘clickable’ nanomedicine platforms and how we can or will be able to reach the goal of clinical translation using this technology.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Yun-Sang Lee

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

    Yun-Sang Lee

  3. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, USA

    Lingyi Sun & Dexing Zeng

  4. Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

    Dexing Zeng

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Lee, YS., Sun, L., Zeng, D. (2018). Click Chemistry for Radionanomedicine Platform. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_12

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