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Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapies

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Oncoimmunology

Abstract

Targeting the immune system therapeutically has been a long-standing approach in oncology treatment. The interaction between the immune system and cancer was already discovered in 1863 by Virchow, who hypothesized that sites of chronic inflammation are likely to be the origin of cancer. More recently, immune evasion was announced a hallmark of cancer. In the early phase of tumor induction, the immune system is still able to eliminate most of the cancer-initiating cells. However, the selection pressure for cells circumventing immune responses results in an equilibrium between immune attack and the growing tumor. Eventually, the cancer cells manage to evade the immune response via several immunosuppressive and escape mechanisms.

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Authors and Affiliations

  1. Clinical Unit for Experimental Oncology, Thoraxklinik, Heidelberg University, Heidelberg, Germany

    Anna S. Berghoff

  2. Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany

    Anna S. Berghoff, Jakob Nikolas Kather & Dirk Jäger

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    Laurence Zitvogel

  2. Gustave Roussy Cancer Center , Villejuif Cedex, France

    Guido Kroemer

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Berghoff, A.S., Kather, J.N., Jäger, D. (2018). Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapies. In: Zitvogel, L., Kroemer, G. (eds) Oncoimmunology. Springer, Cham. https://doi.org/10.1007/978-3-319-62431-0_13

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