Abstract
Aging is characterized by a progressive decline in metabolism and physiology throughout the body, and the complex physiological basis is not fully understood. A key intrinsic mechanism to safeguard our physiological well-being is the circadian clock , the biological timer that coordinates diverse essential processes. Epidemiological and genetic studies in the past two decades have established a crucial role of the clock system in metabolic homeostasis and physiological health. Accumulating evidence also points to a functional link between clock decline (e.g., amplitude dampening) and metabolic aging. In this chapter, we review a close relationship among energy homeostasis, aging and the circadian clock . We also describe the current efforts to identify novel small-molecule therapeutics that enhance circadian and metabolic functions. Given that a weakened clock is in part responsible for the metabolic deterioration during aging, such circadian-based therapeutics could be exploited to decelerate metabolic decline and ultimately promote healthy aging.
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Acknowledgements
This work was in part supported by the Robert A. Welch Foundation (AU-1731) and NIH/NIA (R01 AG045828) to Z.C., and NIH/NIGMS (R01 GM114424) to S.-H.Y.
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Nohara, K., Yoo, SH., Chen, Z. (2017). Developing Circadian Therapeutics Against Age-Related Metabolic Decline. In: Jazwinski, S., Belancio, V., Hill, S. (eds) Circadian Rhythms and Their Impact on Aging. Healthy Ageing and Longevity, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-64543-8_11
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