Skip to main content

Vaginal Cancer

  • Chapter
  • First Online:
Handbook of Evidence-Based Radiation Oncology

Abstract

This chapter will discuss the clinical presentation, pathology, staging, management, and radiation techniques for primary vaginal cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Alonso I, Felix A, Torné A, et al. Human papillomavirus as a favorable prognostic biomarker in squamous cell carcinomas of the vagina. Gynecol Oncol. 2012;125(1):194–9.

    Article  Google Scholar 

  • Beriwal S, Demanes DJ, Erickson B, et al. American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer. Brachytherapy. 2012;11(1):68–75.

    Article  Google Scholar 

  • Beriwal S, Heron DE, Mogus R, et al. High-dose rate brachytherapy (HDRB) for primary or recurrent cancer in the vagina. Radiat Oncol. 2008;3:7.

    Article  Google Scholar 

  • Chyle V, Zagars GK, Wheeler JA, et al. Definitive radiotherapy for carcinoma of the vagina: outcome and prognostic factors. Int J Radiat Oncol Biol Phys. 1996;35:891–905.

    Article  CAS  Google Scholar 

  • de Crevoisier R, Sanfilippo N, et al. Exclusive radiotherapy for primary squamous cell carcinoma of the vagina. Radiother Oncol. 2007;85(3):362–70.

    Article  Google Scholar 

  • Edge SB, American Joint Committee on Cancer. American Cancer Society. AJCC cancer staging manual. 7th ed. New York: Springer Science+Business Media; 2010.

    Google Scholar 

  • Feldbaum VM, Flowers LC, Oprea-Ilies GM. Improved survival in p16-positive vaginal cancers across all tumor stages but no correlation with MIB-1. Am J Clin Pathol. 2014;142(5):664–9.

    Article  Google Scholar 

  • Frank SJ, Deaver MT, Jhingran A, et al. Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure. Gynecol Oncol. 2007;105(2):470–4.

    Article  CAS  Google Scholar 

  • Frank SJ, Jhingran A, Levenback C, et al. Definitive radiation therapy for squamous cell carcinoma of the vagina. Int J Radiat Oncol Biol Phys. 2005;62:138–47.

    Article  Google Scholar 

  • Frumovitz M, Gayed IW, Jhingran A, et al. Lymphatic mapping and sentinel lymph node detection in women with vaginal cancer. Gynecol Oncol. 2008;108(3):478–81.

    Article  Google Scholar 

  • Gardner CS, Sunil J, Klopp AH, et al. Primary vaginal cancer: role of MRI in diagnosis, staging and treatment. BJR. 2015;88(1052):20150033–11.

    Article  CAS  Google Scholar 

  • Green S, Stock RG. Cancer of the vagina. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. 3rd ed. Philadelphia: Saunders; 2010. p. 1067–84.

    Chapter  Google Scholar 

  • Harris EE, Latifi K, Rusthoven C, Javedan K, Forster K. Assessment of organ motion in postoperative endometrial and cervical cancer pts treated with intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2011;81(4):e645–50.

    Article  Google Scholar 

  • Huh WK, Straughn JM Jr, Mariani A, et al. Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience. Int J Gynecol Cancer. 2007;17(4):886–9.

    Article  CAS  Google Scholar 

  • Jhingran A, Salehpour M, Sam M, Levy L, Eifel PJ. Vaginal motion and bladder and rectal volumes during pelvic intensity-modulated radiation therapy after hysterectomy. Int J Radiat Oncol Biol Phys. 2012;82(1):256–62.

    Article  Google Scholar 

  • Joura EA, Leodolter S, Hernandez-Avila M, et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet. 2007;369(9574):1693–702.

    Article  CAS  Google Scholar 

  • Kang J, Viswanathan AN. Vaginal Cancer. In: Perez CA, Brady LW, Halperin EC, et al., editors. Principles and practice of radiation oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2013. p. 1465–501.

    Google Scholar 

  • Klopp AH, Eifel PJ, Berek JS, Konstantinopoulous PA. Cancer of the cervix, vagina, and vulva. In: DeVita Jr VT, Lawrence TS, Rosenberg SA, editors. DeVita, Hellman, and Rosenberg’s cancer principles & practice of oncology. 10th ed. Philadelphia: Wolters Kluwer Health; 2015. p. 1013–47.

    Google Scholar 

  • Lian J, Dundas G, Carlone M, Ghosh S, Pearcey R. Twenty-year review of radiotherapy for vaginal cancer: an institutional experience. Gynecol Oncol. 2008;111(2):298–306.

    Article  Google Scholar 

  • Miyamoto DT, Viswanathan AN. Concurrent chemoradiation for vaginal cancer. PLoS One. 2013;8(6):e65048.

    Article  CAS  Google Scholar 

  • Morris M, Blessing JA, Monk BJ, et al. Phase II study of cisplatin and vinorelbine in squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study. J Clin Oncol. 2004;22(16):3340–4.

    Article  CAS  Google Scholar 

  • Nag S, Yacoub S, Copeland LJ, Fowler JM. Interstitial brachytherapy for salvage treatment of vaginal recurrences in previously unirradiated endometrial cancer pts. Int J Radiat Oncol Biol Phys. 2002;54:1153–9.

    Article  Google Scholar 

  • National Cancer Institute. Vaginal Cancer (PDQ): Treatment. 2016. Available at: http://www.cancer.gov/types/vaginal/hp/vaginal-treatment-pdq. Accessed on 15 Aug 2016.

  • Orton A, Boothe D, Williams N, et al. Brachytherapy improves survival in primary vaginal cancer. Gynecol Oncol. 2016;141(3):501–6.

    Article  Google Scholar 

  • Platta CS, Anderson B, Geye H, Das R, Straub M, Bradley K. Adjuvant and definitive radiation therapy for primary carcinoma of the vagina using brachytherapy and external beam radiation therapy. J Contemp Brachytherapy. 2013;2:76–82.

    Article  Google Scholar 

  • Perez CA, Grigsby PW, Garipagaoglu M, et al. Factors affecting long-term outcome of irradiation in carcinoma of the vagina. Int J Radiat Oncol Biol Phys. 1999;44:37–45.

    Article  CAS  Google Scholar 

  • Rajagopalan MS, Xu KM, Lin JF, Sukumvanich P, Krivak TC, Beriwal S. Adoption and impact of concurrent chemoradiation therapy for vaginal cancer: a National Cancer Data Base (NCDB) study. Gynecol Oncol. 2014;135(3):495–502.

    Article  Google Scholar 

  • Russell AH, Horowitz NS. Vulvar and vaginal carcinoma. In: Gunderson LL, Tepper JE, editors. Clinical radiation oncology. 4th ed. Philadelphia: Churchill Livingstone; 2015. p. 1230–63.

    Google Scholar 

  • Samant R, Lau B, Choan E, et al. Primary vaginal cancer treated with concurrent chemoradiation using cis-platinum. Int J Radiat Oncol Biol Phys. 2007;69:746–50.

    Article  CAS  Google Scholar 

  • Stock RG, Chen AS, Seski J. A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities. Gynecol Oncol. 1995;56(1):45–52.

    Article  CAS  Google Scholar 

  • Tran PT, Su Z, Lee P, et al. Prognostic factors for outcomes and complications for primary squamous cell carcinoma of the vagina treated with radiation. Int J Radiat Oncol Biol Phys. 2006;S66:1052.

    Google Scholar 

Download references

Acknowledgment

We thank Thomas T. Bui MD, Eric K. Hansen MD, and Joycelyn L. Speight MD, PhD for their work on the prior edition of this chapter.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tracy Sherertz .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Choi, S., Sherertz, T. (2018). Vaginal Cancer. In: Hansen, E., Roach III, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-62642-0_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-62642-0_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62641-3

  • Online ISBN: 978-3-319-62642-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics