Skip to main content
SpringerLink
Log in

General Principles of HSCT

  • Chapter
  • First Online:
Establishing a Hematopoietic Stem Cell Transplantation Unit

  • 820 Accesses

Abstract

After a long learning phase, hematopoietic stem cell transplantation (HSCT) has advanced to become an established curative treatment for more than 70,000 patients per year, and worldwide activity continues to increase steadily. For many hematological and non-hematological diseases HSCT remains the only curative treatment option. Improved understanding of the immunological mechanisms of tolerance and anti-tumor reactivity has markedly reduced transplant-related mortality and has led to new techniques that enable HSCT in patients who lack a matched related donor. Further work will be required to reduce relapse incidence. In this chapter we describe the general principles of HSCT in a historical context, pointing out the requirements for establishing an HSCT unit and new developments.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med. 1957;257(11):491–6.

    Article  CAS  PubMed  Google Scholar 

  2. Bortin MM. A compendium of reported human bone marrow transplants. Transplantation. 1970;9(6):571–87.

    Article  CAS  PubMed  Google Scholar 

  3. Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354(17):1813–26.

    Article  CAS  PubMed  Google Scholar 

  4. Appelbaum FR. Hematopoietic-cell transplantation at 50. N Engl J Med. 2007;357(15):1472–5.

    Article  CAS  PubMed  Google Scholar 

  5. Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, Bouzas LF, Confer D, Greinix H, Horowitz M, Iida M, Lipton J, Mohty M, Novitzky N, Nunez J, Passweg J, Pasquini MC, Kodera Y, Apperley J, Seber A, Gratwohl A. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 2016;51(6):778–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Woodruff MF, Sparrow M. Further observation on the induction of tolerance of skin homografts in rats. Transplant Bull. 1957;4(4):157–9.

    CAS  PubMed  Google Scholar 

  7. Barnes WH, Loutit JF. treatment of murine leukaemia with X-rays and homologous bone marrow. II. Br J Haematol. 1957;3:241.

    Article  CAS  PubMed  Google Scholar 

  8. Billingham RE, Brent L. Acquired tolerance in newborn mice. Ann N Y Acad Sci. 1957;69(4):678–80.

    Article  CAS  PubMed  Google Scholar 

  9. Santos GW. Application of marrow grafts in human disease. Am J Pathol. 1971;65(3):653–68.

    CAS  PubMed  Google Scholar 

  10. Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD. Bone-marrow transplantation (second of two parts). N Engl J Med. 1975;292(17):895–902. Review

    Article  CAS  PubMed  Google Scholar 

  11. Storb R, Prentice RL, Thomas ED. Marrow transplantation for treatment of aplastic anemia—an analysis of factors associated with graft rejection. N Engl J Med. 1977;296:61–6.

    Article  CAS  PubMed  Google Scholar 

  12. Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H, Mellits D, Sensenbrenner LL, Stuart RK, Yeager AM. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med. 1983;309:1347–53.

    Article  CAS  PubMed  Google Scholar 

  13. den Haan JM, Meadows LM, Wang W, Pool J, Blokland E, Bishop TL, Reinhardus C, Shabanowitz J, Offringa R, Hunt DF, Engelhard VH, Goulmy E. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science. 1998;279(5353):1054–7.

    Article  Google Scholar 

  14. Huber C, Niederwieser D. Role of cytokines and major histocompatibility complex antigens in graft-versus-host disease: in vitro studies using T-cell lines and keratinocytes or hemopoietic targets. Haematol Blood Transfus. 1990;33:652–4.

    CAS  PubMed  Google Scholar 

  15. Niederwieser D, Grassegger A, Auböck J, Herold M, Nachbaur D, Rosenmayr A, Gächter A, Nussbaumer W, Gaggl S, Ritter M, et al. Correlation of minor histocompatibility antigen-specific cytotoxic T lymphocytes with graft-versus-host disease status and analyses of tissue distribution of their target antigens. Blood. 1993;81(8):2200–8.

    CAS  PubMed  Google Scholar 

  16. Niederwieser D, Auböck J, Troppmair J, Herold M, Schuler G, Boeck G, Lotz J, Fritsch P, Huber C. IFN-mediated induction of MHC antigen expression on human keratinocytes and its influence on in vitro alloimmune responses. J Immunol. 1988;140(8):2556–64.

