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Models of Short-Term Synaptic Plasticity

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The Plastic Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1015))

Abstract

We focus on dynamical descriptions of short-term synaptic plasticity. Instead of focusing on the molecular machinery that has been reviewed recently by several authors, we concentrate on the dynamics and functional significance of synaptic plasticity, and review some mathematical models that reproduce different properties of the dynamics of short term synaptic plasticity that have been observed experimentally. The complexity and shortcomings of these models point to the need of simple, yet physiologically meaningful models. We propose a simplified model to be tested in synapses displaying different types of short-term plasticity.

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Abbreviations

[Ca2+] i :

Intracellular Ca2+ concentration

ACh:

Acetylcholine

CB:

Calbindin

CCK:

Cholecystokinin

DA:

Dopamine

EPSC:

Excitatory postsynaptic current

EPSP:

Excitatory postsynaptic potential

GABA:

Gamma-aminobutyric acid

IPSC:

Inhibitory postsynaptic current

IPSP:

Inhibitory postsynaptic potential

LTS:

Low threshold spiking

LTSP:

Long terms synaptic plasticity

mEPSP:

Miniature excitatory postsynaptic potential

PV:

Parvalbumin SOM somatostatin

STB:

Short term biphasic plasticity

STD:

Short term depression

STF:

Short term facilitation

STSP:

Short term synaptic plasticity

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Acknowledgments

We thank Antonio Laville, Dagoberto Tapia for technical support and advice and to Dr. Claudia Rivera for animal care. Acquisition software was made by Dr. Luis Carrillo-Reid and María Itze Lemus. Experiments were supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT-México) Grant Fronteras de la Ciencia 57 (to J. Bargas and Marco Arieli Herrera-Valdez), the fellowship 290847 (to M.A. Herrera-Valdez), by Dirección General de Asuntos del Personal Académico, UNAM Grants IN-201914 and IN-205610 (to E. Galarraga and J. Bargas, respectively) Marco Arieli Herrera-Valdez thanks the Mathematics Institute at UNAM for the support provided during the initial drafting stages of this manuscript.

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Authors and Affiliations

  1. División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, DF, 04510, Mexico

    Janet Barroso-Flores, Elvira Galarraga & José Bargas

  2. Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, DF, 04510, Mexico

    Marco A. Herrera-Valdez

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  1. Janet Barroso-Flores
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  2. Marco A. Herrera-Valdez
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  3. Elvira Galarraga
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  4. José Bargas
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Correspondence to Janet Barroso-Flores or Marco A. Herrera-Valdez .

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Editors and Affiliations

  1. Pontificia Universidad Católica de Chile, Santiago, Chile

    Rommy von Bernhardi

  2. Universidad de Santiago de Chile, Santiago, Chile

    Jaime Eugenín

  3. University of Miami, Miami, USA

    Kenneth J Muller

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Barroso-Flores, J., Herrera-Valdez, M.A., Galarraga, E., Bargas, J. (2017). Models of Short-Term Synaptic Plasticity. In: von Bernhardi, R., Eugenín, J., Muller, K. (eds) The Plastic Brain. Advances in Experimental Medicine and Biology, vol 1015. Springer, Cham. https://doi.org/10.1007/978-3-319-62817-2_3

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