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Role of Dendritic Cells in Aging

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Handbook of Immunosenescence

Abstract

Immunosenescence is characterized by a decline in immune functions which is responsible for majority of morbidity and mortality associated with aging. The possible consequences of this progressive aging of the immune system are the increase in autoimmune phenomena, incidence of malignancies, and predisposition to infections. Innate immune system is the initial defense against invading pathogens. Moreover, it also initiates and modulates the functions of adaptive immune system. This review focuses on the age-associated changes in the functions of dendritic cells, the major antigen-presenting cells of innate immune system.

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Acknowledgment

Work cited here was in part supported by grant AG 27512 from NIH and partly by new scholar grant from the Ellison Medical Foundation.

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Authors and Affiliations

  1. Division of Basic and Clinical Immunology, University of California at Irvine, Irvine, CA, USA

    Anshu Agrawal, Sudhanshu Agrawal & Sudhir Gupta

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  1. Anshu Agrawal
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  2. Sudhanshu Agrawal
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  3. Sudhir Gupta
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Correspondence to Sudhir Gupta .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Agrawal, A., Agrawal, S., Gupta, S. (2018). Role of Dendritic Cells in Aging. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_25-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_25-1

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