    CAS  PubMed  Google Scholar 

  17. Weiden PL, Flournoy N, Thomas ED, Prentice R, Fefer A, Buckner CD, Storb R. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med. 1979;300(19):1068–73.

    Article  CAS  PubMed  Google Scholar 

  18. Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D, van Rhee F, Mittermueller J, de Witte T, Holler E, Ansari H, European Group for Blood and Marrow Transplantation Working Party Chronic leukemia. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995;86(5):2041–50.

    CAS  PubMed  Google Scholar 

  19. Ruggeri L, Mancusi A, Burchielli E, Aversa F, Martelli MF, Velardi A. Natural killer cell alloreactivity and haplo-identical hematopoietic transplantation. Cytotherapy. 2006;8(6):554–8. Review.

    Article  CAS  PubMed  Google Scholar 

  20. Yoshimi A, Baldomero H, Horowitz M, Szer J, Niederwieser D, Gratwohl A, Kodera Y, Worldwide Network of Blood and Marrow Transplantation (WBMT). Global use of peripheral blood vs bone marrow as source of stem cells for allogeneic transplantation in patients with bone marrow failure. JAMA. 2016;315(2):198–200.

    Article  PubMed  Google Scholar 

  21. Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, Apperley J, Slavin S, Pasquini M, Sandmaier BM, Barrett J, Blaise D, Lowski R, Horowitz M. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant. 2009;15(12):1628–33.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Björkstrand B, Iacobelli S, Hegenbart U, Gruber A, Greinix H, Volin L, Narni F, Musto P, Beksac M, Bosi A, Milone G, Corradini P, Goldschmidt H, de Witte T, Morris C, Niederwieser D, Gahrton G. Tandem autologous/reduced-intensity conditioning allogeneic stem-cell transplantation versus autologous transplantation in myeloma: long-term follow-up. J Clin Oncol. 2011;29(22):3016–22.

    Article  PubMed  Google Scholar 

  23. Schmid C, Schleuning M, Ledderose G, Tischer J, Kolb HJ. Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol. 2005;23(24):5675–87.

    Article  PubMed  Google Scholar 

  24. Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S, Felicini R, Falcinelli F, Velardi A, Ruggeri L, Aloisi T, Saab JP, Santucci A, Perruccio K, Martelli MP, Mecucci C, Reisner Y, Martelli MF. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol. 2005;23(15):3447–54.

    Article  PubMed  Google Scholar 

  25. Munchel A, Kesserwan C, Symons HJ, Luznik L, Kasamon YL, Jones RJ, Fuchs EJ. Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide. Pediatr Rep. 2011;3(Suppl 2):e15.

    PubMed  PubMed Central  Google Scholar 

  26. Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989;321(17):1174–8.

    Article  CAS  PubMed  Google Scholar 

  27. Ruutu T, de Wreede LC, van Biezen A, Brand R, Mohty M, Dreger P, Duarte R, Peters C, Garderet L, Schönland S, Gratwohl A, Niederwieser D, de Witte T, Kröger N, European Society for Blood and Marrow Transplantation (EBMT). Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT. Bone Marrow Transplant. 2015;50(12):1542–50.

    Article  CAS  PubMed  Google Scholar 

  28. Cornelissen JJ, Gratwohl A, Schlenk RF, Sierra J, Bornhäuser M, Juliusson G, Råcil Z, Rowe JM, Russell N, Mohty M, Löwenberg B, Socié G, Niederwieser D, Ossenkoppele GJ. The European LeukemiaNet AML working party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol. 2012;9(10):579–90.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematology and Medical Oncology, University of Leipzig, Johannisallee 32A, 04103, Leipzig, Germany

    Dietger Niederwieser M.D.

Authors
  1. Dietger Niederwieser M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dietger Niederwieser M.D. .

Editor information

Editors and Affiliations

  1. Eurocord Hôpital Saint Louis, Paris, France

    Éliane Gluckman

  2. Department of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany

    Dietger Niederwieser

  3. Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    Mahmoud Aljurf

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Niederwieser, D. (2018). General Principles of HSCT. In: Gluckman, É., Niederwieser, D., Aljurf, M. (eds) Establishing a Hematopoietic Stem Cell Transplantation Unit . Springer, Cham. https://doi.org/10.1007/978-3-319-59358-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59358-6_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59356-2

  • Online ISBN: 978-3-319-59358-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation