Skip to main content

Methods to Improve the Adenoma Detection Rate

  • Chapter
  • First Online:
Colon Polypectomy

Abstract

Colonoscopy, the gold standard for large bowel examination and colorectal cancer screening and surveillance, is still imperfect; adenomas as well as cancers can be missed, thus increasing the risk of interval cancer. Adequate bowel preparation and meticulous inspection of the mucosa during scope withdrawal are of paramount importance for efficient colon examination. Moreover, techniques like a second examination of the right colon either with direct or with retroflexed view and water-assisted colonoscopy promise better quality of the examination. Beyond these procedural issues, new endoscopic modalities including wide-angle view endoscopes and add-on devices have been developed in an effort to improve colonoscopy’s diagnostic yield by either expanding the field of scope view up to 330° or by providing retrograde view of the lumen or by flattering the haustral folds during withdrawal. In this chapter we discuss how these advances affect colonoscopy performance by improving its main quality indicator, namely, adenoma detection rate, which has been clearly associated with examination’s outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403. https://doi.org/10.1016/j.ejca.2012.12.027.

    Article  CAS  PubMed  Google Scholar 

  2. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29. https://doi.org/10.3322/caac.21208.

    Article  PubMed  Google Scholar 

  3. Winawer SJ, Zauber AG, Ho MN, O’Brien MJ, Gottlieb LS, Sternberg SS, Waye JD, Schapiro M, Bond JH, Panish JF, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329(27):1977–81. https://doi.org/10.1056/NEJM199312303292701.

    Article  CAS  PubMed  Google Scholar 

  4. Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, Shi W, Bond JH, Schapiro M, Panish JF, Stewart ET, Waye JD. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366(8):687–96. https://doi.org/10.1056/NEJMoa1100370.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. van Rijn JC, Reitsma JB, Stoker J, Bossuyt PM, van Deventer SJ, Dekker E. Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol. 2006;101(2):343–50. https://doi.org/10.1111/j.1572-0241.2006.00390.x.

    Article  PubMed  Google Scholar 

  6. Heresbach D, Barrioz T, Lapalus MG, Coumaros D, Bauret P, Potier P, Sautereau D, Boustiere C, Grimaud JC, Barthelemy C, See J, Serraj I, D’Halluin PN, Branger B, Ponchon T. Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies. Endoscopy. 2008;40(4):284–90. https://doi.org/10.1055/s-2007-995618.

    Article  CAS  PubMed  Google Scholar 

  7. Triantafyllou K, Sioulas AD, Kalli T, Misailidis N, Polymeros D, Papanikolaou IS, Karamanolis G, Ladas SD. Optimized sedation improves colonoscopy quality long-term. Gastroenterol Res Pract. 2015;2015:195093. https://doi.org/10.1155/2015/195093.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kaminski MF, Regula J, Kraszewska E, Polkowski M, Wojciechowska U, Didkowska J, Zwierko M, Rupinski M, Nowacki MP, Butruk E. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med. 2010;362(19):1795–803. https://doi.org/10.1056/NEJMoa0907667.

    Article  CAS  PubMed  Google Scholar 

  9. Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370(14):1298–306. https://doi.org/10.1056/NEJMoa1309086.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rex DK, Schoenfeld PS, Cohen J, Pike IM, Adler DG, Fennerty MB, Lieb JG 2nd, Park WG, Rizk MK, Sawhney MS, Shaheen NJ, Wani S, Weinberg DS. Quality indicators for colonoscopy. Gastrointest Endosc. 2015;81(1):31–53. https://doi.org/10.1016/j.gie.2014.07.058.

    Article  PubMed  Google Scholar 

  11. Oh CH, Lee CK, Kim JW, Shim JJ, Jang JY. Suboptimal bowel preparation significantly impairs Colonoscopic detection of non-polypoid colorectal neoplasms. Dig Dis Sci. 2015;60(8):2294–303. https://doi.org/10.1007/s10620-015-3628-6.

    Article  CAS  PubMed  Google Scholar 

  12. Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland CR, Giardello FM, Lieberman DA, Levin TR, Rex DK, Cancer USM-STFoC. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology. 2014;147(4):903–24. https://doi.org/10.1053/j.gastro.2014.07.002.

