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Complications with Transsphenoidal Surgery: A Review

Complications of Transsphenoidal Surgery

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Transsphenoidal Surgery

Abstract

Transsphenoidal microscopic and endoscopic surgery are the primary approaches for the vast majority (>95%) of sellar and parasellar lesions. The endonasal route is being increasingly utilized for a variety of anterior skull base lesions. These operations are associated with many uncommon but major risks such as carotid artery injury, visual loss, CSF rhinorrhea, meningitis, and pituitary insufficiency. In addition, there are numerous other frequently encountered but rarely reported minor complications that are individually rare but cumulatively common. Each can affect a patient’s operative experience and include endocrine-related problems, positioning issues, sinonasal and oral complications, anesthesia-related problems, graft donor site complications, and endoscope visualization difficulties. This review summarizes the management of major and minor complications, focusing on prevention and early recognition.

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References

  1. Fatemi N, Dusick JR, de Paiva Neto MA, Malkasian D, Kelly DF. Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery. 2009;64(5):ons269–87.

    Google Scholar 

  2. Hardy J, Wigser S. Trans-sphenoidal surgery of pituitary fossa tumors with televised radiofluoroscopic control. J Neurosurg. 1965;23(6):612–9.

    CAS  PubMed  Google Scholar 

  3. Pant H, Bhatki AM, Snyderman CH, et al. Quality of life following endonasal skull base surgery. Skull Base. 2010;20(1):035.

    Google Scholar 

  4. Klose M, Watt T, Brennum J, Feldt-Rasmussen U. Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury. J Clin Endocrinol Metab. 2007;92(10):3861–8.

    CAS  PubMed  Google Scholar 

  5. Nielsen EH, Lindholm J, Laurberg P, et al. Nonfunctioning pituitary adenoma: incidence, causes of death and quality of life in relation to pituitary function. Pituitary. 2007;10(1):67–73.

    PubMed  Google Scholar 

  6. Crowley R, Sherlock M, Agha A, Smith D, Thompson C. Clinical insights into adipsic diabetes insipidus: a large case series. Clin Endocrinol. 2007;66(4):475–82.

    CAS  Google Scholar 

  7. Esposito F, Dusick JR, Fatemi N, Kelly DF. Graded repair of cranial base defects and cerebrospinal fluid leaks in transsphenoidal surgery. Neurosurgery. 2007;60(4):295–304.

    Google Scholar 

  8. Kelly DF, Laws Jr ER, Fossett D. Delayed hyponatremia after transsphenoidal surgery for pituitary adenoma: report of nine cases. J Neurosurg. 1995;83(2):363–7.

    CAS  PubMed  Google Scholar 

  9. Ciric I, Ragin A, Baumgartner C, Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery. 1997;40(2):225–37.

    CAS  PubMed  Google Scholar 

  10. Cockroft KM, Carew JF, Trost D, Fraser RA. Delayed epistaxis resulting from external carotid artery injury requiring embolization: a rare complication of transsphenoidal surgery: case report. Neurosurgery. 2000;47(1):236–9.

    CAS  PubMed  Google Scholar 

  11. Nishioka H, Ohno S, Ikeda Y, Ohashi T, Haraoka J. Delayed massive epistaxis following endonasal transsphenoidal surgery. Acta Neurochir. 2007;149:523–7.

    CAS  PubMed  Google Scholar 

  12. Raymond J, Hardy J, Czepko R, Roy D. Arterial injuries in transsphenoidal surgery for pituitary adenoma, the role of angiography and endovascular treatment. Am J Neuroradiol. 1997;18(4):655–65.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Berker M, Hazer DB, Yucel T, et al. Complications of endoscopic surgery of the pituitary adenomas: analysis of 570 patients and review of the literature. Pituitary. 2012;15(3):288–300.

    PubMed  Google Scholar 

  14. Cappabianca P, Cavallo LM, Colao A, de Divitiis E. Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg. 2002;97(2):293–8.

