Abstract
The goals of nutritional support in the ICU are to minimize weight loss, loss of protein during the initial phase, and to provide nutrients to support the immune system and healing. Both underfeeding and overfeeding are deleterious. Clinical evaluation of energy needs can be performed with equations, but the reference values are obtained by indirect calorimetry, especially interesting for extreme BMI. Indeed, all formulas are weight based, and actual weight is not always a correct denominator. Energy provision recommended by guidelines is 20–25 kcal/kg body weight/day in the acute phase and 25–30 kcal/kg body weight/day in the recovery phase. It needs to take into account patient obesity and the risk of refeeding syndrome in malnourished people. Carbohydrates and lipids represent 65–70% and 30–35% of energy provision, respectively. The recommended protein provision is 1.3–1.5 g proteins/kg ideal body weight/day or 1.2–2.0 g/kg actual body weight/day. Finally, there is an increased need for most micronutrients that needs to be covered with commercial admixtures; some micronutrients have to be adapted for each patient with a possibility to supplement some with selenium and vitamin C.
References
Preiser JC, Devos P (2006) Physiopathologie du stress sévère. In: Cano N, Barnoud D, Schneider S, Vasson MP, Hasselmann M, Leverve X (eds) Traité de nutrition artificielle de l’adulte : nourrir l’homme malade, 3ème édition edn. Springer, Paris, pp 435–444
Raynard B (2009) Place de la calorimétrie indirecte et des formules estimant la dépense énergétique des malades de réanimation. Nutr Clin Métabol 23(4):192–197
Griffiths RD (1997) Feeding the critically ill—should we do better? Intensive Care Med 23(3):246–247
Kan MN, Chang HH, Sheu WF, Cheng CH, Lee BJ, Huang YC (2003) Estimation of energy requirements for mechanically ventilated, critically ill patients using nutritional status. Crit Care 7(5):R108–R115. doi:10.1186/cc2366
Kreymann KG, Berger MM, Deutz NE, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J, Ebner C, Hartl W, Heymann C, Spies C (2006) ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 25(2):210–223. doi:10.1016/j.clnu.2006.01.021. [pii] S0261-5614(06)00041-0
Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, Griffiths R, Kreyman G, Leverve X, Pichard C, Espen (2009) ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 28(4):387–400. doi:10.1016/j.clnu.2009.04.024. [pii] S0261-5614(09)00098-3
Lefrant JY, Hurel D, Cano NJ, Ichai C, Preiser JC, Tamion F (2014) Guidelines for nutrition support in critically ill patient. Ann Fr Anesth Reanim 33(3):202–218. doi:10.1016/j.annfar.2014.01.008
McClave SA, Taylor B, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C (2015) Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (a.S.P.E.N.) JPEN J Parenter Enteral Nutr 40(2):159–211. doi:10.1177/0148607109335234. [pii] 33/3/277
Stapleton RD, Jones N, Heyland DK (2007) Feeding critically ill patients: what is the optimal amount of energy ? Crit Care Med 35(suppl):S535–S540
Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones GJ, Mehta S, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L (2015) Permissive underfeeding or standard enteral feeding in critically ill adults. NEJM 372(25):2398–2408
Charles EJ, Petroze RT, Metzger R, Hranjec T, Rosenberger LH, Riccio LM, McLeod MD, Guidry CA, Stukenbor GJ, Swenon BR, Wilcutts KF, O'Donnell KB, Sawyer RG (2014) Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial. Am J Clin Nutr 100:1337–1343
Wischmeyer PE (2013) The evolution of nutrition in critical care: how much, how soon? Crit Care 17(Suppl 1):S7. doi:10.1186/cc11505
