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An Overview of the Prophylaxis and Treatment of GvHD in Haploidentical SCT

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Haploidentical Stem Cell Transplantation

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Haploidentical stem cell transplantation (haplo-SCT) is now considered a clinical therapeutic option in patients candidate to allogeneic transplantation. Primary prevention and treatment of Graft-versus-Host Disease (GvHD) has been a major challenge in this peculiar major HLA mismatched setting. Two main platforms have been developed: ex-vivo T-cell depleted and unmanipulated grafts transplantation. Overall, the primary objective of a stable haploidentical hematopoietic engraftment at a low GvHD rate resulted feasible in both platforms in a significant proportion of patients undergoing haplo-SCT for any clinical indication. Haploidentical transplants should be performed in centers with major experience with HSCT procedures and preferentially performed within the framework of a local clinical protocol designed specifically to address the prevention of GvHD.

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  1. IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milano, Italy

    Fabio Ciceri MD

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Correspondence to Fabio Ciceri MD .

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  1. Department of Hematology, Ankara University Medical School, Sıhhiye, Ankara, Turkey

    Taner Demirer

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Ciceri, F. (2017). An Overview of the Prophylaxis and Treatment of GvHD in Haploidentical SCT. In: Demirer, T. (eds) Haploidentical Stem Cell Transplantation. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-65319-8_5

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