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Endoscopic Management of Pancreatic Fistula and Leaks

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Diagnostic and Therapeutic Procedures in Gastroenterology

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Pancreatic fistula result from a disruption of the pancreatic ductal system and may occur in the course of (recurrent) episodes of acute pancreatitis, chronic pancreatitis, pancreatic malignancy, pancreatic resection, or trauma. The clinical consequences depend on multiple factors including etiology, site and extent of the disruption, and the presence of downstream obstruction of the pancreatic duct. A small leak from one of the side branches of an otherwise unobstructed pancreatic duct may resolve spontaneously, whereas a persistent leak from a major main pancreatic duct disruption may be complicated by pseudocyst formation, internal fistula formation causing ascites or pleural effusion, and external pancreatic fistulas. Treatment consists of supportive therapy, medical management, endoscopic intervention, or surgery.

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References

  1. Kozarek RA, et al. Endoscopic transpapillary therapy for disrupted pancreatic duct and peripancreatic fluid collections. Gastroenterology. 1991;100(5 Pt 1):1362–70.

    Article  CAS  PubMed  Google Scholar 

  2. Bhasin DK, et al. Endoscopic management of pancreatic diseases. Indian J Gastroenterol. 1997;16(4):151–2.

    CAS  PubMed  Google Scholar 

  3. Varadarajulu S, Noone TC, Tutuian R. Predictors of outcome in pancreatic duct disruption managed by endoscopic transpapillary stent placement. Gastrointest Endosc. 2005;61:568–75.

    Article  PubMed  Google Scholar 

  4. Pannegeon V, et al. Pancreatic fistula after distal pancreatectomy: predictive risk factors and value of conservative treatment. Arch Surg. 2006;141(11):1071–6.

    Article  PubMed  Google Scholar 

  5. Neoptolemos JP, London NJ, Carr-Locke DL. Assessment of main pancreatic duct integrity by endoscopic retrograde pancreatography in patients with acute pancreatitis. Br J Surg. 1993;80(1):94–9.

    Article  CAS  PubMed  Google Scholar 

  6. Kozarek RA. Endoscopic therapy of complete and partial pancreatic duct disruptions. Gastrointest Endosc Clin N Am. 1998;8(1):39–53.

    CAS  PubMed  Google Scholar 

  7. Fulcher AS, Capps GW, Turner MA. Thoracopancreatic fistula: clinical and imaging findings. J Comput Assist Tomogr. 1999;23(2):181–7.

    Article  CAS  PubMed  Google Scholar 

  8. Zinner MJ, Baker RR, Cameron JL. Pancreatic cutaneous fistulas. Surg Gynecol Obstet. 1974;138(5):710–2.

    CAS  PubMed  Google Scholar 

  9. Seetharam P, Rodrigues GS. Postoperative pancreatic fistula: a Surgeon's nightmare! An insight with a detailed literature review. JOP. 2015;16(2):115–24.

    PubMed  Google Scholar 

  10. Rockey DC, Cello JP. Pancreaticopleural fistula. Report of 7 patients and review of the literature. Medicine (Baltimore). 1990;69(6):332–44.

    Article  CAS  Google Scholar 

  11. Ondrejka P, et al. Isolated massive pleural effusion caused by pancreatico-pleural fistula. Z Gastroenterol. 2000;38(7):583–5.

    Article  CAS  PubMed  Google Scholar 

  12. Francois CJ, Demos TC, Iqbal N. Pancreaticothoracic fistulas: imaging findings in five patients. Abdom Imaging. 2005;30(6):761–7.

    Article  CAS  PubMed  Google Scholar 

  13. Pelaez-Luna M, et al. Disconnected pancreatic duct syndrome in severe acute pancreatitis: clinical and imaging characteristics and outcomes in a cohort of 31 cases. Gastrointest Endosc. 2008;68(1):91–7.

    Article  PubMed  Google Scholar 

  14. Arvanitakis M, et al. Endoscopic treatment of external pancreatic fistulas: when draining the main pancreatic duct is not enough. Am J Gastroenterol. 2007;102(3):516–24.

    Article  PubMed  Google Scholar 

  15. Varadarajulu S, Rana SS, Bhasin DK. Endoscopic therapy for pancreatic duct leaks and disruptions. Gastrointest Endosc Clin N Am. 2013;23(4):863–92.