    Article  PubMed  Google Scholar 

  13. Hassan C, Bretthauer M, Kaminski MF, Polkowski M, Rembacken B, Saunders B, Benamouzig R, Holme O, Green S, Kuiper T, Marmo R, Omar M, Petruzziello L, Spada C, Zullo A, Dumonceau JM, European Society of Gastrointestinal Endoscopy. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2013;45(2):142–50. https://doi.org/10.1055/s-0032-1326186.

    Article  CAS  PubMed  Google Scholar 

  14. Committee ASoP, Saltzman JR, Cash BD, Pasha SF, Early DS, Muthusamy VR, Khashab MA, Chathadi KV, Fanelli RD, Chandrasekhara V, Lightdale JR, Fonkalsrud L, Shergill AK, Hwang JH, Decker GA, Jue TL, Sharaf R, Fisher DA, Evans JA, Foley K, Shaukat A, Eloubeidi MA, Faulx AL, Wang A, Acosta RD. Bowel preparation before colonoscopy. Gastrointest Endosc. 2015;81(4):781–94. https://doi.org/10.1016/j.gie.2014.09.048.

    Article  Google Scholar 

  15. Gurudu SR, Ramirez FC, Harrison ME, Leighton JA, Crowell MD. Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy. Gastrointest Endosc. 2012;76(3):603–608 e601. https://doi.org/10.1016/j.gie.2012.04.456.

    Article  PubMed  Google Scholar 

  16. Clark BT, Rustagi T, Laine L. What level of bowel prep quality requires early repeat colonoscopy: systematic review and meta-analysis of the impact of preparation quality on adenoma detection rate. Am J Gastroenterol. 2014;109(11):1714–1723.; quiz 1724. https://doi.org/10.1038/ajg.2014.232.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Adler A, Wegscheider K, Lieberman D, Aminalai A, Aschenbeck J, Drossel R, Mayr M, Mross M, Scheel M, Schroder A, Gerber K, Stange G, Roll S, Gauger U, Wiedenmann B, Altenhofen L, Rosch T. Factors determining the quality of screening colonoscopy: a prospective study on adenoma detection rates, from 12,134 examinations (berlin colonoscopy project 3, BECOP-3). Gut. 2013;62(2):236–41. https://doi.org/10.1136/gutjnl-2011-300167.

    Article  PubMed  Google Scholar 

  18. Tholey DM, Shelton CE, Francis G, Anantharaman A, Frankel RA, Shah P, Coan A, Hegarty SE, Leiby BE, Kastenberg DM. Adenoma detection in excellent versus good bowel preparation for colonoscopy. J Clin Gastroenterol. 2015;49(4):313–9. https://doi.org/10.1097/MCG.0000000000000270.

    Article  PubMed  Google Scholar 

  19. Clark BT, Laine L. High-quality bowel preparation is required for detection of sessile serrated polyps. Clin Gastroenterol Hepatol. 2016;14(8):1155–62. https://doi.org/10.1016/j.cgh.2016.03.044.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Calderwood AH, Thompson KD, Schroy PC 3rd, Lieberman DA, Jacobson BC. Good is better than excellent: bowel preparation quality and adenoma detection rates. Gastrointest Endosc. 2015;81(3):691–699 e691. https://doi.org/10.1016/j.gie.2014.10.032.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Barclay RL, Vicari JJ, Doughty AS, Johanson JF, Greenlaw RL. Colonoscopic withdrawal times and adenoma detection during screening colonoscopy. N Engl J Med. 2006;355(24):2533–41. https://doi.org/10.1056/NEJMoa055498.

    Article  CAS  PubMed  Google Scholar 

  22. Jover R, Zapater P, Polania E, Bujanda L, Lanas A, Hermo JA, Cubiella J, Ono A, Gonzalez-Mendez Y, Peris A, Pellise M, Seoane A, Herreros-de-Tejada A, Ponce M, Marin-Gabriel JC, Chaparro M, Cacho G, Fernandez-Diez S, Arenas J, Sopena F, de Castro L, Vega-Villaamil P, Rodriguez-Soler M, Carballo F, Salas D, Morillas JD, Andreu M, Quintero E, Castells A, investigators Cs. Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. Gastrointest Endosc. 2013;77(3):381–389 e381. https://doi.org/10.1016/j.gie.2012.09.027.