    PubMed  Google Scholar 

  15. Charalampaki P, Ayyad A, Kockro RA, Perneczky A. Surgical complications after endoscopic transphenoidal pituitary surgery. J Clin Neurosci. 2009;16(6):786–9.

    PubMed  Google Scholar 

  16. Dehdashti AR, Ganna A, Karabatsou K, Gentili F. Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery. 2008;62(5):1006–15; discussion 1015–7.

    Google Scholar 

  17. Harvey RJ, Nogueira JF, Schlosser RJ, Patel SJ, Vellutini E, Stamm AC. Closure of large skull base defects after endoscopic transnasal craniotomy. Clinical article. J Neurosurg. 2009;111(2):371–9.

    PubMed  Google Scholar 

  18. Messerer M, De Battista JC, Raverot G, et al. Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal. Neurosurg Focus. 2011;30(4):E11.

    PubMed  Google Scholar 

  19. Tabaee A, Anand VK, Barron Y, et al. Endoscopic pituitary surgery: a systematic review and meta-analysis. J Neurosurg. 2009;111(3):545–54.

    PubMed  Google Scholar 

  20. Rivera-Serrano CM, Snyderman CH, Gardner P, et al. Nasoseptal “rescue” flap: a novel modification of the nasoseptal flap technique for pituitary surgery. Laryngoscope. 2011;121(5):990–3.

    PubMed  Google Scholar 

  21. Fatemi N, Dusick JR, de Paiva Neto MA, Kelly DF. The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery. 2008;63(4):244–56.

    PubMed  Google Scholar 

  22. Black PM, Zervas NT, Candia GL. Incidence and management of complications of transsphenoidal operation for pituitary adenomas. Neurosurgery. 1987;20(6):920–4.

    CAS  PubMed  Google Scholar 

  23. Cavallo L, Briganti F, Cappabianca P, et al. Hemorrhagic vascular complications of endoscopic transsphenoidal surgery. Minim Invasive Neurosurg MIN. 2004;47(3):145–50.

    CAS  PubMed  Google Scholar 

  24. Couldwell WT, Weiss MH, Rabb C, Liu JK, Apfelbaum RI, Fukushima T. Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases. Neurosurgery. 2004;55(3):539–50.

    PubMed  Google Scholar 

  25. Laws Jr ER. Vascular complications of transsphenoidal surgery. Pituitary. 1999;2(2):163–70.

    PubMed  Google Scholar 

  26. Zada G, Agarwalla PK, Mukundan Jr S, Dunn I, Golby AJ, Laws Jr ER. The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery. J Neurosurg. 2011;114(5):1319.

    PubMed  PubMed Central  Google Scholar 

  27. Weinberger DG, Anand VK, Al-Rawi M, Cheng HJ, Messina AV. Surgical anatomy and variations of the Onodi cell. Am J Rhinol. 1996;10(6):365–70.

    Google Scholar 

  28. Dusick JR, Esposito F, Malkasian D, Kelly DF. Avoidance of carotid artery injuries in transsphenoidal surgery with the doppler probe and micro-hook blades. Neurosurgery. 2007;60(4):322–9.

    PubMed  Google Scholar 

  29. Pham M, Kale A, Marquez Y, et al. A perfusion-based human cadaveric model for management of carotid artery injury during endoscopic endonasal skull base surgery. J Neurol Surg B Skull Base. 2014;75(5):309–13.

    PubMed  PubMed Central  Google Scholar 

  30. Ciric I, Ragin A, Baumgartner C, Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery. 1997;40(2):225–36; discussion 236–7.

    Google Scholar 

  31. Wang J, Bidari S, Inoue K, Yang H, Rhoton Jr A. Extensions of the sphenoid sinus: a new classification. Neurosurgery. 2010;66(4):797–816.

    PubMed  Google Scholar 

  32. Gardner PA, Kassam AB, Snyderman CH, et al. Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series. J Neurosurg. 2008;109(1):6–16.