    Article  PubMed  Google Scholar 

  16. Buchler MW, et al. Pancreatic fistula after pancreatic head resection. Br J Surg. 2000;87(7):883–9.

    Article  CAS  PubMed  Google Scholar 

  17. Bassi C, et al. Pancreatic fistula rate after pancreatic resection. The importance of definitions. Dig Surg. 2004;21(1):54–9.

    Article  PubMed  Google Scholar 

  18. Bassi C, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138(1):8–13.

    Article  PubMed  Google Scholar 

  19. Alexakis N, Sutton R, Neoptolemos JP. Surgical treatment of pancreatic fistula. Dig Surg. 2004;21(4):262–74.

    Article  CAS  PubMed  Google Scholar 

  20. van Berge Henegouwen MI, et al. Incidence, risk factors, and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant. J Am Coll Surg. 1997;185(1):18–24.

    Article  PubMed  Google Scholar 

  21. Ban D, et al. Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients. World J Surg. 2012;36(8):1866–73.

    Article  PubMed  Google Scholar 

  22. Ceroni M, et al. Amylase level in drains after pancreatoduodenectomy as a predictor of clinically significant pancreatic fistula. Pancreas. 2014;43(3):462–4.

    Article  CAS  PubMed  Google Scholar 

  23. Morgan KA, Adams DB. Management of internal and external pancreatic fistulas. Surg Clin North Am. 2007;87(6):1503–13. x

    Article  PubMed  Google Scholar 

  24. Itoh S, et al. Assessment of the pancreatic and intrapancreatic bile ducts using 0.5-mm collimation and multiplanar reformatted images in multislice CT. Eur Radiol. 2003;13(2):277–85.

    PubMed  Google Scholar 

  25. Drake LM, Anis M, Lawrence C. Accuracy of magnetic resonance cholangiopancreatography in identifying pancreatic duct disruption. J Clin Gastroenterol. 2012;46(8):696–9.

    Article  PubMed  Google Scholar 

  26. Soto JA, et al. Traumatic disruption of the pancreatic duct: diagnosis with MR pancreatography. AJR Am J Roentgenol. 2001;176(1):175–8.

    Article  CAS  PubMed  Google Scholar 

  27. Subramanian A, Dente CJ, Feliciano DV. The management of pancreatic trauma in the modern era. Surg Clin North Am. 2007;87(6):1515–32. x

    Article  PubMed  Google Scholar 

  28. Gillams AR, Kurzawinski T, Lees WR. Diagnosis of duct disruption and assessment of pancreatic leak with dynamic secretin-stimulated MR cholangiopancreatography. AJR Am J Roentgenol. 2006;186(2):499–506.

    Article  CAS  PubMed  Google Scholar 

  29. Telford JJ, et al. Pancreatic stent placement for duct disruption. Gastrointest Endosc. 2002;56(1):18–24.

    Article  PubMed  Google Scholar 

  30. Kim HS, et al. The role of endoscopic retrograde pancreatography in the treatment of traumatic pancreatic duct injury. Gastrointest Endosc. 2001;54(1):49–55.

    Article  CAS  PubMed  Google Scholar 

  31. Barish MA, Yucel EK, Ferrucci JT. Magnetic resonance cholangiopancreatography. N Engl J Med. 1999;341(4):258–64.

    Article  CAS  PubMed  Google Scholar 

  32. Freeman ML. Adverse outcomes of ERCP. Gastrointest Endosc. 2002;56(6 Suppl):S273–82.

    Article  PubMed  Google Scholar 

  33. Blero D, Deviere J. Endoscopic complications--avoidance and management. Nat Rev Gastroenterol Hepatol. 2012;9(3):162–72.

    Article  PubMed  Google Scholar 

  34. Takishima T, et al. Pancreatographic classification of pancreatic ductal injuries caused by blunt injury to the pancreas. J Trauma. 2000;48(4):745–51. discussion 751-2

    Article  CAS  PubMed  Google Scholar 

  35. Blatnik JA, Hardacre JM. Management of pancreatic fistulas. Surg Clin North Am. 2013;93(3):611–7.

    Article  PubMed  Google Scholar 

  36. Klek S, et al. Enteral and parenteral nutrition in the conservative treatment of pancreatic fistula: a randomized clinical trial. Gastroenterology. 2011;141(1):157–63. 163 e1.

