Skip to main content

Modeling the Intra-class Variability for Liver Lesion Detection Using a Multi-class Patch-Based CNN

  • Conference paper
  • First Online:
Patch-Based Techniques in Medical Imaging (Patch-MI 2017)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 10530))

Included in the following conference series:

Abstract

Automatic detection of liver lesions in CT images poses a great challenge for researchers. In this work we present a deep learning approach that models explicitly the variability within the non-lesion class, based on prior knowledge of the data, to support an automated lesion detection system. A multi-class convolutional neural network (CNN) is proposed to categorize input image patches into sub-categories of boundary and interior patches, the decisions of which are fused to reach a binary lesion vs non-lesion decision. For validation of our system, we use CT images of 132 livers and 498 lesions. Our approach shows highly improved detection results that outperform the state-of-the-art fully convolutional network. Automated computerized tools, as shown in this work, have the potential in the future to support the radiologists towards improved detection.

M. Frid-Adar and I. Diamant—Equal Contributors

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ben-Cohen, A., Diamant, I., Klang, E., Amitai, M., Greenspan, H.: Fully convolutional network for liver segmentation and lesions detection. In: Carneiro, G., et al. (eds.) LABELS/DLMIA -2016. LNCS, vol. 10008, pp. 77–85. Springer, Cham (2016). doi:10.1007/978-3-319-46976-8_9

    Google Scholar 

  2. Christ, P.F., et al.: Automatic liver and lesion segmentation in CT using cascaded fully convolutional neural networks and 3D conditional random fields. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 415–423. Springer, Cham (2016). doi:10.1007/978-3-319-46723-8_48

    Chapter  Google Scholar 

  3. Deng, X., Du, G.: Editorial: 3D segmentation in the clinic: a grand challenge ii-liver tumor segmentation. In: MICCAI Workshop (2008)

    Google Scholar 

  4. Greenspan, H., van Ginneken, B., Summers, R.: Guest editorial deep learning in medical imaging: overview and future promise of an exciting new technique. IEEE Trans. Med. Imaging 35, 1153–1159 (2016)

    Article  Google Scholar 

  5. Setio, A.A.A., et al.: Pulmonary nodule detection in CT images: false positive reduction using multi-view convolutional networks. IEEE Trans. Med. Imaging 35(5), 1160–1169 (2016)

    Article  Google Scholar 

  6. Shimizu, A., et al.: Ensemble segmentation using AdaBoost with application to liver lesion extraction from a ct volume. In: Proceedings of Medical Imaging Computing Computer Assisted Intervention Workshop on 3D Segmentation in the Clinic: A Grand Challenge II (2008)

    Google Scholar 

  7. Shin, H.C., et al.: Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans. Med. Imaging 35(5), 1285–1298 (2016)

    Article  Google Scholar 

  8. Vedaldi, A., Lenc, K.: Matconvnet: convolutional neural networks for matlab. In: Proceedings of the 23rd Annual ACM Conference on Multimedia Conference, pp. 689–692 (2015)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maayan Frid-Adar .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Frid-Adar, M., Diamant, I., Klang, E., Amitai, M., Goldberger, J., Greenspan, H. (2017). Modeling the Intra-class Variability for Liver Lesion Detection Using a Multi-class Patch-Based CNN. In: Wu, G., Munsell, B., Zhan, Y., Bai, W., Sanroma, G., Coupé, P. (eds) Patch-Based Techniques in Medical Imaging. Patch-MI 2017. Lecture Notes in Computer Science(), vol 10530. Springer, Cham. https://doi.org/10.1007/978-3-319-67434-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67434-6_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67433-9

  • Online ISBN: 978-3-319-67434-6

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics