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Platelets and Innate Immunity in Atherosclerosis

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Platelets, Haemostasis and Inflammation

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 5))

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Abstract

Platelets are classically considered initiators of hemostasis and—in pathology—intravascular thrombosis causing diseases such as myocardial infarction or stroke. However, platelets are also mediators of innate immunity, secrete inflammatory proteins, mediate leukocyte recruitment, and contribute to tissue remodeling. Inflammation and innate immunity have common intersection points with the hemostatic system at various levels. With the complement system being part of the innate immune system, this chapter focuses on the role of platelets and the complement system in the context of atherosclerosis.

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Authors and Affiliations

  1. University Clinic for Cardiovascular Medicine, University of Tuebingen, Tuebingen, Germany

    Johannes Patzelt & Harald F. Langer

  2. Section for Cardioimmunology, Department of Cardiovascular Medicine, University of Tuebingen, Tuebingen, Germany

    Harald F. Langer

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  1. Johannes Patzelt
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  2. Harald F. Langer
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Correspondence to Harald F. Langer .

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Editors and Affiliations

  1. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Andreas Zirlik

  2. Cardiology and Angiology I, University-Heart Center Freiburg, Freiburg, Germany

    Christoph Bode

  3. Department of Cardiology, University Hospital Tübingen, Tübingen, Germany

    Meinrad Gawaz

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  • Conflict of Interest: Johannes Patzelt and Harald F. Langer declares that they have no conflict of interest.

  • Ethical Approval: This article does not contain any studies with human participants or animals performed by any of the authors.

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Patzelt, J., Langer, H.F. (2017). Platelets and Innate Immunity in Atherosclerosis. In: Zirlik, A., Bode, C., Gawaz, M. (eds) Platelets, Haemostasis and Inflammation. Cardiac and Vascular Biology, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-66224-4_13

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