    PubMed  Google Scholar 

  33. Kassam AB, Prevedello DM, Carrau RL, et al. The front door to Meckel’s cave: an anteromedial corridor via expanded endoscopic endonasal approach—technical considerations and clinical series. Neurosurgery. 2009;64(3):ons71–83.

    PubMed  Google Scholar 

  34. Shiley SG, Limonadi F, Delashaw JB, et al. Incidence, etiology, and management of cerebrospinal fluid leaks following trans-sphenoidal surgery. Laryngoscope. 2003;113(8):1283–8.

    PubMed  Google Scholar 

  35. Patel KS, Komotar RJ, Szentirmai O, et al. Case-specific protocol to reduce cerebrospinal fluid leakage after endonasal endoscopic surgery: clinical article. J Neurosurg. 2013;119(3):661–8.

    PubMed  Google Scholar 

  36. Kassam AB, Thomas A, Carrau RL, et al. Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap. Neurosurgery. 2008;63:ONS44–53.

    PubMed  Google Scholar 

  37. Rawal RB, Kimple AJ, Dugar DR, Zanation AM. Minimizing morbidity in endoscopic pituitary surgery: outcomes of the novel nasoseptal rescue flap technique. Otolaryngol Head Neck Surg. 2012;147(3):434–7.

    PubMed  Google Scholar 

  38. Zanation AM, Carrau RL, Snyderman CH, et al. Nasoseptal flap reconstruction of high flow intraoperative cerebral spinal fluid leaks during endoscopic skull base surgery. Am J Rhinol Allergy. 2009;23(5):518–21.

    PubMed  Google Scholar 

  39. McCoul E, Anand V, Singh A, Nyquist G, Schaberg M, Schwartz T. Long-term effectiveness of a reconstructive protocol using the nasoseptal flap after endoscopic skull base surgery. World Neurosurg. 2012;81(1):136-43

    Google Scholar 

  40. Hadad G, Bassagasteguy L, Carrau R, et al. A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. 2006;116(10):1882.

    PubMed  Google Scholar 

  41. Nishioka H, Haraoka J, Ikeda Y. Risk factors of cerebrospinal fluid rhinorrhea following transsphenoidal surgery. Acta Neurochir. 2005;147(11):1163–6.

    CAS  PubMed  Google Scholar 

  42. Kaptain GJ, Kanter AS, Hamilton DK, Laws ER. Management and implications of intraoperative cerebrospinal fluid leak in transnasoseptal transsphenoidal microsurgery. Neurosurgery. 2011;68:ons144–51.

    Google Scholar 

  43. Mehta GU, Oldfield EH. Prevention of intraoperative cerebrospinal fluid leaks by lumbar cerebrospinal fluid drainage during surgery for pituitary macroadenomas: clinical article. J Neurosurg. 2012;116(6):1299–303.

    PubMed  Google Scholar 

  44. Griffiths CF, Cutler AR, Duong HT, et al. Avoidance of postoperative epistaxis and anosmia in endonasal endoscopic skull base surgery: a technical note. Acta Neurochir. 2014;156(7):1393–401.

    PubMed  Google Scholar 

  45. Garcia-Navarro V, Anand VK, Schwartz TH. Gasket seal closure for extended endonasal endoscopic skull base surgery: efficacy in a large case series. World Neurosurg. 2013;80(5):563–8.

    PubMed  Google Scholar 

  46. Sade B, Mohr G, Frenkiel S. Management of intra-operative cerebrospinal fluid leak in transnasal transsphenoidal pituitary microsurgery: use of post-operative lumbar drain and sellar reconstruction without fat packing. Acta Neurochir. 2006;148(1):13.

    CAS  PubMed  Google Scholar 

  47. Açikbaş S, Akyüz M, Kazan S, Tuncer R. Complications of closed continuous lumbar drainage of cerebrospinal fluid. Acta Neurochir. 2002;144(5):475.

    PubMed  Google Scholar 

  48. Roland P, Marple B, Meyerhoff W, Mickey B. Complications of lumbar spinal fluid drainage. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol Head Neck Surg. 1992;107(4):564.

    CAS  Google Scholar 

  49. Haran R, Chandy M. Symptomatic pneumocephalus after transsphenoidal surgery. Surg Neurol. 1997;48(6):575.

    CAS  PubMed  Google Scholar 

  50. Sawka A, Aniszewski J, Young Jr W, Nippoldt T, Yanez P, Ebersold M. Tension pneumocranium, a rare complication of transsphenoidal pituitary surgery: Mayo Clinic experience 1976-1998. J Clin Endocrinol Metab. 1999;84(12):4731.

    CAS  PubMed  Google Scholar 

  51. Schade R, Schinkel J, Visser L, Van Dijk J, Voormolen J, Kuijper E. Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters. J Neurosurg. 2005;102(2):229.

    PubMed  Google Scholar 

  52. Schade R, Schinkel J, Roelandse F, et al. Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis. J Neurosurg. 2006;104(1):101.

    PubMed  Google Scholar 

  53. Grady R, Horlocker T, Brown R, Maxson P, Schroeder D. Neurologic complications after placement of cerebrospinal fluid drainage catheters and needles in anesthetized patients: implications for regional anesthesia. Mayo Perioperative Outcomes Group. Anesth Analg. 1999;88(2):388.

    CAS  PubMed  Google Scholar 

  54. Hoekema D, Schmidt R, Ross I. Lumbar drainage for subarachnoid hemorrhage: technical considerations and safety analysis. Neurocrit Care. 2007;7(1):3.

    PubMed  Google Scholar 

  55. Simmerman S, Fahy B. Retained fragment of a lumbar subarachnoid drain. J Neurosurg Anesthesiol. 1997;9(2):159.

    CAS  PubMed  Google Scholar 

  56. Brown SM, Anand VK, Tabaee A, Schwartz TH. Role of perioperative antibiotics in endoscopic skull base surgery. Laryngoscope. 2007;117(9):1528–32.

    CAS  PubMed  Google Scholar 

  57. Orlando R, Cappabianca P, Tosone G, Esposito F, Piazza M, de Divitiis E. Retrospective analysis of a new antibiotic chemoprophylaxis regimen in 170 patients undergoing endoscopic endonasal transsphenoidal surgery. Surg Neurol. 2007;68(2):145–8.

    PubMed  Google Scholar 

  58. Lai LT, Trooboff S, Morgan MK, Harvey RJ. The risk of meningitis following expanded endoscopic endonasal skull base surgery: a systematic review. J Neurol Surg B Skull Base. 2014;75(1):18.

    PubMed  Google Scholar 

  59. Jahangiri A, Wagner J, Han SW, et al. Morbidity of repeat transsphenoidal surgery assessed in more than 1000 operations: clinical article. J Neurosurg. 2014;121(1):67–74.

    PubMed  Google Scholar 

  60. Little AS, White WL. Short-duration, single-agent antibiotic prophylaxis for meningitis in trans-sphenoidal surgery. Pituitary. 2011;14(4):335–9.

    PubMed  Google Scholar 

  61. Kono Y, Prevedello DM, Snyderman CH, et al. One thousand endoscopic skull base surgical procedures demystifying the infection potential: incidence and description of postoperative meningitis and brain abscesses. Infect Control Hosp Epidemiol. 2011;32(01):77–83.

    PubMed  Google Scholar 

  62. van Aken MO, de Marie S, van der Lely A-J, et al. Risk factors for meningitis after transsphenoidal surgery. Clin Infect Dis. 1997;25(4):852–6.

    PubMed  Google Scholar 

  63. Fatemi N, Dusick JR, Mattozo C, et al. Pituitary hormonal loss and recovery after transsphenoidal adenoma removal. Neurosurgery. 2008;63(4):709–19.

    PubMed  Google Scholar 

  64. Losa M, Mortini P, Barzaghi R, et al. Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence. J Neurosurg. 2008;108(3):525–32.

    PubMed  Google Scholar 

  65. Barkhoudarian G, Cutler AR, Yost S, Lobo B, Eisenberg A, Kelly DF. Impact of selective pituitary gland incision or resection on hormonal function after adenoma or cyst resection. Pituitary. 2015;18(6):868–75.

    CAS  PubMed  Google Scholar 

  66. Laws ER, Jane Jr JA. Pituitary tumors – long-term outcomes and expectations. Clin Neurosurg. 2001;48:306–19.

    CAS  PubMed  Google Scholar 

  67. Nemergut EC, Zuo Z, Jane Jr JA, Laws Jr ER. Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients. J Neurosurg. 2005;103(3):448–54.

    PubMed  Google Scholar 

  68. Bordo G, Kelly K, McLaughlin N, et al. Sellar masses that present with severe hyponatremia. Endocr Pract. 2014;20(11):1178–86.

    PubMed  Google Scholar 

  69. Bohl MA, Ahmad S, Jahnke H, et al. Delayed hyponatremia is the most common cause of 30-day unplanned readmission after transsphenoidal surgery for pituitary tumors. Neurosurgery. 2016;78(1):84–90.

    PubMed  Google Scholar 

  70. Kristof RA, Rother M, Neuloh G, Klingmüller D. Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study: clinical article. J Neurosurg. 2009;111(3):555–62.

    PubMed  Google Scholar 

  71. Colao A, Cerbone G, Cappabianca P, et al. Effect of surgery and radiotherapy on visual and endocrine function in nonfunctioning pituitary adenomas. J Endocrinol Investig. 1998;21(5):284–90.

    CAS  Google Scholar 

  72. Nomikos P, Ladar C, Fahlbusch R, Buchfelder M. Impact of primary surgery on pituitary function in patients with non-functioning pituitary adenomas–a study on 721 patients. Acta Neurochir. 2004;146(1):27–35.

    CAS  PubMed  Google Scholar 

  73. Webb SM, Rigla M, Wägner A, Oliver B, Bartumeus F. Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas. J Clin Endocrinol Metab. 1999;84(10):3696–700.

    CAS  PubMed  Google Scholar 

  74. Inder W, Hunt P. Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab. 2002;87(6):2745.

    CAS  PubMed  Google Scholar 

  75. Nemergut E, Dumont A, Barry U, Laws E. Perioperative management of patients undergoing transsphenoidal pituitary surgery. Anesth Analg. 2005;101(4):1170.

    PubMed  Google Scholar 

  76. Zimmerman M, Coryell W. The dexamethasone suppression test in healthy controls. Psychoneuroendocrinology. 1987;12(4):245.

    CAS  PubMed  Google Scholar 

  77. Keleştimur F. Sheehan’s syndrome. Pituitary. 2003;6(4):181.

    PubMed  Google Scholar 

  78. Vance M. Perioperative management of patients undergoing pituitary surgery. Endocrinol Metab Clin N Am. 2003;32(2):355.

    Google Scholar 

  79. Loh J, Verbalis J. Diabetes insipidus as a complication after pituitary surgery. Nat Clin Pract Endocrinol Metab. 2007;3(6):489.

    PubMed  Google Scholar 

  80. Zada G, Liu C, Fishback D, Singer P, Weiss M. Recognition and management of delayed hyponatremia following transsphenoidal pituitary surgery. J Neurosurg. 2007;106(1):66.

