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HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors

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Neoplastic Diseases of the Blood

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Abstract

Advances in the field of immunogenetics of the human leukocyte antigen (HLA) system have changed the landscape of unrelated hematopoietic cell transplantation (HCT). The advent of molecular tissue typing methods provided an unprecedented level of accuracy in the characterization of the class I and II genes and the much needed tools for querying the genetic diversity and implications of human genetic variation on clinical outcome after unrelated donor HCT. Clinical application of DNA-based typing methods for registry donors, together with the growth of international donor registries, has greatly increased the chances that any given patient may identify a suitable donor and benefit from a life-saving transplant.

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Authors and Affiliations

  1. Division of Medical Oncology, Division of Clinical Research, Department of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA, 98109, USA

    Effie W. Petersdorf M.D.

  2. Department of Medicine, University of Washington, NE Pacific St, Seattle, WA, 98040, USA

    Effie W. Petersdorf M.D. & Paul J. Martin M.D.

  3. Department of Blood and Marrow Transplantation, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Claudio Anasetti M.D.

  4. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2-100, Seattle, WA, 98109, USA

    Paul J. Martin M.D. & John A. Hansen M.D.

  5. Division of Clinical Research, Department of Medicine, University of Washington, NE Pacific St, Seattle, WA, 98040, USA

    John A. Hansen M.D.

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  1. Effie W. Petersdorf M.D.
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Correspondence to Effie W. Petersdorf M.D. .

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  1. Cancer Research Foundation, Chappaqua, New York, USA

    Peter H. Wiernik

  2. Cancer Research Foundation, Chappaqua, New York, USA

    Janice P. Dutcher

  3. Department of Hematology, Mayo Clinic Department of Hematology, Rochester, Minnesota, USA

    Morie A. Gertz

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Petersdorf, E.W., Anasetti, C., Martin, P.J., Hansen, J.A. (2018). HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors. In: Wiernik, P., Dutcher, J., Gertz, M. (eds) Neoplastic Diseases of the Blood. Springer, Cham. https://doi.org/10.1007/978-3-319-64263-5_56

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