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Aging and the Biological Clock

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Circadian Rhythms and Their Impact on Aging

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 7))

Abstract

Aging and the biological clock are linked via metabolism. We explore how different pathways within metabolism link aging and the clock. These linking pathways include those involving: (1) sphingolipid metabolism; (2) the sir2 complex of genes affecting caloric restriction ; (3) pathways underlying oxidative stress ; (4) the cell cycle ; and (5) glucose metabolism . Making these metabolic linkages in Neurospora crassa is facilitated by the availability of an entire transcriptional network for the clock. Emerging themes include epistatic interactions between genes leading to effects on the clock and aging . We also present evidence that these five metabolic linkages affecting aging provide feedback to the clock. Metabolism is not only driven by the clock, but metabolism is likely to provide feedback to the clock by a variety of metabolic mechanisms.

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Acknowledgements

This work was supported by NSF MCB-SSB/PHY-POLS-1713746.

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Authors and Affiliations

  1. Genetics Department, University of Georgia, Athens, GA, 30602, Greece

    Michael Judge, James Griffith & Jonathan Arnold

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  1. Michael Judge
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  2. James Griffith
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Correspondence to Jonathan Arnold .

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Editors and Affiliations

  1. Tulane Center for Aging, Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    S. Michal Jazwinski

  2. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Victoria P Belancio

  3. Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA

    Steven M Hill

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Judge, M., Griffith, J., Arnold, J. (2017). Aging and the Biological Clock. In: Jazwinski, S., Belancio, V., Hill, S. (eds) Circadian Rhythms and Their Impact on Aging. Healthy Ageing and Longevity, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-64543-8_10

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