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Role of Bioinformatics in the Study of Ionic Channels

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Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 227))

Abstract

Ionic channels belong to the group of the most important proteins. Not only do they enable transmembrane transport but they are also the key factors for proper cell function. Mutations changing their structure and functionality often lead to severe diseases called channelopathies. On the other hand, transmembrane channels are very difficult objects for experimental studies. Only 2% of experimentally identified structures are transmembrane proteins, while genomic studies show that transmembrane proteins make up 30% of all coded proteins. This gap could be diminished by bioinformatical methods which enable modeling unknown protein structures, functions, transmembrane location, and ligand binding. Several in silico methods dedicated to transmembrane proteins have been developed; some general methods could also be used. They provide the information unavailable from experiments. Current modeling tools use a variety of computational methods, which provide results of surprisingly high quality.

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Acknowledgments

M. Kurczyńska would like to acknowledge the funding from “Diamond Grant” DI2011 002141. The work was also partly funded by the Statutory Funds of Wroclaw University of Science and Technology.

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  1. Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, 50-370, Wroclaw, Poland

    Monika Kurczyńska, Bogumił M. Konopka & Małgorzata Kotulska

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  1. Monika Kurczyńska
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  2. Bogumił M. Konopka
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  3. Małgorzata Kotulska
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Correspondence to Małgorzata Kotulska .

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  1. Wroclaw Medical University, Dept. of Medical Biochemistry, Wroclaw, Poland

    Julita Kulbacka

  2. Vytautas Magnus University, Bio. Res. Group/Bio Dept., Kaunas, Lithuania

    Saulius Satkauskas

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Kurczyńska, M., Konopka, B.M., Kotulska, M. (2017). Role of Bioinformatics in the Study of Ionic Channels. In: Kulbacka, J., Satkauskas, S. (eds) Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy. Advances in Anatomy, Embryology and Cell Biology, vol 227. Springer, Cham. https://doi.org/10.1007/978-3-319-56895-9_2

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