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Application of LIPUS to Periodontal Tissue Regeneration

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Therapeutic Ultrasound in Dentistry

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Abstract

Exposure to ultrasound during the inflammatory phase of periodontal tissue repair leads to an acceleration of this phase, which may eventually lead to an anti-inflammatory effect by low-intensity pulsed ultrasound (LIPUS) exposure. LIPUS has also been shown to enhance collagen synthesis by fibroblasts. As a consequence, LIPUS may be a promising candidate of treatment remedy for periodontal diseases such as periodontitis and orthodontically induced root resorption. Recent in vitro studies suggested that LIPUS promotes osteogenic differentiation of human periodontal ligament (PDL) cells, which is associated with upregulation of Runx2 and integrin β1 and activation of bone morphogenetic protein-smad signaling. Furthermore, recent in vivo studies have shown that LIPUS can enhance periodontal tissue repair and regeneration, especially if combined with the other treatment remedies for periodontal diseases such as guided tissue regeneration (GTR). These suggest that LIPUS could potentially enhance periodontal tissue repair and regeneration combined with GTR and provide therapeutic benefits in periodontal tissue regeneration.

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Authors and Affiliations

  1. Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Eiji Tanaka

  2. Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia

    Eiji Tanaka

  3. Genetic Disease Program, Sanford Children’s Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

    Toshihiro Inubushi

  4. Dentistry/Orthodontics and Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

    Tarek El-Bialy

Authors
  1. Eiji Tanaka
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  2. Toshihiro Inubushi
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  3. Tarek El-Bialy
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Correspondence to Eiji Tanaka .

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Editors and Affiliations

  1. Dentistry/Orthodontics and Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

    Tarek El-Bialy

  2. Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Eiji Tanaka

  3. Technion—Faculty of Medicine Oral Biology Research Laboratory, Rambam Health Care Campus, Haifa, Israel

    Dror Aizenbud

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Tanaka, E., Inubushi, T., El-Bialy, T. (2018). Application of LIPUS to Periodontal Tissue Regeneration. In: El-Bialy, T., Tanaka, E., Aizenbud, D. (eds) Therapeutic Ultrasound in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-319-66323-4_5

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  • DOI: https://doi.org/10.1007/978-3-319-66323-4_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66322-7

  • Online ISBN: 978-3-319-66323-4

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