    Article  PubMed  Google Scholar 

  23. Butterly L, Robinson CM, Anderson JC, Weiss JE, Goodrich M, Onega TL, Amos CI, Beach ML. Serrated and adenomatous polyp detection increases with longer withdrawal time: results from the New Hampshire colonoscopy registry. Am J Gastroenterol. 2014;109(3):417–26. https://doi.org/10.1038/ajg.2013.442.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lee TJ, Blanks RG, Rees CJ, Wright KC, Nickerson C, Moss SM, Chilton A, Goddard AF, Patnick J, McNally RJ, Rutter MD. Longer mean colonoscopy withdrawal time is associated with increased adenoma detection: evidence from the bowel cancer screening programme in England. Endoscopy. 2013;45(1):20–6. https://doi.org/10.1055/s-0032-1325803.

    CAS  PubMed  Google Scholar 

  25. Vavricka SR, Sulz MC, Degen L, Rechner R, Manz M, Biedermann L, Beglinger C, Peter S, Safroneeva E, Rogler G, Schoepfer AM. Monitoring colonoscopy withdrawal time significantly improves the adenoma detection rate and the performance of endoscopists. Endoscopy. 2016;48(3):256–62. https://doi.org/10.1055/s-0035-1569674.

    Article  PubMed  Google Scholar 

  26. Brenner H, Hoffmeister M, Arndt V, Stegmaier C, Altenhofen L, Haug U. Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Inst. 2010;102(2):89–95. https://doi.org/10.1093/jnci/djp436.

    Article  PubMed  Google Scholar 

  27. Rex DK. How I approach Retroflexion and prevention of right-sided colon cancer following colonoscopy. Am J Gastroenterol. 2016;111(1):9–11. https://doi.org/10.1038/ajg.2015.385.

    Article  PubMed  Google Scholar 

  28. Hewett DG, Rex DK. Miss rate of right-sided colon examination during colonoscopy defined by retroflexion: an observational study. Gastrointest Endosc. 2011;74(2):246–52. https://doi.org/10.1016/j.gie.2011.04.005.

    Article  PubMed  Google Scholar 

  29. Kushnir VM, Oh YS, Hollander T, Chen CH, Sayuk GS, Davidson N, Mullady D, Murad FM, Sharabash NM, Ruettgers E, Dassopoulos T, Easler JJ, Gyawali CP, Edmundowicz SA, Early DS. Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison study. Am J Gastroenterol. 2015;110(3):415–22. https://doi.org/10.1038/ajg.2015.21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Lee HS, Jeon SW, Park HY, Yeo SJ. Improved detection of right colon adenomas with additional retroflexion following two forward-view examinations: a prospective study. Endoscopy. 2016;49(4):334–41. https://doi.org/10.1055/s-0042-119401.

    Article  PubMed  Google Scholar 

  31. Triantafyllou K, Tziatzios G, Sioulas AD, Beintaris I, Gouloumi AR, Panayiotides IG, Dimitriadis GD. Diagnostic yield of scope retroflexion in the right colon: a prospective cohort study. Dig Liver Dis. 2016;48(2):176–81. https://doi.org/10.1016/j.dld.2015.11.024.

    Article  PubMed  Google Scholar 

  32. Leung FW. Water exchange may be superior to water immersion for colonoscopy. Clin Gastroenterol Hepatol. 2011;9(12):1012–4. https://doi.org/10.1016/j.cgh.2011.09.007.

    Article  PubMed  Google Scholar 

  33. Leung FW, Amato A, Ell C, Friedland S, Harker JO, Hsieh YH, Leung JW, Mann SK, Paggi S, Pohl J, Radaelli F, Ramirez FC, Siao-Salera R, Terruzzi V. Water-aided colonoscopy: a systematic review. Gastrointest Endosc. 2012;76(3):657–66. https://doi.org/10.1016/j.gie.2012.04.467.

    Article  PubMed  Google Scholar 

  34. Ramirez FC, Leung FW. A head-to-head comparison of the water vs. air method in patients undergoing screening colonoscopy. J Interv Gastroenterol. 2011;1(3):130–5. https://doi.org/10.4161/jig.1.3.18512.

    PubMed  PubMed Central  Google Scholar 

  35. Hafner S, Zolk K, Radaelli F, Otte J, Rabenstein T, Zolk O. Water infusion versus air insufflation for colonoscopy. Cochrane Database Syst Rev. 2015;5:CD009863. https://doi.org/10.1002/14651858.CD009863.pub2.