McWhirter JP, Pennington CR (1994) Incidence and recognition of malnutrition in hospital. Br Med J 308(6934):945–948
Sheean PM, Peterson SJ, Gomez Perez S, Troy KL, Patel A, Sclamberg JS, Ajanaku FC, Braunschweig CA (2013) The prevalence of sarcopenia in patients with respiratory failure classified as normally nourished using computed tomography and subjective global assessment. J Parenter Enter Nutr 38(7):873–879. doi:10.1177/0148607113500308
Pasinato VF, Berbigier MC, Rubin Bde A, Castro K, Moraes RB, Perry ID (2013) Enteral nutritional therapy in septic patients in the intensive care unit: compliance with nutritional guidelines for critically ill patients. Revista Brasileira de terapia intensiva 25(1):17–24
Caba D, Ochoa JB (2007) How many calories are necessary during critical illness? Gastrointest Endosc Clin N Am 17(4):703–710. doi:10.1016/j.giec.2007.07.004. [pii] S1052-5157(07)00092-X
Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, Heyland DK (2009) The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 35(10):1728–1737. doi:10.1007/s00134-009-1567-4
De Jonghe B, Appere-De-Vechi C, Fournier M, Tran B, Merrer J, Melchior JC, Outin H (2001) A prospective survey of nutritional support practices in intensive care unit patients: what is prescribed? What is delivered? Crit Care Med 29(1):8–12
Wandrag L, Gordon F, O'Flynn J, Siddiqui B, Hickson M (2011) Identifying the factors that influence energy deficit in the adult intensive care unit: a mixed linear model analysis. J Hum Nutr Diet 24(3):215–222. doi:10.1111/j.1365-277X.2010.01147.x
Dvir D, Cohen J, Singer P (2006) Computerized energy balance and complications in critically ill patients: an observational study. Clin Nutr 25(1):37–44. doi:10.1016/j.clnu.2005.10.010. [pii] S0261-5614(05)00187-1
Villet S, Chiolero RL, Bollmann MD, Revelly JP, RNM C, Delarue J, Berger MM (2005) Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr 24(4):502–509. doi:S0261-5614(05)00054-3 [pii]. doi:10.1016/j.clnu.2005.03.006
Tsai JR, Chang WT, Sheu CC, Wu YJ, Sheu YH, Liu PL, Ker CG, Huang MC (2010) Inadequate energy delivery during early critical illness correlates with increased risk of mortality in patients who survive at least seven days: a retrospective study. Clin Nutr 30(2):209–214. doi:10.1016/j.clnu.2010.09.003. [pii] S0261-5614(10)00176-7
Petros S, Engelmann L (2006) Enteral nutrition delivery and energy expenditure in medical intensive care patients. Clin Nutr 25(1):51–59. doi:10.1016/j.clnu.2005.08.013. [pii] S0261-5614(05)00146-9
Arabi YM, Haddad SH, Tamim HM, Rishu AH, Sakkijha MH, Kahoul SH, Britts RJ (2010) Near-target caloric intake in critically ill medical-surgical patients is associated with adverse outcomes. JPEN J Parenter Enteral Nutr 34(3):280–288. doi:10.1177/0148607109353439. [pii] 34/3/280
The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991) Perioperative total parenteral nutrition in surgical patients. N Engl J Med 325(8):525–532
Petit A, Tamion F (2010) Nutrition du patient obèse agressé. Réanimation 19:448–453
McClave SA, Lowen CC, Kleber MJ, Nicholson JF, Jimmerson SC, McConnell JW, Jung LY (1998) Are patients fed appropriately according to their caloric requirements? JPEN J Parenter Enteral Nutr 22(6):375–381
Malone AM (2002) Methods of assessing energy expenditure in the intensive care unit. Nutr Clin Pract 17(1):21–28. [pii] 17/1/21
Jeejeebhoy KN (2004) Permissive underfeeding of the critically ill patient. Nutr Clin Pract 19(5):477–480. [pii] 19/5/477
Sundstrom M, Tjader I, Rooyackers O, Wernerman J (2013) Indirect calorimetry in mechanically ventilated patients. A systematic comparison of three instruments. Clin Nutr 32(1):118–121. doi:10.1016/j.clnu.2012.06.004