    Article  PubMed  Google Scholar 

  37. Heyland DK, et al. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr. 2003;27(5):355–73.

    Article  PubMed  Google Scholar 

  38. Ho KM, Dobb GJ, Webb SA. A comparison of early gastric and post-pyloric feeding in critically ill patients: a meta-analysis. Intensive Care Med. 2006;32(5):639–49.

    Article  PubMed  Google Scholar 

  39. Gans SL, et al. Systematic review and meta-analysis of somatostatin analogues for the treatment of pancreatic fistula. Br J Surg. 2012;99(6):754–60.

    Article  CAS  PubMed  Google Scholar 

  40. Gomez-Cerezo J, et al. Pancreatic ascites: study of therapeutic options by analysis of case reports and case series between the years 1975 and 2000. Am J Gastroenterol. 2003;98(3):568–77.

    Article  CAS  PubMed  Google Scholar 

  41. Li-Ling J, Irving M. Somatostatin and octreotide in the prevention of postoperative pancreatic complications and the treatment of enterocutaneous pancreatic fistulas: a systematic review of randomized controlled trials. Br J Surg. 2001;88(2):190–9.

    Article  CAS  PubMed  Google Scholar 

  42. Ridgeway MG, Stabile BE. Surgical management and treatment of pancreatic fistulas. Surg Clin North Am. 1996;76(5):1159–73.

    Article  CAS  PubMed  Google Scholar 

  43. Fazel A. Postoperative pancreatic leaks and fistulae: the role of the Endoscopist. Tech Gastrointest Endosc. 2006;8(2):92–8.

    Article  Google Scholar 

  44. Saeed ZA, Ramirez FC, Hepps KS. Endoscopic stent placement for internal and external pancreatic fistulas. Gastroenterology. 1993;105(4):1213–7.

    Article  CAS  PubMed  Google Scholar 

  45. Baron TH. Endoscopic drainage of pancreatic fluid collections and pancreatic necrosis. Gastrointest Endosc Clin N Am. 2003;13(4):743–64.

    Article  PubMed  Google Scholar 

  46. Samuelson AL, Shah RJ. Endoscopic management of pancreatic pseudocysts. Gastroenterol Clin N Am. 2012;41(1):47–62.

    Article  Google Scholar 

  47. Smith MT, et al. Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc. 1996;44(3):268–75.

    Article  CAS  PubMed  Google Scholar 

  48. Sherman S, et al. Stent-induced pancreatic ductal and parenchymal changes: correlation of endoscopic ultrasound with ERCP. Gastrointest Endosc. 1996;44(3):276–82.

    Article  CAS  PubMed  Google Scholar 

  49. Raju GS, et al. Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. Endoscopy. 2006;38(3):260–5.

    Article  CAS  PubMed  Google Scholar 

  50. Bhasin DK, Rana SS. Biodegradable pancreatic stents: are they a disappearing wonder? Gastrointest Endosc. 2008;67(7):1113–6.

    Article  PubMed  Google Scholar 

  51. Bhasin DK, et al. Endoscopic transpapillary nasopancreatic drainage alone to treat pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2006;21(6):1059–64.

    Article  PubMed  Google Scholar 

  52. Bracher GA, et al. Endoscopic pancreatic duct stenting to treat pancreatic ascites. Gastrointest Endosc. 1999;49(6):710–5.

    Article  CAS  PubMed  Google Scholar 

  53. Chebli JM, et al. Internal pancreatic fistulas: proposal of a management algorithm based on a case series analysis. J Clin Gastroenterol. 2004;38(9):795–800.

    Article  PubMed  Google Scholar 

  54. Pai CG, Suvarna D, Bhat G. Endoscopic treatment as first-line therapy for pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2009;24(7):1198–202.

    Article  PubMed  Google Scholar 

  55. Cicek B, et al. Endoscopic treatment of pancreatic fistulas. Surg Endosc. 2006;20(11):1706–12.

    Article  CAS  PubMed  Google Scholar 

  56. Kozarek RA, Jiranek GC, Traverso LW. Endoscopic treatment of pancreatic ascites. Am J Surg. 1994;168(3):223–6.

    Article  CAS  PubMed  Google Scholar 

  57. Oh YS, et al. Pancreaticopleural fistula: report of two cases and review of the literature. Dig Dis Sci. 2006;51(1):1–6.

    Article  PubMed  Google Scholar 

  58. Safadi BY, Marks JM. Pancreatic-pleural fistula: the role of ERCP in diagnosis and treatment. Gastrointest Endosc. 2000;51(2):213–5.

    Article  CAS  PubMed  Google Scholar 

  59. Neher JR, et al. Pancreaticopleural fistula in chronic pancreatitis: resolution with endoscopic therapy. Gastrointest Endosc. 2000;52(3):416–8.

    Article  CAS  PubMed  Google Scholar 

  60. Materne R, et al. Pancreaticopleural fistula: diagnosis with magnetic resonance pancreatography. Chest. 2000;117(3):912–4.

    Article  CAS  PubMed  Google Scholar 

  61. Shah HK, et al. Pancreatico-pleural fistula. Endoscopy. 1998;30(3):314.

    Article  CAS  PubMed  Google Scholar 

  62. Garcia-Ricart F, et al. Endoscopic management of a persistent pancreatopleural fistula. Gastrointest Endosc. 1997;46(4):359–61.

    Article  CAS  PubMed  Google Scholar 

  63. Kozarek RA, et al. Transpapillary stenting for pancreaticocutaneous fistulas. J Gastrointest Surg. 1997;1(4):357–61.

    Article  CAS  PubMed  Google Scholar 

  64. Costamagna G, et al. Endoscopic treatment of postsurgical external pancreatic fistulas. Endoscopy. 2001;33(4):317–22.

    Article  CAS  PubMed  Google Scholar 

  65. Howard TJ, et al. Contemporary treatment strategies for external pancreatic fistulas. Surgery. 1998;124(4):627–32. discussion 632-3

    Article  CAS  PubMed  Google Scholar 

  66. Lipsett PA, Cameron JL. Internal pancreatic fistula. Am J Surg. 1992;163(2):216–20.

    Article  CAS  PubMed  Google Scholar 

  67. Boerma D, et al. Endoscopic stent placement for pancreaticocutaneous fistula after surgical drainage of the pancreas. Br J Surg. 2000;87(11):1506–9.

    Article  CAS  PubMed  Google Scholar 

  68. Abe N, et al. Preoperative endoscopic pancreatic stenting for prophylaxis of pancreatic fistula development after distal pancreatectomy. Am J Surg. 2006;191(2):198–200.

    Article  PubMed  Google Scholar 

  69. Frozanpor F, et al. The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg. 2012;255(6):1032–6.

    Article  PubMed  Google Scholar 

  70. Rieder B, et al. Endoscopic pancreatic sphincterotomy and stenting for preoperative prophylaxis of pancreatic fistula after distal pancreatectomy. Gastrointest Endosc. 2010;72(3):536–42.

    Article  PubMed  Google Scholar 

  71. Kozarek RA. Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc. 1990;36(2):93–5.

    Article  CAS  PubMed  Google Scholar 

  72. Sugiyama M, et al. Endoscopic pancreatic stent insertion for treatment of pseudocyst after distal pancreatectomy. Gastrointest Endosc. 2001;53(4):538–9.

    Article  CAS  PubMed  Google Scholar 

  73. Bhasin DK, et al. Management of multiple and large pancreatic pseudocysts by endoscopic transpapillary nasopancreatic drainage alone. Am J Gastroenterol. 2006;101(8):1780–6.

    Article  PubMed  Google Scholar 

  74. Bhasin DK, et al. Endoscopic management of pancreatic pseudocysts at atypical locations. Surg Endosc. 2010;24(5):1085–91.

    Article  PubMed  Google Scholar 

  75. Baron TH, et al. Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc. 2002;56(1):7–17.

    Article  PubMed  Google Scholar 

  76. Nasr JY, Chennat J. Endoscopic ultrasonography–guided transmural drainage of pseudocysts. Tech Gastrointest Endosc. 2012;14(4):195–8.

    Article  Google Scholar 

  77. Kahaleh M, et al. Endoscopic ultrasound drainage of pancreatic pseudocyst: a prospective comparison with conventional endoscopic drainage. Endoscopy. 2006;38(4):355–9.

    Article  CAS  PubMed  Google Scholar 

  78. Cahen D, et al. Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy. 2005;37(10):977–83.

    Article  CAS  PubMed  Google Scholar 

  79. Devie’re J, Bouchard S. Endoscopic treatment for complex biliary and pancreatic duct injuries. J Dig Endosc. 2014;5:2–12.

    Article  Google Scholar 

  80. Deviere J, Antaki F. Disconnected pancreatic tail syndrome: a plea for multidisciplinarity. Gastrointest Endosc. 2008;67(4):680–2.

    Article  PubMed  Google Scholar 

  81. Arvanitakis M, et al. Pancreatic-fluid collections: a randomized controlled trial regarding stent removal after endoscopic transmural drainage. Gastrointest Endosc. 2007;65(4):609–19.

    Article  PubMed  Google Scholar 

  82. Hookey LC, et al. Endoscopic drainage of pancreatic-fluid collections in 116 patients: a comparison of etiologies, drainage techniques, and outcomes. Gastrointest Endosc. 2006;63(4):635–43.

    Article  PubMed  Google Scholar 

  83. Varadarajulu S, Wilcox CM. Endoscopic placement of permanent indwelling transmural stents in disconnected pancreatic duct syndrome: does benefit outweigh the risks? Gastrointest Endosc. 2011;74(6):1408–12.

    Article  PubMed  Google Scholar 

  84. Arvanitakis M, et al. Endoscopic therapy for main pancreatic-duct rupture after Silastic-ring vertical gastroplasty. Gastrointest Endosc. 2005;62(1):143–51.

    Article  PubMed  Google Scholar 

  85. Engler S, Dorlars D, Riemann JF. [Endoscopic fibrin gluing of a pancreatic duct fistula following acute pancreatitis] Endoskopische Fibrinverklebung einer Pankreasgangfistel nach akuter Pankreatitis. Dtsch Med Wochenschr. 1996;121(45):1396–400.

    Article  CAS  PubMed  Google Scholar 

  86. Seewald S, et al. Endoscopic sealing of pancreatic fistula by using N-butyl-2-cyanoacrylate. Gastrointest Endosc. 2004;59(4):463–70.

    Article  PubMed  Google Scholar 

  87. Fischer A, et al. Endoscopic management of pancreatic fistulas secondary to intraabdominal operation. Surg Endosc. 2004;18(4):706–8.

    Article  CAS  PubMed  Google Scholar 

  88. Mutignani M, et al. External pancreatic fistulas resistant to conventional endoscopic therapy: endoscopic closure with N-butyl-2-cyanoacrylate (Glubran 2). Endoscopy. 2004;36(8):738–42.

    Article  CAS  PubMed  Google Scholar 

  89. Irani S, et al. Resolving external pancreatic fistulas in patients with disconnected pancreatic duct syndrome: using rendezvous techniques to avoid surgery (with video). Gastrointest Endosc. 2012;76(3):586–93 e1-3.

    Article  PubMed  Google Scholar 

  90. Luthen R, Jaklin P, Cohnen M. Permanent closure of a pancreatic duct leak by endoscopic coiling. Endoscopy. 2007;39(Suppl 1):E21–2.

    Article  PubMed  Google Scholar 

  91. Gane E, Fata'ar S, Hamilton I. Management of a persistent pancreatic fistula secondary to a ruptured pseudocyst with endoscopic insertion of an expandable metal stent. Endoscopy. 1994;26(2):254–6.

    Article  CAS  PubMed  Google Scholar 

  92. Baron TH, Ferreira LE. Covered expandable metal stent placement for treatment of a refractory pancreatic duct leak. Gastrointest Endosc. 2007;66(6):1239–41.

    Article  PubMed  Google Scholar 

  93. Yamakado K, et al. Metallic stent placement in the pancreatic duct: an experimental study in the normal dog pancreas. J Vasc Interv Radiol. 2003;14(3):357–62.

    Article  PubMed  Google Scholar 

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Kumar, S., Poley, JW., Bruno, M.J. (2018). Endoscopic Management of Pancreatic Fistula and Leaks. In: Sridhar, S., Wu, G. (eds) Diagnostic and Therapeutic Procedures in Gastroenterology. Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-62993-3_33

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