    Google Scholar 

  36. Hsieh YH, Koo M, Leung FW. A patient-blinded randomized, controlled trial comparing air insufflation, water immersion, and water exchange during minimally sedated colonoscopy. Am J Gastroenterol. 2014;109(9):1390–400. https://doi.org/10.1038/ajg.2014.126.

    Article  PubMed  Google Scholar 

  37. Cadoni S, Gallittu P, Sanna S, Fanari V, Porcedda ML, Erriu M, Leung FW. A two-center randomized controlled trial of water-aided colonoscopy versus air insufflation colonoscopy. Endoscopy. 2014;46(3):212–8. https://doi.org/10.1055/s-0033-1353604.

    PubMed  Google Scholar 

  38. Hsieh YH, Tseng CW, Hu CT, Koo M, Leung FW. Prospective multicenter randomized controlled trial comparing adenoma detection rate in colonoscopy using water exchange, water immersion, and air insufflation. Gastrointest Endosc. 2016. https://doi.org/10.1016/j.gie.2016.12.005.

  39. Xu L, Zhang Y, Song H, Wang W, Zhang S, Ding X. Nurse participation in colonoscopy observation versus the Colonoscopist alone for polyp and adenoma detection: a meta-analysis of randomized, controlled trials. Gastroenterol Res Pract. 2016;2016:7631981. https://doi.org/10.1155/2016/7631981.

    PubMed  Google Scholar 

  40. Chalifoux SL, Rao DS, Wani SB, Sharma P, Bansal A, Gupta N, Rastogi A. Trainee participation and adenoma detection rates during screening colonoscopies. J Clin Gastroenterol. 2014;48(6):524–9. https://doi.org/10.1097/MCG.0000000000000022.

    PubMed  Google Scholar 

  41. Buchner AM, Shahid MW, Heckman MG, Diehl NN, McNeil RB, Cleveland P, Gill KR, Schore A, Ghabril M, Raimondo M, Gross SA, Wallace MB. Trainee participation is associated with increased small adenoma detection. Gastrointest Endosc. 2011;73(6):1223–31. https://doi.org/10.1016/j.gie.2011.01.060.

    Article  PubMed  Google Scholar 

  42. Gianotti RJ, Oza SS, Tapper EB, Kothari D, Sheth SG. A longitudinal study of adenoma detection rate in gastroenterology fellowship training. Dig Dis Sci. 2016;61(10):2831–7. https://doi.org/10.1007/s10620-016-4228-9.

    Article  PubMed  Google Scholar 

  43. Harada Y, Hirasawa D, Fujita N, Noda Y, Kobayashi G, Ishida K, Yonechi M, Ito K, Suzuki T, Sugawara T, Horaguchi J, Takasawa O, Obana T, Oohira T, Onochi K, Kanno Y, Kuroha M, Iwai W. Impact of a transparent hood on the performance of total colonoscopy: a randomized controlled trial. Gastrointest Endosc. 2009;69(3 Pt 2):637–44. https://doi.org/10.1016/j.gie.2008.08.029.

    Article  PubMed  Google Scholar 

  44. Park SM, Lee SH, Shin KY, Heo J, Sung SH, Park SH, Choi SY, Lee DW, Park HG, Lee HS, Jeon SW, Kim SK, Jung MK. The cap-assisted technique enhances colonoscopy training: prospective randomized study of six trainees. Surg Endosc. 2012;26(10):2939–43. https://doi.org/10.1007/s00464-012-2288-2.

    Article  PubMed  Google Scholar 

  45. Rastogi A, Bansal A, Rao DS, Gupta N, Wani SB, Shipe T, Gaddam S, Singh V, Sharma P. Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trial. Gut. 2012;61(3):402–8. https://doi.org/10.1136/gutjnl-2011-300187.

    Article  PubMed  Google Scholar 

  46. Kim DJ, Kim HW, Park SB, Kang DH, Choi CW, Hong JB, Ji BH, Lee CS. Efficacy of cap-assisted colonoscopy according to lesion location and endoscopist training level. World J Gastroenterol. 2015;21(20):6261–70. https://doi.org/10.3748/wjg.v21.i20.6261.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Pohl H, Bensen SP, Toor A, Gordon SR, Levy LC, Berk B, Anderson PB, Anderson JC, Rothstein RI, MacKenzie TA, Robertson DJ. Cap-assisted colonoscopy and detection of adenomatous polyps (CAP) study: a randomized trial. Endoscopy. 2015;47(10):891–7. https://doi.org/10.1055/s-0034-1392261.

