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CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function

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The Plastic Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1015))

Abstract

The central nervous system is a highly plastic network of cells that constantly adjusts its functions to environmental stimuli throughout life. Transcription-dependent mechanisms modify neuronal properties to respond to external stimuli regulating numerous developmental functions, such as cell survival and differentiation, and physiological functions such as learning, memory, and circadian rhythmicity. The discovery and cloning of the cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) constituted a big step toward deciphering the molecular mechanisms underlying neuronal plasticity. CREB was first discovered in learning and memory studies as a crucial mediator of activity-dependent changes in target gene expression that in turn impose long-lasting modifications of the structure and function of neurons. In this chapter, we review the molecular and signaling mechanisms of neural activity-dependent recruitment of CREB and its cofactors. We discuss the crosstalk between signaling pathways that imprints diverse spatiotemporal patterns of CREB activation allowing for the integration of a wide variety of stimuli.

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Abbreviations

AC:

Adenylate cyclase

ATF1:

Activating transcription factor 1

BDNF:

Brain-derived neurotrophic factor

b-zip:

Basic leucine zipper domain

CaMKII/IV:

Ca2+/Calmodulin dependent Kinase II and IV

cAMP:

3′,5′-cyclic adenosine monophosphate

CaRE:

Ca2+ Responsive Element

CBP:

CREB Binding Protein

Cn:

Calcineurin

CRE:

cAMP-responsive elements

CREB:

cAMP responsive element binding protein

CRTC:

cAMP-regulated transcriptional coactivator

CREM:

cAMP responsive element modulator ERK

DARPP:

Dopamine and cAMP–regulated phosphoprotein

ERK:

Extracellular signal-regulated kinase

IP3:

Inositol 1,4,5-trisphosphate

KID:

Kinase Inducible Domain

LTP:

Long-term potentiation

MAPK:

Mitogen-activated protein kinase

MSK-I:

Mitogen/Stress Activated Kinase I

NGF:

Nerve growth factor

NMDA:

N-Methyl-d-Aspartate

NMDAR:

N-Methyl-d-Aspartate ionotropic glutamate receptor

PDGF:

Platelet-derived growth factor

PI3K:

Phosphatidylinositol 3-kinase

PIP3:

(3,4,5)-trisphosphate

PKA:

cAMP-dependent Protein Kinase

PKB:

Protein Kinase B

PKC:

Protein Kinase C

pp90RSK:

pp90 ribosomal S6 kinase

Shh:

Sonic hedgehog

SIK1:

Salt-inducible kinase 1

TORC:

Transducer of regulated CREB

TRPC:

Transient receptor potential canonical channel

VGCC:

Voltage-gated Ca2+ channel

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Acknowledgements

Research in the laboratory has been supported by the Basil O’Connor Starter Scholar Research Award Grant 5-FY09-131 from the March of Dimes Foundation, Klingenstein Foundation Award in Neuroscience, NSF 1120796, NIH-NINDS R01NS073055 and Shriners Hospital for Children 86500-NCA and 85220-NCA grants to LNB and Shriners Hospital for Children Fellowship, Brain and Behavior foundation NARSAD grant #25356, IMERA grant and fellowship with the support of INSERM / Labex RFIEA / ANR (Investissements d'avenir), and Prestige / Marie Curie fellowship #PRESTIGE-2016-3-0025 to YHB.

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Authors and Affiliations

  1. INMED, Aix-Marseille Univ, INSERM, Marseille, France and Aix-Marseille Université, IMéRA, F-13000, Marseille, France

    Yesser H. Belgacem

  2. Department of Physiology & Membrane Biology and Institute for Pediatric Regenerative Medicine, University of California Davis School of Medicine and Shriners Hospital for Children Northern California, Sacramento, CA, USA

    Laura N. Borodinsky

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  1. Yesser H. Belgacem
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  2. Laura N. Borodinsky
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Correspondence to Yesser H. Belgacem .

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  1. Pontificia Universidad Católica de Chile, Santiago, Chile

    Rommy von Bernhardi

  2. Universidad de Santiago de Chile, Santiago, Chile

    Jaime Eugenín

  3. University of Miami, Miami, USA

    Kenneth J Muller

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Belgacem, Y.H., Borodinsky, L.N. (2017). CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function. In: von Bernhardi, R., Eugenín, J., Muller, K. (eds) The Plastic Brain. Advances in Experimental Medicine and Biology, vol 1015. Springer, Cham. https://doi.org/10.1007/978-3-319-62817-2_2

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