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Role of Transforming Growth Factor Beta Family in Angiogenesis

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

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Abstract

Transforming growth factor-beta (TGFβ) is a pleiotropic factor that plays pivotal roles in both vasculogenesis and angiogenesis, and thus is indispensable for development and homeostasis of the vascular system. TGFβ drives vascular responses via its binding to a TGFβ receptor complex formed by type I and type II receptors, as well a type III co-receptors present on both endothelial and mural cells. Signaling by these receptors is context dependent and tightly regulated, particularly on cultured endothelial cells, where TGFβ can either promote or suppress endothelial migration, proliferation, permeability and sprouting. These, together with evidence obtained from knock-out animals for different TGFβ receptor types, and genetic studies in humans linking mutations in TGFβ signaling components to cardiovascular syndromes, suggest that TGFβ is a central mediator of angiogenesis, where it may play contrasting roles depending on the stage of the process. This review presents an overview of knowledge accumulated to date on TGFβ’s role in angiogenesis as well as vascular biology and vascular disease, and discusses potential applications of this knowledge to the treatment of angiogenesis-dependent diseases such as cancer.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1

    Alicia Viloria-Petit, Amy Richard, Sonja Zours, Mai Jarad & Brenda L. Coomber

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Editors and Affiliations

  1. Divison of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA

    Jawahar L. Mehta

  2. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Pankaj Mathur

  3. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Viloria-Petit, A., Richard, A., Zours, S., Jarad, M., Coomber, B.L. (2017). Role of Transforming Growth Factor Beta Family in Angiogenesis. In: Mehta, J., Mathur, P., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-61115-0_5

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