    Article  PubMed  Google Scholar 

  48. Lee YT, Lai LH, Hui AJ, Wong VW, Ching JY, Wong GL, Wu JC, Chan HL, Leung WK, Lau JY, Sung JJ, Chan FK. Efficacy of cap-assisted colonoscopy in comparison with regular colonoscopy: a randomized controlled trial. Am J Gastroenterol. 2009;104(1):41–6. https://doi.org/10.1038/ajg.2008.56.

    Article  PubMed  Google Scholar 

  49. Ng SC, Tsoi KK, Hirai HW, Lee YT, Wu JC, Sung JJ, Chan FK, Lau JY. The efficacy of cap-assisted colonoscopy in polyp detection and cecal intubation: a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2012;107(8):1165–73. https://doi.org/10.1038/ajg.2012.135.

    Article  PubMed  Google Scholar 

  50. Tsiamoulos ZP, Saunders BP. A new accessory, endoscopic cuff, improves colonoscopic access for complex polyp resection and scar assessment in the sigmoid colon (with video). Gastrointest Endosc. 2012;76(6):1242–5. https://doi.org/10.1016/j.gie.2012.08.019.

    Article  PubMed  Google Scholar 

  51. Lenze F, Beyna T, Lenz P, Heinzow HS, Hengst K, Ullerich H. Endocuff-assisted colonoscopy: a new accessory to improve adenoma detection rate? Technical aspects and first clinical experiences. Endoscopy. 2014;46(7):610–4. https://doi.org/10.1055/s-0034-1365446.

    Article  PubMed  Google Scholar 

  52. Biecker E, Floer M, Heinecke A, Strobel P, Bohme R, Schepke M, Meister T. Novel endocuff-assisted colonoscopy significantly increases the polyp detection rate: a randomized controlled trial. J Clin Gastroenterol. 2015;49(5):413–8. https://doi.org/10.1097/MCG.0000000000000166.

    Article  PubMed  Google Scholar 

  53. Floer M, Biecker E, Fitzlaff R, Roming H, Ameis D, Heinecke A, Kunsch S, Ellenrieder V, Strobel P, Schepke M, Meister T. Higher adenoma detection rates with endocuff-assisted colonoscopy - a randomized controlled multicenter trial. PLoS One. 2014;9(12):e114267. https://doi.org/10.1371/journal.pone.0114267.

    Article  PubMed  PubMed Central  Google Scholar 

  54. van Doorn SC, van der Vlugt M, Depla A, Wientjes CA, Mallant-Hent RC, Siersema PD, Tytgat K, Tuynman H, Kuiken SD, Houben G, Stokkers P, Moons L, Bossuyt P, Fockens P, Mundt MW, Dekker E. Adenoma detection with Endocuff colonoscopy versus conventional colonoscopy: a multicentre randomised controlled trial. Gut. 2015;66(3):438–45. https://doi.org/10.1136/gutjnl-2015-310097.

    Article  PubMed  Google Scholar 

  55. Chin M, Karnes W, Jamal MM, Lee JG, Lee R, Samarasena J, Bechtold ML, Nguyen DL. Use of the Endocuff during routine colonoscopy examination improves adenoma detection: a meta-analysis. World J Gastroenterol. 2016;22(43):9642–9. https://doi.org/10.3748/wjg.v22.i43.9642.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Triantafyllou K, Polymeros D, Apostolopoulos P, Brandao C, Gkolfakis P, Repici A, Papanikolaou IS, Dinis-Ribeiro M, Alexandrakis G, Hassan C. Endocuff-assisted colonoscopy outperforms conventional colonoscopy to detect missed-adenomas: european multicenter, randomized, back-to-back study. United European Gastroenterol J. 2016;2 Suppl 1.

    Google Scholar 

  57. Bevan R, Ngu WS, Saunders BP, Tsiamoulos Z, Bassett P, Hoare Z, Rees CJ. The ADENOMA study. Accuracy of detection using Endocuff vision optimization of mucosal abnormalities: study protocol for randomized controlled trial. Endosc Int Open. 2016;4(2):E205–12. https://doi.org/10.1055/s-0041-107900.

    PubMed  Google Scholar 

  58. Dik VK, Gralnek IM, Segol O, Suissa A, Belderbos TD, Moons LM, Segev M, Domanov S, Rex DK, Siersema PD. Multicenter, randomized, tandem evaluation of EndoRings colonoscopy--results of the CLEVER study. Endoscopy. 2015;47(12):1151–8. https://doi.org/10.1055/s-0034-1392421.

    Article  PubMed  Google Scholar 

  59. Gralnek IM, Suissa A, Domanov S. Safety and efficacy of a novel balloon colonoscope: a prospective cohort study. Endoscopy. 2014;46(10):883–7. https://doi.org/10.1055/s-0034-1377968.

    Article  PubMed  Google Scholar 

  60. Halpern Z, Gross SA, Gralnek IM, Shpak B, Pochapin M, Hoffman A, Mizrahi M, Rochberger YS, Moshkowitz M, Santo E, Melhem A, Grinshpon R, Pfefer J, Kiesslich R. Comparison of adenoma detection and miss rates between a novel balloon colonoscope and standard colonoscopy: a randomized tandem study. Endoscopy. 2015;47(4):301. https://doi.org/10.1055/s-0034-1391894.

    Article  PubMed  Google Scholar 

  61. Rubin M, Lurie L, Bose K, Kim SH. Expanding the view of a standard colonoscope with the third eye panoramic cap. World J Gastroenterol. 2015;21(37):10683–7. https://doi.org/10.3748/wjg.v21.i37.10683.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Gralnek IM, Segol O, Suissa A, Siersema PD, Carr-Locke DL, Halpern Z, Santo E, Domanov S. A prospective cohort study evaluating a novel colonoscopy platform featuring full-spectrum endoscopy. Endoscopy. 2013;45(9):697–702. https://doi.org/10.1055/s-0033-1344395.

    Article  PubMed  Google Scholar 

  63. Gralnek IM, Siersema PD, Halpern Z, Segol O, Melhem A, Suissa A, Santo E, Sloyer A, Fenster J, Moons LM, Dik VK, D’Agostino RB Jr, Rex DK. Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial. Lancet Oncol. 2014;15(3):353–60. https://doi.org/10.1016/S1470-2045(14)70020-8.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Papanikolaou IS, Apostolopoulos P, Tziatzios G, Vlachou E, Sioulas AD, Polymeros D, Karameris A, Panayiotides I, Alexandrakis G, Dimitriadis GD, Triantafyllou K. Lower adenoma miss rate with FUSE vs. conventional colonoscopy with proximal retroflexion: a randomized back-to-back trial. Endoscopy. 2017;49(5):468–75. https://doi.org/10.1055/s-0042-124415.

    Article  PubMed  Google Scholar 

  65. Hassan C, Senore C, Radaelli F, De Pretis G, Sassatelli R, Arrigoni A, Manes G, Amato A, Anderloni A, Armelao F, Mondardini A, Spada C, Omazzi B, Cavina M, Miori G, Campanale C, Sereni G, Segnan N, Repici A. Full-spectrum (FUSE) versus standard forward-viewing colonoscopy in an organised colorectal cancer screening programme. Gut. 2016:gutjnl-2016-311906. https://doi.org/10.1136/gutjnl-2016-311906.

  66. van den Broek FJ, Kuiper T, Dekker E, Zwinderman AH, Fockens P, Reitsma JB. Study designs to compare new colonoscopic techniques: clinical considerations, data analysis, and sample size calculations. Endoscopy. 2013;45(11):922–7. https://doi.org/10.1055/s-0033-1344434.

    Article  PubMed  Google Scholar 

  67. Uraoka T, Tanaka S, Oka S, Matsuda T, Saito Y, Moriyama T, Higashi R, Matsumoto T. Feasibility of a novel colonoscope with extra-wide angle of view: a clinical study. Endoscopy. 2015;47(5):444–8. https://doi.org/10.1055/s-0034-1390870.

    PubMed  Google Scholar 

Download references

Conflict of Interest Statement

The authors declare no conflict of interest related to this publication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Konstantinos Triantafyllou .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Papadopoulos, V., Triantafyllou, K. (2018). Methods to Improve the Adenoma Detection Rate. In: Facciorusso, A., Muscatiello, N. (eds) Colon Polypectomy. Springer, Cham. https://doi.org/10.1007/978-3-319-59457-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59457-6_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59456-9

  • Online ISBN: 978-3-319-59457-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics