Abstract
This study aims to estimate and describe the incidence of adverse events (AE) registered in Portuguese public hospitals and consequently to determine the feasibility of using hospital administrative data as a tool for AE surveillance. A retrospective observational study using hospital administrative data was performed to detect the incidence of AE based on a selection of ICD-9-CM codes (diagnoses and external causes). All episodes in public hospitals in the period 2000–2010 were included. AE were divided in three main categories: complications of surgical or medical procedures, misadventures of surgical and medical care, and adverse drug events (ADE). The ADE subgroup was further subdivided in: poisoning, late effect, and adverse drug reaction. Over the studied period, the algorithm was able to detect 543,242 episodes with AE events (3.7% of all episodes), with an in-hospital mortality rate of 6.3%, and a median length-of-stay of 8 days. In a scenario of underreporting of AE, this administrative data approach in an important complement to the other existing surveillance techniques.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hazell, L., Shakir, S.A.: Under-reporting of adverse drug reactions: a systematic review. Drug Saf. 29(5), 385–396 (2006)
Stergiopoulos, S., Brown, C.A., Felix, T., Grampp, G., Getz, K.A.: A survey of adverse event reporting practices among us healthcare professionals. Drug Saf. 39(11), 1117–1127 (2016)
Griffin, F.A., Resar, R.K.: IHI Global Trigger Tool for Measuring Adverse Events, 2nd edn. IHI Innovation Series White Paper. Institute for Healthcare Improvement, Cambridge (2009). www.IHI.org
Ker, K., Edwards, P., Roberts, I.: Misadventures to patients during surgical and medical care in England and Wales: an analysis of deaths and hospital episodes. J. R. Soc. Med. 104(7), 292–298 (2011). doi:10.1258/jrsm.2011.100408
Sharek, P.J., Parry, G., Goldmann, D., Bones, K., Hackbarth, A., Resar, R., Griffin, F.A., Rhoda, D., Murphy, C., Landrigan, C.P.: Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients. Health Serv. Res. 46(2), 654–678 (2011). doi:10.1111/j.1475-6773.2010.01156.x
Michel, P., Quenon, J.L., Djihoud, A., Tricaud-Vialle, S., de Sarasqueta, A.M.: French national survey of inpatient adverse events prospectively assessed with ward staff. Qual. Saf. Health Care. 16(5), 369–377 (2007)
Soop, M., Fryksmark, U., Köster, M., Haglund, B.: The incidence of adverse events in Swedish hospitals: a retrospective medical record review study. Int. J. Qual. Health Care 21(4), 285–291 (2009). doi:10.1093/intqhc/mzp025
Zegers, M., de Bruijne, M.C., Wagner, C., Hoonhout, L.H., Waaijman, R., Smits, M., Hout, F.A., Zwaan, L., Christiaans-Dingelhoff, I., Timmermans, D.R., Groenewegen, P.P., van der Wal, G.: Adverse events and potentially preventable deaths in Dutch hospitals: results of a retrospective patient record review study. Qual. Saf. Health Care 18(4), 297–302 (2009). doi:10.1136/qshc.2007.025924
Baker, G.R., Norton, P.G., Flintoft, V., Blais, R., Brown, A., Cox, J., Etchells, E., Ghali, W.A., Hébert, P., Majumdar, S.R., O’Beirne, M., Palacios-Derflingher, L., Reid, R.J., Sheps, S., Tamblyn, R.: The Canadian adverse events study: the incidence of adverse events among hospital patients in Canada. CMAJ 170(11), 1678–1686 (2004)
Levinson, D.: Adverse events in hospitals: methods for identifying events. Report no. OEI-06-08-00221, US Department of Health and Human Services, Office of the Inspector General, Washington, DC, March 2010
Miguel, A., Azevedo, L.F., Lopes, F., Freitas, A., Pereira, A.C.: Methodologies for the detection of adverse drug reactions: comparison of hospital databases, chart review and spontaneous reporting. Pharmacoepidemiol. Drug Saf. 22(1), 98–102 (2013). doi:10.1002/pds.3348
Avery, A.J., Anderson, C., Bond, C.M., Fortnum, H., Gifford, A., Hannaford, P.C., Hazell, L., Krska, J., Lee, A.J., McLernon, D.J., Murphy, E., Shakir, S., Watson, M.C.: Evaluation of patient reporting of adverse drug reactions to the UK ‘yellow card scheme’: literature review, descriptive and qualitative analyses, and questionnaire surveys. Health Technol. Assess. 15(20), 1–234, iii–iv. doi:10.3310/hta15200
Miguel, A., Bernardo, M., Freitas, A., Lopes, F., Azevedo, L., Pereira, A.C.: Detection of adverse drug reactions using hospital databases-a nationwide study in Portugal. Pharmacoepidemiol. Drug Saf. 22(8), 907–913 (2013). doi:10.1002/pds.3468
Miguel, A., Henriques, F., Azevedo, L.F., Pereira, A.C.: Ophthalmic adverse drug reactions to systemic drugs: a systematic review. Pharmacoepidemiol. Drug Saf. 23(3), 221–233 (2014). doi:10.1002/pds.3566