Weekes CE (2007) Controversies in the determination of energy requirements. Proc Nutr Soc 66(3):367–377. doi:S0029665107005630 [pii]. doi:10.1017/S0029665107005630
Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M, Lev S, Grozovski E, Theilla M, Frishman S, Madar Z (2011) The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med 37(4):601–609. doi:10.1007/s00134-011-2146-z
Harris JA, Benedict FG (1919) A biometric study of basal metabolism in man. Carnegie Institute of Washington, Washington
Kleiber M (1932) Body size and metabolism. Hilgardia 6:315–353
Roza AM, Shizgal HM (1984) The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass. Am J Clin Nutr 40(1):168–182
Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO (1990) A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51(2):241–247
Liu HY, Lu YF, Chen WJ (1995) Predictive equations for basal metabolic rate in Chinese adults: a cross-validation study. J Am Diet Assoc 95(12):1403–1408. doi:10.1016/S0002-8223(95)00369-X. [pii] S0002-8223(95)00369-X
Fusco MA, Mills ME, Nelson LD (1995) Predicting caloric requirements with emphasis on avoiding overfeeding. JPEN 19(suppl):18S. (abstract)
Black AE, Coward WA, Cole TJ, Prentice AM (1996) Human energy expenditure in affluent societies: an analysis of 574 doubly-labelled water measurements. Eur J Clin Nutr 50(2):72–92
Fick A (1855) Über diffusion. Poggendorff's Annalen der Physik und Chemie 94:59–86
Swinamer DL, Grace MG, Hamilton SM, Jones RL, Roberts P, King EG (1990) Predictive equation for assessing energy expenditure in mechanically ventilated critically ill patients. Crit Care Med 18(6):657–661
Ireton-Jones CS, Turner WW Jr, Liepa GU, Baxter CR (1992) Equations for the estimation of energy expenditures in patients with burns with special reference to ventilatory status. J Burn Care Rehabil 13(3):330–333
Frankenfield DC, Omert LA, Badellino MM, Wiles CE 3rd, Bagley SM, Goodarzi S, Siegel JH (1994a) Correlation between measured energy expenditure and clinically obtained variables in trauma and sepsis patients. JPEN J Parenter Enteral Nutr 18(5):398–403
Raurich JM, Ibanez J, Marse P, Velasco J, Bergada J (1997) Energy expenditure in patients with multiple organ failure. Clin Nutr 16(6):307–312. [pii] S0261-5614(97)80016-7
Brandi LS, Bertolini R, Calafa M (1997) Indirect calorimetry in critically ill patients: clinical applications and practical advice. Nutrition 13(4):349–358
Faisy C, Guerot E, Diehl JL, Labrousse J, Fagon JY (2003) Assessment of resting energy expenditure in mechanically ventilated patients. Am J Clin Nutr 78(2):241–249
MacDonald A, Hildebrandt L (2003) Comparison of formulaic equations to determine energy expenditure in the critically ill patient. Nutrition19:233–9
Chioléro R, Revelly JP, Tappy L (1997) Energy metabolism in sepsis and injury. Nutrition 13(9 Suppl):45S–51S
Frankenfield DC, Wiles CE 3rd, Bagley S, Siegel JH (1994b) Relationships between resting and total energy expenditure in injured and septic patients. Crit Care Med 22(11):1796–1804
Attof Y, Hachemi M, Cannesson M, Souza Neto EP, Rosamel P, Chambrier C, Bastien O, Lehot JJ (2007) De la conception à l’évaluation d’un programme d’aide à la prescription en nutrition artificielle sous Palm OS®. Ann Fr Anesth Reanim 26(12):1031–1036. doi:10.1016/j.annfar.2007.09.026. [pii] S0750-7658(07)00515-1
Thibault R, Pichard C (2010) Nutrition and clinical outcome in intensive care patients. Curr Opin Clin Nutr Metab Care 13(2):177–183. doi:10.1097/MCO.0b013e32833574b9
Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G (2011) Early versus late parenteral nutrition in critically ill adults. N Engl J Med 365(6):506–517. doi:10.1056/NEJMoa1102662
Davis KA, Kinn T, Esposito TJ, Reed RL 2nd, Santaniello JM, Luchette FA (2006) Nutritional gain versus financial gain: the role of metabolic carts in the surgical ICU. J Trauma 61(6):1436–1440. doi:10.1097/01.ta.0000242269.12534.79. [pii] 00005373-200612000-00021
Daly JM, Heymsfield SB, Head CA, Harvey LP, Nixon DW, Katzeff H, Grossman GD (1985) Human energy requirements: overestimation by widely used prediction equation. Am J Clin Nutr 42(6):1170–1174
Port AM, Apovian C (2010) Metabolic support of the obese intensive care unit patient: a current perspective. Curr Opin Clin Nutr Metab Care 13(2):184–191. doi:10.1097/MCO.0b013e328335f1e6
Hamwi GJ (1964) Therapy: changing dietary concepts. In: Danowski TS (ed) Diabetes mellitus: diagnosis and treatment, vol 1. American Diabetes Association, New York
Stahel PF, Flierl MA, Moore EE (2010) "metabolic staging" after major trauma - a guide for clinical decision making? Scand J Trauma Resusc Emerg Med 18:34. doi:10.1186/1757-7241-18-34
Ishibashi N, Plank LD, Sando K, Hill GL (1998) Optimal protein requirements during the first 2 weeks after the onset of critical illness. Crit Care Med 26(9):1529–1535
Plank LD, Connolly AB, Hill GL (1998) Sequential changes in the metabolic response in severely septic patients during the first 23 days after the onset of peritonitis. Ann Surg 228(2):146–158
Plank LD, Hill GL (2000) Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma. World J Surg 24(6):630–638. doi:10.1007/s002689910104
Plank LD, Hill GL (2003) Energy balance in critical illness. Proc Nutr Soc 62(2):545–552
Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H (1993) Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med 21(7):1012–1019
Uehara M, Plank LD, Hill GL (1999) Components of energy expenditure in patients with severe sepsis and major trauma: a basis for clinical care. Crit Care Med 27(7):1295–1302
Jolliet P, Pichard C, Biolo G, Chiolero R, Grimble G, Leverve X, Nitenberg G, Novak I, Planas M, Preiser JC, Roth E, Schols AM, Wernerman J (1998) Enteral nutrition in intensive care patients: a practical approach. Working group on nutrition and metabolism, ESICM. European Society of Intensive Care Medicine. Intensive Care Med 24(8):848–859
Umpierrez GE, Spiegelman R, Zhao V, Smiley DD, Pinzon I, Griffith DP, Peng L, Morris T, Luo M, Garcia H, Thomas C, Newton CA, Ziegler TR (2012) A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med 40(6):1792–1798. doi:10.1097/CCM.0b013e3182474bf9
Friesecke S, Lotze C, Kohler J, Heinrich A, Felix SB, Abel P (2008) Fish oil supplementation in the parenteral nutrition of critically ill medical patients: a randomised controlled trial. Intensive Care Med 34(8):1411–1420. doi:10.1007/s00134-008-1072-1
Manzanares W, Dhaliwal R, Jurewitsch B, Stapleton RD, Jeejeebhoy KN, Heyland DK (2014) Parenteral fish oil lipid emulsions in the critically ill: a systematic review and meta-analysis. JPEN J Parenter Enteral Nutr 38(1):20–28. doi:10.1177/0148607113486006
Christman JW, McCain RW (1993) A sensible approach to the nutritional support of mechanically ventilated critically ill patients. Intensive Care Med 19(3):129–136
Radrizzani D, Iapichino G (1998) Nutrition and lung function in the critically ill patient. Clin Nutr 17(1):7–10
Rousseau AF, Losser MR, Ichai C, Berger MM (2013) ESPEN endorsed recommendations: nutritional therapy in major burns. Clin Nutr 32(4):497–502. doi:10.1016/j.clnu.2013.02.012
Bellomo R, Martin H, Parkin G, Love J, Kearley Y, Boyce N (1991) Continuous arteriovenous haemodiafiltration in the critically ill: influence on major nutrient balances. Intensive Care Med 17(7):399–402
Frankenfield DC, Reynolds HN, Badellino MM, Wiles CE 3rd (1995) Glucose dynamics during continuous hemodiafiltration and total parenteral nutrition. Intensive Care Med 21(12):1016–1022
Fiaccadori E, Regolisti G, Maggiore U (2013) Specialized nutritional support interventions in critically ill patients on renal replacement therapy. Curr Opin Clin Nutr Metab Care 16(2):217–224. doi:10.1097/MCO.0b013e32835c20b0
Casaer MP, Langouche L, Coudyzer W, Vanbeckevoort D, De Dobbelaer B, Guiza FG, Wouters PJ, Mesotten D, Van den Berghe G (2013) Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness. Crit Care Med 41(10):2298–2309. doi:10.1097/CCM.0b013e31828cef02
Jackson NC, Carroll PV, Russell-Jones DL, Sonksen PH, Treacher DF, Umpleby AM (1999) The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism. Am J Phys 276(1 Pt 1):E163–E170
Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE (1988) Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg 123(8):992–999
Japur CC, Monteiro JP, Marchini JS, Garcia RW, Basile-Filho A (2010) Can an adequate energy intake be able to reverse the negative nitrogen balance in mechanically ventilated critically ill patients? J Crit Care 25(3):445–450. doi:10.1016/j.jcrc.2009.05.009. [pii] S0883-9441(09)00122-1
Heyland DK, Jones N, Cvijanovich NZ, Wong H (2008) Zinc supplementation in critically ill patients: a key pharmaconutrient? JPEN J Parenter Enteral Nutr 32(5):509–519. doi:10.1177/0148607108322402. [pii] 0148607108322402
Mishra V, Baines M, Wenstone R, Shenkin A (2005) Markers of oxidative damage, antioxidant status and clinical outcome in critically ill patients. Ann Clin Biochem 42(Pt 4):269–276. doi:10.1258/0004563054255461
Murphy SP, Barr SI, Yates AA (2006) The recommended dietary allowance (RDA) should not be abandoned: an individual is both an individual and a member of a group. Nutr Rev 64(7 Pt 1):313–315. discussion 315-318
Moison RM, Bloemhof FE, Geerdink JA, de Beaufort AJ, Berger HM (2000) The capacity of different infusion fluids to lower the prooxidant activity of plasma iron: an important factor in resuscitation? Transfusion 40(11):1346–1351
Perlot I, Preiser JC (2010) Besoins en vitamines et oligo-éléments. In: Barnoud D, Fraipont V, Hasselmann M, Preiser JC, Schneider SM (eds) Questions de nutrition clinique de l'adulte en réanimation et soins intensifs. SFNEP-SBNC-K'Noë, Paris, pp 39–49
Heyland DK, Dhaliwal R, Suchner U, Berger MM (2005) Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 31(3):327–337. doi:10.1007/s00134-004-2522-z
Huang TS, Shyu YC, Chen HY, Lin LM, Lo CY, Yuan SS, PJ CH (2013) Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS One 8(1):1–9
Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG, Canadian Critical Care Trials G (2013) A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 368(16):1489–1497. doi:10.1056/NEJMoa1212722
Kuklinski B, Zimmermann T, Schweder R (1995) Decreasing mortality in acute pancreatitis with sodium selenite. Clinical results of 4 years antioxidant therapy. Med Klin (Munich) 90(Suppl 1):36–41
Berger MM (2009) Vitamin C requirements in parenteral nutrition. Gastroenterology 137(5 Suppl):S70–S78. doi:10.1053/j.gastro.2009.08.012. [pii] S0016-5085(09)01448-6
Berger MM, Baines M, Raffoul W, Benathan M, Chiolero RL, Reeves C, Revelly JP, Cayeux MC, Senechaud I, Shenkin A (2007) Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations. Am J Clin Nutr 85(5):1293–1300
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Bachand, MP., Hébuterne, X., Schneider, S.M. (2018). Nutritional Requirements in Intensive Care Unit. In: Ichai, C., Quintard, H., Orban, JC. (eds) Metabolic Disorders and Critically Ill Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-64010-5_18
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