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Functional Biocomposites of Calcium Phosphate–Chitosan and Its Derivatives for Hard Tissue Regeneration Short Review

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Functional Biopolymers

Part of the book series: Springer Series on Polymer and Composite Materials ((SSPCM))

Abstract

This short review presents an actual innovation in functional biopolymers related with a research and developments in chitosan/calcium phosphate composites studies. It is a promising biomaterial to face new problems and challenges in the field of materials science, biology, and medicine, related with musculoskeletal tissues, bones, and cartilage which are under extensive investigation in regenerative medicine and advanced biomaterials research. A growing number of cases requiring medical devices, which is related with many factor such as bone fractures, defects, or diseases in addition to other various problems which need to be cured, make the scientist research and develop a great number of biodegradable and bioresorbable biocomposites. New developments in this interdisciplinary and multidisciplinary field related with new materials, new methods possibly, will increase in the near future the feasibility to design a new biocomposite tailored for specific patients and disease treatment. The global socioeconomic situation of the modern world has raised the interest in renewable materials to use in regenerative medicine. The generation of functional biocomposites from chitosan and calcium phosphates is derived from two or more different organic and inorganic materials, keeping the main characteristics of both materials like bioactivity and biodegradability and biocompatibility of the physiological environment of the human tissues. The chemical characteristics of the micro- and nano-chitosan and ceramic formation between nano-B-TCP/HAp complex showed any secondary products formation in the biocomposite, with a good stability of the nano-ceramic formation in the chitosan salt solutions. This research showed also a new method of preparations nanoparticles of the commercial calcium phosphates founded in micro-size in chitosan solution. These materials can be used in future for medical applications as a base for scaffolds production in regenerative medicine and for drug delivery.

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Acknowledgements

Lutheran University of Brazil, Biomatter lab, Post-Graduation program of Toxicology and Genetic and Materials Engineering. Ministry of Science and Higher Education in 2009–2012 as research project no: N N508 445636. European Community’s Seventh Framework Program (Marie-Curie), FP7/2007–2013 under grant agreement no: PITN-GA-2008-214015. Institute of Polymer and Dye Technology of the Technical University, Lodz, Poland. Institute of Biopolymers and Chemical Fibres, Lodz, Poland. Thuringian Institute of Textile and Plastics Research, Rudolstadt, Germany (TITK).

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Authors and Affiliations

  1. Biomatter Lab, Lutheran University of Brazil, Av. Farroupilha, no. 8001, Canoas, RS, 92425-900, Brazil

    L. Pighinelli, M. F. Guimarães, R. L. Paz, G. Zanin, M. Kmiec, M. F. Tedesco, M. Silva & O. V. Reis

  2. Institute of Biopolymers and Chemical Fibers—IBWCh, Sklodowskiej-Curie 19/27, 90-570, Lodz, Poland

    D. Wawro

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  1. L. Pighinelli
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  3. M. F. Guimarães
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Correspondence to L. Pighinelli .

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  1. Faculty in Manufacturing, Enhanced Composites and Structures Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Cranfield, Bedfordshire, United Kingdom

    Vijay Kumar Thakur

  2. Division of Chemistry, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Manju Kumari Thakur

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Pighinelli, L. et al. (2018). Functional Biocomposites of Calcium Phosphate–Chitosan and Its Derivatives for Hard Tissue Regeneration Short Review. In: Thakur, V., Thakur, M. (eds) Functional Biopolymers. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-66417-0_4

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