Sousa-Pinto, B., Freitas, A., Araújo, L.: CO 22 - Internamentos em crianças com registo de alergia a penicilinas: uma avaliação de custos, comorbilidades e tempo de internamento. Rev Portuguesa Imunoalergologia (2016)
Hougland, P., Xu, W., Pickard, S., Masheter, C., Williams, S.D.: Performance of international classification of diseases, 9th revision, clinical modification codes as an adverse drug event surveillance system. Med. Care 44(7), 629–636 (2006)
Bourgeois, F.T., Mandl, K.D., Valim, C., Shannon, M.W.: Pediatric adverse drug events in the outpatient setting: an 11-year national analysis. Pediatrics 124(4), e744–e750 (2009). doi:10.1542/peds.2008-3505
Sarkar, U., López, A., Maselli, J.H., Gonzales, R.: Adverse drug events in U.S. adult ambulatory medical care. Health Serv. Res. 46(5), 1517–1533 (2011). doi:10.1111/j.1475-6773.2011.01269.x
Utah health data committee. adverse events related to medical care, Utah (1995–1999). Utah Department of Health, Salt Lake City, UT (2001)
Morimoto, T., Gandhi, T.K., Seger, A.C., Hsieh, T.C., Bates, D.W.: Adverse drug events and medication errors: detection and classification methods. Qual. Saf. Health Care. 13(4), 306–314 (2004)
Evans, R.S., Classen, D.C., Stevens, L.E., Pestotnik, S.L., Gardner, R.M., Lloyd, J.F., Burke, J.P.: Using a hospital information system to assess the effects of adverse drug events. In: Proceedings of Annual Symposium on Computer Application in Medical Care, pp. 161–165 (1993)
Tuinen, M.V., Elder, S., Link, C., Li, S., Song, J.H., Pritchett, T.: Surveillance of surgery-related adverse events in Missouri using ICD-9-CM codes. In: Henriksen, K., Battles, J.B., Marks, E.S., Lewin, D.I. (eds.) Advances in Patient Safety: From Research to Implementation, vol. 1, Research Findings. Agency for Healthcare Research and Quality (US), Rockville, MD, February 2005
Nebeker, J.R., Barach, P., Samore, M.H.: Clarifying adverse drug events: a clinician’s guide to terminology, documentation, and reporting. Ann. Int. Med. 140(10), 795–801 (2004)
WHO: International drug monitoring. The role of the hospital. World Health Organ. Tech. Rep. Ser. 425, 5–24 (1969)
Johnston, K., Vowels, M., Carroll, S., Neville, K., Cohn, R.: Failure to lactate: a possible late effect of cranial radiation. Pediatr. Blood Cancer 50(3), 721–722 (2008)
Freitas, A., Silva-Costa, T., Marques, B., Costa-Pereira, A.: Implications of data quality problems within hospital administrative databases. In: Bamidis, P.D., Pallikarakis, N. (eds.) IFMBE Proceedings, vol. 29, 823–826. Springer, Heidelberg (2010)
Saff, R.R., Camargo, C.A. Jr., Clark, S., Rudders, S.A., Long, A.A., Banerji, A.: Utility of ICD-9-CM codes for identification of allergic drug reactions. J. Allergy Clin. Immunol. Pract. 4(1), 114–119.e1 (2016). doi:10.1016/j.jaip.2015.07.013
Hougland, P., Nebeker, J., Pickard, S., Van Tuinen, M., Masheter, C., Elder, S., Williams, S., Xu, W.: Using ICD-9-CM codes in hospital claims data to detect adverse events in patient safety surveillance. In: Henriksen, K., Battles, J.B., Keyes, M.A., Grady, M.L. (eds.) Advances in Patient Safety: New Directions and Alternative Approaches, vol. 1, Assessment. Agency for Healthcare Research and Quality, Rockville (MD) (2008)
Hohl, C.M., Kuramoto, L., Yu, E., Rogula, B., Stausberg, J., Sobolev, B.: Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study. BMC Health Serv. Res. 12(13), 473 (2013). doi:10.1186/1472-6963-13-473
Murff, H.J., Patel, V.L., Hripcsak, G., Bates, D.W.: Detecting adverse events for patient safety research: a review of current methodologies. J. Biomed. Inf. 36(1–2), 131–143 (2003)
Acknowledgments
The authors would like to thank the support given by the Project “NORTE-01-0145-FEDER-000016” (NanoSTIMA), financed by the North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, and through the European Regional Development Fund (ERDF). The authors wish also to thank the Portuguese Ministry of Health’s Authority for Health Services (Administração Central do Sistema de Saúde I. P. – ACSS) for providing access to national hospitalizations data.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Marques, B., Sousa-Pinto, B., Silva-Costa, T., Lopes, F., Freitas, A. (2017). Detection of Adverse Events Through Hospital Administrative Data. In: Rocha, Á., Correia, A., Adeli, H., Reis, L., Costanzo, S. (eds) Recent Advances in Information Systems and Technologies. WorldCIST 2017. Advances in Intelligent Systems and Computing, vol 570. Springer, Cham. https://doi.org/10.1007/978-3-319-56538-5_83
Download citation
DOI: https://doi.org/10.1007/978-3-319-56538-5_83
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-56537-8
Online ISBN: 978-3-319-56538-5
eBook Packages: EngineeringEngineering (R0)