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Angiogenesis and Prostate Cancer: Friends or Foes

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

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Abstract

A key-hallmark of cancer is the promotion of angiogenesis. While there are currently no markers of the net angiogenic activity of prostate cancer (PCa) that can help investigators to design specific anti-angiogenic strategies, it is reasonable to assume that the quantification of various aspects of tumor vasculature may provide an indication of angiogenic activity. It has been ascertained that malignant tumors can generate their vasculature in seven distinct ways, including sprouting angiogenesis, vasculogenesis, intussusceptive angiogenesis, vascular co-option, mosaic vessels, vasculogenic mimicry and trans-differentiation of cancer stem-like cells into tumor endothelial cells. Here we briefly review these ways to get blood supply for the progression of PCa, its predictive and prognostic role and the actual discrepancies in the quantitative evaluation of neovascularity.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000, Rijeka, Croatia

    Sanja Stifter

  2. Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Milan, Italy

    Federica Patrinicola & Fabio Grizzi

  3. Department of Urology, Ospedale Humanitas Mater Domini, Via Gerenzano, 2, Castellanza, 21053, Varese, Italy

    Gianluigi Taverna

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  1. Sanja Stifter
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  2. Federica Patrinicola
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  3. Gianluigi Taverna
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  4. Fabio Grizzi
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Correspondence to Sanja Stifter .

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Editors and Affiliations

  1. Divison of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA

    Jawahar L. Mehta

  2. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Pankaj Mathur

  3. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Stifter, S., Patrinicola, F., Taverna, G., Grizzi, F. (2017). Angiogenesis and Prostate Cancer: Friends or Foes. In: Mehta, J., Mathur, P., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-61115-0_11

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