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Understanding the Physiological Significance of GPCR Dimers and Oligomers

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G-Protein-Coupled Receptor Dimers

Part of the book series: The Receptors ((REC,volume 33))

Abstract

The significance of G protein-coupled receptor (GPCR) oligomerization has been a subject of intense study which still remains controversial. Functional class C GPCRs are well accepted as obligate dimers but scepticism still remains with regards to the generalizability of this phenomenon when considering other classes of GPCRs. Here, we focus on understanding the organization and relationships between receptor equivalents in oligomeric receptor complexes. We discuss receptor properties such as ligand binding cooperativity which can be best explained in the context of functional oligomeric entities, and the asymmetries in receptor structure and function created by oligomers as well as their implications for drug discovery.

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Acknowledgments

This work was supported by grants from the Canadian Institutes of Health Research to T.E.H (MOP-130309). R.S. was awarded scholarships from the McGill CIHR Drug Development Training Program.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, Room 1303 McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montréal, QC, H3G 1Y6, Canada

    Rory Sleno, Dominic Devost & Terence E. Hébert Ph.D.

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  1. Rory Sleno
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  2. Dominic Devost
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  3. Terence E. Hébert Ph.D.
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Correspondence to Terence E. Hébert Ph.D. .

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Editors and Affiliations

  1. Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA

    Katharine Herrick-Davis

  2. Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

    Graeme Milligan

  3. Department of Physiology and Biochemistry, University of Malta, Msida, Malta

    Giuseppe Di Giovanni

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Sleno, R., Devost, D., Hébert, T.E. (2017). Understanding the Physiological Significance of GPCR Dimers and Oligomers. In: Herrick-Davis, K., Milligan, G., Di Giovanni, G. (eds) G-Protein-Coupled Receptor Dimers. The Receptors, vol 33. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60174-8_18

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