    CAS  PubMed  Google Scholar 

  81. Kelleher H, Henderson S. Severe hyponatremia due to desmopressin. J Emerg Med. 2006;30(1):45.

    PubMed  Google Scholar 

  82. Palmer B, Gates J, Lader M. Causes and management of hyponatremia. Ann Pharmacother. 2003;37(11):1694.

    PubMed  Google Scholar 

  83. Blumenberg R, Barton E, Gelfand M, Skudder P, Brennan J. Occult deep venous thrombosis complicating superficial thrombophlebitis. J Vasc Surg Off Publ Soc Vasc Surg Int Soc Cardiovasc Surg North Am Chapter. 1998;27(2):338.

    CAS  Google Scholar 

  84. Chengelis D, Bendick P, Glover J, Brown O, Ranval T. Progression of superficial venous thrombosis to deep vein thrombosis. J Vasc Surg Off Publ Soc Vasc Surg Int Soc Cardiovasc Surg North Am Chapter. 1996;24(5):745.

    CAS  Google Scholar 

  85. Grüne F, Schrappe M, Basten J, Wenchel H, Tual E, Stützer H. Phlebitis rate and time kinetics of short peripheral intravenous catheters. Infection. 2004;32(1):30.

    PubMed  Google Scholar 

  86. Tagalakis V, Kahn S, Libman M, Blostein M. The epidemiology of peripheral vein infusion thrombophlebitis: a critical review. Am J Med. 2002;113(2):146.

    PubMed  Google Scholar 

  87. Belcaro G, Nicolaides A, Errichi B, et al. Superficial thrombophlebitis of the legs: a randomized, controlled, follow-up study. Angiology. 1999;50(7):523.

    CAS  PubMed  Google Scholar 

  88. Scheer BV, Perel A, Pfeiffer UJ. Clinical review: complications and risk factors of peripheral arterial catheters used for haemodynamic monitoring in anaesthesia and intensive care medicine. Crit Care. 2002;6(3):199.

    PubMed  PubMed Central  Google Scholar 

  89. McGee D, Gould M. Preventing complications of central venous catheterization. N Engl J Med. 2003;348(12):1123.

    PubMed  Google Scholar 

  90. Merrer J, De Jonghe B, Golliot F, et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA. 2001;286(6):700.

    CAS  PubMed  Google Scholar 

  91. Hartrey R, Kestin I. Movement of oral and nasal tracheal tubes as a result of changes in head and neck position. Anaesthesia. 1995;50(8):682.

    CAS  PubMed  Google Scholar 

  92. Toung T, Grayson R, Saklad J, Wang H. Movement of the distal end of the endotracheal tube during flexion and extension of the neck. Anesth Analg. 1985;64(10):1030.

    CAS  PubMed  Google Scholar 

  93. Kitahata L. Airway difficulties associated with anaesthesia in acromegaly. Three case reports. Br J Anaesth. 1971;43(12):1187.

    CAS  PubMed  Google Scholar 

  94. Messick Jr J, Cucchiara R, Faust R. Airway management in patients with acromegaly. Anesthesiology. 1982;56(2):157.

    PubMed  Google Scholar 

  95. Ovassapian A, Doka J, Romsa D. Acromegaly – use of fiberoptic laryngoscopy to avoid tracheostomy. Anesthesiology. 1981;54(5):429.

    CAS  PubMed  Google Scholar 

  96. Young ML, Hanson 3rd C. An alternative to tracheostomy following transsphenoidal hypophysectomy in a patient with acromegaly and sleep apnea. Anesth Analg. 1993;76(2):446.

    CAS  PubMed  Google Scholar 

  97. Juvin P, Lavaut E, Dupont H, et al. Difficult tracheal intubation is more common in obese than in lean patients. Anesth Analg. 2003;97(2):595.

    PubMed  Google Scholar 

  98. Drinka P. Complications of chronic indwelling urinary catheters. J Am Med Dir Assoc. 2006;7(6):388.

    PubMed  Google Scholar 

  99. Platt R, Polk B, Murdock B, Rosner B. Risk factors for nosocomial urinary tract infection. Am J Epidemiol. 1986;124(6):977.

    CAS  PubMed  Google Scholar 

  100. Warren J. Catheter-associated urinary tract infections. Infect Dis Clin N Am. 1997;11(3):609.

    CAS  Google Scholar 

  101. Tambyah P, Maki D. Catheter-associated urinary tract infection is rarely symptomatic: a prospective study of 1,497 catheterized patients. Arch Intern Med. 2000;160(5):678.

    CAS  PubMed  Google Scholar 

  102. Tambyah P, Maki D. The relationship between pyuria and infection in patients with indwelling urinary catheters: a prospective study of 761 patients. Arch Intern Med. 2000;160(5):673.

    CAS  PubMed  Google Scholar 

  103. Stallard S, Prescott S. Postoperative urinary retention in general surgical patients. Br J Surg. 1988;75(11):1141.

    CAS  PubMed  Google Scholar 

  104. Tammela T, Kontturi M, Lukkarinen O. Postoperative urinary retention. I. Incidence and predisposing factors. Scand J Urol Nephrol. 1986;20(3):197.

    CAS  PubMed  Google Scholar 

  105. Alessandri F, Mistrangelo E, Lijoi D, Ferrero S, Ragni N. A prospective, randomized trial comparing immediate versus delayed catheter removal following hysterectomy. Acta Obstet Gynecol Scand. 2006;85(6):716.

    PubMed  Google Scholar 

  106. Cravens D, Zweig S. Urinary catheter management. Am Fam Physician. 2000;61(2):369.

    CAS  PubMed  Google Scholar 

  107. Yoshikawa T, Nicolle L, Norman D. Management of complicated urinary tract infection in older patients. J Am Geriatr Soc. 1996;44(10):1235.

    CAS  PubMed  Google Scholar 

  108. Chandler M. Tracheal intubation and sore throat: a mechanical explanation. Anaesthesia. 2002;57(2):155.

    CAS  PubMed  Google Scholar 

  109. Lacau SGJ, Boisson-Bertrand D, Monnier P. Lesions to lips, oral and nasal cavities, pharynx, larynx, trachea and esophagus due to endotracheal intubation and its alternatives. Paper presented at: Annales françaises d'anesthèsie et de rèanimation. 2003.

    Google Scholar 

  110. Lieberman P. Anaphylactic reactions during surgical and medical procedures. J Allergy Clin Immunol. 2002;110(2 Suppl):S64.

    PubMed  Google Scholar 

  111. Tarrac S. A description of intraoperative and postanesthesia complication rates. J Perianesth Nurs Off J Am Soc PeriAnesth Nurs/Am Soc PeriAnesth Nurs. 2006;21(2):88.

    Google Scholar 

  112. Grover V, Kumar K, Sharma S, Sethi N, Grewal S. Comparison of methods of eye protection under general anaesthesia. Can J Anaesth J Canadien d'anesthésie. 1998;45(6):575.

    CAS  Google Scholar 

  113. White E, Crosse M. The aetiology and prevention of peri-operative corneal abrasions. Anaesthesia. 1998;53(2):157.

    CAS  PubMed  Google Scholar 

  114. Bloomfield E, Schubert A, Secic M, Barnett G, Shutway F, Ebrahim Z. The influence of scalp infiltration with bupivacaine on hemodynamics and postoperative pain in adult patients undergoing craniotomy. Anesth Analg. 1998;87(3):579.

    CAS  PubMed  Google Scholar 

  115. Berry C, Sandberg D, Hoh D, Krieger M, McComb J. Use of cranial fixation pins in pediatric neurosurgery. Neurosurgery. 2008;62(4):913.

    PubMed  Google Scholar 

  116. Lee MJ, Lin EL. The use of the three-pronged Mayfield head clamp resulting in an intracranial epidural hematoma in an adult patient. Eur Spine J. 2010;19(Suppl 2):187.

    PubMed Central  Google Scholar 

  117. Bruce I, Simmons M, Hampal S. ‘Horseshoe-shaped’post-operative alopecia following lengthy head and neck surgery. J Laryngol Otol. 2002;116(3):230.

    CAS  PubMed  Google Scholar 

  118. Davies K, Yesudian P. Pressure alopecia. Int J Trichol. 2012;4(2):64.

    Google Scholar 

  119. Bilgen C, Oner K, Ovül I, Uluöz U. ‘The columellotomy modification’ of transseptal hypophysectomy. Auris Nasus Larynx. 2003;30(2):153.

    PubMed  Google Scholar 

  120. Wilson W, Khan A, Laws Jr E. Transseptal approaches for pituitary surgery. Laryngoscope. 1990;100(8):817.

    CAS  PubMed  Google Scholar 

  121. Zada G, Kelly D, Cohan P, Wang C, Swerdloff R. Endonasal transsphenoidal approach for pituitary adenomas and other sellar lesions: an assessment of efficacy, safety, and patient impressions. J Neurosurg. 2003;98(2):350.

    PubMed  Google Scholar 

  122. Jane Jr J, Han J, Prevedello D, Jagannathan J, Dumont A, Laws Jr E. Perspectives on endoscopic transsphenoidal surgery. Neurosurg Focus. 2005;19(6):E2.

    PubMed  Google Scholar 

  123. Spencer W, Levine J, Couldwell W, Brown-Wagner M, Moscatello A. Approaches to the sellar and parasellar region: a retrospective comparison of the endonasal-transsphenoidal and sublabial-transsphenoidal approaches. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol Head Neck Surg. 2000;122(3):367.

    CAS  Google Scholar 

  124. Alobid I, Enseñat J, Mariño-Sánchez F, et al. Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularised septal flap reconstruction for skull base tumors. Neurosurgery. 2012;72(4): 540–546.

    Google Scholar 

  125. Black P, Zervas N, Candia G. Management of large pituitary adenomas by transsphenoidal surgery. Surg Neurol. 1988;29(6):443.

    CAS  PubMed  Google Scholar 

  126. Dusick J, Esposito F, Mattozo C, Chaloner C, McArthur D, Kelly D. Endonasal transsphenoidal surgery: the patient’s perspective-survey results from 259 patients. Surg Neurol. 2006;65(4):332.

    PubMed  Google Scholar 

  127. Sharma K, Tyagi I, Banerjee D, Chhabra D, Kaur A, Taneja H. Rhinological complications of sublabial transseptal transsphenoidal surgery for sellar and suprasellar lesions: prevention and management. Neurosurg Rev. 1996;19(3):163.

    CAS  PubMed  Google Scholar 

  128. Rodziewicz G, Kelley R, Kellman R, Smith M. Transnasal endoscopic surgery of the pituitary gland: technical note. Neurosurgery. 1996;39(1):189.

    CAS  PubMed  Google Scholar 

  129. Leonhard M, Cappabianca P, de Divitiis E. The endoscope, endoscopic equipment and instrumentation. In:Endoscopic endonasal transsphenoidal surgery. Vienna: Springer; 2003. p. 9–19.

    Google Scholar 

  130. Yaniv E, Rappaport Z. Endoscopic transseptal transsphenoidal surgery for pituitary tumors. Neurosurgery. 1997;40(5):944.

    CAS  PubMed  Google Scholar 

  131. Gutowski K, ASPS FGTF. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg. 2009;124(1):272.

    CAS  PubMed  Google Scholar 

  132. Porter K, O'Connor S, Rimm E, Lopez M. Electrocautery as a factor in seroma formation following mastectomy. Am J Surg. 1998;176(1):8.

    CAS  PubMed  Google Scholar 

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Correspondence to Garni Barkhoudarian MD .

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Barkhoudarian, G., Kelly, D.F. (2017). Complications with Transsphenoidal Surgery: A Review. In: Laws, Jr, E.R., Cohen-Gadol, A.A., Schwartz, T.H., Sheehan, J.P. (eds) Transsphenoidal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-56691-7_19

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